Acne.org Products
So a better question will be: How did the skin regenerate in pigs? Did it take on the properties of the surrounding skin or the donor site? At least Polarity knows the answer to that question. Polarityexpects that the human skin willrespond the same way as the skin in pigs, right?
In all honesty, the phrase complete regeneration is misleading if the skin doesnt compare 100% to the surrounding skin.
9 minutes ago, Frasier said:So a better question will be: How did the skin regenerate in pigs? Did it take on the properties of the surrounding skin or the donor site? At least Polarity knows the answer to that question. Polarityexpects that the human skin willrespond the same way as the skin in pigs, right?
In all honesty, the phrase complete regeneration is misleading if the skin doesnt compare 100% to the surrounding skin.
It was indistinguishable for the surrounding skin, outside of the margin, according to their site and my talk with him. So yes, in pigs it took on the characteristics of the surrounding tissue, but keep in mind that the skin biopsy was probably taken from the same location (the pig's back).
4 hours ago, golfpanther said:It was indistinguishable for the surrounding skin, outside of the margin, according to their site and my talk with him. So yes, in pigs it took on the characteristics of the surrounding tissue, but keep in mind that the skin biopsy was probably taken from the same location (the pig's back).
Maybe that the margin is invisible in the naked eye, Because the images on the site it is in the microscope. Will soon have us the results
1 hour ago, SimpleMutton said:
https://marketexclusive.com/polarityte-inc-nasdaqcool-files-an-8-k-regulation-fd-disclosure-6/2018/01/
I do not think there's much news yet.
2 hours ago, SimpleMutton said:Holy fuck, PolarityTE is up almost 7% today after the conference.....
they must have shared good news
22 minutes ago, DinkumFridge said:https://marketexclusive.com/polarityte-inc-nasdaqcool-files-an-8-k-regulation-fd-disclosure-6/2018/01/
I do not think there's much news yet.
Yeah, I looked at the investor presentation and it's mostly what they had before with the additions that it's on patients now and new info about their scaling up their production in light of the facility.
This may have had a subtle effect on the stock price (up around 4% on the day as of now), but it doesn't appear that they presented, or have, any concrete data on human use as of now. I'd say it's more likely that some of the people at that conference weren't aware of the product or recent developments (i.e. that it's on patients and the 200k sqft facility) and decided to buy shares based on that alone.
It took ten weeks in pigs for them to know what they had (full thickness regeneration with appendages and pore development) so given that the press release about it being on patients was December 15th, we're still a bit out from that, even if the product was on patients 2 or 3 weeks prior, which I'm guessing it was (my own call with Swanson was on December 13th and he said it was already on patients then). The earliest we'd probably hear anything is next week to mid-February and remember, Swanson said it will be up to the provider to write up reports about the product, not Polarity. That being said, if it works, PolarityTE will blast that news everywhere.
I should add that for me it's encouraging that the investor presentation maintains the same consistent language from their previous statements. If there was ever a time to pivot to changing their language to lower expectations, it's now. So far, they haven't done that at all and are still maintaining it can provide full-thickness, hair-bearing skin. If prior to the results coming out you see that shift at all, I'd say it's time for doubt. However, they have stayed on message since June of last year, which is great.
[]ValueInvestingIsDead2 points1 month ago
Can someone explain why tf a failed video-game publisher merged with PolarityTE? That seems extremely...odd.
Majesco Entertainment Company (formerly Majesco Sales Inc.) was an American video game publisher and distributor based in South Plainfield, New Jersey. The company was founded as Majesco Sales in Edison, New Jersey in 1986, and was a privately held company until acquiring operation-less company ConnectivCorp in a reverse takeover, becomings its subsidiary and thus a public company, on December 5, 2003.[1] ConnectivCorp later changed its name to Majesco Holdings Inc. on April 13, 2004.[2] On December 1, 2016, Majesco Entertainment was acquired by PolarityTE, Inc., a biotech company, in a reverse takeover, because of which it formally ceased all video game operations on December 8, 2016.[3]
A reverse merger allows the acquiring company (in this case PolarityTE) to be public without having to go through the regulatory hurdles and scrutiny of the offering process.
It's basically the preferred method of scams of all types. In this case, I think their CFO John Stetson picked up Majesco in 2015 in order to have a traded shell to put another company into (PolarityTE), which he later did.
14 minutes ago, 36512 said:[]ValueInvestingIsDead2 points1 month ago
Can someone explain why tf a failed video-game publisher merged with PolarityTE? That seems extremely...odd.
Majesco Entertainment Company (formerly Majesco Sales Inc.) was an American video game publisher and distributor based in South Plainfield, New Jersey. The company was founded as Majesco Sales in Edison, New Jersey in 1986, and was a privately held company until acquiring operation-less company ConnectivCorp in a reverse takeover, becomings its subsidiary and thus a public company, on December 5, 2003.[1] ConnectivCorp later changed its name to Majesco Holdings Inc. on April 13, 2004.[2] On December 1, 2016, Majesco Entertainment was acquired by PolarityTE, Inc., a biotech company, in a reverse takeover, because of which it formally ceased all video game operations on December 8, 2016.[3]
A reverse merger allows the acquiring company (in this case PolarityTE) to be public without having to go through the regulatory hurdles and scrutiny of the offering process.
It's basically the preferred method of scams of all types. In this case, I think their CFO John Stetson picked up Majesco in 2015 in order to have a traded shell to put another company into (PolarityTE), which he later did.
you do realize they're treating patients right now with SkinTE? how can that be a scam?
a scam wouldn't be allowed to get inside a OR
these guys posting bullshit analysis on the internet are idiots
1 hour ago, SimpleMutton said:you do realize they're treating patients right now with SkinTE? how can that be a scam?a scam wouldn't be allowed to get inside a OR
these guys posting bullshit analysis on the internet are idiots
I'll be honest, when I first found out about PolarityTE the fact that they were a reverse merger scared me a bit. For some companies it is a sign that something foul is afoot.
However, at this point I'm not too worried about it any longer. For one, they've had ample opportunity to get in and get out while making a killing. For another, they're exposing themselves to a lot of risk as I've written before with the leasing of the facility, putting it on actual patients and continuing to express their belief that it will work in humans. These aren't small things.
Of course, they don't directly mean that SkinTE will work. Only the actual results will, or won't, show that. But in terms of it being an outright scam? That relies on the belief that PolarityTE knowingly mislead investors with their results or outright made them up in pigs. And if that's the case... why on Earth take it farther when the stock price jumped to over 30 dollars following the release of the data on pigs? And why have members of their board continued to buy stock since then?
Look, anything is possible. But if PolarityTE is an outright scam (i.e. they knowingly are lying to drive up the stock price and make a ton of money) they are doing a lot of bizarre things that run counter to that.
53 minutes ago, DinkumFridge said:I'm losing hope.I have been waiting since last June, but I do not know how long I have to wait.
Don't despair! Even if SkinTE doesn't provide perfect regeneration, you can be okay. And the results will be coming sooneither directly from PolarityTE or from providers that have used it.
I've just read the new presentation, as of now they don't use SkinTE for acne scars.
In the scar revision section they clearly mention "removal of healed standard of care skin graft replacement with SkinTE". That's what they intend for scar revision
But they're using for wounds and burns right now
There are also some pics where they show the excised skin and the application of SkinTE, but of course no before/after.
Total excision of skin is also very invasive, I hope for partial excision
22 minutes ago, SimpleMutton said:I've just read the new presentation, as of now they don't use SkinTE for acne scars.
In the scar revision section they clearly mention "removal of healed standard of care skin graft replacement with SkinTE". That's what they intend for scar revisionBut they're using for wounds and burns right now
There are also some pics where they show the excised skin and the application of SkinTE, but of course no before/after.
Total excision of skin is also very invasive, I hope for partial excision
Could subcision be enough to create a wound bed under the skin followed by dermabrasion on top to renew skin texture? Thus avoiding full excision and possible margins....
I cant think of how else they can use this product for multiple smaller scars. But I suppose if Margin is not a concern as they note and Skinte regenerates skin near 100% like we all hope then excision shouldnt be a worry of you have a plastic surgeon who has used it and trust it. Roll on Mid to late Feb!!! I wanna know already!
3 minutes ago, Sniffy said:Could subcision be enough to create a wound bed under the skin followed by dermabrasion on top to renew skin texture? Thus avoiding full excision and possible margins....I cant think of how else they can use this product for multiple smaller scars. But I suppose if Margin is not a concern as they note and Skinte regenerates skin near 100% like we all hope then excision shouldnt be a worry of you have a plastic surgeon who has used it and trust it. Roll on Mid to late Feb!!! I wanna know already!
You can look at some of the pics here:
https://seekingalpha.com/filing/3827146
The main problem with SkinTE is that PolarityTE never mention SkinTE as a potential treatment for acne scars, I think they intend to use it only for acute wounds, chronic wounds, burns, replacing skin graft and big surgical scars.
Of course if it can treat these things, it can also treat acne scars but apparently they don't want to use it for that (cosmetic), at least for now
Anyway I emailed them
It states in this link under Skinte- A simple process for an exceptional product
Patient wounds- "scar revision"
Im fully behind the urgency with burns because its life and death and victims are 1000 times worse off than us. Whats so different from replacing an old skin graft with Skinte then replacing old acne scar area with skinte? I can only imagine grafts that cause patient discomfort but what about the emotional stress people suffer from scars on there face. If this is the answer then why hold back. So if you were indeed desperate you would need to cause a serious injury to area of skin where scars are and be taken to hospital to recieve skinte lols.
Im hoping it will only be a matter of finding a plastic surgeon with an interest or specialty in scar revision who can help acne scar sufferers with skinte Once it becomes more used commercially.
I also get the feeling they are using the phrase scarless healing less and leaning towards "reduced" scar tissue now. But then go on to say fully regenrated that looks just like native skin a little confusing. The margin where Skinte meets native skin is nothing really as stated its less than the width of a hair shaft.
1 hour ago, Sniffy said:It states in this link under Skinte- A simple process for an exceptional product
Patient wounds- "scar revision"
Im fully behind the urgency with burns because its life and death and victims are 1000 times worse off than us. Whats so different from replacing an old skin graft with Skinte then replacing old acne scar area with skinte? I can only imagine grafts that cause patient discomfort but what about the emotional stress people suffer from scars on there face. If this is the answer then why hold back. So if you were indeed desperate you would need to cause a serious injury to area of skin where scars are and be taken to hospital to recieve skinte lols.
Im hoping it will only be a matter of finding a plastic surgeon with an interest or specialty in scar revision who can help acne scar sufferers with skinte Once it becomes more used commercially.
I also get the feeling they are using the phrase scarless healing less and leaning towards "reduced" scar tissue now. But then go on to say fully regenrated that looks just like native skin a little confusing. The margin where Skinte meets native skin is nothing really as stated its less than the width of a hair shaft.
Hair shaft is large in my opinion..if it is compared to hair shaft then we will have something like "glasgow smile" if it is in our cheeks.. this margin thing will fuck us up
2 hours ago, Sniffy said:It states in this link under Skinte- A simple process for an exceptional product
Patient wounds- "scar revision"
Im fully behind the urgency with burns because its life and death and victims are 1000 times worse off than us. Whats so different from replacing an old skin graft with Skinte then replacing old acne scar area with skinte? I can only imagine grafts that cause patient discomfort but what about the emotional stress people suffer from scars on there face. If this is the answer then why hold back. So if you were indeed desperate you would need to cause a serious injury to area of skin where scars are and be taken to hospital to recieve skinte lols.
Im hoping it will only be a matter of finding a plastic surgeon with an interest or specialty in scar revision who can help acne scar sufferers with skinte Once it becomes more used commercially.
I also get the feeling they are using the phrase scarless healing less and leaning towards "reduced" scar tissue now. But then go on to say fully regenrated that looks just like native skin a little confusing. The margin where Skinte meets native skin is nothing really as stated its less than the width of a hair shaft.
If you look through their old investor presentation on their site it's pretty much the same language verbatim. In that presentation they also used reduced in regards to the margin. This could be a way for them to reduce expectations, but yes, as you pointed out they also say complete regeneration in the wound bed. I think it's just their way of acknowledging the margin, which means they can't say completely scarless.
4 hours ago, SimpleMutton said:You can look at some of the pics here:https://seekingalpha.com/filing/3827146
The main problem with SkinTE is that PolarityTE never mention SkinTE as a potential treatment for acne scars, I think they intend to use it only for acute wounds, chronic wounds, burns, replacing skin graft and big surgical scars.
Of course if it can treat these things, it can also treat acne scars but apparently they don't want to use it for that (cosmetic), at least for now
Anyway I emailed them
On the conference call they did back in June they were asked by an investment group about the cosmetic market. This is where their whole "it's likely too invasive for smaller scars" rhetoric comes from. On the call they said they were working on derivatives for smaller scars and reiterated this to me (look back at my convo with themSwanson talked about an injectable version, a less invasive version of SkinTE and some other things). This is also when they said that SkinTE's use would be left up to provider and patient in terms of indications and invasiveness.
Let us know if they get back to you. I imagine they're going to be pretty tight-lipped and busy until the results come out, and even more so afterwards if it works.
2 minutes ago, golfpanther said:If you look through their old investor presentation on their site it's pretty much the same language verbatim. In that presentation they also used reduced in regards to the margin. This could be a way for them to reduce expectations, but yes, as you pointed out they also say complete regeneration in the wound bed. I think it's just their way of acknowledging the margin, which means they can't say completely scarless.On the conference call they did back in June they were asked by an investment group about the cosmetic market. This is where their whole "it's likely too invasive for smaller scars" rhetoric comes from. On the call they said they were working on derivatives for smaller scars and reiterated this to me (look back at my convo with themSwanson talked about an injectable version, a less invasive version of SkinTE and some other things). This is also when they said that SkinTE's use would be left up to provider and patient in terms of indications and invasiveness.
Let us know if they get back to you. I imagine they're going to be pretty tight-lipped and busy until the results come out, and even more so afterwards if it works.
the injectable product of skinte may not lead to margin because margin happens from the excision
Just now, slave of jesus said:It would be necessary to ask the question to Dr swanson. if ever he injects their derivative product, if there is a possibility to have no margin.
I honestly don't understand how an injectable would work. I know they show that SkinTE propagates into existing scar tissue following application into a wound bed, but I don't see how it could give us complete regeneration. More than likely, it would be about providing improvement.
20 minutes ago, golfpanther said:I honestly don't understand how an injectable would work. I know they show that SkinTE propagates into existing scar tissue following application into a wound bed, but I don't see how it could give us complete regeneration. More than likely, it would be about providing improvement.
Look at thia they said when skinte deployed INTO TISSUE DEFECT undergo integrative regenerative healing............
golfpanther,
What you just mentioned, which appears in one of the skinTE slides on their site is what has had me the most excited if it actually means what I think:
"SkinTE not only regenerates full thickness organized skin in wound beds, but will also propagate into old scar tissue and regenerate full thickness skin".
What else could that possibly mean other than they could inject it into scar tissue and change it into healthy tissue?.....This is something I'd like to ask them if that is what they really mean. That would be incredible, though I can't possibly believe they can actually achieve that. I remember reading not long ago some other researchers made a direct quote "It will probably be 10 years before we can do that".
Removing scar tissue and creating almost scarless healing in a would bed and turning scar tissue healthy are on two different levels. But what the hell do I know, I just would like an answer on that from them and I've yet to see anyone else anywhere make a comment about that quote they made.
It looks like the company themselves don't think it will work for acne scars.
*glass shattering sound for many people in this thread*
And fair enough. Acne scars are nothing compared to burn victims. We can still live and function properly
Share price slumped 3% last night. Doh!
In my opinion if SkinTE actually regenerates a third degree burn, why would not it regenerate a skin with acne scars?
It would be as if a product regenerates an entire arm, but could not regenerate only the hand, excuse me but I see no logic in this, there is not that they fail or do not come to a regeneration, just an improvement ... (Sorry my English)
1 minute ago, c0017 said:In my opinion if SkinTE actually regenerates a third degree burn, why would not it regenerate a skin with acne scars?
It would be as if a product regenerates an entire arm, but could not regenerate only the hand, excuse me but I see no logic in this, there is not that they fail or do not come to a regeneration, just an improvement ... (Describe my English)
Yeah, I agree. If it works in a wound bed... it should work in any wound bed. Once you strip away all layers of skin it's just an open wound.
I think their hesitance comes from, again, the invasiveness of the product. But in my convo with Swanson he reiterated that they believe it will work on any wound type after excision, just that some indications would likely be too invasive for a patient. In the end, it would be left up to the provider and patient to decide.
32 minutes ago, ScarRight said:It looks like the company themselves don't think it will work for acne scars.
*glass shattering sound for many people in this thread*
And fair enough. Acne scars are nothing compared to burn victims. We can still live and function properly
Share price slumped 3% last night. Doh!
You hit the nail on the head right now. I don't believe SkinTE will be used for acne scars at least in the beginning. For burn victims, it's a life and death situation, so they get a free pass over us with acne scars.
We need to wait for the results mid February on patients who accepted to get SkinTE on their chronic wounds or severe burns. If their product works, then at least we have some hope that scarless healing is possible even if it's not 100% complete regeneration in the beginning. This can also pave the way to full limb regeneration in the future. Our evolutionary path may change forever.Through gene engineering, future generations may not have to deal with lost limbs, scars and painful disfigurement. I believe this would make us the perfect species on the evolutionary scale. Although the most basic lifeforms are capable of regeneration as well as some reptiles, nature decided to remove regeneration in more complex species. They say evolution decided to close wounds with scar tissue to prevent infections but how come reptiles are capable of this. Aren't these organisms also susceptible to wound infections? Let's state the obvious, our bodies are too lazy and just won't work as hard to achieve regeneration.
If they are able to get somewhat functional looking skin regardless of the margin that would be a major breakthrough in itself. Skin grafts and skin substitutes for burn victims will be slowly phased out. Then Polarity could slowly focus in creating derivatives on existing scars and smaller wounds. This might take a while but other competitors might come into play and come up with better alternatives than Polarity. Unfortunately, we live in a world of politics, ethics, power and money. Therefore, a lot of new discoveries that make us progress never see the light of day.
I am being quite silly here but I am a little bit paranoid. What if Polarity decided to place AI chips inside their product and that new regenerated skin transmits info about their patients to some secret agency. What if their intention was for mind control after all. We just don't know who to trust these days. Of course, this is just humorous from my part.
Here's to hoping that SkinTE will bring us complete regeneration in a few weeks and finally an acne cure is found this year.