What are collagen? What are elastin? What topicals and nutrients are needed to best stimulate collagen/elastin synthesis? What about treatments? They're all covered here. Seriously, take the time and read it.
Neocollagenesis and Neoelastinogenesis: From the Laboratory to the Clinic
2 hours ago, Anish004 said:these all form scar tissue not normal tissue ?
"Neo-" usually meansnewor modified. As such, neocollagenesis is a controlled damage to the existing scar through the process of fibroblast to induce new collagen. Neverthelesss, our body does not differentiate between "normal" tissue vs "scar" tissue. These are just one long elongated collagen fibrils.
31 minutes ago, Anish004 said:you want to say skin and scar contain same fibred but arrangement and size differs ?
Well, kinda. Scar tissues are made of the same component as their healthy counterpart, namely, protein. But scar tissues are more dense than normal tissues. Without sounding too geeky or pretentious, I'm just gonna let you dive into the world of "extracellular matrix", which plays a critical role in the development of new tissues. Hope that helps.
This Molecule Found in Royal Jelly is the Secret Ingredient to Speed Up Wound Healing
(This study was earlier published inScientific Reports)
When skin is damaged, two main types of cells need to spring into action. These are fibroblasts and keratinocytes, which kick in to produce molecules that speed up the proliferation of new cells the skin can use to repair the damage.
The royal jelly molecule that helps skin cells with this job turns out to be a peptide called defensin-1. It belongs to a large class of smallantimicrobial proteins found in plants and animals [Link removed], including humans.
This particular defensin-1 peptide speeds up the production of an enzyme called MMP-9, which plays an important role in rebuilding the cell matrix in the skin.
In previous work the team investigated a different protein they thought was responsible for accelerated wound healing, but it turned outto not speed up the production [Link removed]of the helpful enzyme in human keratinocytes.
"One potential candidate that potentially participates in wound healing is MRJP1, which is the dominant honeybee protein present at high levels in both royal jelly and honey,"the researchers write in the study [Link removed].
Bee defensin-1, on the other hand, significantly increased the production of MMP-9 when the researchers tested it on keratinocytes in a petri dish.
"Similar to MRJP1, defensin-1 is a common but quantitatively variable factor present in both royal jelly and honey,"the team writes. [Link removed]
After isolating this peptide and testing it in the dish, the researchers then went ahead to see how it would perform on actual wounds. They anaesthetised 20 rats and gave each of them four wounds on the back.
One wound was treated with a royal jelly ointment, one with an isolated defensin-1 ointment, one was treated with just the neutral vehicle gel that was used for these ointments, and the last one was left untreated.
After 15 days, there was a significant difference in the healing speed of the treated wounds versus the controls. Both the royal jelly and the defensin-1 ointments had helped the wounds close over, while the controls were still partially open.
"Taken together, histological analyses showed that royal jelly as well as defensin-1 promoted a complete re-epithelialization of the wound surface and scar formation in the dermis,"the researchers concluded [Link removed].