Fractional CO2 Laser with Platelet-rich Plasma

Compare To Other Treatments

What Is It?

Fractional CO2 laser refers to a laser that shines an intense beam of light at the skin in a dot-matrix (imagine tiny polka dots) pattern. The light completely removes (ablates) the epidermis in this dot-matrix pattern, leaving some of the skin intact. This stimulates the underlying dermis to produce more collagen and elastin over time. 

After the fractional CO2 laser, platelet-rich plasma (PRP) is applied to the skin. Platelet-rich plasma is extracted from the patient’s own blood just before the start of the treatment and contains high levels of growth factors, which help further stimulate the skin to produce collagen and elastin. Applying PRP also shortens skin recovery time after laser treatment.

This procedure is normally repeated 3 times in 1-month intervals, and you should see gradual results with each session. And after your last session, your skin should continue to improve.

Good or Excellent Response

Strength of Evidence
1
2
3
4
5
71% of patients achieved a good (>50%) or excellent (>75%) improvement in scarring after 3 sessions

Moderate Response

Strength of Evidence
1
2
3
4
5
94% of patients achieved at least a moderate (>25%) improvement in scarring
▸ Based on These Clinical Studies & Trials
▾ Based on These Clinical Studies & Trials
  1. Priya, D. & Patil, S. A split face comparative interventional study to evaluate the efficacy of fractional carbon dioxide laser against combined use of fractional carbon dioxide laser and platelet-rich plasma in the treatment of acne scars. Indian Dermatol Online J 14, 371–374 (2023).
  2. El Dakrory, F., El-Mongy Mohammed, S., Gomaa, S. & Alashry, S. Fractional CO2 laser with platelet-rich plasma versus fractional CO2 laser with topical insulin in the treatment of postacne atrophic scars. Dermatology Research and Reports 2, (2023).
  3. Puram, K., Laul, R. & Asia, A. Efficacy of fractional CO2 laser with topical platelet rich plasma in treatment of acne scars. International Journal of Medical Science And Diagnosis Research 4, (2020).
  4. Neinaa, Y. M. E.-H., Al-Khayat, L. A.-E., Suliman, G. A. M. & Ameen, T. E.-S. Fractional carbon dioxide laser-assisted delivery of lyophilized-growth factors is a promising treatment modality of post-acne scars. Dermatol Ther 33, e14488 (2020).
  5. Mahamoud, W. A., El Barbary, R. A., Ibrahim, N. F., Akmal, E. M. & Ibrahim, S. M. Fractional carbon dioxide laser combined with intradermal injection of autologous platelet-rich plasma versus noncross-linked hyaluronic acid in the treatment of atrophic postacne scars: a split face study. J Cosmet Dermatol 19, 1341–1352 (2020).
  6. El-Hawary, E. E., Nassar, S., Hodeib, A. A., Shareef, M. M. & Fawzy, M. M. Ablative fractional carbon dioxide laser and autologous platelet-rich plasma in the treatment of atrophic acne scars: a comparative clinico-immuno-histopathological study. Lasers Surg Med (2020) doi:10.1002/lsm.23306.
  7. Banker, K. A split face comparative study of microneeding with platelet rich plasma versus fractional CO2 laser with platelet rich plasma in management of atrophic acne scars. (2020).
  8. Arsiwala, N. Z., Inamadar, A. C. & Adya, K. A. A comparative study to assess the efficacy of fractional carbon dioxide laser and combination of fractional carbon dioxide laser with topical autologous platelet-rich plasma in post-acne atrophic scars. J Cutan Aesthet Surg 13, 11–17 (2020).
  9. Galal, O., Tawfik, A. A., Abdalla, N. & Soliman, M. Fractional CO2 laser versus combined platelet-rich plasma and fractional CO2 laser in treatment of acne scars: image analysis system evaluation. J Cosmet Dermatol 18, 1665–1671 (2019).
  10. Al Taweel, A.-A. I., Al Refae, A.-A. A.-S., Hamed, A. M. & Kamal, A. M. Comparative study of the efficacy of platelet-rich plasma combined with carboxytherapy vs its use with fractional carbon dioxide laser in atrophic acne scars. J Cosmet Dermatol 18, 150–155 (2019).
  11. Abdel-Maguid, E. M. et al. Efficacy of stem cell-conditioned medium vs. platelet-rich plasma as an adjuvant to ablative fractional CO2 laser resurfacing for atrophic post-acne scars: a split-face clinical trial. J Dermatolog Treat 1–8 (2019) doi:10.1080/09546634.2019.1630701.
  12. Min, S. et al. Combination of platelet rich plasma in fractional carbon dioxide laser treatment increased clinical efficacy of for acne scar by enhancement of collagen production and modulation of laser-induced inflammation. Lasers Surg Med 50, 302–310 (2018).
  13. Abdel Aal, A. M., Ibrahim, I. M., Sami, N. A. & Abdel Kareem, I. M. Evaluation of autologous platelet-rich plasma plus ablative carbon dioxide fractional laser in the treatment of acne scars. J Cosmet Laser Ther 20, 106–113 (2018).
  14. Shah, S. D., Mehta, B. D., Borkar, M. A. & Aswani, R. C. Study of safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser in the treatment of post acne scars: a comparative simultaneous split-face study. International Journal of Research in Medical Sciences 5, 1344–1351 (2017).
  15. Kar, B. R. & Raj, C. Fractional CO2 laser vs fractional CO2 with topical platelet-rich plasma in the treatment of acne scars: a split-face comparison trial. J Cutan Aesthet Surg 10, 136–144 (2017).
  16. Faghihi, G. et al. Efficacy of autologous platelet-rich plasma combined with fractional ablative carbon dioxide resurfacing laser in treatment of facial atrophic acne scars: a split-face randomized clinical trial. Indian J Dermatol Venereol Leprol 82, 162–168 (2016).
  17. Gawdat, H. I., Hegazy, R. A., Fawzy, M. M. & Fathy, M. Autologous platelet rich plasma: topical versus intradermal after fractional ablative carbon dioxide laser treatment of atrophic acne scars. Dermatol Surg 40, 152–161 (2014).

Side Effects

Medium-High
Medium-high side effects and adverse reactions

Reviews

View All
0.0
0 Reviews

Relevant Forum(s):