I was wondering if anyone has come across myomin when researching estrogen dominance. I saw my dr. and I'm waiting for my hormone tests to come back, but she thinks that in addition to high androgens I also have high estrogen. So far, I have been treating high androgens and low progesterone with good results, but haven't address estrogen in my treatment.

Anyway, the doctor told me to look into myomin and see if I'm comfortable taking it. I've seen it mentioned briefly on PCOS forums but not here. I need to make a decision by next week when I go back to get my lab results. I am thinking of going with DIM instead of this because this one has too many herbs in the blend and I don't know how I will react to it. Plus, most reviews about myomin don't even mention acne, and it seems that it's mostly pre & menopausal women with fibroids take it. No idea why the dr recommended this over DIM. She even asked me to consider going back on vitex, but I'd rather take something less strong. Does myomin seem similar to how DIM functions? Does this seem to increase free testosterone like DIM does? I'm not taking anything else until I get my lab test back, but unfortunately my insurance didn't cover the saliva testing so they just drew blood instead. It was on my most hormonal day of the month, and I figured maybe something might show up in the lab but I'm still a bit disappointed that I had to do blood testing.

Here's the description from the Chinese herbal site that sells it: http://www.chi-health.co.uk/p_myomin.htm

There are two ways to block the action of estrogen. On is by attaching to its receptors (selective estrogen receptor modulation). This stops the signalling that triggers cell division in target tissues. Another method is aromatase inhibition, which reduces estrogen production by blocking its conversion from androstenedione and testosterone.

Myomin is an all-natural herbal formula that can perform both functions. It contains Aralia, Smilax glabra, Curcurma zedoria, and Cyperus rotundus. These herbs have been traditionally used for various female ailments and hormone related disorders. Aralia and Cyperus rotundus both can reduce estradiol. Cyperus is also effective against cervical endometriosis and cervical carcinoma. Additionally, Aralia has been found to be cytotoxic against several human cancer cell lines.

Myomin has three functions

• It inhibits the aromatase enzyme, effectively reducing estradiol levels by preventing the conversion of androgens to estrone and estradiol. This allows testosterone and estriol (the good estrogen) to accumulate. Aromatase inhibition has become a worthwhile target in many estrogen-dominant disorders
• It competes with estradiol at the estrogen receptors. This function is particularly effective in cases where estrogen receptors are fully stimulated (e.g. after HRT). Competing with estradiol prevents estradiol from binding to receptors. As a result, proliferation of cells is avoided and abnormal growth inhibited.
• In increase interferon (IFN) and interleukin-2 (IL-2). IL-2 induces the proliferation of immune cells, enhancing the body's ability to kill tumor cells. IFN stimulates natural killer cells and is active against tumors.