Oral Retinoid
Reviews
3.9
2791 Reviews
Oral Retinoid
Efficacy
87%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Note: Use with EXTREME CAUTION: Causes severe birth defects and fetal death.
Oral Retinoid
Side Effects
High
Oral Retinoid
Acne.org’s Real World Take
The nuclear option. It works reliably and provides long-term remission of acne, and even severe acne, in about ⅔ of people who properly take an adequate dosage. However, it permanently and irreversibly changes the skin and the body forever and users may experience long-term side effects for the rest of their lives. It’ll nuke it, but there is no going back.
Oral Retinoid
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Read All About Isotretinoin (Accutane®)
Compare To Other Treatments
5
37.1%
4
33.4%
3
15.5%
2
7.3%
1
6.6%

Used Isotretinoin (Accutane®)? Rate It:

Choose from 1 to 5 stars
June 15, 2016
Trip to Hell
I was so excited to try this after 30 years with acne. I've never had any side effect to any medication and never been on antidepressants or had mental health issues. From the reviews I read I got the impression most people were fine on it, that the main problem was that it might not work, and that a few people who had bad effects had caused it to be prescribed more carefully than was maybe helpful for acne sufferers. I was started on only 20mg and told that would be put up to 40 and 60. By about day 2 I noticed my thoughts were harder to stop than normal, eg I would find it hard to switch off at night, and I woke up from vivid dreams (thoughts still persistently going on in the background) and found it hard to get back to sleep. I had read about this from other reviews who just persisted with treatment so thought that was to be expected and carried on. After about a week I had hardly any dryness on that dose but could tell that my skin was becoming less acne prone - it just felt un-itchy and after suffering from acne for as long as I have I can generally feel when my skin is in a state where I'm liable to break out or not, and the isotretinoin was obviously doing its job, but I kept bursting into tears. By day 9, my skin was clear, but I was in hell. I could only see the bad things about my life, which were blown out of all proportion to a psychotic degree, I was constantly crying, there was no hope, I didn't see anything positive in life or feel the same about my family, and the back of my brain felt like it was coated with tar. I was missing sleep and had lost my appetite. The thought of raising the dose even higher and being on it for months more was unthinkable. There seemed to be no guarantees that this mental change would not be permanent to some degree (I could find studies that showed depression and brain changes after taking it, but none that showed the depression and brain changes as having then gone away after say a few months of stopping treatment, which I would have expected the drug companies might do if it was possible) and the two people I know who have taken accutane don't get spots but are miserable - one is constantly having headaches and is just generally unhealthy and the other is depressed. So I stopped and thankfully the stuff is out of my system (6 weeks ago). I guess we're all different and you can't tell what your response will be.
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June 8, 2016
Regret
Took it for 6months left with indented scarrings. I never get scars before accutane no matter how big my zit was wether i pop it or not, it never left a scar. But every pimple i got during my course left dents. I don't know if i'm gonna keep getting them but accutane is my biggest regret. I should've tried other options. If you're planning to go on accutane, pls don't risk it. You may or may not get the results you want. You can't be sure. I'm having a lot of gas and constipation as well.
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July 15, 2016
Have you been picking on your skin while on the drug? If you do ANYTHING to your face it will likely leave a scar.
August 5, 2017
My dermatologist gave me facials and injected steroid on my cystic acne while I was on accutane. I suspected that the ones she injected are those that left scars.
May 2, 2016
Don't risk it
I was on accutane 10mg for 3 weeks. (I'm female, 5'3 and around 126 pounds) Then got moved up to 20mg which I have been taking for a month. My dermatologist appointment is tomorrow,and I'm telling her I'm not taking this medication anymore. I know this is a very low dose to be on, but my side effects show just how harsh this drug is. I have SEVERE abdominal pain 3-4 times a day with back pain and nausea. I'm so worried, I have no idea what it is but I've never ever had stomach problems before and it's a coincidence how this comes up when I get on accutane.. I have researched this side effect and it's supposedly rare,which doesn't make me feel any better. No amount of clear skin is worth the pain I'm in at the moment. It's a shame because my skin was starting to look like it was improving, but I can't spend every morning dreading the day ahead of me knowing I'll be in agonising pain. I know what it's like to read the bad reviews on accutane and just think of the clear skin you'll have so you use the whole "it won't happen to me" but honestly, if I could go back a couple of months and someone told me this is what was going to happen, no way would I of taken it. I know accutane has helped so many people clear their skin but many of those same people get health issues years and years later. This drug should be banned, I wish I never considered it. Update: I told my dermatologist and she didn't seem shocked at all. She suggested moving me back down to 10mg but didn't seem concerned about the worrying side effects I'm having. I've stopped the medication and I'm going to my family doctor to hopefully get some tests done to put my mind at ease, or potentially find out what's gone wrong. Biggest regret of my life. Last update: I've had 3 doctors and 2 surgeons examine my stomach. I've had blood tests, and even an ultrasound, but nothing is showing up. I've been off of accutane for almost a month and the pain is still awful. My dermatologist still insists it was not the drug that caused this, but doctors think otherwise. My digestive system has also been effected horribly by this drug, as well as the back pain and nausea continuing..
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May 31, 2016
I ended up with the same fate. Went to Doctors over and over again in till i got a endoscopy done. I would recommend getting one. Got on antacids back in 2011 and to this day I still have to take them sometimes. Still experience stomach pain sometimes. I know this dosent happened to everyone but I would just be careful you can potentially ruin your stomach. Worst decision I ever made in my life.
June 26, 2016
I hadn't seen anyone else on here experiencing the same side effect so I assumed I was a very rare case, it was honestly the most pain I've ever been in in my life,and that's on one of the lowest doses! My digestive system seems to have improved but I'm the same where I still get stomach pains and bad back pain every now and again, and I've been off of the drug for almost 2 months. It has helped so many people but in my opinion it's just not worth it, I've been eating dairy free since coming off of accutane and my skin has cleared up like 90% already, I'd recommend giving that a try to anyone before considering going on accutane!!
June 27, 2016
How's ur acne after a month?
July 3, 2016
Very common story. thanks for sharing.
August 11, 2016
Hi Dou, My acne has prettymuch gone now all I'm dealing with is scarring and the odd spot every now and then (I'm still in my teens). I really recommend everyone to try switching to "LUSH" skincare (or other natural products) and eliminating dairy from their diet for a few months to see if it makes a difference to their skin, the combination of the two has made my skin the best it's been in years. I think people under estimate how bad dairy is for us, the hormones and pus in milk is going to break us out because it's meant for baby cows not the human body!! Just remember to check the ingredients on EVERYTHING because milk can even be found in some brands of crisps ect. Good luck:)
April 16, 2016
The side effects are awful!
In 2008, I took Accutane for 7 months, 3 pills/day, After 2 months, my skin was indeed clear, but it was incredibly dry, red and irritated. So my dermatologist reccomended Bioderma Sensibio moisturizer while taking Accutane. It did saved me a bit but I had to apply it like 3-4 times a day. Now, the side effects were awful... I was anxious, aggressive with people around me, angry, depressed and I became an antisocial kind of person. After stopping it, my face was great..for almost 4 months. Then I started breaking out again, badly. I really think that the dosage & time are really important. For instance, my bestfriend took only 1 pill/day for 1 year and she is acne-free for almost 8 years now :) And if you have hormonal acne(jawline and chin), Accutane is not a long-term solution.
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December 3, 2015
4 stars
Unlike many people, I received no side-effects from Accutane aside from poor night vision and obviously dry skin. While I was taking Accutane (I was 14 and/or 15) my acne was 100% gone. Sadly, it did come back and it was still fairly bad, but it wasn't nearly as bad as it used to be. I honestly have no idea why I didn't go back on this stuff. It worked great and I had no problems with it. I should've gone back on it when my acne returned. I was told my acne would return to a certain extent, but I think mine was a little worse than necessary. When I first started taking Accutane, my acne got worse for about a month. Don't worry: this is normal. I also want to add that I had no scarring afterwards.
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November 12, 2015
The only cure
This is the only product that can help me The creams,gels didn't work for me,my acne was so bad and my face was really greasy and my hair too,now my face it's normal but i have to use sunscreen and moustrizer but it's nothing compared to the past
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November 12, 2015
hi! what dosage were you on, and please describe yourself
July 15, 2015
It didn't wok for me but
Been on accutane twice and both times yielded mixed results. Each time has cleared me up for a certain amount of time but my acne has always came back. But it never comes back as bad. I've went from severe cysts down to lots of clogged pores. So it's good BUT it does not cure every one always, Please think about that before putting your body through this strong medication. Personally, I didn't find the side effects too deliberating but they are definitely not something to brush off. Dry flaky skin which is easily combated with a good lotion. Dry, cracked lips which I kept under control with Fucidin H and nose bleeds which were rather annoying. The only side effect which seems to have permanently affected me is the joint pain and weakness. All in - for a lot people it's a long time cure, but please educate yourself and don't rush into it.
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June 14, 2015
Brilliant but not so brilliant!
Brief description of myself: Female, 32 years old, 63KG. On 40mg- 60mg. I started taking this med in March, all seemed ok until around 3/4th day where I was ready to just give up, I started getting extremely hot, my face was on fire constantly, I was always red and of course peeling! Honestly I had "snake skin!". I was prescribed double based cream which I felt like I had to keep on putting on my face. Anyhow I didn't give up, what I did was adjust a few things- instead of using the cream I started using raw organic coconut oil (previously used now and again)- my god what a difference! My face was constantly moisturised and it tackled the horrid scars! I only used coconut oil for my face nothing else. Beauty regime- Morning- "cream" face with coconut oil (quite a bit), shower (water dries your face so be sure to put quite a bit of oil PRIOR to the shower), pat dry your face after shower, apply make up (I used Double Wear by Estée Lauder- amazing!). At night I would "cream" my face with the oil (over the make up) then with cotton wool rub it off gently, wash with warm water, pat dry and apply a decent amount of oil before bed! Always keep Vaseline near you, dry lips are terrible, and over time they get worse 😩.. My scalp got very dry too, again I used coconut oil. Put a good amount on your scalp, go sleep and wash in the morning! This problem was tackled within a couple of days! I never broke out, in fact within a week or so I saw a huge improvement - my face was literally almost cleared! I couldn't believe it.. a couple of weeks ago I saw my derm and was hoping I would be told that my treatment was complete- however I still have 2 months to go at 60mg (previously on 40mg). I started taking the extra pill and the side effects got worse to the point that I almost gave up again, so I've decided to go back down to 40mg and unfortunately will have to stay on for a little longer.. I gave this med 4 stars purely down to the side effects, it is a rough ride but I personally think it's so worth it! My skin looks amazing, not ONE spot! (I've previously counted 30+!) . My scars are next to none (maybe the coconut oil has helped).. If your about to start good luck, hope you don't have such a rough ride that you decide to give up.. All the best!! Ahh yes- joints hurt too. 6months later..... I previously wrote a review whilst on this treatment, so thought it would be good to let you all know what life is like once you finish yours! Absolutely fantastic! Not one single spot on my face or back.. I finished my treatment at the end of sept 2015, and since then I haven't had any breakouts , skin is back to normal (no longer feels sensitive), no more dry lips, or aching joints. I do wish I had taken this stuff sooner. I had previously given the medication 4 stars due to the side affects, it is a rough ride, but it's worth it.. I still only use raw coconut oil as a moisturiser, hardly ever wear foundation (only wear if I'm going out, for a smoother finish!) - that was a big thing for me when I had spots, I couldn't leave the house without - and I mean layers and layers of it! I have absolutely no scars what so ever, I don't know if it's because I used the coconut oil instead of double base cream but either way I'm happy I made the decision not to use the cream provided.. Please feel free to read my other review, it has some tips. I also went on holiday whilst taking this, and was fine. Didn't burn at all, I used factor 50, applied fairly frequently- I had a lovely tan.. Good luck !
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June 9, 2015
My story
I have suffered from acne since I was 11 I am now 27. When I was about 14 I got the benzoyl peroxide cream which made it worse so I stopped using it and it soon went back to "normal' which was bad but not as bad as when I was using th cream. When I was 16/17 I got oxcicetricyline and it reduced my blackheads and cleared my skin a lot but still not completely clear I was given this medication another couple of times after that spaced out through 8 years. To b honest I just thought that was me I had bad skin and that's it......deal with it!! After having my son at 19 I thought my skin would get better and to some effect I think it did as I was at the doctors a lot less than before about my skin. About 5 months ago I started to get big spots more like a cyst on my forehead when I never really got them there before. So I went to the doctors, he gave me the oxcicetricyline as it worked before.....this time however it didn't it got WORSE!!!! I got loads of huge cysts on my forehead chin and the side of my head along with other smaller "spot" type ones!! I was gutted! After that ran out I went on an antibiotic for a week I googled it and it was for th treatment of abscesses can't remember name.....did nothing! Then I got a 2 month suppy of lymecycline 408mg while I waited for an app with dermatologist. Didn't have to wait long only 3weeks as my doctor put it as urgent as it was so bad, really sore and swollen so I struggled to sleep at nights as I had a huge cyst right next to my ear on the side I sleepðŸ˜" so anyway in the 3 weeks it done nothing either. Was at derm yesterday and he gave me prednisolone a type of steroid to take for a month and accutane to start on the 3rd week. Think steroid to calm it and hopefully help keep an initial breakout at bay if I get 1. So I am just starting this and I hope that after this treatment I finally after 17 years have clear skin😊 can update if anyone wants to knowðŸ'ðŸ½
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July 25, 2015
Hey just an update!! I am currently on day 37 of accutane. For the 1st 28 days I was on 20mg and as I said on the post above I also had steroids for th 1st 2 weeks. 3 weeks in I went for bloods and as my cysts were still there my deem gave me more steroids for 2 weeks. And upped my dose of accutane to 50mg. That was a week and a half ago. My cysts are goin down.....slowly but never the less they are getting smaller. The rest of my face is clearing as well although red marks are still there even though the spots are gone. SIDE EFFECTS SO FAR •dry lips and mouth •dry patches of skin on hands •little back and neck pain •bloody crusty boogers on right nostril🙈 so expecting nose bleed soon I use the brand simple for my face wash, face wipes and day and night moisturisers. So far so good as I can now see an improvement, fingers crossed it starts to go away a lot quicker now I am on a higher dose😊
July 25, 2015
forgot to say I also had an increased heart rate for the 1st month, since being on 50mg that's stopped, maybe my body is getting used to th drug
August 30, 2015
How are you doing now?
June 9, 2015
I don't know how other people are able to take it for so long
Roaccutane is one of the worst medication I've ever been on. Within half an hour after taking the first 20mg Isotretinoin, I became extremely irritable and had uncontrollable anger and snapped at my mom for no reason. On the second day, I started getting severely depressed and cried in middle of the day for no reason. I also became extremely fatigued and I could only run for 20 minutes on the treadmill when I normally run for 50 minutes. I also started having memory problems and I couldn't even remember the 4 digit number that I always use at work. I felt not right being on Roaccutane and I felt like I was dying inside. Because of these side effects, I eventually quit on Day 5 and I didn't quit because of the horror stories I've read online, I quit since I couldn't handle the side effects any longer. On the contrary, I'm currently on SSRIs after the depression caused by Roaccutane. And there are just as many horror stories from SSRIs but I'm still taking it because the side effects are nowhere near as horrible as Roaccutane.
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August 20, 2015
There is no way you could have felt any effects within half an hour, or even the first couple of days. Definitely no way you could have developed depression from 5 days of 20mg pills. Sounds like a combination of hypochondria and some other personal issues that needed addressing before treatment. Good luck

Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.