Isotretinoin (Accutane®)Oral Retinoid Compare To Other Treatments OverviewHow to UseSide EffectsHow It WorksPregnancy & BreastfeedingIsotretinoin works through the following mechanism:Anti-sebaceous activityIsotretinoin decreases skin oil (sebum). Relevant Article(s):Accutane (Isotretinoin)What are the side effects of Accutane (isotretinoin)?Does Isotretinoin Help with Acne Scars? Relevant Review(s):TretinoinAdapalene Relevant Forum(s):Prescription acne medications