No doubt there will be some especially motivated person that will get this done for his/her acne scars as soon if the results are successful. There is no shortage of people who will try any means to get rid of their scars.

`

6 hours ago, Raster said:

No doubt there will be some especially motivated person that will get this done for his/her acne scars as soon if the results are successful. There is no shortage of people who will try any means to get rid of their scars.

6 hours ago, Candy Says said:

and I am pretty sure this person will come from this thread

Rez77 Volunteers as tribute (guinea pig)

Interesting The patient who had what must of been only 2nd degree burn scar or at least a scar that was not full thickness "partially resurfaced" with dermabrasion or shave technique or some other method who knows but to regenerate skin with normal pigment so quick is positive even if its in early progressive healing stage. Residual scar (margin) at wound edge but no mention if it is less than width of a hair shaft but again very early stages.

6 hours ago, ScarRight said:

Even if this does work, an injectable option could be years away. I'm not sure I want my face cut out.

why it will take years ? the technology is the same just the application changes it will still be from patient to patient and autologous homologous product look at the conservation of Swanson with Tano1 Yea you know, it's hard to give the exact answer on every single one of those indications. Some of those could potentially be addressed with the SkinTE product as it stands today and others we are in the process of developing derivative products using similar technology to address." "It's a lot of nuances to what would be best in each situation, but you know I think that old scars, large scars can certainly be removed and have SkinTE applied to the base of the wound if the provider and patient think that could be beneficial."
"And, you know, if we're talking about smaller scars like acne scars or fine line scars in sensitive areas like on the face, then those might be things that people would rather address with some derivative products we're developing right now in our research and development department."

1 minute ago, damnBOY said:

why it will take years ? the technology is the same just the application changes it will still be from patient to patient and autologous homologous product look at the conservation of Swanson with Tano1 Yea you know, it's hard to give the exact answer on every single one of those indications. Some of those could potentially be addressed with the SkinTE product as it stands today and others we are in the process of developing derivative products using similar technology to address." "It's a lot of nuances to what would be best in each situation, but you know I think that old scars, large scars can certainly be removed and have SkinTE applied to the base of the wound if the provider and patient think that could be beneficial."
"And, you know, if we're talking about smaller scars like acne scars or fine line scars in sensitive areas like on the face, then those might be things that people would rather address with some derivative products we're developing right now in our research and development department."

the skin biopsy will still be needed BUT they will take a peace of skin from your body not your face ... the regeneration will be the same it doesn't matter where you take the skin the application is the problem here removing the entire dermis from your face and put a paste on it come on nobody will do this .......

I think when they talk about derivitaves they mean about different type of application of skinTE it will be skinTE in the box with different instructions how to use it that's the derivative product

12 minutes ago, damnBOY said:

why it will take years ? the technology is the same just the application changes it will still be from patient to patient and autologous homologous product look at the conservation of Swanson with Tano1 Yea you know, it's hard to give the exact answer on every single one of those indications. Some of those could potentially be addressed with the SkinTE product as it stands today and others we are in the process of developing derivative products using similar technology to address." "It's a lot of nuances to what would be best in each situation, but you know I think that old scars, large scars can certainly be removed and have SkinTE applied to the base of the wound if the provider and patient think that could be beneficial."
"And, you know, if we're talking about smaller scars like acne scars or fine line scars in sensitive areas like on the face, then those might be things that people would rather address with some derivative products we're developing right now in our research and development department." the skin biopsy will still be needed BUT they will take a peace of skin from your body not your face ... the regeneration will be the same it doesn't matter where you take the skin the application is the problem here removing the entire dermis from your face and put a paste on it come on nobody will do this .......

I think when they talk about derivitaves they mean about different type of application of skinTE it will be skinTE in the box with different instructions how to use it that's the derivative product

when the results come out hopefully they will achieve skin regeneration we should call them to learn more about the cosmetics application of skinTE and their derivatives

How about using an existing Skinte instead of releasing a separate derivative? shallow
The scar is a laser dressing. Deep scars inject the syringe into the scar. Using existing Skinte products will not take time. Of course this can be done after human results. All of this is my guess.

Hi all,

Just an update for you guys. Like I said, I'm currently going down the list of clinical advisors to see if any of them would be willing to use SkinTE on my scars. I'm in communication with a nurse of a doctor in Ohio and she is checking with him to see if he would be willing. Someone asked what type of scars I have. They're two small atrophic surgical scars. They're pretty small (a few centimeters) and similar to rolling acne scars. Not too deep but deep enough that they cast a shadow.  I've had just about every treatment out there. I will let you all know what happens  

Also, nut sure if anyone else pointed this out but I do think this is interesting -  œI have used SkinTE to partially resurface extensive burn scars...". Wouldn't that indicate that he didn't fully excise the scar when he administered SkinTE to the scar and that he maybe used some type of partial ablation instead (dermabrasion or laser)? If that's the case, that's great news for us, isn't it? This would mean that they wouldn't necessarily need to fully excise our scars in order for us to be treated with SkinTE. If I'm interpreting that wrong, please let me know.

39 minutes ago, sousou_bella said:

Hi all,

Just an update for you guys. Like I said, I'm currently going down the list of clinical advisors to see if any of them would be willing to use SkinTE on my scars. I'm in communication with a nurse of a doctor in Ohio and she is checking with him to see if he would be willing. Someone asked what type of scars I have. They're two small atrophic surgical scars. They're pretty small (a few centimeters) and similar to rolling acne scars. Not too deep but deep enough that they cast a shadow.  I've had just about every treatment out there. I will let you all know what happens  

Also, nut sure if anyone else pointed this out but I do think this is interesting -  œI have used SkinTE to partially resurface extensive burn scars...". Wouldn't that indicate that he didn't fully excise the scar when he administered SkinTE to the scar and that he maybe used some type of partial ablation instead (dermabrasion or laser)? If that's the case, that's great news for us, isn't it? This would mean that they wouldn't necessarily need to fully excise our scars in order for us to be treated with SkinTE. If I'm interpreting that wrong, please let me know.

I noticed that for sure.

I think it could be either: 1. As you suspect that the burned skin was not fully excised but rather reaurfaced with a laser, peel, dermabrasion etc. and then treated with SkinTE.  Or 2. The skin was excised but the doctor only removed a section of the burned skin. Hence the use of œpartially.

From a strict grammatical interpretation, I think #1 makes the most sense. However, given that the doctor said that he and the patient™s parents are discussing treating the rest of the scars with SkinTE, and that everything PolarityTE has released about the product says you excise the wound completely, I feel like that lends itself to #2.

All speculation. really, but we could reach out to the doctor directly and just ask him. 
 

https://www.businessinsider.com.au/botox-maker-allergan-buys-elastagen-2018-2

Quote

 

University of Sydney spin-off Elastagen, which has a product to fix stretch marks and acne scars, has been bought by multi billion dollar global biopharmaceutical Allergan, the manufacturer of Botox, for $US95 million ($A120 million).

 

`

8 hours ago, sousou_bella said:

 Someone asked what type of scars I have. They're two small atrophic surgical scars. They're pretty small (a few centimeters) and similar to rolling acne scars. Not too deep but deep enough that they cast a shadow.  I've had just about every treatment out there. I will let you all know what happens  

Did you get any improvement with existing treatment? Have you tried infini rf? Apparently that sometimes helps with atrophic scars. All the best with finding a skin TE doctor. 

34 minutes ago, Candy Says said:

Can someone pay 300$ for availability to read this article?
https://www.lifescienceleader.com/doc/polarityte-beyond-cells-to-whole-tissue-0001

300$ equals 2cm square of your scar treated with SkinTE

`

1 hour ago, rudy1986 said:

300$ equals 2cm square of your scar treated with SkinTE

That is a lot cheaper than what I thought it would be. So doing cheeks only would be 2-3 thousand?

1 hour ago, ScarRight said:

Did you get any improvement with existing treatment? Have you tried infini rf? Apparently that sometimes helps with atrophic scars. All the best with finding a skin TE doctor. 

I haven™t had much improvement from anything besides Infini. I™ve done two infini treatments so far. I™m getting my third in a week. Infini is effective but only with very small scars from what I™ve seen so far.  You would think it would work great for most acne scars because it almost completely filled up the two tiny scars that I sustained when I had a ultrapulse deepfx treatment. My two Infini treatments definitely filled up the two depressed areas so I can understand why ppl are excited about Infini but for some reason it™s not doing too much for the scars that actually bother me and I think it™s because they™re bigger. I™ve only had two treatments though so maybe that™s why. Although, come to think of it, my scars have become a bit less deep ever since I had my first Infini treatment and maybe it was because my first treatment was much more intense than my second one. I will definitely continue on with my infini treatments in the meantime while I™m looking for a SkinTE Doctor. 

Just an update, I contacted a SkinTE clinical advisor in New York and in Ohio and they both said they aren™t using the product yet. So far I™ve contacted 3 doctors total - two have said they aren™t using SkinTE yet, & one has said that it™s too early to recommend SkinTE in my specific case. I™m currently waiting to hear back from a doctor in New Orleans. For some reason, I™m feeling very positive about this doctor  

On 2/7/2018 at 10:13 AM, ScarRight said:

Even if this does work, an injectable option could be years away. I'm not sure I want my face cut out.

I want do it if it really works, and I guess many other too. I suffered for too long.

On 2/3/2018 at 2:53 PM, golfpanther said:

We should all take the moderator's advice and just ignore Rez77.

To fill in those curious about the hydrogel, I actually spoke to Dr. Sun directly and posted the convo in a private thread. He achieved what he called "perfect skin" in pigs but is choosing to go through clinical trials in humans to prove its efficacy. He also said that he will likely need to optimize the product for humans because nothing goes "0-100." On top of that he needs a lot of investment money to just conduct trials. His research is not vague or ambiguous and the entire paper was free to read over the last quarter of last year. It's just extremely hard to get that kind of money if you're not working on a commercial product. It's a catch-22”investors want results that only the trials can give you, which of course you need the money for in the first place.

This is why any suspicions I had about PolarityTE going public so soon were tempered greatly by the fact that it just made more sense. If you can (and they can because they fall under the 361 regulatory pathway of the FDA) become a company with an actual product as soon as possible far more investors will be enticed by that setup than a researcher conducting trials. Of course someone (and many on here have) could equate that to a get rich quick scheme but for me it just was a smart business move.
 
Great work! 

Pretty much as Sniffy said”this is an expected response when there are no results. Just to clarify, there haven't been any results released on humans so it's unknown what level of regeneration it achieves in us.

I'm assuming it's Dr. William Hickerson you got in touch with at Tennessee. I wonder if he'd share any initial observations he has about the results thus far. I doubt he'd be willing but could be worth a shot.

Regardless, nicely done! The more proactive members of this board are the less guess work. 

Dr Hickerson emailed you back??? I have been waiting to hear back from him for weeks. I have been in touch with Precious his medical assistant and now she is out of the office so yesterday I spoke to his NP. Still have not heard anything and they won't give me his email to send pics. I am so confused how you got this response so quickly. Obv I don't want to go there if he just wants to use lasers or some other b.s. on me

12 hours ago, sousou_bella said:

Hi all,

Just an update for you guys. Like I said, I'm currently going down the list of clinical advisors to see if any of them would be willing to use SkinTE on my scars. I'm in communication with a nurse of a doctor in Ohio and she is checking with him to see if he would be willing. Someone asked what type of scars I have. They're two small atrophic surgical scars. They're pretty small (a few centimeters) and similar to rolling acne scars. Not too deep but deep enough that they cast a shadow.  I've had just about every treatment out there. I will let you all know what happens  

Also, nut sure if anyone else pointed this out but I do think this is interesting -  œI have used SkinTE to partially resurface extensive burn scars...". Wouldn't that indicate that he didn't fully excise the scar when he administered SkinTE to the scar and that he maybe used some type of partial ablation instead (dermabrasion or laser)? If that's the case, that's great news for us, isn't it? This would mean that they wouldn't necessarily need to fully excise our scars in order for us to be treated with SkinTE. If I'm interpreting that wrong, please let me know.

HI please share the docs name in Ohio. I would like to consult if they are using the skinte as I can drive there instead of fly thanks

2 hours ago, sousou_bella said:

I haven™t had much improvement from anything besides Infini. I™ve done two infini treatments so far. I™m getting my third in a week. Infini is effective but only with very small scars from what I™ve seen so far.  You would think it would work great for most acne scars because it almost completely filled up the two tiny scars that I sustained when I had a ultrapulse deepfx treatment. My two Infini treatments definitely filled up the two depressed areas so I can understand why ppl are excited about Infini but for some reason it™s not doing too much for the scars that actually bother me and I think it™s because they™re bigger. I™ve only had two treatments though so maybe that™s why. Although, come to think of it, my scars have become a bit less deep ever since I had my first Infini treatment and maybe it was because my first treatment was much more intense than my second one. I will definitely continue on with my infini treatments in the meantime while I™m looking for a SkinTE Doctor. 

Just an update, I contacted a SkinTE clinical advisor in New York and in Ohio and they both said they aren™t using the product yet. So far I™ve contacted 3 doctors total - two have said they aren™t using SkinTE yet, & one has said that it™s too early to recommend SkinTE in my specific case. I™m currently waiting to hear back from a doctor in New Orleans. For some reason, I™m feeling very positive about this doctor  

Hi can you tell me the doc in NO that you are consulting with. Is the doc on the list from this thread? thanks! I am calling all the docs on the list. TBH its difficult because when I call places every single person including Dr. HIckerson's NP has said that they have never heard of it 

SkinTE= Epibone

`

1 hour ago, kim6288 said:

Dr Hickerson emailed you back??? I have been waiting to hear back from him for weeks. I have been in touch with Precious his medical assistant and now she is out of the office so yesterday I spoke to his NP. Still have not heard anything and they won't give me his email to send pics. I am so confused how you got this response so quickly. Obv I don't want to go there if he just wants to use lasers or some other b.s. on me HI please share the docs name in Ohio. I would like to consult if they are using the skinte as I can drive there instead of fly thanks Hi can you tell me the doc in NO that you are consulting with. Is the doc on the list from this thread? thanks! I am calling all the docs on the list. TBH its difficult because when I call places every single person including Dr. HIckerson's NP has said that they have never heard of it

The doctor from New Orleans has to be Dr. Gerhard S. Mundinger.

This is from PolarityTE's press release:

I have used SkinTE to partially resurface extensive burn scars and skin graft contractures in an adolescent patient. Although early in the post-operative period, the product has quickly regenerated skin with minimal marginal wound contracture and areas of regenerated skin are re-pigmenting rapidly, said Gerhard S. Mundinger, MD, Director of Plastic Surgery at Childrens Hospital in New Orleans, Assistant Clinical Professor of Plastic Surgery, and Assistant Professor of Cell Biology and Anatomy at LSU Health New Orleans.

He's one of the docs on their clinical advisory board and unless he's part of some grand conspiracy (as others seem to think on this board) he's 100% used the product as stated in the above quote.

In terms of Hickerson, I speculated that Sousa contacted him because Sousa was going down the list of clinical advisors and he's the one in Tennessee. Perhaps Sousa found someone else there, but I doubt it.

so the marginal wound is visible to naked eye

8 hours ago, kim6288 said:

Dr Hickerson emailed you back??? I have been waiting to hear back from him for weeks. I have been in touch with Precious his medical assistant and now she is out of the office so yesterday I spoke to his NP. Still have not heard anything and they won't give me his email to send pics. I am so confused how you got this response so quickly. Obv I don't want to go there if he just wants to use lasers or some other b.s. on me HI please share the docs name in Ohio. I would like to consult if they are using the skinte as I can drive there instead of fly thanks Hi can you tell me the doc in NO that you are consulting with. Is the doc on the list from this thread? thanks! I am calling all the docs on the list. TBH its difficult because when I call places every single person including Dr. HIckerson's NP has said that they have never heard of it

Hi Kim,

As soon as I find a doctor who uses the product and is willing to use it on new patients even if they say they wouldn't recommend it for me but they would be willing to use it on a different candidate, I will 100% for sure come back and tell you all. Yes, the doctor I have reached out to in New Orleans is Dr. Mundinger. His nurse hadn't heard of the product but she said she would forward my email and pictures to him and ask him. The thing is we already know that he uses the product because it says in the article that he revised a child's burn scar with SkinTE so it's just a matter of seeing if he would be willing to use it on anyone else. Maybe he's only using it on patients who have had previous skin grafts etc or in cases which in his opinion are "extreme" for lack of a better term.

Not sure how I got a response from Dr. Hickerson so quickly maybe it was just luck. I was quite surprised as well when he emailed me back on the same night that I sent the pictures to him. I then sent him a response because he said he would give me some recommendations on my scars and even said he would recommend some good doctors in my area which I thought was very sweet of him (he asked me for some more info so that he could give me some recommendations). I spoke to Precious as well..very nice lady.

Hi, first time poster but long time lurker here. I don't suffer with acne scars but do have lots of stretch marks all over my body that badly affect my self confidence. I found this forum whilst looking up skin regeneration. I know I won't get a definite answer but I'm just wondering what your thoughts on SkinTe working for stretch marks?

34 minutes ago, Giselle1625 said:

Hi, first time poster but long time lurker here. I don't suffer with acne scars but do have lots of stretch marks all over my body that badly affect my self confidence. I found this forum whilst looking up skin regeneration. I know I won't get a definite answer but I'm just wondering what your thoughts on SkinTe working for stretch marks?

I have the same problem with you ....... we wait the results of skinte on humans if skinTE rwgenerate the skin then stretch marks could be vanished 1) removal of the dermis and application of skinTE 2) directly propagation of skinte into stretch marks I don't know how....maybe with injections I say about the second option because polarityTE told that skinTE propagates and axpands into old scars and regenerates healthy skin, from what they are saying I understand that they don't remove the scar and then put the skinTE into the wound bed but somhow they put the skinTE into the scar that's the meaning of propagation also one guy from here spoke with polarityte and they told him that they create derivatives to treat smaller scars with no aggressive procedures

6 minutes ago, damnBOY said:

34 minutes ago, Giselle1625 said:

Hi, first time poster but long time lurker here. I don't suffer with acne scars but do have lots of stretch marks all over my body that badly affect my self confidence. I found this forum whilst looking up skin regeneration. I know I won't get a definite answer but I'm just wondering what your thoughts on SkinTe working for stretch marks?

I have the same problem with you ....... we wait the results of skinte on humans if skinTE rwgenerate the skin then stretch marks could be vanished 1) removal of the dermis and application of skinTE 2) directly propagation of skinte into stretch marks I don't know how....maybe with injections I say about the second option because polarityTE told that skinTE propagates and axpands into old scars and regenerates healthy skin, from what they are saying I understand that they don't remove the scar and then put the skinTE into the wound bed but somhow they put the skinTE into the scar that's the meaning of propagation also one guy from here spoke with polarityte and they told him that they create derivatives to treat smaller scars with no aggressive procedures

don't forget that stretch marks are a type of scars ''skinTE propagated and expanded into the residual burn scar that remained in addition to regenerating full-thickness, hair-bearing skin'' words from polarityTE what do you understand from these words guys?

5 hours ago, ermete55 said:

so the marginal wound is visible to naked eye

Judging from the press release and the words of Dr. Mundinger the marginal wound likely is visible, but again, this is very early in the healing process. If you look at the pics of the pigs in the preclinical tests you'll see that during the mid-stage of wound healing with SkinTE the margin was quite visible but by the end they need to point it out with the little arrows and magnification.

I'm not saying that it will be the same in humans, but the best part of that press release for me are the words of Dr. C. Scott Hultman:

"Furthermore, there appears to be dynamic healing: the texture and biomechanics of the grafted areas appear to change over time, during the early phases of wound healing, for the better."

This means that the wound in that child is following the results in pigs. No idea yet if it will completely regenerate all layers with appendages, but given that it has rapidly healed and repigmented and is improving over time, it seems like thus far it's along the same path as the pig results. Or, as PolarityTE stated, correlative.

2 hours ago, sousou_bella said:

Hi Kim,

As soon as I find a doctor who uses the product and is willing to use it on new patients even if they say they wouldn't recommend it for me but they would be willing to use it on a different candidate, I will 100% for sure come back and tell you all. Yes, the doctor I have reached out to in New Orleans is Dr. Mundinger. His nurse hadn't heard of the product but she said she would forward my email and pictures to him and ask him. The thing is we already know that he uses the product because it says in the article that he revised a child's burn scar with SkinTE so it's just a matter of seeing if he would be willing to use it on anyone else. Maybe he's only using it on patients who have had previous skin grafts etc or in cases which in his opinion are "extreme" for lack of a better term.

Not sure how I got a response from Dr. Hickerson so quickly maybe it was just luck. I was quite surprised as well when he emailed me back on the same night that I sent the pictures to him. I then sent him a response because he said he would give me some recommendations on my scars and even said he would recommend some good doctors in my area which I thought was very sweet of him (he asked me for some more info so that he could give me some recommendations). I spoke to Precious as well..very nice lady.

I suspect that anyone using the product right now is being pretty tight-lipped about it. Also, one thing to keep in mind is that the nurse in his office probably isn't going to the operating room with him. He also specializes in craniofacial surgery, so SkinTE isn't exactly a product he would normally use.

It's also possible that PolarityTE has asked the doctors using it to keep the early test cases hush hush. The reasons are obviousas a publicly traded company the results are their lifeblood. Out of respect to their shareholders and for the health of their company, PolarityTE needs to maximize the impact of any encouraging results, and control the damage of any setbacks.

Another possible reason is that while the 361 regulatory arm of the FDA allowed them to go to market without human trials, PolarityTE does face post-market approval and regulation. I suspect someone could read up on this, but it wouldn't surprise me if only a certain amount of patients are possible per the FDA guidelines until it proves it's safety and efficacy.

1 hour ago, damnBOY said:

I have the same problem with you ....... we wait the results of skinte on humans if skinTE rwgenerate the skin then stretch marks could be vanished 1) removal of the dermis and application of skinTE 2) directly propagation of skinte into stretch marks I don't know how....maybe with injections I say about the second option because polarityTE told that skinTE propagates and axpands into old scars and regenerates healthy skin, from what they are saying I understand that they don't remove the scar and then put the skinTE into the wound bed but somhow they put the skinTE into the scar that's the meaning of propagation also one guy from here spoke with polarityte and they told him that they create derivatives to treat smaller scars with no aggressive procedures don't forget that stretch marks are a type of scars ''skinTE propagated and expanded into the residual burn scar that remained in addition to regenerating full-thickness, hair-bearing skin'' words from polarityTE what do you understand from these words guys?

I'm the one who talked with Swanson, along with Tano. Swanson stated that they definitely are moving forward with cosmetic applications and have an R&D arm that is solely devoted to this side of things. Here are the applications he mentioned directly:

a. applications for aesthetics - much smaller scars
b. a derivative applied over a wound bed created by excising a smaller scar. this may or may not need a skin biopsy
c. an injectable paste into existing scars (he could not provide specifics for what the results might be at this time)
d. hair loss
e. figuring out the mechanism that allowed SkinTE to eliminate wound contraction over time
f. off the shelf products - he said this one would be trickiest because the FDA would have more to regulate at this point.

R,

We received your inquiry about Skin TE.