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If accutane and other toxins are expelled, if the body return to a good state, those "epigenetic" change will be no more, the body will readapt itself. It's just that the body can't deal with all things at the same times. Epigenetic is a really bad excuse, i'm convinced of that, at least saying that it's permanent. If it was permanent, my neurological symptoms will be still here, but they are gone.
And epigenetic about accutane is just a theory, i don't even think that it can cause modification. I think accutane directly block some gene expression in certain part of the body but it's limited and doesn't do any modification. It affect the gene expression system in itself, not the mechanism who make a real modification or not (my opinion). If he was doing change, our body within 2 years will be completely malformated like babys who born after accutane, all trans retinoic acid regulate too much genes, if it was doing modification, we will be simply dead.
Isotherapy is homeopathy but with the exact same molecule who caused the problems. You can't do it yourself it's too dangerous.. ask an homeopathic lab. There is 1 or 2 who can do it in europe, don't know for usa.
Again, epigenetics, strictly defined, is about heritable changes in gene expression. What is being described here is any change in gene expression that can be induced by outside influences. They are not the same. Again, epigenetic changes are long term changes that are potentially heritable, and, as I pointed out above, most epigenetic changes are not passed on to offspring, certainly not to the point that they have a detectable effect on evolution. The rest is gene regulation, which is often transient but, depending on the process, can continue long term for as long as the stimulus causing the change in regulation is present. As is frequently pointed out, the quickest way to get an organ to start to return to normal is to stop doing the bad things to it that were causing it dysfunction in the first place. As P.Z. Myers put it:
In part, the root of the problem here is that were falling into an artificial dichotomy, that there is the gene as an enumerable, distinct character that can be plucked out and mapped as a fixed sequence of bits in a computer database, and there are all these messy cellular processes that affect what the gene does in the cell, and we try too hard to categorize these as separate. Its a lot like the nature-nurture controversy, where the real problem is that biology doesnt fall into these simple conceptual pigeonholes and we strain too hard to distinguish the indistinguishable. Grok the whole, people! You are the product of genes and cellular and environmental interactions.
Do you realize what you just did!?
Consider reading the entire article for a fine counterpoint to the argument you are trying to make here.
The article you linked openly bashes the alternative medicine community's misuse of epigenetic discoveries for the purpose of scamming customers. The author uses about two-thirds of the post for that purpose:
He is also griping about how loosely the idea of environmental factors reversing epigenetic modifications is thrown around.
If you think I'm not very open-minded, check out this guy's writings.
In fact, you should totally email him and ask him to chime-in on this thread with his thoughts on homeopathic isotherapy! That would be a treat.
There actually does seem to be a misunderstanding between you and me concerning our definitions of epigenetics.
You are thinking of isotretinoin's active influence on gene regulation/transcription, intracellular and extracellular signalling, hormonal profiles, etc...
You are right in saying those processes should theoretically cease soon after the drug is stopped.
I am speaking of isotretinoin's influence on heritable epigenetic traits through gene methylation. These alterations in methylation can persist through multiple generations of cells as described here:
http://www.aps.anl.gov/Science/Highlights/Content/APS_SCIENCE_20080910.php
Imagine having to copy an entire book by hand without missing a comma. Our cells face a similar task every time they divide. They must duplicate both their DNA and a subtle pattern of punctuation-like modifications on the DNA known as methylation.................
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Scientists refer to methylation, the addition of a methyl group to DNA, as an "epigenetic" modification because it adds a layer of information on top of the genetic sequence of the DNA itself. It marks genes for silencing, which means they do not manufacture proteins.
"The processes that copy the methylation pattern have to be faithful," says senior author Xiaodong Cheng, professor of biochemistry at Emory. "Otherwise, losing DNA methylation marks can have serious consequences, causing genes to become active at the wrong places and times."
These modifications often like to "stick" once they occur.
Why not actually read this instead of blowing it off?:
http://www.ncbi.nlm.nih.gov/pubmed/19501473
(This researcher, Anthony Csoka, also authored a paper concerning epigenetic mechanisms underlying persistent SSRI-related sexual dysfunction)
The term "Epigenetics" refers to DNA and chromatin modifications that persist from one cell division to the next, despite a lack of change in the underlying DNA sequence. The "epigenome" refers to the overall epigenetic state of a cell, and serves as an interface between the environment and the genome. The epigenome is dynamic and responsive to environmental signals not only during development, but also throughout life; and it is becoming increasingly apparent that chemicals can cause changes in gene expression that persist long after exposure has ceased. Here we present the hypothesis that commonly-used pharmaceutical drugs can cause such persistent epigenetic changes. Drugs may alter epigenetic homeostasis by direct or indirect mechanisms. Direct effects may be caused by drugs which affect chromatin architecture or DNA methylation. For example the antihypertensive hydralazine inhibits DNA methylation. An example of an indirectly acting drug is isotretinoin, which has transcription factor activity. A two-tier mechanism is postulated for indirect effects in which acute exposure to a drug influences signaling pathways that may lead to an alteration of transcription factor activity at gene promoters. This stimulation results in the altered expression of receptors, signaling molecules, and other proteins necessary to alter genetic regulatory circuits. With more chronic exposure, cells adapt by an unknown hypothetical process that results in more permanent modifications to DNA methylation and chromatin structure, leading to enduring alteration of a given epigenetic network. Therefore, any epigenetic side-effect caused by a drug may persist after the drug is discontinued. It is further proposed that some iatrogenic diseases such as tardive dyskinesia and drug-induced SLE are epigenetic in nature. If this hypothesis is correct the consequences for modern medicine are profound, since it would imply that our current understanding of pharmacology is an oversimplification. We propose that epigenetic side-effects of pharmaceuticals may be involved in the etiology of heart disease, cancer, neurological and cognitive disorders, obesity, diabetes, infertility, and sexual dysfunction. It is suggested that a systems biology approach employing microarray analyses of gene expression and methylation patterns can lead to a better understanding of long-term side-effects of drugs, and that in the future, epigenetic assays should be incorporated into the safety assessment of all pharmaceutical drugs. This new approach to pharmacology has been termed "phamacoepigenomics", the impact of which may be equal to or greater than that of pharmacogenetics. We provide here an overview of this potentially major new field in pharmacology and medicine.....................
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Excerpt: " The following adverse effects have been reported to persist, even after discontinuing therapy, suggesting persistent (or perhaps slowly-reversing) gene expression changes and epigenetic effects: alopecia, arthralgias, ocular abnormalities, inflammatory bowel disease, keloids, osteopenia, hyperlipidemia, erectile dysfunction, and psychiatric disturbances. Isotretinoin is postulated to have complex effects on the brain and central nervous system."
This is a theory, and also the only rational explanation concerning the persitency of our side effects, although it leaves much to be discovered.
If I'm writing science fiction here by relating Accutane to more specific epigenetic changes than the author of the above article, then Accutane being "gummed up" in our cells after several years or more is pure fantasy.
TaneAbomination: Thank you very much for taking the time to post your recovery here!
Yes, i linked this because he say that the environment influence gene expression, and is reversible if the thing who caused those perturbation of gene expression go away.
Anyway think what you want, but for me epigenetic is a complete scam people use to try to explain what they don't understand. My experience proved me i'm right.
The drug causes permanent damage no question , why are people chronically dehydrated , lose there hair , have joint pain years later , deal with depression and or anxiety , have dry red eyes , sexual dysfunction etc... years later , some people are just lucky due to there genetic makeup and have fewer side effects , also most people who took acctuane and
drink alcohol are hung over for days after why is that , permanent change that's why at a cellular level bottom line it's poison and there is a reason there are tons of law suits against the manufacturer Roche , some derms say it's the lesser of the evil meaning acne , I beg to disagree unless a person has severe cystic acne and
has tried everything else it's not worth the gamble of your future health. But here we are trying to solve problems caused by this drug , typical allopathic medicine
treat one problem and cause ten others ..... white coat ...... black art..... for me the best thing to do is exercise it makes me feel alive and good that's my remedy .
Ski season is back so that's what I'm doing... and loving it.
ps my word editor is ^&* up and doesn't space my sentences correctly sorry.... damn computers lol...
I totally agree with Annoy. It is clear that accutane stays in the body for a very long time 10-20 years or even more, it seems the more it stays in the body , more mineral and vitamin deficient it causes, also damage to the organs, cells and tissue . It's all about deficiency and toxicity , unfortunatelly it seems that most of us here had or still have those two problems that were caused by accutane.
The reason why I think some people take the drug and take longer or never get side effects are simply because their body detox organs such as the liver , pancreas , kidneys, skin etc were functioning better than the people who got the nasty side effects while taking accutane. You got keep in mind that accutane didn't do this alone, your body has to deal with thousands of toxins each day and remove it somehow from your system , such as Genetically modified organism, gluten, growth hormone ( dairy , meat ) ,fluoride, chlorine, aspartame, MSG, chemicals in tap water, chemicals and additives in your food, toxic vaccines with loads of mercury and aluminum in it and the list goes on and on .
Believe me guys. I spent a lot of time and money trying to find a cure, but the cure is within every single one of us. You just need to give your body time and don't do any harm to it ( every single pharmaceutical drugs does harm ) . Diet will help your body eliminate not only accutane but all the mucus, chemicals and heavy metals that you have consumed. First of, dairy and meat will clog you , even in small ammount, it will cause mucus and it will poison your body further . Gluten will do the same , and ruin your D.I tract, some grains also does damage .
It seems a bit extreme but the best healing program for accutane sufferes is a low fat raw vegan diet ( organic, fresh , natural fruits ,veggies some nuts and seeds ) and if you have the will power and motivation to do it a long water or juice fasting which will be a thousand times better than just the detox diet alone.
I came here to share this with you guys because I had the courage to change radically my lifestyle and heal myself. I used to live in Canada and I am now in the tropics , growing my own organic fruit and veggies. Accutane gave me some unbeliavable rough time but it has taught me so many great things . Hope you guys can heal all your problems soon..
cheers
"Every single pharmaceutical drugs does harm." I'm sorry but that's just ridiculous.
And I've said before that I'd be willing to pursue a low fat vegan or even raw diet, but I feel like some folks here are over correcting. I saw someone suggest that fluoride is part of our problem.
More importantly, none of you can prove that adhering to whatever diet/avoidance plan that worked for you will work for the next person, so it's just preposterous to claim that you have universal cures, to be frank. Not enough is known to make claims like that. Period.
Yes, i linked this because he say that the environment influence gene expression, and is reversible if the thing who caused those perturbation of gene expression go away.
Anyway think what you want, but for me epigenetic is a complete scam people use to try to explain what they don't understand. My experience proved me i'm right.
I'm a firm believer in doing whatever works for you, and I'm glad you were helped by your own treatments, but I think it is foolish to ignore the fact that the "Epigenetic hypothesis" is the most probable etiology in the case of long term Accutane side effects. I came to this conclusion independently, and then I was surprised to see like-mineded people propounding the same theory and presenting some of the same evidence that had convinced me. Its true that epigenetics is a shadowy area in medicine at this time, and as such, it is appropriate to be skeptical of it, but in order to beat this I feel that we must unite behind a single cause and investigate it until we come to some helpful conclusions. Reading this thread you can see that most people are throwing around anecdotal evidence and proposing all kinds of causes for our problems. Currently, this theory is the one that makes the most sense, given the scientific data.
I totally agree with Annoy. It is clear that accutane stays in the body for a very long time 10-20 years or even more, it seems the more it stays in the body , more mineral and vitamin deficient it causes, also damage to the organs, cells and tissue . It's all about deficiency and toxicity , unfortunatelly it seems that most of us here had or still have those two problems that were caused by accutane.
The reason why I think some people take the drug and take longer or never get side effects are simply because their body detox organs such as the liver , pancreas , kidneys, skin etc were functioning better than the people who got the nasty side effects while taking accutane. You got keep in mind that accutane didn't do this alone, your body has to deal with thousands of toxins each day and remove it somehow from your system , such as Genetically modified organism, gluten, growth hormone ( dairy , meat ) ,fluoride, chlorine, aspartame, MSG, chemicals in tap water, chemicals and additives in your food, toxic vaccines with loads of mercury and aluminum in it and the list goes on and on .
Believe me guys. I spent a lot of time and money trying to find a cure, but the cure is within every single one of us. You just need to give your body time and don't do any harm to it ( every single pharmaceutical drugs does harm ) . Diet will help your body eliminate not only accutane but all the mucus, chemicals and heavy metals that you have consumed. First of, dairy and meat will clog you , even in small ammount, it will cause mucus and it will poison your body further . Gluten will do the same , and ruin your D.I tract, some grains also does damage .
It seems a bit extreme but the best healing program for accutane sufferes is a low fat raw vegan diet ( organic, fresh , natural fruits ,veggies some nuts and seeds ) and if you have the will power and motivation to do it a long water or juice fasting which will be a thousand times better than just the detox diet alone.
I came here to share this with you guys because I had the courage to change radically my lifestyle and heal myself. I used to live in Canada and I am now in the tropics , growing my own organic fruit and veggies. Accutane gave me some unbeliavable rough time but it has taught me so many great things . Hope you guys can heal all your problems soon..
cheers
"Every single pharmaceutical drugs does harm." I'm sorry but that's just ridiculous.
And I've said before that I'd be willing to pursue a low fat vegan or even raw diet, but I feel like some folks here are over correcting. I saw someone suggest that fluoride is part of our problem.
More importantly, none of you can prove that adhering to whatever diet/avoidance plan that worked for you will work for the next person, so it's just preposterous to claim that you have universal cures, to be frank. Not enough is known to make claims like that. Period.
Every single pharmaceutical drug has side effects. This is what my doctor told me when I visited him last time. Just looking at TV ads for new drugs makes you aware of the bad possibilities that exist for every drug. Those ads, combined with my horrific experience with Accutane has given me a near-phobia of drugs, which I feel is quite justifiable.
100% understand about fear of pharmaceutical drugs. But Accutane is still in a class of its own, literally.
That said, I am terrified to take much of anything, too. I read an article where one gal cycled through 10+ antidepressants after Accutane to no avail. I am trying to find the article. She was so young.
I know the time is coming where my parents and I are going to get into a big argument as I do not wish to go on an antidepressant right now. I feel like it will be throwing darts at the problem. I am going to the Cleveland Clinic soon. Should be interesting. I expect it to be more diagnostic than curative.
100% understand about fear of pharmaceutical drugs. But Accutane is still in a class of its own, literally.
That said, I am terrified to take much of anything, too. I read an article where one gal cycled through 10+ antidepressants after Accutane to no avail. I am trying to find the article. She was so young.
I know the time is coming where my parents and I are going to get into a big argument as I do not wish to go on an antidepressant right now. I feel like it will be throwing darts at the problem. I am going to the Cleveland Clinic soon. Should be interesting. I expect it to be more diagnostic than curative.
If anything try lithium orotate a natural form of lithium with no negative side effects , and stay far away from ssri's all you need is more poison in your system , not good.
The drug causes permanent damage no question , why are people chronically dehydrated , lose there hair , have joint pain years later , deal with depression and or anxiety , have dry red eyes , sexual dysfunction etc... years later , some people are just lucky due to there genetic makeup and have fewer side effects , also most people who took acctuane and
drink alcohol are hung over for days after why is that , permanent change that's why at a cellular level bottom line it's poison and there is a reason there are tons of law suits against the manufacturer Roche , some derms say it's the lesser of the evil meaning acne , I beg to disagree unless a person has severe cystic acne and
has tried everything else it's not worth the gamble of your future health. But here we are trying to solve problems caused by this drug , typical allopathic medicine
treat one problem and cause ten others ..... white coat ...... black art..... for me the best thing to do is exercise it makes me feel alive and good that's my remedy .
Ski season is back so that's what I'm doing... and loving it.
ps my word editor is ^&* up and doesn't space my sentences correctly sorry.... damn computers lol...
The drug doesn't do permanent damage. It just temporarly poison the body and damage the liver, kidney, skin and make us impossible to get rid of accutane and other poison unless we stop eating bad food and take herbs & remedy to restore those organs. It's the only reason that the effects last so long, our body can't expell all of those toxins, repair the damage, etc.. at the same times, thanks to accutane he can't do any of this.
Epigenetic is a bad excuse, you can't reprogram your body that easy, it's nearly impossible.
Hair loss, gum problem, depression; sexual disfunction, etc.. is the same cause, acidity, toxicity, poisoned enteric nervous system (second brain) & exhaustion of our glandular system.
Anyway i give up, believe what you want, continue to search in other drugs & poison instead of changing your lifestyle and helping your body. It's just sad for you and people who maybe came for a cure and read your lies & negativity here, founded only on a really bad theory who is known false.
Those of who suffer super dry skin, hair loss, painful dry lips: read this:
http://www.victoriahealth.com/product/Skin-Restoring-Phytoceramides/9092
I been taking phytoceramides for a week now, and have noticed drastic improvements in my skin. Wouldn't have posted it here if i didnt see good results. I also started taking it together with hyaluronic acid to see if it can also help my joints.
@JosephBuchignani - you got it. No further summary necessary - although I did notice that AccutaneIsPoison's original post was removed which is a bit unnerving. Anyhow, end of the line for me. If that didn't work I was exploring very expensive stem cell therapy - thank goodness it didn't come to that. Cheers!
NIH research on cermides:
@JosephBuchignani - you got it. No further summary necessary - although I did notice that AccutaneIsPoison's original post was removed which is a bit unnerving. Anyhow, end of the line for me. If that didn't work I was exploring very expensive stem cell therapy - thank goodness it didn't come to that. Cheers!
Pleased to hear you're all sorted TaneAbormination - hope myself and others on here can share the same feeling oneday!
As the original post detailing this protocol has gone, can you just confirm how much you were taking? I.e. 3 drops daily or whatever, and assuming this was it - it wasn't combined even with a regular juice fasting or anything like that? And how long until you felt positive effects? Thanks!
where in the world would rick simpson oil be economically feasible? even where its legal? a quick look up states to expect 3 to 4 grams of oil from a ounce of high grade cannabis. not sure what they charge in Colorado or possibly online. but around here to come across that your looking at $300. unless home grown. which would take some serious resources and risk.
Eh, I dunno. There are plenty of good reasons to be skeptical of Rick Simpson Oil, a "half-baked" (pun intended) cure.
The claims made by proponents are a little far-fetched, but I believe TaneAbomination is being sincere about recovering.
It's not like he has posted a dozen recovery stories from a dozen different treatments in the past.
Just a warning; there appears to be a recent surge of scammers selling bogus oil. Anyone here wanting to try this might want to consider making their own at home or at least being extremely careful when choosing sources.
TA, have you quit using it yet? Has your recovery lasted if you have?
Thanks again for posting about your recovery and use of the oil without trying to shove some baseless conjecture down our throats at the same time. That's commendable and rare.
Eh, I dunno. There are plenty of good reasons to be skeptical of Rick Simpson Oil, a "half-baked" (pun intended) cure.
The claims made by proponents are a little far-fetched, but I believe TaneAbomination is being sincere about recovering.
It's not like he has posted a dozen recovery stories from a dozen different treatments in the past.
Just a warning; there appears to be a recent surge of scammers selling bogus oil. Anyone here wanting to try this might want to consider making their own at home or at least being extremely careful when choosing sources.
TA, have you quit using it yet? Has your recovery lasted if you have?
Thanks again for posting about your recovery and use of the oil without trying to shove some baseless conjecture down our throats at the same time. That's commendable and rare.
If your going to try hemp oil I would recommend to make your own and NEVER buy it online a lot of these web sites are actually government run and sting
operations someone told me that not so long ago.... or if your lucky you live in a place where it is legal..... this stuff is said to even cure stage 4 cancer
and is non harmful unlike conventional orthodox chemo treatment which as we all know is pure poison.
I would be curious if someone tried this and reported back to us on the benefits.
Making the R.S. oil is best. Go to the Phoenix tears website and that has the complete set instructions & videos / how-to's. Follow the exact dosage instructions too. Took it as directed for 5 months. Important to note that during this time, I took about a year off work and had to leave the States while undergoing this treatment. I'm not on the treatment any longer, back in the States, and still doing well.
Recovery was slow - I didn't think it was working but about the 3rd month I noticed slow return of spontaneous erections.
As for fasting - no way! On this treatment you will want to eat everything in sight 
As for diet, I did some juicing , soups, bone broths, filtered water, mostly organic paleo diet. Tried to avoid processed foods & toxicity as much as possible though I wasn't always 100%.
Hope this helps. Feel free to send me PM.
@JosephBuchignani - you got it. No further summary necessary - although I did notice that AccutaneIsPoison's original post was removed which is a bit unnerving. Anyhow, end of the line for me. If that didn't work I was exploring very expensive stem cell therapy - thank goodness it didn't come to that. Cheers!
I am so very happy for you!! I knew I wanted to follow up on that for good reason!!! On to CALI!
Another high-profile Accutane suicide:
"Jenny Pitman's nephew killed himself while taking controversial acne drug.":
Talented horseman and showjumper Jack Bowlby, 16, was found by his friends in his dorm room at the prestigious Cheltenham College after complaining of very dark thoughts whilst taking drug Roacutane.
The day before his death he had decided to put himself back on the acne drug, despite being taken off it after concerns were raised by close family friend and horse owner Lady Anne Vestey.
How many go unnoticed?
where in the world would rick simpson oil be economically feasible? even where its legal? a quick look up states to expect 3 to 4 grams of oil from a ounce of high grade cannabis. not sure what they charge in Colorado or possibly online. but around here to come across that your looking at $300. unless home grown. which would take some serious resources and risk.
Like how high grade does this have to be? I'd assume anything from a medical dispensary would be sufficient? Where I'm from you $300 you can get an oz of absolutely top grade (medically tested) medicine. From the brief amount I have read, even a small amount of the oil (1 drop) would have you on your ass for quite a few hours. I'm not sure I could function taking this multiple times a day.
Personally, I have found that MJ does significantly increase libido, so its not too much of a stretch to suppose that it could help with other symptoms related to our condition.
You don't need to make this complicated oil get benefit from THC & others cannabinoid. You can just heat the herb (to convert THCa -> THC) and eat it (but its irritant this way) with fat or not to bypass the liver. There is Cannabis butter, space cake etc. too but i don't recommand to take it like that with fat, it's too hard for the nervous system and not medicinal at all. Better way should be to juice it then heat it (and take it away from fatty meal). But to juice it require fresh herb... so i don't know maybe there is other techniques.
Do I also get benefits when I smoke it? this would be my preferred option. To be honest I would not even know where to buy Rick Simpson Oil. I live in Germany and Rick Simpson Oil is illegal here. And much more difficult to get than MJ.
You don't need to make this complicated oil get benefit from THC & others cannabinoid. You can just heat the herb (to convert THCa -> THC) and eat it (but its irritant this way) with fat or not to bypass the liver. There is Cannabis butter, space cake etc. too but i don't recommand to take it like that with fat, it's too hard for the nervous system and not medicinal at all. Better way should be to juice it then heat it (and take it away from fatty meal). But to juice it require fresh herb... so i don't know maybe there is other techniques.
Vaporized is better than smoked. I don't know if you will get same benefit when smoked, i think it will be far less potent but still a bit effective. Cause the liver transform the THC into 11-OH-THC who is a lot more beneficial. If you eat it maybe the THC will be transformed more effectively (my theory).
Epigentic or not, the part I don't understand is why does the symptoms slowly get worse over time for a lot of people. Normal logic should be if you took 8 months of accutane, your symptoms should be at their worst during the regimen or immediately after. But, most people report the severity of their symptoms as creeping slowly over 1-2 years after they have already stopped the drug.
Tons of people are still getting nasty side effects even though they are eating super healthy, taking all kinds of supplements to flush their liver, and help their joints and GI.
Not sure if its Epigentic or annoy's argument of liver storage. Only thing we know is that Accutane is a very powerful drug. It has the ability to permanently change your body. 90% of the people that took accutane is cured of their Acne forever. The same thing for other Chemo drugs, it completely kills their cancer and it never comes back.
Only thing we can do is eat healthy and just continuously bathe our bodies with nutrients.
If accutane and other toxins are expelled, if the body return to a good state, those "epigenetic" change will be no more, the body will readapt itself. It's just that the body can't deal with all things at the same times. Epigenetic is a really bad excuse, i'm convinced of that, at least saying that it's permanent. If it was permanent, my neurological symptoms will be still here, but they are gone.
And epigenetic about accutane is just a theory, i don't even think that it can cause modification. I think accutane directly block some gene expression in certain part of the body but it's limited and doesn't do any modification. It affect the gene expression system in itself, not the mechanism who make a real modification or not (my opinion). If he was doing change, our body within 2 years will be completely malformated like babys who born after accutane, all trans retinoic acid regulate too much genes, if it was doing modification, we will be simply dead.
Isotherapy is homeopathy but with the exact same molecule who caused the problems. You can't do it yourself it's too dangerous.. ask an homeopathic lab. There is 1 or 2 who can do it in europe, don't know for usa.
Again, epigenetics, strictly defined, is about heritable changes in gene expression. What is being described here is any change in gene expression that can be induced by outside influences. They are not the same. Again, epigenetic changes are long term changes that are potentially heritable, and, as I pointed out above, most epigenetic changes are not passed on to offspring, certainly not to the point that they have a detectable effect on evolution. The rest is gene regulation, which is often transient but, depending on the process, can continue long term for as long as the stimulus causing the change in regulation is present. As is frequently pointed out, the quickest way to get an organ to start to return to normal is to stop doing the bad things to it that were causing it dysfunction in the first place. As P.Z. Myers put it:
In part, the root of the problem here is that were falling into an artificial dichotomy, that there is the gene as an enumerable, distinct character that can be plucked out and mapped as a fixed sequence of bits in a computer database, and there are all these messy cellular processes that affect what the gene does in the cell, and we try too hard to categorize these as separate. Its a lot like the nature-nurture controversy, where the real problem is that biology doesnt fall into these simple conceptual pigeonholes and we strain too hard to distinguish the indistinguishable. Grok the whole, people! You are the product of genes and cellular and environmental interactions.
I don't think that it's stored in the liver, certainly in other fatty tissue. But the main problem is the real cause of acne, an excess of toxins & acids who was already overwhelming the kidney & the liver, so the body was trying to expell them with his third kidney (the skin). Accutane destroyed this third kidney, but also the liver, the intestines, kidneys, glands, etc... our body are suffocating from inside cause he can't expell any toxins and natural cellular waste. Immune reaction is natural, the body doesn't recognize those malfunctioning full of toxins & waste cells, so he try to kill & expell them. I think that's why the body cannot recover. Accutane doesn't heal acne, he destroy the body to eliminate the symptoms, it's like shooting on ourselves, completely retarded to take such a poison.