My face would sometimes be itchy from the Differin in the morning when I first woke up. It went away though after a couple of weeks. I do know that if you itch one place on your body, it makes it likely you might become itchy someplace else - it has to do with histamine and the biomechanics of what an itch is... You might try using an antihistamine like benadryl or loratadine... I know of people who've had excellent results with Zyrtec, which is non-sedating. Differin is actually really, really effective for a lot of people - myself included - you just have to stick with it and use it consistently... My skin has never looked so healthy as it does now, and I've only been on it for a couple of months.