Can I Cure My Extre...
 
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Can I Cure My Extremely Oily Skin?

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(@john-mcaurthur)

Posted : 08/17/2016 3:28 am

hi, this is my first post. you could probably tell from the title that I have extremely oily skin, some acne and blackheads too. Ive done hours of research online and have done everything they say to do (like moisturize, wash my face with a gentle cleanser, use witch hazel day and night etc) but my skin is still extremely oily. I'm a guy and still at school and during the day, even at 11am I can feel the oil on my face and especially on my big nose. I hate it because it not only affects my appearance dramatically but also prevents me from fully concentrating in class because of the greasy feeling (and its even worse by 3pm). Im getting so sick of it. I am now trying cod liver oil and if that doesn't work maybe some vit d3. does anyone have any suggestions for a cure? should I use the cod liver oil? or should I just go to the doctor and see what they recommend. thanks :) 

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(@zeroe)

Posted : 09/08/2016 4:37 pm

Try both those didn't work for me

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(@nicola_g20)

Posted : 09/08/2016 5:28 pm

I know youre a guy but you could try using a translucent powder, that will get rid of the shine and wont be noticeable as makeup on your face. you can also buy blotting sheets which you dab on your skin and they suck up all the oil, I have never tried them but they might help a bit.

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(@veronixue)

Posted : 09/09/2016 2:45 am

Hi, you could try the oil cleansing method. It might seem weird to cleanse your face with oil. It's hard to explain but you can "dry " your face up(slow the oil production down) with this method. First you have to do some research ofcourse and find wich are the best oils for you. I tried it once and it's a Great method !!!

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(@john-mcaurthur)

Posted : 09/27/2016 12:30 am

thanks guys

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(@rsbsc)

Posted : 09/28/2016 2:54 pm

There are only two proven options:

Low-dose accutane (5 -10mg/day)
Vitamin B5 (15 - 20GRAMS/day)

Everything else is trivial.

Emerging sebum inhibitors coming down the pipeline. Should see them by 2018. Both in phase 3 trials with the FDA.

Topical Sebum Inhibitors.Sebum production is a key driver of acne development. Newer acne drugs use sebum inhibition as a therapeutic target. DRM01 is a topical drug that inhibits coenzyme-A carboxylase, a key enzyme involved in fatty acid synthesis. The drug has demonstrated dose-dependent inhibition of lipid synthesis in human sebocyte cultures and reduced the size of sebaceous glands in an animal model. In a first-in-human, Phase 2a study, its safety and efficacy were evaluated for the treatment of moderate-to-severe facial acne in 108 subjects. Twice daily application of DRM01 7.5% gel demonstrated statistical reductions in both inflammatory and comedonal lesions as early as week 4 (inflammatory, p = 0.0666; comedonal, p = 0.0328) and at the end of the study at week 12 (inflammatory, p = 0.0006; comedonal, p = 0.0025). In addition, at week 12, a greater proportion achieved a 2-grade improvement in IGA compared to vehicle (p=0.0070). The drug was well tolerated with minimal local cutaneous adverse events reported.5DRM01 is being developed by Dermira.

SB204.Nitric oxide (NO) is an endogenous, short-acting molecule with both anti-microbial and anti-inflammatory activity. NO has demonstrated activity againstP. acnes, is anti-inflammatory, and has been shown to inhibit lipogenesis. SB204 is a topical NO containing gel that has been evaluated in the treatment of acne. In a Phase 2a study, two concentrations of SB204 (1% and 4%) were compared to vehicle. Statistical decreases in the mean percent change in both inflammatory and comedonal lesions were observed in the 4% formulation compared to vehicle at week 12 (p0.05), with approximately a 55 percent and 25 percent reduction in inflammatory and comedonal lesions, respectively. Moreover, total sebum levels were found to be reduced at the end of the study along with a dose-dependent decrease in squalene and percent of free fatty acids in the sebum.6SB204 is being developed by Novan Therapeutics.

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