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^ That doesn't sound very scientific.
What would make it sound more scientific? A bunch of big words nobody understands to go along with an uncontrolled clinical study that can be manipulated to show about anything? There isn't much money to be had in a $3 bottle of Niacin so it's not something high on the priority list for scientific research.
When it comes to niacin the first thing you need to understand is simply what is causing the flush and the side effects to happen and why they are more pronounced for some more than others. Niacin causes what's called vasodilation which is the flush effect you experience. It's the opening of hte small blood vessels, the capillaries, so that more blood flows through them. Your skin relies on these small blood vessels for oxygen and nutrients so it doesn't matter how healthy you eat if your body isn't transporting the right amount of oxygen and nutrients to the skin. So before when you had maybe one blood cell flowing through at a certain capillary the vasodilation can allow two or three to flow through at a time. This also helps to eliminate toxin buildup in the fatty tissues of the body.
And when toxins are released your bodies immune response is to release histamine. Histamine is what is also released when you have an allergic reaction to something like pollen or dust. That's why you take anti-histamines when you have an allergic reaction. The histamine is what is causes the side effects such as itching and headaches. So for those that have more severe allergic reactions and more toxins in the body the amount of histamine released may be what's causing the more intense reactions for some.
I like how you put faith in an article where not one link to a source is given. I found that source, and it's apparently written by a doctor: http://www.alternativecancerdiet.com/artic...acin_its_a.html , but still, without much credible evidence I would not rely off of a lot of speculation on toxin removal over certainty. Besides, isn't it the inflammatory effects of niacin that helps out people's complexion, rather than toxin removal?
Heck, people who do internal flushes and poop out green stones think they're passing out real gall-stones, but it's really something completely different...what was it, epsom salt, grapefruit juice, and olive oil all bounded up create a similar looking stone.
It was successful for a couple of days, then something aggravted my acne, now it is horrible. I did it again today, and got the biggest flush, was good, I'll keep on doing it =)
So you had also a bad breakout? Did you drink alcohol? It's wierd.. Niacin definitely has affect on acne, it's just that it seems to have bad affect on mine, I've got a lot of small white heads and break outs during these days I've been on it. I'm using Niacinamide, the non-flush. I've also got regular Niacin, maybe I'll switch to that. But if it just gets worse I'll give it up.
It was successful for a couple of days, then something aggravted my acne, now it is horrible. I did it again today, and got the biggest flush, was good, I'll keep on doing it =)
So you had also a bad breakout? Did you drink alcohol? It's wierd.. Niacin definitely has affect on acne, it's just that it seems to have bad affect on mine, I've got a lot of small white heads and break outs during these days I've been on it. I'm using Niacinamide, the non-flush. I've also got regular Niacin, maybe I'll switch to that. But if it just gets worse I'll give it up.
Yes I have. A slow breakout, over the course of a few days where things slowly grew horrible.
I do not drink alcohol, but occasionally, socially only, enjoy a bit of marijuana, however this is vaporized so the smoke shouldn't have caused a breakout, but I did eat about 3X the amount of sugar (from yogurt) than what I do in a day.
Well like I said, not all acne medications work for everybody. Personally I'm encountering success with Niacin. Not one single new breakout and my current ones are healing rather fast. I'm also less oily. For the record I have nodular acne, not whiteheads.
If I have continued success, I think I'm going to have some bloodwork done just to make sure my triglyceride levels are relatively normal and I'm not doing any harm to my liver.
I'm also using Clindamycin Phosphate lotion as spot treatment which is working better since I started taking Niacin.
http://www.wellcorps.com/Therapeutic-Effec...iacinamide.html
Mechanisms of Action
Niacinamide acts as an antioxidant by preventing NAD depletion during DNA repair by inhibiting poly (ADP-ribose) polymerase (PARP), which also modulates major histocompatibility complex (MHC) class II expression. Niacinamide inhibits free radical formation and facilitates beta-cell regeneration in vivo and in vitro.7,8 Additional protection from macrophage toxins may be involved in prevention of type 1 diabetes.9 Specifically, niacinamide has been shown, via PARP inhibition, to protect pancreatic islet-cell lysis after exposure to oxygen free radicals10 and nitric oxide.11,12 Niacinamide has also been found to stimulate
GABA receptors, without binding to the receptor sites, thus creating a benzodiazepine-like effect.13
Anti-inflammatory action affecting neutrophil chemotaxis has been reported for niacinamide.14
Additionally, due to its inhibition of ADP-ribosylation, niacinamide has been shown to suppress cytokinemediated induction of nitric oxide synthase in a number of cells, thus effecting interleukin-1-exposed chondrocytes, resulting in decreased inflammation.15
Dermatological Conditions
Niacinamide has been used to treat several types of dermatological pathologies.32,33 In a review of treatments for bullous pemphigoid, treatment with a niacinamide/tetracycline combination showed promising results compared to other treatment effectiveness and side effects.34 In addition, niacinamide has been used successfully in the treatment of other blistering skin diseases when used in conjunction with tetracycline.35
Niacinamide has also been shown to be effective in the treatment of cutaneous hyperpigmentation, which occurs in multiple conditions. In clinical trials, a five-percent niacinamide moisturizer provided 35-68 percent inhibition of melanosome transfer from melanocytes to keratinocytes, proving to be an effective skin-lightening agent.36 Further studies to investigate the use of niacinamide in regulating melanocytekeratinocyte interactions are underway.37
More stuff on niacinimide, i dont know. It just seems that the best results come from niacinimide and there just may be that difference.
What i don't get is why doesn't a company make a niacinimide topical for acne and fading redmarks? You don't need a prescription for a vitamin so it could be one of the most effective OTCs and it's safer than BP or SA.
They do. It's termed nicotinamide, another derivative of vitamin B3. It's sold as, among other thing, Nicam Gel and Freederm. It's good for both treating acne and reducing hyperpigmentation. You may get good results applying it topically while using niacin/niacinamide orally.
Got some niacin n shit, doesnt say whether it's flush or no flush but yeah 100mg ,fingers crossed n jizz.
"Niacin n shit," so you got Niacin, and perhaps other supplements? Or you are just trying to create some sort of image by adding in curse words where possible?
Everyone else, I might try get my hands on the insitol kind. I have nicotinic acid (or whatever it is) and yeah, so I'm going to get hold of the insitol.
Whats a good brand that is working for someone? And where can I get it that will ship internationally for relatively cheap?
Got some niacin n shit, doesnt say whether it's flush or no flush but yeah 100mg ,fingers crossed n jizz.
"Niacin n shit," so you got Niacin, and perhaps other supplements? Or you are just trying to create some sort of image by adding in curse words where possible?
Everyone else, I might try get my hands on the insitol kind. I have nicotinic acid (or whatever it is) and yeah, so I'm going to get hold of the insitol.
Whats a good brand that is working for someone? And where can I get it that will ship internationally for relatively cheap?
Hey! Acni Boy...people can say whatever they want on here..and besides your not a moderator or anything.
Got some niacin n shit, doesnt say whether it's flush or no flush but yeah 100mg ,fingers crossed n jizz.
"Niacin n shit," so you got Niacin, and perhaps other supplements? Or you are just trying to create some sort of image by adding in curse words where possible?
Everyone else, I might try get my hands on the insitol kind. I have nicotinic acid (or whatever it is) and yeah, so I'm going to get hold of the insitol.
Whats a good brand that is working for someone? And where can I get it that will ship internationally for relatively cheap?
Hey! Acni Boy...people can say whatever they want on here..and besides your not a moderator or anything.
Did I say I was a moderator? I was simply asking for confirmation on whether he bought other supplements which maybe a chemist recommended that we might like to know about, or if he is just trying to act "gangsta."
I never said he can't say things like that.
I just bought the 500 mg Niacin "Flush Free" pills from my local Target.
After loosing my medical insurance and not being able to take Doryx anymore I'm hoping this stuff works. After reading some people's success stories I'm hoping this works for me!
I will update my progress as time goes on.
So I've been taking no-flush for around 2.5 weeks now...
As soon as I started taking it, I thought I saw a reduction. But that might have just been a temporary respite, because I had another breakout soon after.
Since then, my acne has remained more or less stagnant.
On top of that, ever since I started taking niacin I've been experiencing extremely flaky skin in areas such as my scalp, around my nose, and inside/around my ears.
So here are two questions I have:
1) Since there's been little to no effect in over two weeks, do you think that niacin will continue to not work for me in the future?
2) Could niacin be the cause of excessively flaky skin?
Day 5.
First off, I'm 32 and I don't have a lot of acne, but when I do/did get it, it's always been deep, nodular and leaves behind red marks which takes ages to heal.
Anyway, I haven't had any new breakouts and the one's I had continue to shrink, become less red and less sore. I've also noticed a reduction in oil and my skin feels a lot smoother. Overall I have a much better complexion and it continues to improve everyday. I hope it stays that way. I really can't afford for this to be a fluke as I've tried everything short of Accutane and I'd rather not go down that road again.
I've definitely seen some improvement. Nothing phenomenal, but enough that my mom commented yesterday that my skin looks really good. For about the first week I was taking 500 mg of GNC niacinamide. Then I switched to Spring Valley flush free niacin, but I was still using the niacinamide topically (one teaspoon crushed into 4 ounces of aloe, as suggested in this thread: http://www.acne.org/messageboard/guys-Niac...gh-t186417.html ). Around the same time that I started taking the niacinamide I also started using Dr. Bronner's peppermint soap.
I think most of the improvement can be attributed to the niacin though. The topical niacinamide may or may not be helping...I'm not really sure. But my back has also started to clear up, and I haven't used the niacinamide on my back. And although I guess it could be the soap, I really don't think so.
I also recently got myself on a more regular sleep schedule, after spending much of the summer staying up until the wee hours of the morn. So that may be contributing as well.
And yesterday I started taking Nature's Way Garden Veggies...I'm hoping that might help a bit as well, since some people have had success with broccoli pills. If not, veggies are good for you regardless.