What Is It?
Minocycline is a newly approved medication. Details coming soon. Until then, here is a link to information on Minocycline from the U.S. National Library of Medicine.
Strength of Evidence
Average 52% reduction in acne after 12 weeks
- Del Rosso, J. Q. et al. A prospective, multicenter, randomized, double-blind, vehicle-controlled Phase II study to evaluate the safety and e cacy of a combination of 3% minocycline and 0.3% adapalene topical foam formulation for the treatment of moderate-to-severe acne. J Clin Aesthet Dermatol. 14, 8–30 (2021).
- Raoof, T. J. et al. Efficacy and safety of a novel topical minocycline foam for the treatment of moderate to severe acne vulgaris: A phase 3 study. Journal of the American Academy of Dermatology 82, 832–837 (2020).
- Gold, L. S. et al. A novel topical minocycline foam for the treatment of moderate-to-severe acne vulgaris: Results of 2 randomized, double-blind, phase 3 studies. Journal of the American Academy of Dermatology 80, 168–177 (2019).
- Shemer, A., Shiri, J., Mashiah, J., Farhi, R. & Gupta, A. K. Topical minocycline foam for moderate to severe acne vulgaris: Phase 2 randomized double-blind, vehicle-controlled study results. Journal of the American Academy of Dermatology 74, 1251–1252 (2016).
Low-medium side effects and adverse reactions
Acne.org's Real World Take
Topical minocycline is different from oral minocycline. You apply topical minocycline directly to the skin. It is similar to topical clindamycin, but is new on the market and much more expensive. It may also be slightly less effective. It should never be used on its own or for longer than 3 months and may lead to resistant strains of bacteria. It may provide a slight improvement in mild acne in some people