Acne.org Products
On 12/11/2017 at 6:33 PM, guitarman01 said:DYSAUTONOMIA EVALUATION SERUM Positive
HDL Cholesterol 43 mg/dL Reference is greater than >39 This is very low(major cardiovascular risk factor) the higher the better, should be in the 60s
CARDIAC STRESS TEST
Abnormal ECG response to stress. 2 mm flat depressed ST segment in leads
III occuring in Stage 2 using Bruce protocol. The patient exercised for
11 mins. Persisting up to 3 minutes into recovery.
EKG 12-LEAD
POSSIBLE LEFT ATRIAL ENLARGEMENT
Glucose, Plasma 88 mg/dL 70 - 99 mg/dL
Im going to repost some tests here.
Association Between Oral Isotretinoin Therapy and Unmasked Latent Immuno-Mediated Diabetes
http://care.diabetesjournals.org/content/32/8/e99
"the only remarkable change of lipid profile consisted in a reduction of HDL cholesterol during isotretinoin treatment"
During. Thats the scariest part. Ongoing remission and ongoing symptoms could mean Accutane sides just like in the pamphlet and beyond could happen very far down the line.
Anyone else have their HDL tested btw?
Yes, Ive had cholesterol checked many times and its high.
What to do about it even if Accutane is to blame?
Exercise, watch what you eat - as Dr says, eat more vegetables - watch the meat intake!!
I take fibre capsules ( psyllium husk ) to help elimination etc
There is the option of medication if it doesnt come down naturally - given the bullshit weve been through though,thats not an option for me right now
As Im trying to get off all dairy with gut treatment - this should also help cholesterol theoretically
Is there anyone who had a bad reaction or worsening of symptoms with Milk Thistle? Because in the propeciahelp forum people who took Finasteride there are people who got way worse after milk thistle. I guess it was safe because Finasteride is different from Roaccutane and there is no mention of anyone worsening on milk thistle (I searched the whole thread). Now Im actually scared because Ive been taking this since 6 months and on the propeciahelp they all saying that you should avoid milk thistle because its a 5ar inhibitor (I dont even understand). Hope someone can help me,..
thanks in advance
Hi all. I feel happy about having found all of you. I also had roaccutane when I was 16 or so, ....44 now.
First of all... you all
Stop eatinggluten.
...you also might have to stop eating sugar (fruit as well), lactosa or something else. In my case gluten and "glucose" is enough to feel healthy as I felt before having roacutan, or even better.
You can believe it, I'm not trying to sell you anything. I have suffer for ..30 years..that side efects all of you talk about. I know how horrible are these side efects and taking them apart from you would be enough to make me happy.
I will write more later, have a lot to tell you. I'm Spanish so I hope to be able to write well enough in order to be understood. I pray for sorry if I sound rude at any moment or misunderstood. My knowledge of the language is not good enough to completely avoid that to happends.
7 hours ago, Francisco..Blanquez said:Hi all. I feel happy about having found all of you. I also had roaccutane when I was 16 or so, ....44 now.
First of all... you all
Stop eatinggluten.
...you also might have to stop eating sugar (fruit as well), lactosa or something else. In my case gluten and "glucose" is enough to feel healthy as I felt before having roacutan, or even better.
You can believe it, I'm not trying to sell you anything. I have suffer for ..30 years..that side efects all of you talk about. I know how horrible are these side efects and taking them apart from you would be enough to make me happy.
I will write more later, have a lot to tell you. I'm Spanish so I hope to be able to write well enough in order to be understood. I pray for sorry if I sound rude at any moment or misunderstood. My knowledge of the language is not good enough to completely avoid that to happends.
Interested Inhearing more,Francisco. Seems to be a theme of people getting better with diet changes. Everyone though isa little different in what foods they are sensitive to.
Hi again, someone here asked me about blood test to detect celiac disease...
You may know it's not easy to detect it. I found a document the protocol to detect celic disease from the Spanish Health Ministery written by a group of expert. It is writen in Spanish, anyway I supose you can find english information about it in internet. Well, the talk about how dificuld is to detect that. Blood test are not enough. If the test is positive it means you are celiac , but if it is negative it doen't meant you are not celiac. It means more test have to be done...in the end they should look inside your intestine andtake samples to test it.... even so... they could they could make it the wrong way taking samples from where there is no damage and your test give a negative result... you will go on eating gluten ...feel bad and still came here to find the answer to your health. The answer is that, the document say that the most acurate test is stop eating gluten, if you feel good after two days.... you got celiac disease.
Another point, it is really important to do it the right way. Be sure about what you eat. Write a list with food you can eat this two or three days and dont eat any procesed food.... you could think sun flower seeds dont have gluten..... but they have, salt mixed with flour make the salt easier to stick to the seeds.
...to be continued
Well, while I find the time (maybe now) to write more... you could have a look to this study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248518/#!po=35.7143
I told to my doctor I had stoped eating gluten so he decided to test my b12 level(I'm not sure why till nex Febrary).... I got the text and saw that the level was 350 , the safe range is suposed to be from 250 to 950.... so I have investigated about this vitamin, I read this is the ENERGY vitamin... ...... fatigue is something usual among us, moreover it's fundamental for the brain and liver to work properly, even in a "safe" and low range you can feel the foggy brain, depresion and so on...like us.
Our bodies should work properly in a high b12 level... we had as the study say. I think so, because I had a high IQ, so b12 most be quite related to mental funtion. High level..clever...low leved..depresed, sad, foggy brain...
....I forgot to mention...roacutane decreased our b12 vitamin levels as well as our b9 (folic accid) as you can read in the study.
3 hours ago, Francisco..Blanquez said:Well, while I find the time (maybe now) to write more... you could have a look to this study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248518/#!po=35.7143
I told to my doctor I had stoped eating gluten so he decided to test my b12 level(I'm not sure why till nex Febrary).... I got the text and saw that the level was 350 , the safe range is suposed to be from 250 to 950.... so I have investigated about this vitamin, I read this is the ENERGY vitamin... ...... fatigue is something usual among us, moreover it's fundamental for the brain and liver to work properly, even in a "safe" and low range you can feel the foggy brain, depresion and so on...like us.
Our bodies should work properly in a high b12 level... we had as the study say. I think so, because I had a high IQ, so b12 most be quite related to mental funtion. High level..clever...low leved..depresed, sad, foggy brain...
....I forgot to mention...roacutane decreased our b12 vitamin levels as well as our b9 (folic accid) as you can read in the study.
Can you provide some information on your diet and the exact foods that you are eating on a day to day basis?
13 hours ago, Francisco..Blanquez said:....I forgot to mention...roacutane decreased our b12 vitamin levels as well as our b9 (folic accid) as you can read in the study.
my b12 was fairly low one time when I had it tested. I had a follow up test and it was right in the middle.
Vitamin B12 564 pg/mL 211 - 946
Regarding this though, this is a probiotic speciesI have been looking at closely,
Decreased Vitamin B12and Folic Acid Concentrations in Acne Patients After Isotretinoin Therapy: A Controlled Study
biosynthetic pathways of bifidobacteria include synthesis ofVitamin B12and folates
https://www.sciencedirect.com/science/article/pii/S0944501316304323
On celiac disease, I have been biopsied and tested multiple times negative.
On diet. Its maybe not enough for some. looking at dysbiosis, takeP. acnes for example.it's mostly gone or greatly depleted.its species isn't entirely isolated to a negative skin condition. Same for other possible protectors or beneficial species. If they're gone they're gone.
shifts induced by accutanemight need more help then diet alone.
Diet almost seems more like some people feel better not eating. They cant handle many types of foods anymore without negative consequence that maybe leads to inflammation type pathways.
Very good point
And even if we happen to need both B12 and Folic Acid in particular,its not as easy as just supplementing,particularly ifyour gut is destroyed - you wont absorb it correctly
So, has anyone done B12 injections or Folic Acid, curious if one experiences a massive increase in energy or not??even mentalalertness given how these two interact with the brain...
On 12/22/2018 at 1:59 AM, guitarman01 said:Diet almost seems more like some people feel better not eating. They cant handle many types of foods anymore without negative consequence that maybe leads to inflammation type pathways.
I used to do a bit of fasting... after 16 hours without eating I felt great, light and I could walk with no paint (I got psoriasic arthritis after roacune)
Finally I have figure out that the reason I felt great after 16h fasting is quite simple, I wasnot eating gluten and sugar.
I know it because now Idont eat gluten or sugar and I feel like when doing fasting.
I also have to saythat the sad mood and foggy brain is reduced as well.
I keep my hopes on that document about celiacdisease as it says that avoiding gluten the intestine will start rapairing itself it can take from 6month to 2 years to be fine.... depending on how good you are avoiding eating gluten. I can't tell beyond this point because it is the point where I'm now. Fighting to keep myfelf clean of gluten and sugar. I'm "clean" now and without feelings the cravings for sugar or gluten. It is something you have to learn. I can tell you that when you stay clean of gluten or sugar you will not feel cravings at all. But if you one day eat an apple...the next day a pear...the next an apple..banana...watermelon............ You will be back to that cravings ......foggy brain... dry eyes...
....As I said you can stay clean and without cravings. I have experiences all these stepsalready.
https://www.regulations.gov/docket?D=FDA-2018-P-4088
Only 20 comments so far!
Anyone going to comment?
Previouspetition for anyone who is interested.
https://www.change.org/p/tell-roche-pharmaceuticals-give-us-the-truth-about-accutane
On 8/11/2014 at 11:56 PM, Crank92 said:For those messaging me; my RSO is prepped and ready in the fridge at home. I cannot start though till I return from holiday in 2 weeks time. I will update with progress.
Of note is that a PFS'er I recently initiated conversation with due to what I deemed to be someone who could stick to a protocol in a somewhat religious manner. I shared my research and under my non-medically qualified suggestion he has commenced vaping recently and for the first time since pre-finasteride (2+years) he has been able to have sex without viagra. He has also ordered some cannabis oil from Holland which from my perspective looks more legit than anything else I've ever seen on the internet. I'll keep you updated on any progress he receives. Furthermore, there are few individuals on this thread that are undergoing RSO treatment. They will post when they are ready. So patience people.
Those of you remaining productive &/or positive on this thread. Congratulations.
Once again newbies, can you please report your side effects to the links listed in mine/Dubya's signature. The study that pathtorecovery91 has posted is due to people doing exactly that!
Wish Crank was still around. He was only 18 when he took accutane but even then he knew that everyone should be reporting their side effects.
On 12/19/2018 at 11:33 AM, HideAndSeek said:Is there anyone who had a bad reaction or worsening of symptoms with Milk Thistle? Because in the propeciahelp forum people who took Finasteride there are people who got way worse after milk thistle. I guess it was safe because Finasteride is different from Roaccutane and there is no mention of anyone worsening on milk thistle (I searched the whole thread). Now Im actually scared because Ive been taking this since 6 months and on the propeciahelp they all saying that you should avoid milk thistle because its a 5ar inhibitor (I dont even understand). Hope someone can help me,..
thanks in advance
I takemilk thistle orglutathione oftenwhen I want to aid the liver. Its especially important when using exogenous hormones, or before/afterconsuming large amounts of alcohol.
Ive only noticed relief. Hangover decreased by 1/3. And digestion functions better for me. Only positives in my subjective opinion.
Its been a long, long time since my last post. But on the topic of gut health...
I had mentioned back then that GI Microb X by Designs for Health had been very helpful to me. I started taking it at the instruction of a holistic doctor (both MD and naturopathic medicine). I think this supplement helped me the most back then and was intended to attack bad bacteria in the gut.I really think there is something there with the gut health approach Guitarman is taking (btw, thanks so much for being so consistent andposting over the years). I have since started using other approaches to address bacteria in the gut. One was bacteriophages (viruses designed to attackbad bacteria apparently), and I used another designs for health supplement called probiphage df that has a probiotic blend (only 5 billion CFU so who knows if thats doing anything) on top of the bacteriophages. In addition, I started using taking two40 billion CFU probiotic by BioSchwartz morning and night.The combination of those two seemed to help. Honestly Im not sure which brands are bestbut Designs for Health was one my doctor trusted, its just really expensive so kinda tapered off that.
However, I just recently bought a purely bifidobaterium longum supplement on amazon (all this stuff can be found there) called Bifido GI Balance by LifeExtension.Ive taken other probiotics with 15 or so strains and they just dont seem to get the job done or make it worse (the BioSchwartz one has been the best for me, but not a complete solution). Im going to try a targeted approach with that plus a prebiotic and see if that helps the bacteria take hold in there. Ill give an update on that in a few weeks.
Also very interested to hear from Scott242. Seems like you might be on to something there.
And Im not writing off the stem cell approach method mentioned a couple pages back. Could very well be the answer. But it seems difficult to implement at the moment so Im going with the microbiome approach for a bit.
22 hours ago, comishcf said:I just recently bought a purely bifidobaterium longum supplement on amazon (all this stuff can be found there) called Bifido GI Balance by LifeExtension.
Its kind of funny scanning whats available as bifido only supplements, I come up with about 3 or 4. This is out of all the probiotics on the market.
life extension, probiotic pearls (the 100 percent bifido version) and Align.
They are giving babies 8 billion, a study on inflammatory markers in Cfs used 10 billion, to give an idea of dosage. Anything higher then that becomes less fessabilecost wise depending on what your trialing.
Im not sure yet about prebiotics as they can be less selective or capable of growing multiple bacterias.
Anyways, this was real quick but on that certain strain in life extension, its actually very old and well researched from a japan based company.
https://www.mygenefood.com/psychobiotics-can-probiotics-make-brains-work-better/
Found some nice suggestions on an online stem cell forum.
"I wouldnt use any steroids. Im on LDN at 4.5mg and on RG3 its helping my brain inflammation. I would try both these first. Also curcumin is very anti inflammatory."
User recommends (LDN - Low dose naltrexone). Mentioned here a bunch, I'm sure at one point in time.
And RG3 - Panax Ginseng.
https://pdlabsrx.com/pages/rg3?fbclid=IwAR3D9hHR_r_WSjaFlat0q41ueKkvpfAJEQyj-DHLCT3pszlD6ZJYn1QIFvM
Hey,
Probably you all are familiar with the topic : https://forums.phoenixrising.me/index.php?threads/roaccutane-caused-depression-isotretinoin.12117/ - as in Poland our methylation panel is composed with 5 test ( b6,b12, homocysteine , folic acid, MTHFR mutation-2 types ) i wanted to ask if any of you did this whole methylation pathway which is Rich talking about. Did anyone had a contact with him ? He writes that he is researcher. Did anyone get any possitives from the therapy ?
PS. started account on phoenixrising.me to contact rich, but found he died in 2012. But maybe some of us had any contact before ?
Remember this study. I cant copy the image, but I want you to look at the first image.
Published: 04 Jul, 2018
Severe Acne in Female Patients Treated with Isotretinoin is associated with Dysbiosis and its Consequences
Conclusion: In female patients, isotretinoin is associated with dysbiosis, malabsorption and dysimmunity.
Isotretinoin is associated with dysbiosis, malabsorption (with visceral fat decrease) and signs of dysimmunity. Symptoms develop more than 20 years after the intake of the medication taken at usual range and duration. A facilitating role of Propionibacterium acnes cannot be excluded. Isotretinoin is known to impair stem cells renewal and TLR2 expression in the mucosa of the small gut. These pharmacological effects, explaining the efficacy of the medication on acne (the metabolic syndrome of the pilosebaceous gland) may induce the progressive atrophy of the jejunal mucosa and its long-lasting consequences. No therapy is available yet. Patients, prescribers and authorities should be aware of this adverse event which incidence is high (2.6% of outward gastroenterological consultations) especially when multi-annual surveillance for several years are expected.
16 hours ago, guitarman01 said:Remember this study. I cant copy the image, but I want you to look at the first image.
Published: 04 Jul, 2018
Severe Acne in Female Patients Treated with Isotretinoin is associated with Dysbiosis and its Consequences
Conclusion: In female patients, isotretinoin is associated with dysbiosis, malabsorption and dysimmunity.
So now I understand why I can't digest fat/fructose/dairy/wheat after treatment with Accutane...because it can inducepermanentmucosal atrophy(just like in the case of Celiac Disease?) which in turn leads to permanent dysbiosis/SIBO.
Quote
[...] when SIBO is severe and prolonged [...] In such instances, the incidence of associated pathologies increases: like depression [6-10], overweight [11] and liver steatosis [12], type 2 diabetes mellitus [13], cancers [14], or chronic HPV infections [15].
Some really scary stuff, especially when you consider the factthat "No therapy is available yet".
On 1/1/2019 at 6:35 PM, guitarman01 said:Remember this study. I cant copy the image, but I want you to look at the first image.
Published: 04 Jul, 2018
Severe Acne in Female Patients Treated with Isotretinoin is associated with Dysbiosis and its Consequences
Conclusion: In female patients, isotretinoin is associated with dysbiosis, malabsorption and dysimmunity.
Isotretinoin is associated with dysbiosis, malabsorption (with visceral fat decrease) and signs of dysimmunity. Symptoms develop more than 20 years after the intake of the medication taken at usual range and duration.A facilitating role of Propionibacterium acnes cannot be excluded. Isotretinoin is known to impair stem cells renewal and TLR2 expression in the mucosa of the small gut. These pharmacological effects, explaining the efficacy of the medication on acne (the metabolic syndrome of the pilosebaceous gland) may induce the progressive atrophy of the jejunal mucosa and its long-lasting consequences. No therapy is available yet. Patients, prescribers and authorities should be aware of this adverse event which incidence is high (2.6% of outward gastroenterological consultations) especially when multi-annual surveillance for several years are expected.
sorry for spamming, but i think this is worth reposting to keep it on a current page for abit.
This study was published about a half a year ago, some of these newer thoughts and research didnt exist back in the 80s or 90s.Just like technology, they are discovering more and more at a rapid pace. At least there's still plenty of current research on Accutane.
switching gears for the moment, this is kind of what im looking at right now.
Possibilities.
JANUARY 10, 2018
Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration
- Western style diet impairs penetrability and growth of the colonic mucus layer in mice
- Mucus defects are accompanied by distinct alterations in microbiota composition
- Microbiota transplant from chow-fed mice prevents mucus aberrations in mice fed a WSD
- Mucus aberrations can be prevented byBifidobacterium longumand inulin treatment
Bacterial-modulated host immunity and stem cell activation for gut homeostasis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758744/
Immunoregulatory Effect of Bifidobacteria Strains in Porcine Intestinal Epithelial Cells through Modulation of Ubiquitin-Editing Enzyme A20 Expression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608626/
We show new data regarding the mechanism involved in the anti-inflammatory effect of immunobiotics. Several strains with immunoregulatory capabilities used a common mechanism to induce tolerance in PIE cells. Immunoregulatory strains interacted with TLR2, upregulated the expression of A20 in PIE cells, and beneficially modulated the subsequent TLR4 activation by reducing the activation of MAPK and NF-B pathways and the production of proinflammatory cytokines. We also show that the combination of TLR2 activation and A20 induction can be used as biomarkers to screen and select potential immunoregulatory bifidobacteria strains.
Isolation of bacterial species directly from the mucosa of healthy humans, rather than from the feces, is a preferred means of identifying strains of probiotic bacteria, since this isolates the bacteria from the environment where it needs to be able to function to be effective. At University College Cork, it was recognized that while lactobacilli isolated from human feces have been studied for some time, there is a scarcity of information regarding bacterial strains isolated directly from a healthy GI environment. One of the strains identified in this pivotal work, Bifidobacterium infantis 35624 (Bifantis) is the first and only probiotic ingredient that was isolated directly from the epithelium of a healthy adult.
^this is the strain im trialing at 10 billion per day. We will see, if anything. I do know nothing will happen overnight.
On 1/2/2019 at 11:35 AM, guitarman01 said:Remember this study. I cant copy the image, but I want you to look at the first image.
Published: 04 Jul, 2018
Severe Acne in Female Patients Treated with Isotretinoin is associated with Dysbiosis and its Consequences
Conclusion: In female patients, isotretinoin is associated with dysbiosis, malabsorption and dysimmunity.
Isotretinoin is associated with dysbiosis, malabsorption (with visceral fat decrease) and signs of dysimmunity. Symptoms develop more than 20 years after the intake of the medication taken at usual range and duration.A facilitating role of Propionibacterium acnes cannot be excluded. Isotretinoin is known to impair stem cells renewal and TLR2 expression in the mucosa of the small gut. These pharmacological effects, explaining the efficacy of the medication on acne (the metabolic syndrome of the pilosebaceous gland) may induce the progressive atrophy of the jejunal mucosa and its long-lasting consequences. No therapy is available yet. Patients, prescribers and authorities should be aware of this adverse event which incidence is high (2.6% of outward gastroenterological consultations) especially when multi-annual surveillance for several years are expected.
Thx for this, Ive printed this report ready to show my kinesiologist next week. Itll be interesting to hear their take on it as we work on Gut - granted the test was for females,none the less I dont see why males would be any less affected!!?
Guitarman: whats your take on MTHFR testing? Have you done it?
I think I might just do the test to rule things out, My kinesiologist did pick up recently that my B12 was low, Im curious too about Folic Acid levels.
Im wanting to know if I should spendmore time investigating this or instead continue working on the gut.
On 12/16/2018 at 3:38 AM, guitarman01 said:I'd actually be looking at a more targeted approach as opposed to a fecal transplant.Alot of current research is looking at very specific strains.
What truly is a probiotic? Different strains and species have shown to be competitive at times and not all benefit the host. So just throwing the kitchen sink at the problem (fecal transplant) and hoping for the best, to me doesn't seem the best way to look at this.
Hey I think you're misunderstanding one thing. My fecal transplants were not "throwing the kitchen sink at the problem". I tested multiple possible donors to see their microbiome make up, and chose the donor with the most beneficial make-up and with no dysbiotic bacteria, plus a history of 0 antibiotic use. If you look into issues that are fixed with probiotics (such as issues like C Diff), and look at a lot of different cases, you can see that fecal transplants can correct these issues while no amount of man-made probiotics can.
More importantly, I saw an older post of yours where you talked about mitochondrial dysfunction. I think this is where it's at. First off, because Nicotinamide Riboside fixed many of my issues rapidly, but also because dysbiosis, inflammatory issues are often a SYMPTOM of mitochondrial dysfunction. You can try to fix the balance of your gut biome, like I did, but I think you're not hitting it at the root. The most common issues with Accutane are skin inflammation and colitis/digestive issues, now read these passages from recent studies:
"Numerous cellular processes are dependent upon healthy mitochondria for an adequate energy supply. The intestinal mucosa of IBD (Inflammatory Bowel Disease )patients has been demonstrated to be in a state of energy deficiency characterized by low ATP levels and low energy charge potential, (Roediger,1980a; Kameyama et al.,1984; Soderholm et al.,2002a), calling into question the functionality of this organelle during disease. Indeed, the colonic epithelial cells of patients with ulcerative colitis exhibit mitochondrial alterations before other ultrastructural abnormalities in the epithelium are apparent and before the onset of mucosal inflammation (Delpre et al.,1989; Hsieh et al.,2006). The integrity of the intestinal epithelium, tight junction maintenance, and -oxidation are key cellular processes within the intestinal epithelium that are not only dependent upon properly functioning mitochondria, but are also known to be altered in animal models of intestinal inflammation and in humans with IBD."
And this study:
Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function
https://www.nature.com/articles/s41419-018-0765-9
And from https://www.sciencedaily.com/releases/2017/05/170517101159.htm :
"To demonstrate how MDR1 dysfunction leads to bowel damage, the scientists then showed that mice lacking MDR1 had faulty mitochondria -- parts of the cell often referred to as 'batteries'. These play a vital role in energy generation and cell health.
This mitochondrial dysfunction resulted in colitis -- inflammation in the inner lining of the bowel that is a defining feature of IBD."
Inflammation, Dysbiosis, as well as the most defining features of Post Accutane Syndrome: Skin inflammation and Ulcerative Colitis literally stem from Mitochondrial Dysfunction.
People if you're reading this, look into a supplement containing "NT Factor", and take it, see if it helps after a month or two, and report here. It's something called "Lipid Replacement". Sorry I'm in a hurry, no time to explain. They also found mitochondrial DNA leak ( a symptom of mitochondrial membrane damage) to be a possible cause of colitis. Add the fact that an earlier study I shared shows that Accutane is a mitochondrial toxicant, seems like something to look into. Remember the key isn't mitochondrial supplements like COQ10, we need to target repairing the lipid walls of the mitochondria, not just making the body make new mitochondria.