On Ž6Ž.Ž11Ž.Ž2016 at 6:27 PM, IhateAccutane said:

Today it was sunny and I realised how much I recovered from floaters. I found this pic, this is how my vision was, even worse. Now they are gone. 
Second goal is tinnitus and ED

Floaters are gone 99%. This is how my floaters were.

Getting these well overdue tests done tomorrow. Had been fighting my doc for ages and finally just purchased them via walkinlab

Total T
Free T
FSH
LH
DHEA
DHT
Estradiol
Progesterone
Prolactin

Gotta start somewhere and hopefully we find something abnormal. Considering Im gaining weight like no other, sweating like a pig and have been in the worst form of depersonalization for over a year now.

10 hours ago, flynn said:

whats up bro. It won't let me message you for some reason. Maybe the new website format.

I don;t know why that is. My box is full I know but I deleted some msg and I got a PM yesterday.

Anyway, do you live in the UK and are you interested in raising awareness?
There is a meeting on the 7th march in London and it would be great to get numbers there.
Do you know any one who wants to help? I find parents are the one who are more about
highlighting the dangers of accutane where most victims understandably want to concentrate on getting well.
I find it heartbreaking that so many of you guys feel shame and don't want anyone to know about what accutane does re the sexual sides. I totally get this but we must protect kids going forward.
The shame is not yours, it is for everyone who is complicit in the prescribing of accutane and the regulators who allow it.

Who can attend this meeting on the 7th?
Any parents out there who want to get involved?

Flynn, I will clear my mailbox but if you are still unable to pm me or need or want my email address -
ask dubya for it.

On 15.12.2016 at 4:30 AM, ehohel said:

So my Telomere results pre Epitalon have came in.. I guess I have the telomere length of a 90 year old?......

Hi, ehohel! I know its been a while but I just need to know.. Have you done telomere length test after epithalone? Any changes?

2 hours ago, Orevantum said:

On 15/12/2016 at 0:30 PM, ehohel said:

So my Telomere results pre Epitalon have came in.. I guess I have the telomere length of a 90 year old?......

Hi, ehohel! I know its been a while but I just need to know.. Have you done telomere length test after epithalone? Any changes?

Guys, as always great when you post test results on given subject but PLEASE can you give some insight/detail on the follow up part of it!!!

Usually we™ve seen a specialist yeah to get these tests done? How bout some info on what they said about the results please, good or bad!!

Its that little tid bit of info that will help us latch on to something yeah....the follow up procedure...

Is that a good thing your telomere lenth

13 hours ago, Colinboko said:

Getting these well overdue tests done tomorrow. Had been fighting my doc for ages and finally just purchased them via walkinlab

Total T
Free T
FSH
LH
DHEA
DHT
Estradiol
Progesterone
Prolactin

This is good. You should have results a few days after the tests. They will send you a email.
Too bad your doctor wouldn't even test something as basic as testosterone, forcing you to pay out of pocket. At least you have a pretty comprehensive profile here.
Was this one test package?

9 hours ago, guitarman01 said:

This is good. You should have results a few days after the tests. They will send you a email.
Too bad your doctor wouldn't even test something as basic as testosterone, forcing you to pay out of pocket. At least you have a pretty comprehensive profile here.
Was this one test package?

No actually! Was cheaper to just add each test separately! Didnt need some of the ones included in the packages so I pieced together what I thought would be a good starter. And yes, my doctor is a piece of shit. Hoping we find something so I can throw the results in his face lol

On 02/03/2018 at 10:56 AM, guitarman01 said:

So you had eye floaters and they went away on their own? That's good news at least.
So your main symptoms currently are Ed and tinnitus?

Muscle weakness, nerve connections, blood flow. I think they all could be related.
My tinnitus has seemed permanent. But im not sure if it really is, or would even qualify as tinnitus.

Someone came on here awhile back and had been diagnosed with collapse of the sinus structure.
The doctor threw some antibiotics and steroids at it I believe. Probably didnt help, maybe even made things worse. idk he never came back on.

I envision muscle weakness of the entire face, skull, even in the brain, that regulate blood flow.
It all might start in the muscles.

New cause discovered for arterial stiffness, a contributor to cardiovascular disease

https://www.sciencedaily.com/releases/2015/05/150511125358.htm

Previous studies of aortic stiffness have focused on changes in structural proteins that alter the properties of vascular walls causing them to become rigid. Now, researchers have determined that smooth muscle cells, which line the interior of vascular walls, are a major contributing factor to vascular stiffness, one of the major causes of hypertension.

What is a muscle protein doing in the brain? The Biochemist Blog

https://thebiochemistblog.com/2017/09/.../what-is-a-muscle-protein-doing-in-the-brai...

This is interesting, with nearly everyone finding nothing when it comes to the usual blood tests, looking into this could be the next step!!

It might also explain why our side effects are far reaching, everything from general fatigue to the more serious sexual sides.

Accutane thickening the blood, it is possible but is it permanent?

Im looking at muscles pumping blood flow. Including the heart as a muscle.
Just thinning the blood wouldnt affect this. Maybe make it worse.
But yes I have also been borderline positive for hypercoagulability
through lupus anticoagulantblood testing.

Im also looking at equalized blood pressure not too high or low.
"Pressurized" and pushed equally and effectively, this involves muscle.
Blood vessel homeostasis.

Vascular smooth muscle - Wikipedia

Arteries have a great deal moresmooth musclewithin their walls than veins, thus their greater wall thickness. This is because they have to carry pumpedbloodaway from the heart to all the organs and tissues that need the oxygenatedblood.

Vitamin K2 Ameliorates Damage of Blood Vessels by Glucocorticoid: a ...

Guitarman - sorry are you leaning towards a thickening of the blood or thinning post tane?

As I learn more about Vit K, I know it can assist with blood clotting and that can be an issue say for the elderly as their blood can get very thin.

What Vit K would do for someone with thick blood I dont know?, it could be very dangerous if I didnt know any better and potentially the last thing you really should be taking...

Happy to learn more....

Everything is with caution. Im very aware of this.
I posted this not too long ago. Did you catch it?
What could be an interpretation for this @TrueJustice?

Anticoagulants Tied With Stroke, Hemorrhage in CKD

https://www.renalandurologynews.com/chronic-kidney-disease-ckd/chronic-kidney-disease-afib-anticoagulants-tied-ischemic-stroke-bleeding/article/744827/

Anticoagulant - meaning reducing the ability of the blood to clot.

Correct me if Im wrong but this would be the opposite of say Vit K which helps the blood to clot!?

Why do we need to be concerned with anticoagulants? Unless youre heavily into taking say Aspirin or if you think Accutane thinned the blood....Why the need to look at anticoagulants??

My original question might be slightly off, perhaps tane hasnt changed the blood but has rather increased cardiovascular, I dont want to say disease but rather altered the blood vessels which move the blood around the body.

might of just answered my own question

Found the above extract when reading up on Vit K. Everything from the eye floaters to varicose veins, these are blood vessel issues in my book. Some issues present themselves minor while others like varicose veins present themselves larger....

photo didnt attach - cant you just copy and paste photos??

15 hours ago, TrueJustice said:

Happy to learn more....

I'm going to slow this down and go back over this. This is all information that's previously been posted.

Chronic kidney disease patients, especially those on dialysis have been shown to be vitamin k deficient as of recent.
One of the main risks of death in patients on dialysis is excessive calcification of the arteries.
Here this study is showing that while taking anticoagulants it increased the risk of both blood clotting and bleeding.
72 percent were taking vitamin k antagonists.

Here is a list of tests that some of you have probably never heard of.
Dont forget about these tests. You never know which one might lead to the breakthrough we are looking for.
There is more im looking into as well.
There is a chance this is what's been under the radar.

Cardio IQ Tests
http://questdiagnostics.com/home/patients/health-test-info/chronic-disease/heart-disease/cardio-IQ-testing.html?utm_source=vigorate&utm_medium=email&utm_content=what-cardio-id-can-tell-you-button-cardioiq-feb&utm_campaign=2018-quest-patient-marketing
Lipid Panels
Lipoprotein Subfractionation
Apolipoproteins
Inflammation Biomarkers
Heart Failure
Metabolic Markers
Genetic Cardiovascular Markers

Anyone tried Modafinil yet?
The 200mg modalert. 
If you want to remove your brain fog, listen to music like pre-tane and have energy like you did try it.
I know its a short cut, and maybe at some cost, but I went from a spectator in a meeting to the lead in a meeting. I like this energy  again.

33 minutes ago, Walden Rev said:

Anyone tried Modafinil yet?
The 200mg modalert. 
If you want to remove your brain fog, listen to music like pre-tane and have energy like you did try it.
I know its a short cut, and maybe at some cost, but I went from a spectator in a meeting to the lead in a meeting. I like this energy  again.

Haven™t tried it.

I don™t imagine you can stay on it indefinitely? So how do you feel when you don™t take it, do you revert back to having tane brain?

I can see why you™d be attracted to it, sounds like it kickstarts your cognitive parts.

35 minutes ago, Walden Rev said:

Anyone tried Modafinil yet?
The 200mg modalert. 
If you want to remove your brain fog, listen to music like pre-tane and have energy like you did try it.
I know its a short cut, and maybe at some cost, but I went from a spectator in a meeting to the lead in a meeting. I like this energy  again.

This is interesting. Pretty sure modafinil increases dopaminergic activity in prefrontal cortex. This is a region which is underactive in people suffering from negative symptoms of schizophrenia

@Babis
This was one of Babis last posts on here.
" By the way, after 4 years of workup and every endocrinology test available, my official diagnosis ishypogonadotropic hypogonadism and subfertility secondary to partial hypothalamic insufficiency, due to isotretinoin treatment. I hope this helps other people with problems: find a good reproductive endocrinologist (don't go to a generic endocrinologist, they are clueless) and get your hypothalamic function tested."

Examples of symptoms of hypogonadism with underdevelopment of theGonads(testiclesandovaries) includedelayed, reduced, or absent puberty, lowlibido, andinfertility.

What if this was something you could turn back on? Its not necessarily age dependant.
These are different causes, but same idea.

Catch-Up Growth after Hypothyroidism Is Caused by Delayed Growth Plate Senescence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276705/
Catch-up growth is defined as a linear growth rate greater than expected for age after a period of growth inhibition.

Sometimes I picture what happened as a fd up version of peter pan for some people. Never grew into adults. Never matured both mentally and physically.
You can look right on the pamphlet, it says Accutane may cause "premature closure of growth plates"

Excessive mineralization with growth plate closure in rats on chronic warfarin treatment.

Speaking of mineralization, just like you want calcium in bone, the same goes for the other minerals.
Bone homeostasis might regulate mineral homeostasis, not just calcium.

And the follow up procedure.... for fuck sake!!!

I wish these guys who find something could avoid being vague, you get tested, they found something, yes got that but then what?????

Im sure at some point the specialist who ordered the test wanted to go over the results with the patient with a plan moving forward- what was that plan?

Can anyone repost the info regarding accutane metabolism? I remember someone posted something which basically showed that different people metabolise vit A differently. Which could result in some users of accutane have far higher amounts of accutane metabolites in their body than other people.

8 hours ago, flynn said:

different people metabolise vit A differently

For me, I'm not looking at circulating levels of retinoic acid at the time of exposure being the biggest issue.
(A higher than necessary dosage would have a greater effect though im sure.)
How would this relate to PFS sufferers that didn't take Accutane?

I want to go back to what I posted a few days ago.
Genetic Cardiovascular Markers
This is one of them.
ApoE Genotype

This is when it starts to get pretty interesting.
This is also known as the Alzheimer's Gene.

11 hours ago, guitarman01 said:

For me, I'm not looking at circulating levels of retinoic acid at the time of exposure being the biggest issue.
(A higher than necessary dosage would have a greater effect though im sure.)
How would this relate to PFS sufferers that didn't take Accutane?

I want to go back to what I posted a few days ago.
Genetic Cardiovascular Markers
This is one of them.
ApoE Genotype

	The ApoE genotype test assesses your risk of heart disease, as well as your response to different amounts of dietary fats. There are six APOE genotypes: 2/2, 2/3, 3/3, 2/4, 3/4, and 4/4. If you have the 3/4 or 4/4 genotype, you may have a higher risk of heart disease

This is when it starts to get pretty interesting.
This is also known as the Alzheimer's Gene.

Yes but its possible that if people metabolise vit A in a significantly different way due to some gene variant etc. Than during accutane treatment they would be exposed to far higher dosages than other people, and the risks associated with vit A ability to alter gene expression etc. would be greatly enhanced. Which would explain why only a subset of patients develop PAS. Alternatively people with PAS may just have a set of genes which make them far more susceptible to developing PAS. We will never know the answer to this question until genome sequencing becomes cheap enough, so that all PAS people can get their genes sequenced.

Well if PFS and PAS share a common underlying cause such as 5AR inhibition. It doesn't seem like accutane has as much of a direct effect on 5AR, and its action on 5AR (if it has any) is relatively small. However if metabolism in PAS sufferers is different and they get a huge dose of accutane metabolites, this may make accutanes effect on 5AR substantial enough to cause PAS.

Why does the ApoE gene interest you? Cardiovascular problems don't seem to be a common nor significant problem for people with PAS? Also what has Alzheimer's got to do with PAS? I appreciate some people have memory problems and brain fog but these are likely to be completely unrelated mechanisms as the worsening of symptoms seems to happens on a completely different timescale to something like Alzheimers.

7 hours ago, flynn said:

Why does the ApoE gene interest you? Cardiovascular problems don't seem to be a common nor significant problem for people with PAS? Also what has Alzheimer's got to do with PAS? I appreciate some people have memory problems and brain fog but these are likely to be completely unrelated mechanisms as the worsening of symptoms seems to happens on a completely different timescale to something like Alzheimers.

These are pretty direct connections. The rest I will get into later when I have more time.

Impact of 6-month course of 1 mg finasteride tablets on levels of lipid profile in men with androgenic alopecia
http://www.endocrine-abstracts.org/ea/0029/ea0029p277.htm

Atherosclerosis constitutes one of the most frequent diseases and one of the important predisposing factor for atherosclerosis is lipid profile change.

Findings: A significant decreases in fasting plasma level of HDL was observed after 6 months of therapy (P<0.001). Moreover, a statistically significant rise in fasting plasma level of triglyceride was observed after 3 months of therapy

Conclusion: Our study demonstrated for the first time that using 1mg finasteride tablets to treat androgenic hair loss may lead to complications of the lipid profile through reducing HDL and increasing total cholesterol. Finasteride may decrease dihydrotestosterone and increased testosterone this change in lipid profile may be due to testosterone elevation by using finasteride.

You can look at various examples of vascular disease and nervous system deterioration going hand in hand.
Again this is coming directly from the Accutane pamphlet.
"May cause blood vessel inflammation."
We know what people have looked into extensively already, I have an idea what they haven't.
All of this isnt guaranteed to stay true over a period of time, but it might start to paint a picture.