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lol, my acne is too stubborn for niacin. niacin is good, dont get me wrong. i've been having good results with it but i still do get a cyst once in a while and i still got tons of stubborn blackheads and comedones. I think i'll just try both and see how it works out. If b5 fails, i might have to resort to accutane 
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hi,
i'm new here and am interested in niacin/niacinamide. my husband is a doctor so i asked to borrow his research site that doctors use to look up information on [removed].
it states only niacinamide is used for treatment of acne, due to the anti-inflammatory effects, so may only help with excisting pimples and reduce the size of future one. however it only recommends using a topical version of the drug. it doesnt actually state that tablets will help with acne. but in my opinion its the same drug, inside or out, but just no research on the does required orally. (there was a link on the niacin page to use as a acne treatment, which took me to niacinamide),
the topical is only 30mg of the drug, but this goes directly on the face and doesnt have to fight through your system to get to your skin, where orally i'm sure some would be lost. the oral tablet recommendation is 100-300mg per day, but again does not state its for acne but for pellegra (a vitamin deficency).
from what i read, niacinamide is the main topical that is made for acne treatment, dont know if this means it's better to use than niacin.
the difference between the 2 is not much, just different active formuals of vitamin B3, from what i could tell, but niacin is alot more toxic. it says to take tablets after a meal, close to bed time with milk (to reduce GI upsets). its also says you can take an aspirin 30 mins before taken niacin to reduce flushing.
all of this is just from my understand of the information i read, please do not take it as medical advise! and please remember its not really recommend in the tablet form as a acne treatment, and niacin isnt specifically stated either. but at least there is some medical support behind the use of vitamin b3 in the treatment of acne.
p.s hope it all made sense!!!
http://www.pgdermatology.com/images/learni...INAL-090105.pdf
wow this article has tones of research info on treating acne with a niacinimide topical
time to update yall.
Ive been taking niacin NON FLUSH nature valley brand for 3 weeks. I am still acne free. I thank god that I came across this. I havnt washed my face with any soap for the past 2 weeks. Just once with water every 2 days or so. NIACIN GAVE ME MY LIFE BACK!
I feel the same way 
im taking cetirizine hydrochloride (anti-histamine) for an allergy how would this affect going on niacin which i read flushes histamines into the body. would i have to stop the cetirizine or just take them at opposite ends of the day?
also ive just gotten over a light case of uticaria (hives) small itchy white bumps around my temples which lasted for about 6 weeks, i read this is something to do with histamine being released in the system. would niacin flare me up again?
also ive got some B5 complex tablets which have 50mg NE (dont know what the NE stands for) of Niacin would these help me until i get some pure niacin tablets or at least get my body used to a little bit of flushing?
^ That doesn't sound very scientific.
What would make it sound more scientific? A bunch of big words nobody understands to go along with an uncontrolled clinical study that can be manipulated to show about anything? There isn't much money to be had in a $3 bottle of Niacin so it's not something high on the priority list for scientific research.
When it comes to niacin the first thing you need to understand is simply what is causing the flush and the side effects to happen and why they are more pronounced for some more than others. Niacin causes what's called vasodilation which is the flush effect you experience. It's the opening of hte small blood vessels, the capillaries, so that more blood flows through them. Your skin relies on these small blood vessels for oxygen and nutrients so it doesn't matter how healthy you eat if your body isn't transporting the right amount of oxygen and nutrients to the skin. So before when you had maybe one blood cell flowing through at a certain capillary the vasodilation can allow two or three to flow through at a time. This also helps to eliminate toxin buildup in the fatty tissues of the body.
And when toxins are released your bodies immune response is to release histamine. Histamine is what is also released when you have an allergic reaction to something like pollen or dust. That's why you take anti-histamines when you have an allergic reaction. The histamine is what is causes the side effects such as itching and headaches. So for those that have more severe allergic reactions and more toxins in the body the amount of histamine released may be what's causing the more intense reactions for some.
http://www.pgdermatology.com/images/learni...INAL-090105.pdf
wow this article has tones of research info on treating acne with a niacinimide topical
I wonder how the topical niacinamide differs from niacin though? Would it affect the skin in the same way, but from the inside out?
after doing some research i'm starting to think that there is actually a difference between niacinimide and normal niacin besides no flushing. everywhere i've read it refers to niacinimide as anti-inflammatory and for skin care while niacin is for heart health and cholesterol. i'm gonna switch to niacinimide to see if there are better results.
at the moment i have been getting breakouts but it seems like its turning around now and for the last two days i haven't had a new blemish. i started washing with cetaphil and just leaving it on twice a day 2 weeks ago so it could be due to that or the fact that ive been jogging every morning.
edit
If you have more toxins in your body than niacin, you will not feel a flush, but if have more niacin present in the blood opposed to toxins, you will feel a flush. The stronger the flush, the better. At this point, begin cutting back on the milligrams of niacin.
This is bullshit really. Your body builds a tolerance to niacin so the flushing becomes less severe and eventually goes away. That doesn't mean theres more toxins, there should be technically less since you're taking niacin in the first place. I can take 500 mg and I won't feel anything, doesn't mean theres more toxins because i remember having an intense flush after 300mg.
What that post is basically saying is that taking niacin increases toxin levels in the body, which doesn't make sense.
after doing some research i'm starting to think that there is actually a difference between niacinimide and normal niacin besides no flushing. everywhere i've read it refers to niacinimide as anti-inflammatory and for skin care while niacin is for heart health and cholesterol. i'm gonna switch to niacinimide to see if there are better results.
Niacinimide is nothing more than what the body converts niacin into so anything niacinimide can do so can niacin. If you'll Google "niacin anti-inflammatory" you'll you'll see that it has the same anti-inflammatory properties. I'd say the reason you're seeing more results for the niacinimide being for skin care is simply because of the fact people don't want to put up with the flush so they focus they're testing on "no-flush" niacinimide. As you've seen even in this thread some people have a lot worse reaction to the histamine release from the flush. And then with heart health and cholesterol naturallyyou're not going to see niacinimide referred to because it's the flush you get with niacin prior to its conversion by the body into niacinimide that helps with that.
Another thing to consider I suppose though would also be the conversion rate of niacin into niacinimide. Obviously it's probably not 1:1 so maybe niacinimide once converted offers benefits to things like fighting acne that aren't offered prior to conversion from niacin.
after doing some research i'm starting to think that there is actually a difference between niacinimide and normal niacin besides no flushing. everywhere i've read it refers to niacinimide as anti-inflammatory and for skin care while niacin is for heart health and cholesterol. i'm gonna switch to niacinimide to see if there are better results.
Niacinimide is nothing more than what the body converts niacin into so anything niacinimide can do so can niacin. If you'll Google "niacin anti-inflammatory" you'll you'll see that it has the same anti-inflammatory properties. I'd say the reason you're seeing more results for the niacinimide being for skin care is simply because of the fact people don't want to put up with the flush so they focus they're testing on "no-flush" niacinimide. As you've seen even in this thread some people have a lot worse reaction to the histamine release from the flush. And then with heart health and cholesterol naturallyyou're not going to see niacinimide referred to because it's the flush you get with niacin prior to its conversion by the body into niacinimide that helps with that.
Another thing to consider I suppose though would also be the conversion rate of niacin into niacinimide. Obviously it's probably not 1:1 so maybe niacinimide once converted offers benefits to things like fighting acne that aren't offered prior to conversion from niacin.
Update: well ive been taking NIACIN 500 mg with flush for about 2 1/2 weeks now and me skin is improving..but i don't get the flushes anymore..and to tell you the truth i kinda miss them lol..but i will try posting up pictures of my progress... or at least current pics cus i dont have past pics..ok.
Update: well ive been taking NIACIN 500 mg with flush for about 2 1/2 weeks now and me skin is improving..but i don't get the flushes anymore..and to tell you the truth i kinda miss them lol..but i will try posting up pictures of my progress... or at least current pics cus i dont have past pics..ok.
Awesome dude. The stuff is pretty amazing and I'm only on my 3rd day. Have you experienced any sort of symptoms or side effects from it?
http://www.wellcorps.com/Therapeutic-Effec...iacinamide.html
Mechanisms of Action
Niacinamide acts as an antioxidant by preventing NAD depletion during DNA repair by inhibiting poly (ADP-ribose) polymerase (PARP), which also modulates major histocompatibility complex (MHC) class II expression. Niacinamide inhibits free radical formation and facilitates beta-cell regeneration in vivo and in vitro.7,8 Additional protection from macrophage toxins may be involved in prevention of type 1 diabetes.9 Specifically, niacinamide has been shown, via PARP inhibition, to protect pancreatic islet-cell lysis after exposure to oxygen free radicals10 and nitric oxide.11,12 Niacinamide has also been found to stimulate
GABA receptors, without binding to the receptor sites, thus creating a benzodiazepine-like effect.13
Anti-inflammatory action affecting neutrophil chemotaxis has been reported for niacinamide.14
Additionally, due to its inhibition of ADP-ribosylation, niacinamide has been shown to suppress cytokinemediated induction of nitric oxide synthase in a number of cells, thus effecting interleukin-1-exposed chondrocytes, resulting in decreased inflammation.15
Dermatological Conditions
Niacinamide has been used to treat several types of dermatological pathologies.32,33 In a review of treatments for bullous pemphigoid, treatment with a niacinamide/tetracycline combination showed promising results compared to other treatment effectiveness and side effects.34 In addition, niacinamide has been used successfully in the treatment of other blistering skin diseases when used in conjunction with tetracycline.35
Niacinamide has also been shown to be effective in the treatment of cutaneous hyperpigmentation, which occurs in multiple conditions. In clinical trials, a five-percent niacinamide moisturizer provided 35-68 percent inhibition of melanosome transfer from melanocytes to keratinocytes, proving to be an effective skin-lightening agent.36 Further studies to investigate the use of niacinamide in regulating melanocytekeratinocyte interactions are underway.37
More stuff on niacinimide, i dont know. It just seems that the best results come from niacinimide and there just may be that difference.
What i don't get is why doesn't a company make a niacinimide topical for acne and fading redmarks? You don't need a prescription for a vitamin so it could be one of the most effective OTCs and it's safer than BP or SA.
i started me 500 mg no flush niacin last night. im very optimistic after reading the success stories. i will bee keeping up with my improvement on this thread
Good luck, my success is gone, I gave it up for a day, and am starting again today. Along with good diet and exercise, I really hope it improves.
i started me 500 mg no flush niacin last night. im very optimistic after reading the success stories. i will bee keeping up with my improvement on this thread
Good luck, my success is gone, I gave it up for a day, and am starting again today. Along with good diet and exercise, I really hope it improves.
If it was successful, why did you give it up for a day? I'm guessing like several other acne treatments, it won't work for everyone.