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[Sticky] Scarless Healing

 
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(@sw-cub)

Posted : 07/04/2008 1:31 pm

Tgan, I've heard the pure ECM is here on the 15th, I cant wait.

 

Edited.

 

Kirk- what is this pure ECM going to be used for? Why all the excitement if its not going to be used for acne scars?

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(@antimatter)

Posted : 07/04/2008 3:23 pm

join the army or armed forces and you can probably get it dont for free.i know they will do a lot of plastic surgery for free...well nothing is really free....you have to put you time in...serving the country.

 

You can try to "negotiate" and sign a contract and let them "cure" you first.

 

I would consider this. Let's face it people, only way we'll fix this thing is if the government is involved. 250 million in research would be an incredible amount for us, but would be like chump change for them.

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(@antimatter)

Posted : 07/04/2008 3:30 pm

Well my husband is army and he has a friend that was shot thru the jaw with the bullet coming out around between the eyes, he is fine now, but to fix the scar the doctor injected silicone into him and although you can still see the difference in tissue, there is no hole. He looks pretty good. I just saw him last week and was kind of surprised the army suggested the silicone.

 

Were you surprised because they didn't do anything special?

 

Also, what exactly do you mean by "pretty good?" So he still didn't get back his pre-scarred face?

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(@seabs135)

Posted : 07/04/2008 3:35 pm

Tgan, I've heard the pure ECM is here on the 15th, I cant wait.

 

Edited.

 

Kirk- what is this pure ECM going to be used for? Why all the excitement if its not going to be used for acne scars?

 

 

Regeneration of wounds is what it is to be used for. Also healing tendons with a regeneration process instead of a scarring process is what it will be used for...

 

If it can be used for any type of wound on any tissue in the body that scars that means it can be used on acne scars, on any scar revision process.

 

The optimism comes from logic which comes from the results it has had in its pure form that is not denatured: regenerating aortas, regenerating two finger tips, fur from 4X4 gaping wounds on animals, tissue on previously unhealing tissues of a diabetic...

 

 

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(@antimatter)

Posted : 07/04/2008 3:36 pm

Test on me, cut up my back, throw bacteria on me. I don't fucking care! I just don't get how I can put myself in a situation to try this stuff? I'm ready and willing. This sort of thing needs to be cured, acne is terrible. If they have all these treatments that they are reserving for soldiers then why not release them to the general public at a cost? We can help finance them. The medical industry is so fucked up since it is protected from free markets.

 

Join the military my friend. Only thing that concerns me is that fucking no curtains in the shower thing. Fucking life is making me choose now huh

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(@sw-cub)

Posted : 07/04/2008 5:22 pm

Tgan, I've heard the pure ECM is here on the 15th, I cant wait.

 

Edited.

 

Kirk- what is this pure ECM going to be used for? Why all the excitement if its not going to be used for acne scars?

 

 

Regeneration of wounds is what it is to be used for. Also healing tendons with a regeneration process instead of a scarring process is what it will be used for...

 

If it can be used for any type of wound on any tissue in the body that scars that means it can be used on acne scars, on any scar revision process.

 

The optimism comes from logic which comes from the results it has had in its pure form that is not denatured: regenerating aortas, regenerating two finger tips, fur from 4X4 gaping wounds on animals, tissue on previously unhealing tissues of a diabetic...

 

 

yes, it may do all those wonderful things, but the problem is it won't be applied to acne scars until ample research is done that proves its effectiveness on acne scars specifically. It seems all the researchers are worried about different problems and acne scars arent thought of as serious enough to warrant the research.

 

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(@tricia)

Posted : 07/04/2008 5:44 pm

 

 

 

Antimatter,

 

Concerning the guy in the military, I was surprised he'd had it done with Tricare paying because silicone is not FDA approved for cosmetic use. I didn't question him a whole lot about it though, but I assume Tricare did pay for it. I'm sure it was a long ordeal for him to get back to normal, but he looks good in that I didn't percieve him at first to be "scarred" it was only after he pointed them out telling his war stories that I really paid attention to the scars. Silicone can't bring perfection, but I'm sure it looked a whole lot worse at first. He did get this done at least three years ago, so maybe now they are doing different things with scars, don't know. They do give you excellent care when you are hurt in war, but that's no reason to join. Being married to a guy in the army has caused me plenty of breakouts :ninja:

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(@nikkigirl)

Posted : 07/04/2008 11:02 pm

well...i would think the military would rather test on a acne scar patient before they applyed this stuff to a gaping wound.especially if it was done on ones acne scarred back...all i did was read the link from the article and it says the military has a enzyme that eats scars.it probably hasnt been used yet by whole military but just on a few patients.if this enzyme really does eat away scars and return scarred tissue into healthy tissue then scarring as we know it will end.but again....you know how many years it might take to get to the private sector and even when it does..the docs will be charging a forture for it.

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(@sgxyo3man)

Posted : 07/05/2008 1:39 am

Whoa! What is this about a scar tissue dissolving enzyme? I read that in the article from the previous page. Nikkis right. If this exists, it needs to be combined with a pure ECM (Acell) and people like me can be happy for the first time in their life.

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(@sgxyo3man)

Posted : 07/05/2008 2:16 am

That sounds like a lot of work. The extracellular matrix harvested from a big's bladder can achieve the same results (in it's purest form). I guess I wouldn't want to cut all of my skin off in order to replace it though. This guy is having it etched on over his old skin. Sounds intriguing, yet somewhat disgusting...

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(@franklins-tower)

Posted : 07/05/2008 7:53 am

Tgan, I've heard the pure ECM is here on the 15th, I cant wait.

 

Edited.

 

Is Acell the pure ECM that you are referring to? If not, where did you hear about this?

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(@bulgarian-r)

Posted : 07/05/2008 8:51 am

The Wake Forest Institute that will apparently be helping Mr. Williams remove his tattoos is actually spearheading one of the two academic groups that have recently come to be known as AFIRM. I believe you will find the article below very interesting for it demonstrates how many researchers in the US alone are involved in a cause that will help us beat acne scars. There are at least as many such researchers in other countries working in regenerative medicine as well, so all in all both financial and human ressources in this field have increased dramatically over the last few years. Things are starting to move quickly... because the $$$ and budding biotech revolution are paving the road to a scar free world. :)

 

Here's the article below:

 

Wake Forest Institute for Regenerative Medicine to Co-lead Massive Project Directed at Battlefield Injuries

 

WINSTON-SALEM, N.C. ¯¿½¯¿½‚Å¡¯¿½¯¿½…œ A consortium spearheaded by the Institute for Regenerative Medicine at Wake Forest University Baptist Medical Center has been awarded $42.5 million over five years to co-lead one of two academic groups that will form the Armed Forces Institute of Regenerative Medicine (AFIRM).

 

The consortiums, working with the U.S. Army Institute of Surgical Research, will use the science of regenerative medicine to develop new treatments for wounded soldiers.

The Wake Forest-led collaboration will be headed by Anthony Atala, M.D., director of the Wake Forest Institute for Regenerative Medicine, and Alan J. Russell, Ph.D., director of the McGowan Institute for Regenerative Medicine at the University of Pittsburgh. A second consortium will be managed by Rutgers and the Cleveland Clinic.

 

AFIRM will be dedicated to repairing battlefield injuries through the use of regenerative medicine, science that takes advantage of the body¯¿½¯¿½‚Å¡¯¿½¯¿½‚ž¯¿½s natural healing powers to restore or replace damaged tissue and organs. Therapies developed by AFIRM will also benefit people in the civilian population with burns or severe trauma.

 

"For the first time in the history of regenerative medicine, we have the opportunity to work at a national level to bring transformational technologies to wounded soldiers, and to do so in partnership with the armed services," said Atala. "This field of science has the potential to significantly impact our ability to successfully treat major trauma."

 

The Wake Forest-McGowan team has committed to develop clinical therapies over the next five years that will focus on the following five areas:

 

- Burn repair

- Wound healing without scarring

- Craniofacial reconstruction

- Limb reconstruction, regeneration or transplantation

- Compartment syndrome, a condition related to inflammation after surgery or injury that can lead to increased pressure, impaired blood flow, nerve damage and muscle death.

 

AFIRM will have multiple groups working in each area. For example, in the area of burns, researchers will pursue treatments including engineered skin products, bio-printing of skin in the field, and repairs using stem cells derived from amniotic fluid.

 

The consortium¯¿½¯¿½‚Å¡¯¿½¯¿½‚ž¯¿½s ability to deliver new treatments is based on a four-year history of the McGowan and Wake Forest institutes working in partnership with the U.S. Department of Defense on regenerative medicine projects.

 

For example, the group is pursuing projects such as developing a product to quickly stop bleeding and engineering ear implants for surgical reconstruction. In addition, scientists have successfully grown muscle, bone and blood vessels in the laboratory with the goal of one day combining them to create more complex organs.

 

"Our ability to provide these treatments is in part due to our team¯¿½¯¿½‚Å¡¯¿½¯¿½‚ž¯¿½s long experience in this field and our broad pipeline of technologies," said Russell. "Our goal is to use our position as the international leaders in developing restorative therapies for battlefield trauma to improve the outcomes for our wounded.¯¿½¯¿½‚Å¡¯¿½¯¿½

 

The Wake Forest and McGowan partnership leverages more than 375 faculty members focusing on regenerative medicine. Several treatments developed during their existing partnership are now being evaluated in patients. More than 50 technologies from the AFIRM team already have had a wide impact on treatments for illness and injury. Researchers have launched more than 10 clinical trials (three with the Army) using tissue-engineered products that have now been implanted in more than 1 million patients.

 

In addition to developing clinical treatments, AFIRM will serve as a training facility to develop experts in treating trauma with regenerative medicine, and as a resource to help the military develop tissues as needs are identified.

 

Collaborators for the Wake Forest-McGowan team include Allegheny Singer Research Institute, the California Institute of Technology, Carnegie Mellon University, Georgia Institute of Technology, Intercytex, North Carolina State University, Oregon Medical Laser Center at Providence St. Vincent Medical Center, Organogenesis, Pittsburgh Tissue Engineering Initiative, Rice University, the Stanford University School of Medicine, Tufts University, the University of California, Santa Barbara, the University of North Carolina, the University of Texas Health Science Center at Houston, the University of Wisconsin, and Vanderbilt University.

 

Government sponsors of AFIRM are the U.S. Army Medical Research and Materiel Command, the Office of Naval Research, the U.S. Air Force Office of the Surgeon General, the Department of Veterans Affairs and the National Institutes of Health. In addition to this funding, Wake Forest and its partners will provide more than $150 million from academic institutions, industry and state and federal agencies for the projects ¯¿½¯¿½‚Å¡¯¿½¯¿½…œ for a total of almost $200 million available for soldier regeneration research.

 

Link to article: http://www1.wfubmc.edu/news/NewsArticle.htm?Articleid=2350

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(@nikkigirl)

Posted : 07/05/2008 3:14 pm

i think the research should come out of the defense budget.the only thing is will anyone be able to afford the treatment when it does hit the private sector?with the price of gasoline and everything else...im just having trouble paying my bills.

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(@seabs135)

Posted : 07/05/2008 4:50 pm

Tgan, I've heard the pure ECM is here on the 15th, I cant wait.

 

Edited.

 

Kirk- what is this pure ECM going to be used for? Why all the excitement if its not going to be used for acne scars?

 

 

Regeneration of wounds is what it is to be used for. Also healing tendons with a regeneration process instead of a scarring process is what it will be used for...

 

If it can be used for any type of wound on any tissue in the body that scars that means it can be used on acne scars, on any scar revision process.

 

The optimism comes from logic which comes from the results it has had in its pure form that is not denatured: regenerating aortas, regenerating two finger tips, fur from 4X4 gaping wounds on animals, tissue on previously unhealing tissues of a diabetic...

 

 

yes, it may do all those wonderful things, but the problem is it won't be applied to acne scars until ample research is done that proves its effectiveness on acne scars specifically. It seems all the researchers are worried about different problems and acne scars arent thought of as serious enough to warrant the research.

 

 

 

You said, "It seems all the researchers are worried about different problems and acne scars arent thought of as serious enough to warrant the research."

 

Scientific researchers should be able to see that it is about social weight on a human in the humans subjectivity, not scarring that has been seperated into a hierachy of labels. If not they are ignorant fucks if they accept spin that one scarring disfugurement is different to another...

 

Sw cub, from my perception of logic, from what I've read over the years the scarring response is similar on any part of the body, that means if it works on another bigger scar it will work on 3mm scars.

 

Also I don't think this material needs much research because it is an application that has been tested, though I may be wrong. It is accepted for human use.

 

Franklins Tower,

 

Yes Acell is the pure ECM I was refering to, in order to differentiate it from other ecms that are denatured.

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(@sgxyo3man)

Posted : 07/05/2008 6:34 pm

Wound healing without scarring appears to be our number one concern here on these boards. I believe Acell to be the answer, but only with a proper treatment to remove scar tissue first. The two procedures will go hand in hand and will be our answer. Someone please tell me if this is true.

 

Also, will Serrapeptase play a part in this answer?

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(@cotton)

Posted : 07/05/2008 9:09 pm

After reading all this stuff about excisions and subcision of scars, I went to see a bunch of dermatologist and plastic surgeons about it. Most of them said I would not be a good candidate for excisions because it causes a new scar, plus I tend to hyperpigmentate at the drop of a hat. However in my quest I asked about dermbrasion too, which most of them said no because of that reason.

I went to see this plastic surgeon at the University of Chicago's surgical department. His name is DR. Raphael Lee. This guy is a genius, you can google him and see what I'm talking about. Anywho, he gave wrote a prescription for me for this stuff called Avosil. He gave me a prescription for this stuff for it to be mixed with Verapamil. He said that this stuff breaks down the scars. He said after six months, that I probably would be happy enough with the results that I wouldn't want dermabrasion, he said it wouldnt' be perfect but I would see a big improvement in my scars and discoloration. I just started using this stuff. It tingles.

Today, I actually gave myself a 12.5% TCA peel.I figure if I re-injure my skin, and use this Avosil/Verapamil mix, I could trigger my own regeneration process of my skin. Mind you I only used 12.5% TCA, I am a light brown skin woman, and I hear that TCA can be pretty harsh on people my color, but I did frost. So this strength of TCA did something. The Avosil/Verapamil ointment will help with the healing. I am experimenting in the mean time, just in case I luck up on something.

I have severe acne scars, and I don't think this Dr. would have given me this stuff if it didn't do anything. He has a reputation to uphold. But he is not a dermatologist and is used to working with burn and cosmetic surgery patients, so someone with acne most likely would never see him. That's the sad part. I think this stuff will work I paid 140.00 for like 60 grams. Here is the link to the stuff.

 

 

REad the Facts About Scars Section-Under Mechanical Tension Blockers is where he talks about the Verapamil.

 

I think the Verapamil amps it up for old scars like mine. I saw another dermatologist whom is like an old guru, He suggest smoothbeam laser my scars. Here's the deal, the smoothbeam cost 300.00 per treatement and he said I needed like 4-5 treatments. One per month. So for like 1500.00 over a 5 month period I can "hopefully" see improvement in my scars versus the AVosil/Verapamil ointment which is 140.00 which will probably last me like 2 months. You do the math, I am going to try this ointment from Dr. Lee first. I have had Levulan, which burned my face, several chemical peels, and Pixel. I dont' want to do the laser thing, and several other doctors refused to do Fraxel on me.

I will let you all know how this goes. I've been perusing this board for months but never posted. I feel inclined to share my knowledge.

 

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(@ai3forever)

Posted : 07/06/2008 7:26 pm

Pharrell Williams is splashing out hundreds of thousands of dollars on new skin.

 

The producer has grown bored of the numerous tattoos he has etched onto his body so is paying a firm to grow him replacement skin in a test tube, which they will then stitch over his old permanent markings.

 

He told MySpace.com: "It's going to be pricey, but f**k it, it's worth it. I got fire on my arms, I don't need fire on my arms! I'm a grown man."

 

"There's an institute called the Wake Forest Institute in North Carolina for Regenerative Skin Treatment. It's basically like getting a skin graft, but you're not taking skin from you a** or legs - these guys actually grow the skin for you."

 

"First you have to give them a sample of your skin, which they then replicate. Once that's been done, they sew it on - and it's seamless."

 

Once his new skin is ready, the NERD star is planning to have new body art. He said: "When it is healed you can go get whatever tattoo you want."

 

New skin? Hundereds of thousands of dollars? sounds like a ripoff. He says the skin heals seamlessly, sounds real good but remember tattoo ink is only on the epidermis. Scars are on the dermis so i doubt this treatment would help us acne scars sufferers.

 

Even so, I wouldnt have the money to pay hundereds of thousands.

 

btw: won won, why did u have that signature on?

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(@sgxyo3man)

Posted : 07/07/2008 3:29 am

btw: won won, why did u have that signature on?

I was using the sig to support the thread's goals, but that was a long time ago. I'm going to remove it now seeing as how it's a dead thread and Acell is just around the corner for me to try.

 

BTW: Anyone know about this fleetingly mentioned "scar-tissue-dissolving" enzyme that they use on war victims and the like? It would have been nice to mention the exact substance's name!

 

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(@sw-cub)

Posted : 07/07/2008 1:09 pm

btw: won won, why did u have that signature on?

I was using the sig to support the thread's goals, but that was a long time ago. I'm going to remove it now seeing as how it's a dead thread and Acell is just around the corner for me to try.

 

BTW: Anyone know about this fleetingly mentioned "scar-tissue-dissolving" enzyme that they use on war victims and the like? It would have been nice to mention the exact substance's name!

 

 

 

I don't think this is a dieing thread, but rather just beginning. I think we are right around the corner from incredible advancements in scar treatments. What I got from the article with the scar-dissolving tissue was that it was something that they were developing and nothing that was finalized yet(?)

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(@sgxyo3man)

Posted : 07/07/2008 4:10 pm

I don't think this is a dieing thread, but rather just beginning. I think we are right around the corner from incredible advancements in scar treatments. What I got from the article with the scar-dissolving tissue was that it was something that they were developing and nothing that was finalized yet(?)

I didn't mean this thread was dying. That's an obvious no. I was talking about the thread that my sig linked to which had to do with fundraising for scar treatments.

 

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(@neca)

Posted : 07/08/2008 2:33 pm

More media attention from this time PopSci.com on tissue/bone/limb regeneration:

 

"Skin guns. Organ printers. Pig dust. Biochemist Alan Russell believes tools like these could one day be standard-issue for the battlefield medic. The skin gun would heal burns. The organ printer would replace badly wounded livers, kidneys, even hearts. And the pig dust?"

 

http://www.popsci.com/military-aviation-sp...ng-troops?page=

 

It mentions all the current research areas we have posted about here including of course A-cell and Doc Badylak. However, one extremely interesting aspect detailed here which I have yet to read about is:

 

"For already scarred-over limbs, researchers have developed an enzyme that eats away scar tissue so they can dust the healthy cells below."

 

Oh wow if this is true then it's exactly what a lot of us have been searching for -- a scar dissolver so to speak :). Now we have to find out who are the researchers?

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(@sgxyo3man)

Posted : 07/08/2008 4:24 pm

Good post Neca. From what I gather, the wording suggests that this scar tissue eating enzyme has already been developed and we are just waiting on a name for it. That in combination with Acell will be the answer for most people here. I want the details on that enzyme!!!

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(@sw-cub)

Posted : 07/08/2008 4:31 pm

Problem is I don't think that it has been proven that acell can heal all wounds without any sort of scar. I fear that it is a healing agent like oasis, which aids in wound healing, but doesnt stop scarring all together. I hope not. That needs to be proven without doubt, because it is very risky cutting chunks of skin out of someones face, unless no scar tissue at all is produced.

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(@sgxyo3man)

Posted : 07/08/2008 5:50 pm

Problem is I don't think that it has been proven that acell can heal all wounds without any sort of scar. I fear that it is a healing agent like oasis, which aids in wound healing, but doesnt stop scarring all together. I hope not. That needs to be proven without doubt, because it is very risky cutting chunks of skin out of someones face, unless no scar tissue at all is produced.

No no no. This is pure extra cellular matrix we are talking about here. If the scar tissue is completely removed, there will be little to no room for it to regenerate after ACell is applied. There are impure ECM's that may not do the trick, but I'm expecting at least a 95% improvement on my first go. I'm sure this will not be a cheap endeavor.

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(@ai3forever)

Posted : 07/08/2008 6:23 pm

Problem is I don't think that it has been proven that acell can heal all wounds without any sort of scar. I fear that it is a healing agent like oasis, which aids in wound healing, but doesnt stop scarring all together. I hope not. That needs to be proven without doubt, because it is very risky cutting chunks of skin out of someones face, unless no scar tissue at all is produced.

No no no. This is pure extra cellular matrix we are talking about here. If the scar tissue is completely removed, there will be little to no room for it to regenerate after ACell is applied. There are impure ECM's that may not do the trick, but I'm expecting at least a 95% improvement on my first go. I'm sure this will not be a cheap endeavor.

 

 

I dont know how many percent improvement acell would give but Ive known it healed full dermal thickness wounds before, Im not sure whether there was scarring left but I think there was slight scarring. However, it is still promising and the tricky thing is finding a doctor to cut out your scars like what everyone else has says. I think acell might work for smaller scars? But bigger boys they would have to refined the product first I guess. What you guys think?

 

Also, I think its possible that a surgeon can cut out slightly to the level of the dermis THEN apply acell, thus getting some improvements...

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