I've read in a few different threads that some people are under the mistaken belief that P. acnes, the bacteria that causes acne, can become resistant to benozyl peroxide (BP). Biologically, this is as far-fetched as believing bacteria can become resistant to alcohol. Because of what BP does on a biochemical level to P. acnes, bacteria cannot develop resistance or immunity to BP.
However, BP dosage may need to be eventually amped up in order to maximize BP exposure to the acne-causing bacteria and thus kill off more bacteria.
Here's a couple of supporting scientific articles for those interested:
First read: http://www.buzzle.com/editorials/6-20-2006-99918.asp
Then skim: http://blog.glaswater.com/articles/2/1/How...gens/Page1.html
Thanks for the post.
Dan also has some info on this in the FAQ's.
Q Will my skin become resistant to the beneficial effect of benzoyl peroxide?
A Propionibacterium acnes (P. acnes), the bacteria in acne lesions, cannot survive in the presence of oxygen. Benzoyl peroxide creates oxygen. Therefore, it is physically impossible for this bacteria to develop a resistance. If The Regimen works at first, it should always work.