Hi, and welcome to the forums . I used aczone for close to 2 years a long time ago. For the first year it worked pretty well, not as good as BP, but still good enough. However, after around a year, my acne slowly got worse and worse. I was still using the aczone like normal, and I didn't know what was going on. I later learned that aczone is a topical antibiotic, and just like all antibiotics, the bacteria adapts and the antibiotic loses its effectiveness. I think this is what happened to me, and now I'm using Dan's BP and it is SO MUCH more effective than aczone. My advice is to not waste your time with aczone, and if you're not using Dan's BP, you should definitely look into it.