Thanks guys yea I get that all the time
i hate doctors
some along the way have been great
but mention tane ur psycho

On 8/17/2017 at 2:07 AM, TrueJustice said:

The proof would be in the pudding with Vit K though wouldn't it?

I haven't felt anything change whilst being on it? Has anyone felt or noticed anything whilst supplementing Vit K?

Its definitely worth pursuing and staying on it for a good period to really see if it does change anything but currently I'm just as fatigued as I've ever been unfortunately

What brand and dosage are you using? im looking right now at synthetics that are mostly free of cis isomers, meaning more pure, less contaminants so the stated dosage is the actual dosage. Im no longer looking at fermented mk7 products with some of our sensitivities for less variables . im also still looking at mk-4 vs mk7. how mk-4 generation might relate to epigenetics, gene variations that relate to vitamin D receptors, xenobiotics and steroid genesis. There is more I will post on this when I get a chance.

I believe in common law I guess but how is this legal?!?

I am an accutane victim. I am looking for a lawyer who can pull of the accutane case. willing to split profits (compensation) in half with him/her. I feel like a a SHELL from accutane. It took away WHO I WAS at 15 suddenly I fell out of school and lost my charm?" Yep thats 8 mos of 80mg accutane results. Two months off I was on my knees. But I plain-flat-out-simply should NEVER have taken this drug.

And im TRAPPED THIS WAY. Retinoids fried me.. made my depression a permanent battle. I basically feel tired and like crap all the time even though I eat raw. 24 MALE. I had to stop towing my trailer due to mental fatigue (and anxiety from acutane). Pretty sad excuse of a man. Think it is because the isotretinoin gellets are formulated with SOY (PROBABLY part of the GMO testing project). Unfortunately my health has steadily declined since accutane, with no other reason to blame shoot, I don't drink or do drugs! Yet I am left with this emptiness feeling and permanent diarrhea :(.
I feel like I was bombed on this drug. My eyes now suck, and are burning and half moons because there dry. Its inflammation from accutane destroying my immune system i think. or just dry, whatever you want to "call it." Blurry vision and blood sugar problems are possible from accutane too. and tiredness. And isn't life all about chrones flare ups? Sure is! I cant tell you if it is because of all the soy and other bullshit I was fed as a kid but it is ALL part of this case. Accutane should have been a rejected drug. It is very powerful in moderate doses. It caused me to have 0 libido and depression. I feel weaker and have muscle pains a lot. time for neck surgery? wish I could afford it. oh look i have my original phamplet it says..... organ damage. Why did I not get a verbal warning at the LEAST of organ damage from accutane. hmm? so maybe posioning yourself stops acne, but its WRONG!!!!!!!! ITS...............................................EVIL! We should hang those labrotory chemists by there necks and keep the fda chairmen crew in cages and feed them all different terrible things and make them watch each other all die at different rates. The side effects are endless from mild to very disturbing (mentally). Thanks for listening. Life goes on. I farm and grow a ton of food, (hasnt fixed me at all but throught fasting and proper diet i can hardly just get up in the morning.....). WE SHOULD BE COMPENSATED FOR THE ACCUTANE DAMAGE ..

If you take accutane or the generic version you are literally making a deal with the DEVIL.

1 hour ago, accutane_victim_799 said:

I believe in common law I guess but how is this legal?!?

I am an accutane victim. I am looking for a lawyer who can pull of the accutane case. willing to split profits (compensation) in half with him/her. I feel like a a SHELL from accutane. It took away WHO I WAS at 15 suddenly I fell out of school and lost my charm?" Yep thats 8 mos of 80mg accutane results. Two months off I was on my knees. But I plain-flat-out-simply should NEVER have taken this drug.

And im TRAPPED THIS WAY. Retinoids fried me.. made my depression a permanent battle. I basically feel tired and like crap all the time even though I eat raw. 24 MALE. I had to stop towing my trailer due to mental fatigue (and anxiety from acutane). Pretty sad excuse of a man. Think it is because the isotretinoin gellets are formulated with SOY (PROBABLY part of the GMO testing project). Unfortunately my health has steadily declined since accutane, with no other reason to blame shoot, I don't drink or do drugs! Yet I am left with this emptiness feeling and permanent diarrhea :(.
I feel like I was bombed on this drug. My eyes now suck, and are burning and half moons because there dry. Its inflammation from accutane destroying my immune system i think. or just dry, whatever you want to "call it." Blurry vision and blood sugar problems are possible from accutane too. and tiredness. And isn't life all about chrones flare ups? Sure is! I cant tell you if it is because of all the soy and other bullshit I was fed as a kid but it is ALL part of this case. Accutane should have been a rejected drug. It is very powerful in moderate doses. It caused me to have 0 libido and depression. I feel weaker and have muscle pains a lot. time for neck surgery? wish I could afford it. oh look i have my original phamplet it says..... organ damage. Why did I not get a verbal warning at the LEAST of organ damage from accutane. hmm? so maybe posioning yourself stops acne, but its WRONG!!!!!!!! ITS...............................................EVIL! We should hang those labrotory chemists by there necks and keep the fda chairmen crew in cages and feed them all different terrible things and make them watch each other all die at different rates. The side effects are endless from mild to very disturbing (mentally). Thanks for listening. Life goes on. I farm and grow a ton of food, (hasnt fixed me at all but throught fasting and proper diet i can hardly just get up in the morning.....). WE SHOULD BE COMPENSATED FOR THE ACCUTANE DAMAGE ..

I agree this drug has done a number on people
I wish everyone could post there symptoms and see if we are all in Similar boat

i feel like we're battling diff things
some similar

Just now, Nemesisbrady said:

I agree this drug has done a number on people
I wish everyone could post there symptoms and see if we are all in Similar boat

i feel like we're battling diff things
some similar

Here in America

Has anyone had their prostaglandin levels tested? Take some baby aspirinfor a few days. feels like everything wants to turn back on.

Effect of aspirin administration on retinoic acid toxicity in mice

S. D.HARRISONJR, E. J.HIXON, J. A.BURDESHAW&E. P.DENINE

Southern Research Institute, 2000 Ninth Avenue South, Birmingham, Alabama 35205

THIS study was designed to provide an indirect assessment of the possible role of prostaglandins in retinoid intoxication. If the symptoms of retinoid toxicity are mediated by prostaglandins, an inhibitor of prostaglandin synthesis should ameliorate the symptoms of sublethal intoxication and perhaps even increase the lifespan of mice treated with lethal doses of retinoids. The observations reported here indicate that aspirin can antagonise the toxic effects of retinoic acid.

Administration of excessive amounts of retinol (vitamin A) and of certain derivatives and synthetic analogs (retinoids) produces a characteristic set of symptoms, including head- ache, vomiting, pruritus, skeletal pain, and bone resorption in experimental animals [l, 21 and man [3-61. In animals, administration of retinyl esters [2] or retinoic acid (vitamin A acid) [7] at sufficiently high doses can result in lethality. The symptoms of retinoid toxicity are similar to reported physiologic effects of prostaglandins [8-111 so it seemed reasonable to us that retinoid toxicity may be mediated in some way by prostaglandins. If this were the case, co- administration of an inhibitor of prostaglandin synthesis might interfere with the toxicity resulting from retinoid administration. We have demonstrated that concurrent administration of aspirin, an inhibitor of prostaglandin synthesis [8,12], protects mice against the toxicity resulting from administration of retinoic acid at the LDso [13] or LD~O [14]. This study was designed to compare the abilities of nonsteroidal anti-inflammatory (NSAI) drugs of known potency as inhibitors of prostaglandin synthetase to protect mice against retinoic acid toxicity.

http://www.livestrong.com/article/253170-how-to-naturally-lower-prostaglandins-with-foods/

http://www.livestrong.com/article/166102-prostaglandin-inhibitor-drug-list/

So far on LDN 3mg/day, my moodhasn't got any better, if anything I'm a bit more flat now, but not depressed or anything. My aches really havn't improved, although I do sleep a bit more. Sex drive no different, if anything a bit less. Appetite is less.

3 hours ago, mikez said:

So far on LDN 3mg/day, my moodhasn't got any better, if anything I'm a bit more flat now, but not depressed or anything. My aches really havn't improved, although I do sleep a bit more. Sex drive no different, if anything a bit less. Appetite is less.

How did you get LDN? I'm not so sure of it doing much with us. In my opinion we need strong immunosuppressants not immunomodulators.

@tanedout@guitarman01

Guys this is a very major one : I try to explain how Endoplasmic Reticulum stress, autophagy , TAM Receptors (dependent on Vitamin K), Vitamin D3 and Myosins (especially MYO9B) are related to our condition :

They will be reviewing this from Stanford, hopefully they will consider it.

[removed]

7 hours ago, tryingtohelp2014 said:

Has anyone had their prostaglandin levels tested? Take some baby aspirinfor a few days. feels like everything wants to turn back on.

Interesting. The only time I ever came across that word was after reading the chinese study i posted before suggesting the drug Mifepristone to alleviate depressive symptoms in retinoid toxicity mice. Coincidentally, mifepristone is often used in conjunction with a "prostaglandin analogue" for female abortion.

A bit off topic, but check this study out, fairly recent. Can't believe they tormented a bunch of tree shrews to observe efficacy. Drug seems promising though...

https://www.ncbi.nlm.nih.gov/pubmed/26476437

Ok my testosterone is almost 900 higj
and my estradiol is 52 high
range 0-39.8

wgat causes this and what's going on

43 minutes ago, Nemesisbrady said:

Ok my testosterone is almost 900 higj
and my estradiol is 52 high
range 0-39.8

wgat causes this and what's going on

This of course could relate to other causes, but this is what im still looking into atm.
At least be glad your testosterone is high.

2005 Apr 8;76(21):2473-82.

Vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism.

5 hours ago, mariovitali said:

Guys this is a very major one : I try to explain how Endoplasmic Reticulum stress, autophagy , TAM Receptors (dependent on Vitamin K), Vitamin D3 and Myosins (especially MYO9B) are related to our condition :

Myosins. involved in muscle contraction. This could almost be a paralysis in some cases, that could create tension that could cause headaches. anyone have a muscle tightness in the neck on both sides? Theres a neurological term for this (cant remember it) that can create pain just resting your head on a pillow. it can be related to nerve damage or nerve inflammation. Thinking of this when you consider lost sensitivity in ED, the same type of thing might be going on your head creating the "brain fog" your not feeling nerves you should be feeling (lost connections), if severe enough based on disease processes, this can literally drive you crazy.

I'm glad it's high
despite my anger and mood swings
but why is estrogen high
coukd that be why I'm cold and flushing and dry?

also vitamin k interesting....

i have
rheum coming up where where I have to discuss my Ana positive speckled diffuse again
snd igg4 elevated
asking for lip biopsy and paroid gland x ray
because they swell when eating pizza sometimes the dough
hands locking up when carrying stuff and my knee was locked up couldn't move it when I woke up few years ago
and schimers test showed no tears at all
i have every symptom of sjorgens and lupus rash on face

i have medicinal weed place coming up asking for edibles as smoking is too drying I need this for SLEEp I want off my
xanax

i have the nutritionist where I'm on gluten dairy wheat low sugar free diet 10 months now
no relief
asking if I can add dairy I avoid eggs also so I have no vitamin a in diet
which may be bad or good....levels were normal but now I avoid all that

going to ask about b and milk thistle if I can up my dose

ask about vitamin c
maybe cod liver oil scared tho

sea salt little things

also have endo
whwre I'm going to ask about this estriadol and MRI pituratry they want
I had brain one which was normal thank god

and allergist

all of this is coming weeks

ill kee u posted

maybe we should all add a forum post with all our symptoms

i currently have about 30
least half are driving me insane

stay strong guys

23 hours ago, guitarman01 said:

What brand and dosage are you using? im looking right now at synthetics that are mostly free of cis isomers, meaning more pure, less contaminants so the stated dosage is the actual dosage. Im no longer looking at fermented mk7 products with some of our sensitivities for less variables . im also still looking at mk-4 vs mk7. how mk-4 generation might relate to epigenetics, gene variations that relate to vitamin D receptors, xenobiotics and steroid genesis. There is more I will post on this when I get a chance.

Brand is Essential Nutrition.

Ive been a bit hit n miss with Vit K so I'll take with a bit more regularity.

On 8/20/2017 at 2:57 AM, macleod said:

Interesting. The only time I ever came across that word was after reading the chinese study i posted before suggesting the drug Mifepristone to alleviate depressive symptoms in retinoid toxicity mice. Coincidentally, mifepristone is often used in conjunction with a "prostaglandin analogue" for female abortion.

A bit off topic, but check this study out, fairly recent. Can't believe they tormented a bunch of tree shrews to observe efficacy. Drug seems promising though...

https://www.ncbi.nlm.nih.gov/pubmed/26476437

test.. im betting anyone with active joint pain will test high in this.

[Edited link out]

On 8/18/2017 at 0:33 AM, Nemesisbrady said:

I had to take break so much stress
my MRI was fine. But said they did brain and not specific to pituatry so need new one
the hormones fine t levels were high
ana is positive speckled again
idk if I have sjorgens or lupus
my anxiety depression OCD bdd can't be treated with meds

my questions are this
i may never find answers 
the dry eyes and nose mouth get worse with meds

so

the flushing and rosacea like skin
has anyone fixed that?

i guess I can deal with the other shit
but will v beam and lasers work for red skin?

dont mind me looking ghastly white in summer
im
hlusebound Ron he anxiety of this rash
it gets worse heat sex masturbating lifting
it's either Rosacea or lupus
since Ana is high 
it's very flaky on nose and beard area to do maybe seb derm

does anything work?
i it out dairy gluten wheat low sugar 10 months now

I've had v beam once and it left white marks on side
so maybe it heloed
the flushing anxiety wise beta blockers do help and ssri kind of
but not an option 

feel pike my epidermis is ruined
any suggestions?
im ode to giving up on answers so next step is lasers 

sexond pic is few years ago I scrapped it and was summer 

Your skin is a lot like mine... only better lol

I have a lot of the same problems: Seb Derm, redness, BDD etc.

What I've found works for me recently is ingesting Glycine and Niacinamide. They help rebuild the skin barrier and this makes the skin less sensitive.

Here's a thread where a guy claims to have pretty much cured all of his Accutane sides from taking Magnesium Glycinate: https://rosaceagroup.org/The_Rosacea_Forum/showthread.php?32846-Accutane-side-effects-GONE!!-after-3-years&s=2b0428d31f7215484fc81d67fc9c32c9

He attributes his healing to the magnesium but it's most likely from the Gycine component which makes up 85% of Magnesium Glycinate. A guy on page 18 of that thread (2nd post from the top) informs him of this. As he says, this could be due to Accutane's ability to upregulate the GNMT enzyme which would deplete glycine.

As for OCD and BDD, here's a study about a guy who had marked improvement from high doses of glycine: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825652/

On 8/20/2017 at 8:04 AM, tryingtohelp2014 said:

test.. im betting anyone with active joint pain will test high in this.

[Edited link out]

The joint pain I can handle.

Its the fixing of my brain that is the most crucial thing!!!

3 hours ago, Recreant said:

Your skin is a lot like mine... only better lol

I have a lot of the same problems: Seb Derm, redness, BDD etc.

What I've found works for me recently is ingesting Glycine and Niacinamide. They help rebuild the skin barrier and this makes the skin less sensitive.

Here's a thread where a guy claims to have pretty much cured all of his Accutane sides from taking Magnesium Glycinate: https://rosaceagroup.org/The_Rosacea_Forum/showthread.php?32846-Accutane-side-effects-GONE!!-after-3-years&s=2b0428d31f7215484fc81d67fc9c32c9

He attributes his healing to the magnesium but it's most likely from the Gycine component which makes up 85% of Magnesium Glycinate. A guy on page 18 of that thread (2nd post from the top) informs him of this. As he says, this could be due to Accutane's ability to upregulate the GNMT enzyme which would deplete glycine.

As for OCD and BDD, here's a study about a guy who had marked improvement from high doses of glycine: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825652/

First off I want to say thank u!!!!
Second im sorry I have similar issues as well
if u ant some of my suggestions I'm here
i really want to wish u s wel as everyone on here the best
and that post u sent me hit home
i really will try my blood levels were low recently magnesium
i have insomnia for 10 years
flushing bad anxiety so hope this helps
im thinking of adding eggs and dairy back to diet
because I heard lack of those and meats ages u quicjer
if u ant to dissucss bdd I'm all ears

thank u so much

For those with gut problems, have any of you considered food intolerances? It's something I never considered much until I thought hard about my IBS that I've had for years. This girls video pretty much summed up my life (IBS, terrible acne, accutane, continuousIBS worsening, failed diagnosis because of problems) and so getting a food intolerance test is my next step. I suggest looking into it because the never ending gut problems could be caused by something so simple as gluten, yeast or even certain grains. Food intolerances can also cause eczema, headaches, weight loss/gain, brain fog and so much more.I hope this helps someone
[Edited video out]

On 8/17/2017 at 1:50 AM, mariovitali said:

Did you have a Fibroscan/Liver Elastograpy by any chance?

no. I have a appointment at a university soon though and I believe they might offer something similar to a fibroscan. With all the testings ive had this would be a good test to rule things out or in. The liver, and gut health could be related. Which one was affected first? how would you detect even the most minor of changes? When looking at a Fibroscan, I find it hard to swollow that taking propecia (for how many years was it?) and same for others on low short dosage, that this resulted in fibrosis of the liver. This seems something that would happen gradually over a period of time.
I do agree with possible changes in the gut and or liver, that could lead to fibrosis down the line, so I will try to get this test before the end of the year. Id also like a legitimate SIBO test as well from one of the machines they use in some hospitals, because gastric motility and liver issues can lead to this and vice versa.

Speaking of liver health, this is oil of oregano. This also has been medically proven to treat SIBO, so it could possibly address multiple issues.

The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response.

https://www.ncbi.nlm.nih.gov/pubmed/26350272
In the treatment groups, AST, ALT and LDH were reduced. Besides, necrosis, coagulation and inflammation in the liver were alleviated (p<0.05). We suggest that CAR could be a safe and potent new drug candidate for treating AP through its antioxidative mechanism of action for the treatment of a wide range of disorders related to hepatic dysfunction.

This shows that menaquinones not only are produced by bacteria, but they fight bacteria as well.
https://www.researchgate.net/publication/295582020_Coating_of_polylactide_films_to_generate_their_antimicrobial_properties

Coating of polylactide films to generate their antimicrobial properties

Polilactide film was coated with emulsan or metaquinones produced in situ by Acinetobacter calcoaceticus and Chitinophaga arvensicola bacteria on methylhydroxypropylcellulose (MHPC) and methylcellulose (MC) carriers and studied for antimicrobial properties against Bacillus atrophaeus, Micrococcus luteus, Staphylococcus auresus, Escherichia coli and Citrobacter freundii bacteria. Menaquinones on MHPC showed good antimicrobial activity against M. luteus and B. atrophaeus while emulsan on MC showed microbicidal activity against M. luteus, S. aureus and B. atrophaeus. The B. atrophaeus cells were more sensitive to menaquinone and emulsan attacks than the M. luteus and S. aureus ones. The menaquinones on MHPC decreased also the growth of E. coli and C. freundii cells. The microbiocidal activity of emulsan against Gram-negative cells was higher when MHPC was used as carrier. The E. coli strain was more sensitive to emulsan and menaquinones than C. freundii one.

On 8/20/2017 at 10:04 AM, tryingtohelp2014 said:

test.. im betting anyone with active joint pain will test high in this.

http://www.questdiagnostics.com/testcenter/BUOrderInfo.action?tc=10180N&labCode=QPT
[Edited link out[

Doctor doesn't see a reason to test Protaglandins...now what?

Symptoms are just not enough. Something tells me if you want uncommon tests done you'll need to jump around from practice to practice until you find a doc willing.

Even if you were somehow plain lucky enough to find one of the culprits into the mechanisms of action of this drug, you'll never get a doctor to write off on the blood test. We're sandbagged at every corner.

Life dealing with isotretinoin damage and health effects nonstop everyday while trying to make enough to live is a shitty existence. Literally all I can do most the time psychologically is just try to stop my brain from thinking about it and ignore as much as possible. Cause it really is that bad there's no silver lining to this crap. but then try to ignore symptoms when your hypothalamus is screaming at you every second to fix it. You could invent a form of torture out of this.

The prostaglandins are inflammation markers and a doctor would test levels of CRP and another one to measure it. They might come back normal and then you get brushed off (me). It could anything chronic infections to immune disorder to just increased fat oxidation or insulin resistance (they're made from polyunsaturated fats). If you do get a test, get off supplements first, they'll skew it.

Aspirin is worth a shot anywhere from 100mg-4g (yes 4g) with some stuff to buffer the stomach (incl. glycine). But most of you guys afaik already tried tons of fish oil and it's similar anti-inflam effects. The aspirin might do extra stuff not as well known like lowering fat burning and improving insulin resistance, but it's not magic. You'd have to add more to aspirin but what, I can't tell you at this moment. Didn't fix it.

High doses of glycine affect the pituitary and it's good to try but it just doesn't do enough for me and sometimes it worsens my head.

This isn't a good post cause this isn't a good day

Now my rheum said do u want plaquenil I'm like well do I have lupus or sjorgens
ana positive. Lip negative and she goes idk but do u want it?
reading plaquenil ages u dry hair loss and more
like wtf