ForumsArchive of old foru...Acne and its treatm...Prescription acne m...Epiduo Notifications Clear all Unless you have severe, widespread, and scarring acne, The Regimen is normally my suggestion for the most effective acne treatment.My suggested acne treatment Learn The Regimen → Learn The Regimen → Epiduo Giovanna. 13 MemberMember0(@giovanna-13) Posted : 10/11/2015 8:43 am I recently got Epiduo and it says to use ONCE a day but I was wondering do you still cleanse twice a day ? Is it just talking about the gel or everything in general ? I have not applied it btw Quotemolly beltran MemberMember0(@molly-beltran) Posted : 10/11/2015 6:03 pm Yeah you cleanse twice a day morning and night. Quote