Ive never had an initial break-out from 2.5 benzoyl peroxide.(you may get redness/irritation if you use too much bp or any topical so you may want to apply less). Ive also taken oral minocyclen with no initial break-out.

I can see how certain meds like accutane cause increased acne before it gets better but to be honest, if youre getting worse instead of better with topicals/meds they probably wont work. Antibiotics work well for a temporary fix, just not a long-term solution.

Hi. I actually forgot to mention that i meant a prescription cream that you get from a dermatologist only and not an over the counter cream like benzoyl peroxide.

I mean like retin a, differin, eludio and stuff like that...

I had no initial breakout from Epiduo - and it's not an antibiotic, it's 2.5% BP plus a retinoid.