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40 mg isn't a high dose, but it can be for some people. If you experience side effects from Vitamin A overdose you are consuming too much:
http://en.wikipedia.org/wiki/Hypervitaminosis_A
That is why it is so important to get blood tests every month.
I never went higher than 40 mg and still ate vitamin A foods everyday (spinach/sweet potato). However I got horrible rashes, hair loss, and got sick a lot throughout
treatment. This has all gone away since (1 month after accutane)