ForumsAcne and its treatm...Prescription acne m...Epiduo Notifications Clear all Epiduo Giovanna. 13 MemberMember0(@giovanna-13) Posted : 10/11/2015 8:43 am I recently got Epiduo and it says to use ONCE a day but I was wondering do you still cleanse twice a day ? Is it just talking about the gel or everything in general ? I have not applied it btw Quotemolly beltran MemberMember0(@molly-beltran) Posted : 10/11/2015 6:03 pm Yeah you cleanse twice a day morning and night. Quote