Oral Retinoid
Reviews
3.9
2786 Reviews
Oral Retinoid
Efficacy
87%
Based on All Available Studies
Strength of Evidence
1
2
3
4
5
Note: Use with EXTREME CAUTION: Causes severe birth defects and fetal death.
Oral Retinoid
Side Effects
High
Oral Retinoid
Acne.org’s Real World Take
The nuclear option. It works reliably and provides long-term remission of acne, and even severe acne, in about ⅔ of people who properly take an adequate dosage. However, it permanently and irreversibly changes the skin and the body forever and users may experience long-term side effects for the rest of their lives. It’ll nuke it, but there is no going back.
Oral Retinoid
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Read All About Isotretinoin (Accutane®)
Compare To Other Treatments
5
37.1%
4
33.4%
3
15.6%
2
7.4%
1
6.6%

Used Isotretinoin (Accutane®)? Rate It:

Choose from 1 to 5 stars
May 14, 2015
Accutane so far
I am beginning my third month of accutane and what can I say, I LOVE IT! I have experienced the usual dry skin and lips but nothing too bad. I recommend using carmex for your lips, it is a life saver. Before accutane my face was super oily. I noticed after 2 weeks on accutane I was not producing oil. My makeup would stay on all day and I could go days without washing my hair, awesome right?! If any of you are nervous about taking accutane I would give it a try. Talk it over with your dermatologist and determine what is best for you. I am so glad that I made this decision. Sure, the monthly blood tests and pregnancy tests are a hurdle to go through, but if you want clear skin its totally worth it. I hope that my skin will stay clear even after accutane so fingers crossed! Good luck to all.
This Was Helpful

11 user(s) found this helpful

Report
December 10, 2015
What BC did you take while on accutane? Did that affect your acne as well?
May 10, 2015
6 months course, acne free.
Extremely harsh drug, experienced side effects during the whole course ( hair loss body wide, back pain, jaw lock, bloody nose, eyes dryness) but the outcome was excellent. Works phenomenal with Comedonal acne (had +200 closed comedones on my face, i'm not counting the ones on my back/chest) and obviously also with inflammatory acne. Unfortunately after 5 months of finishing the course i'm still experiencing back pain (not serious at all, but scary) and dry lips.
This Was Helpful

7 user(s) found this helpful

Report
August 4, 2017
Did your closed comodones leave scars
May 4, 2015
Seven years after Accutane; still clear!
I had terrible, painful cystic acne all over my face, back, and chest from the time I was 12 until I was 23, when I was finally put on Accutane. I took a six month course of 40mg and had very few side effects; just the usual dry skin, dry lips, and a few days my eyes were too dry to wear my contacts, but I have had no long term effects. I turn 30 next month and my skin is still clear (I still get a bump or two every now and then, but it's drastically smaller than my old cysts and goes away in a matter of days instead of weeks.) I still have pretty noticeable and bad scaring on my cheeks and back, but the Accutane even seemed to smooth those out a little bit, too. Accutane was seriously a miracle cure for me, before I finally got my prescription I had tried years of scrubs, washes, medicated lotions, antibiotics, etc. I do believe it is important for everyone to fully research what they plan of taking and look into several options, but don't be afraid of Accutane. :3 It wasn't nearly as scary as I expected and I'm incredibly thankful for the results I received.
This Was Helpful

19 user(s) found this helpful

Report
April 30, 2015
It is your only option and the best thing I have ever done.
I'm a 32 year old female and broke out with very severe acne all over my face about a year and a bit ago. I've never had flawless skin but I've also never had acne before. This was very sudden and there is no obvious cause for it. Before starting my course of accutane, I spent over a year on this site (and many others) reading people's reviews trying to pick out the positives and trying desperately hard to ignore all the scary negative reviews. About this time last year I was offered accutane as my final solution to my hideous acne and I turned it down. I wasn't particularly convinced by the suicide claims but put off more of the apparent ageing of your body and the fact that you have to sign a disclaimer before you take the drug ( I don't know of any other). Anyway after a year of trying apple cider vinegar, tea tree, jojoba oil, diet changes etc etc and of crying everyday as I tried, unsuccessfully, to cover huge cysts that were so bad they changed the shape of my face I decided to go back to my docs and asked for a referral. By this point, I'd had holidays ruined (one's were I don't appear in any photo's, where people cruelly stared at me on trains probably because they thought I had a contagious disease), so many night's out missed, so many old friends falling by the wayside as I didn't want them to see me how I was, that I really didn't care about the side effects anymore. If anything, I was panicking that the derm would find a reason not to give me accutane and I'd be stuck that way forever. When I started taking 30mg, I was ultra-aware of every change in my body and immediately blamed any aches and pains on the tablets. Nothing I have experienced so far has made me want to stop taking them. It was after two weeks that I started getting dryness and I was pretty dry already..I could live with this and as for the initial breakout (which didn't happen for me) I don't think I would have noticed as my skin was so bad anyway. I am now over a month in and on 40mg, my skin on my face is dry - about 4hrs after washing my face and moisturising I get sort of like tiger-striped peeling on my lower cheeks, chin and a bit on my forehead. My skin is also quite red and I have dry circular patches on my arms and chest which I know will go when I stop taking the drug (somedays if I moisturise well it's barely noticeable and it has calmed down loads as my body gets used to the dosage increase). The real deal-breaker though is that after a month, loads of people have commented on how much better my skin looks and I feel that although I have some way to go, if I had to stop the tablets for any reason I would be far happier to have it as the way it is now. I'm no longer in pain, I don't spend every minute of the day thinking about my acne (or what other's think), not rushing home to wash my face so I feel clean. If you do any of that, you at least need to give accutane a try, I know a lot of people say this but I really wish I had taken it sooner. I saw a lad sat at a bus stop the other day with skin that was as bad as mine and I wanted to tell him to take it. There is absolutely no reason why you shouldn't have clear skin like everyone else. Products I find useful are: Liz Earle's Skin Repair Moisturiser for dry/sensitive skin - when I was doing research all I read about was Cetaphil. I bought both the moisturiser and the wash and hate them both. They are full of chemicals and they made my skin feel like I'd put aftershave on it. Clarins Santal Oil - this is great under moisturiser when your skin gets REALLY dry Liz Earle's Instant Boost Skin Tonic - nice calming softening toner. La Roche Posay Effaclar Purifying Foaming Gel - I've used this on and off since I first started getting acne, I always want to try new things but this is good at cleansing and it's very mild. I use it with Liz Earle's muslin cloths which I use to scrub the dead skin off my face. These are great because even though the derm will tell you not to exfoliate, there is absolutely no way you won't...you just can't leave it like that, especially if you are a girl and wear foundation. I use Neutrogena Deep Moisture Comfort Balm for my body and this stuff is brilliant, I even use it on my face sometimes when I need more moisture than usual. You get a 300ml tub for £6 and it is so soothing and lasts ages ( I know this as my skin feels slimy when I wash in the morning) For my lips, which get really really dry - I tried Burt's Bees lip balm, Palmer's Coco Butter lip balm, a Vitamin E rescue balm from Superdrug, oil, Cetaphil and nothing stopped that weird cracked and greasy feeling you get. I found an old lip balm in my bag that I got from Germany and it is the only thing that works for me. I paid £8 to get it delivered to the UK and I wouldn't hesitate spending that again when it runs out it is so worth it. It is called Med Protection SPF 15 by Labello and it's amazing. Labello is the German version of Nivea and I'm not sure whether the UK version matches up but I would definitely recommend just trying Labello. I know this has been a lengthy review but I really want to help people who are agonising over whether to take accutane. Acne is a horrible and heart-breaking thing to have to go through and I sympathise with anyone who is. Please give it a try!
This Was Helpful

24 user(s) found this helpful

Report
April 23, 2015
Changed my life
Honestly, accutane is a miracle worker. Just a little over a year since I've been off of it and I feel amazing! It shrank my poors and got rid of my acne, completely. I'm left with just a few acne scars but that would happen either way (it's not because of the drug). I had chronic acne since the age of 11. Not even kidding you, it was awful! I was made fun of and it really lowered my self esteem and made me very insecure about myself. I started taking the drug when I was about 13 and know, at 15 my acne went away and stayed away. It's quite ironic because the people who used to make fun of me for it are now actually asking me for advice because they have bad acne now. I would recommend this to anyone. The only side effects I got were dry skin, but don't worry that's normal. That's the one side effect that almost everyone who takes accutane gets. Don't worry about it though, it's only temporary and if you just use moisturizer it's really not that hard to control. I took it for about 7 months with a dose of two pills per day. I was kind of disappointed at first because nothing seemed to happen for the first 4 months! But after that it really kicked in and I started clearing up like crazy! The one thing I would recommend to people though is that keep it up and don't stop taking it even if your skin looks clear. TAKE THE FULL DOSE PROVIDED BY YOUR DERMATOLOGIST!!! I cannot stress that enough. The acne will come back if you stop taking it while you are supposed to be taking it. Anyways it worked for me and it really changed my life! And for anyone that is scared or nervous, don't be. Just think of the future, how great it will be to have clear skin and NO PIMPLES!!!
This Was Helpful

16 user(s) found this helpful

Report
April 23, 2015
Complete clear-up of acne but be mindful of side effects
I was on Accutane for 5 months after developing acne in my early twenties and it getting persistently worse until I decided at age 25 to do something about it. I tried antibiotics, skin gels and creams but nothing worked and I didn't want to go on the contraceptive pill. Accutane completely cleared up my acne, all I have left now is some scars and redness which i've been told will gradually dissappear as Accutane apparently continues to renew your skin after stopping taking it. My life is so much easier now not having to worry about covering up my bad skin with lots of make up and not having the soreness I would sometimes feel from the spots. However, for me, there were some serious drawbacks as it gave me extremely dry and sore eyes, lowered my immune system which meant I had a cold for 3 months in winter, chest tightness and occasional heart palpitations, rashes on my hands, oily hair and extremely dry lips. The side effects have almost gone now, my lips and eyes are a bit dry still but nowhere near as bad as when I was on it. I had to stop the medication at 5 months as I was starting to feel so run down with all the side effects and was getting concerned. If I could go back in time I would still have taken Accutane as acne-free skin trumps a few months bad side effects but just be aware of when the medication is getting too much for your body. I can't even remember the last time I had a spot!
This Was Helpful

5 user(s) found this helpful

Report
April 19, 2015
Worst decision of my life
I took Amnesteem for two weeks and it completely destroyed my eyes by giving me tons of vitreous floaters. Eye floaters are permanent and there is no safe surgical procedure to get rid of them. It also gave me tinnitus (constant ringing in my ears). So I basically just ruined my life AND I still have acne.
This Was Helpful

6 user(s) found this helpful

Report
May 27, 2015
Do you have these floaters all the time or do they just occur when you do something like sneeze or cough?
April 12, 2015
Really great at clearing up acne
I have been on the higher end Canadian version of accutane called epuris. It's only considered more high end because you can take it with any sort of food, whereas, with the lower end ones you have to take it with a large meal and you're not supposed to drink milk with it. I have been taking 40 mg daily of epuris for about two months now, though I take breaks when my hands or lips get too dry. My doctor told me it doesn't matter if you continuously take it, as long as you get the required mg/kg within the next 4-6 months. That way, I won't have as many side effects, which I appreciated. Initially, it did get a little bit worse so don't worry if that happens to you. I don't have severe acne, it might be considered moderate and it's only on my cheeks. Most of it is scarring and redness so it looks worse than it is. The initial flare up may be worse if you have more severe acne. After a few days, I started to see it work. It dried my skin so the acne went away more quickly. A couple other flare ups happened but then they cleared up quickly and now it has been awhile since I've had one. I wash with cetaphil morning and night and use a tea tree/eucalyptus cream spot treatment. I think plain tea tree oil might be too harsh because your face gets very, very dry. It's also important to use lots of moisturizer and if possibly, get a prescription for hydrocortisone cream for your lips and hands. I have 1%. The only really inconvenient side effect is the dry lips. I have dry lips in the first place so this made them 10x worse. Currently, my lips are cracked and scabbed at the corners. I kind of look like the joker but it's still better than acne. I'll power through it until the treatment is done. The acne clearing benefits outweigh not being able to wear lipstick for a few months. Hopefully this was helpful! I recommend it! Just make sure you don't take a super high dosage in too little time because the side effects may be too much to deal with. xx
This Was Helpful

6 user(s) found this helpful

Report
April 6, 2015
45 year old female on accutane
I have been on accutane for 9 months (40mg/day first 6 months and 60mg/day last 3 months) and this is my last month. My cystic acne has cleared up very early on but I keep getting these little pimples. I have about 2 pimples a week although they go away within a day or two without leaving any marks, I am very discouraged. I was hoping I am 100% clear by now and I worry what is going to happen when I go off accutane. My derm said accutane is not as effective on middle age patients, what is your experience?
This Was Helpful

1 user(s) found this helpful

Report
March 29, 2015
Avoid
I took a full course of Accutane over the course of 8 months. I got my dream come true because I got gorgeous skin!!....at a price. I have developed chronic dry eye syndrome that they directly relate to Accutane. My eyes hurt pretty much 99% of the time and I can no longer wear contacts. I have been off Accutane for one year, and my acne has returned right back to where it was prior to the tane. It's not worth it.
This Was Helpful

7 user(s) found this helpful

Report
July 20, 2015
How are you doing now?
July 14, 2016
Yeah I have dry eyes too , big bad pHARMa.

Finding a Doctor

The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:

  1. Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
  2. Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
  3. Do your research and go to your first appointment with questions prepared.
  4. Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.

Finding a Doctor

Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.

Be sure to:

  • Look at before and after photos, the more the better, especially patients with similar scarring to your own.
  • Be realistic about results. Look for improvement, not a cure.

Questions to ask a potential scar revision specialist:

  • Are you board certified? Be certain that they are board certified.
  • How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
  • Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.

Red flags:

  • Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
  • Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.