Minocycline (Amzeeq®)

What Is It?

Topical minocycline, sold under the brand name Amzeeq^®, is a broad-spectrum topical antibiotic that helps slow or stop the growth of various types of bacteria in the skin and also helps reduce skin inflammation.

It is usually applied once daily, before going to bed.

Results

Strength of Evidence: Very Strong

Average 52% reduction in acne after 12 weeks

▸ Based on These Clinical Studies & Trials

▾ Based on These Clinical Studies & Trials

Del Rosso, J. Q. et al. A prospective, multicenter, randomized, double-blind, vehicle-controlled Phase II study to evaluate the safety and e cacy of a combination of 3% minocycline and 0.3% adapalene topical foam formulation for the treatment of moderate-to-severe acne. J Clin Aesthet Dermatol. 14, 8–30 (2021).
Raoof, T. J. et al. Efficacy and safety of a novel topical minocycline foam for the treatment of moderate to severe acne vulgaris: A phase 3 study. Journal of the American Academy of Dermatology 82, 832–837 (2020).
Gold, L. S. et al. A novel topical minocycline foam for the treatment of moderate-to-severe acne vulgaris: Results of 2 randomized, double-blind, phase 3 studies. Journal of the American Academy of Dermatology 80, 168–177 (2019).
Shemer, A., Shiri, J., Mashiah, J., Farhi, R. & Gupta, A. K. Topical minocycline foam for moderate to severe acne vulgaris: Phase 2 randomized double-blind, vehicle-controlled study results. Journal of the American Academy of Dermatology 74, 1251–1252 (2016).

Side Effects

Low-medium side effects and adverse reactions

Acne.org's Real World Take

Topical minocycline is different from oral minocycline. You apply topical minocycline directly to the skin. It is similar to topical clindamycin, but is new on the market and much more expensive. It may also be slightly less effective. It should never be used on its own or for longer than 3 months and may lead to resistant strains of bacteria. It may provide a slight improvement in mild acne in some people

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