3 minutes ago, Colinboko said:Never said anything about dry eyes. If you actually read my post you'd see it was a yearly check up for contacts and they happen to take blood pressure during the exam, and it was high.I think you and several others on this page need to fix your attitudes, and stop thinking your problems are the only ones that matter. I could comment on all of your genetic tests with snarky responses but I don't. So, save the attitude for someone else.
it was a joke man, lighten up. and i was mentioning the tear test to try to be helpful, alot of people have dry, messed up eyes post tane. If you got any insights on my genetic questions, snarky or not, I welcome them. I can take a joke too, or controversy. we are all in the same shit. Really it was a joke. This is all a joke isnt it? you think I want to spend my time doing this? and "this" is a very broad category.
6 minutes ago, guitarman01 said:it was a joke man, lighten up. and i was mentioning the tear test to try to be helpful, alot of people have dry, messed up eyes post tane. If you got any insights on my genetic questions, snarky or not, I welcome them. I can take a joke too, or controversy. we are all in the same shit. Really it was a joke. This is all a joke isnt it? you think I want to spend my time doing this? and "this" is a very broad category.
I'm just saying it's posts like yours that make people not want to post on this page cause they're scared of getting laughed at. We need to accept everyone's fight and take in all of the information that we can.
1 minute ago, Colinboko said:9 minutes ago, guitarman01 said:it was a joke man, lighten up. and i was mentioning the tear test to try to be helpful, alot of people have dry, messed up eyes post tane. If you got any insights on my genetic questions, snarky or not, I welcome them. I can take a joke too, or controversy. we are all in the same shit. Really it was a joke. This is all a joke isnt it? you think I want to spend my time doing this? and "this" is a very broad category.I'm just saying it's posts like yours that make people not want to post on this page cause they're scared of getting laughed at. We need to accept everyone's fight and take in all of the information that we can.
yea dont be afraid to post. No one should be afraid to post. I think the more posts the better. No ones laughing, I try to keep it light sometimes though. I have 595 posts because i do not give a fuck, and Im trying to sort through this as quickly as possible. Trust me they have all not been winners. mostly bs. and when you see me post random studies its because im tired and i dont feel like explaining shit, but still feel they might be related and worth documenting/posting.
All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB.
Abstract
Retinoids are signaling molecules that are involved in proliferation, differentiation, and apoptosis during development. Retinoids exert their effects, in part, by binding to nuclear receptors, thereby altering gene expression. Clinical use of retinoids in the treatment of neuroblastoma is of interest due to their success in management of acute promyelocytic leukemia. Using the SK-N-SH human neuroblastoma cell line we investigated the effects of the differentiation agent all-trans-retinoic acid (ATRA) on the expression of manganese superoxide dismutase (MnSOD), an enzyme previously shown to enhance differentiation in vitro. Manganese superoxide dismutase mRNA, protein, and activity levels increased in a time-dependent manner upon treatment with ATRA. Nuclear levels of the NF-kappaB proteins p50 and p65 increased within 24 h of ATRA administration. This increase paralleled the degradation of the cytoplasmic inhibitor IkappaB-beta. Furthermore an increase in DNA binding to a NF-kappaB element occurred within a 342-bp enhancer (I2E) of the SOD2 gene with 10 microM ATRA treatment. Reporter analysis showed that ATRA-mediated I2E-dependent luciferase expression was attenuated upon mutation of the NF-kappaB element, suggesting a contribution of this transcription factor to retinoid-mediated upregulation of MnSOD. This study identifies SOD2 as a retinoid-responsive gene and demonstrates activation of the NF-kappaB pathway in response to ATRA treatment of SK-N-SH cells. These results suggest that signaling events involving NF-kappaB and SOD2 may contribute to the effects of retinoids used in cancer therapy.
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer.
Maybe the number one type of doctor we should be seeking for help is ageneticist who would have a interest in making the connections. If accutane could permanently mutate some genes this would be huge. Anyone else have sod2 mutations? I've heard this talked about on another forum in relation to accutane.
2 hours ago, guitarman01 said:All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB.
Abstract
Retinoids are signaling molecules that are involved in proliferation, differentiation, and apoptosis during development. Retinoids exert their effects, in part, by binding to nuclear receptors, thereby altering gene expression. Clinical use of retinoids in the treatment of neuroblastoma is of interest due to their success in management of acute promyelocytic leukemia. Using the SK-N-SH human neuroblastoma cell line we investigated the effects of the differentiation agent all-trans-retinoic acid (ATRA) on the expression of manganese superoxide dismutase (MnSOD), an enzyme previously shown to enhance differentiation in vitro. Manganese superoxide dismutase mRNA, protein, and activity levels increased in a time-dependent manner upon treatment with ATRA. Nuclear levels of the NF-kappaB proteins p50 and p65 increased within 24 h of ATRA administration. This increase paralleled the degradation of the cytoplasmic inhibitor IkappaB-beta. Furthermore an increase in DNA binding to a NF-kappaB element occurred within a 342-bp enhancer (I2E) of the SOD2 gene with 10 microM ATRA treatment. Reporter analysis showed that ATRA-mediated I2E-dependent luciferase expression was attenuated upon mutation of the NF-kappaB element, suggesting a contribution of this transcription factor to retinoid-mediated upregulation of MnSOD. This study identifies SOD2 as a retinoid-responsive gene and demonstrates activation of the NF-kappaB pathway in response to ATRA treatment of SK-N-SH cells. These results suggest that signaling events involving NF-kappaB and SOD2 may contribute to the effects of retinoids used in cancer therapy.
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer.
Maybe the number one type of doctor we should be seeking for help is ageneticist who would have a interest in making the connections. If accutane could permanently mutate some genes this would be huge. Anyone else have sod2 mutations? I've heard this talked about on another forum in relation to accutane.
Guitarman and colinboko - have either of you reported your sides?
13 hours ago, Colinboko said:I think you and several others on this page need to fix your attitudes, and stop thinking your problems are the only ones that matter. I could comment on all of your genetic tests with snarky responses but I don't. So, save the attitude for someone else.
Listen, when you've been through the system back and forth and seen countless doctors dismiss every one of your symptoms, you'll understand. No one here thinks their problems matter more because the truth of the matter is None of our problems matter, to anyone else, fact.
1 hour ago, macleod said:Listen, when you've been through the system back and forth and seen countless doctors dismiss every one of your symptoms, you'll understand. No one here thinks their problems matter more because the truth of the matter is None of our problems matter, to anyone else, fact.
I agree, but this thread is often swamped with negativity. I understand joking around but making someone feel insecure about what they're posting is only going to cause them to not want to post anymore, and that's the last thing we want/need.
I feel ur pain, believe me. I suffered a transient ischemic attack at the age of 20. I been through hell n back, and still deal with random bs this drug has caused. I am at 20 miles a week in running and have a normal rate of 120/80. However, if I drink a single soda or half a coffee, I can exhibit hypertension with a bp of 160/90. It's fucking bullshit. The havoc this drug causes is egregious, but at the same time subtle and underlying.
Hey,
Probably best that I check in as I think Im pretty much done with this page now.
To recap, I took accutane when I was 19, at the end of 2011 and after 3 months developed a variety of negative repercussions.
- Terrible stammer, forming sentences was nearly impossible, I remember thinking somedays, 'ok, today will be the day when I don't trip over my words at least 5 times, and that would rarely happen, I sounded stupid af.
- Short/long term memory loss. Remembering events from school and how to complete simple tasks was painful. I always lost my keys or found myself freezing on the spot, trying to remember what I was doing.
- 0 Libido. Chasing girls had no relevance to my life. While before accutane, being 18 and able to drink and party, this was all I was doing.
- Depression. everything sucked basically, not very attractive to friends let alone girls.
- Anxiety. Would start to feel cold around people, start shaking, I found it hard to have a smooth breathing pattern, always nervous sort of.
- ED.Possibly from the anxiety but even alone in my room I suffered. Mostly, and while it didnt happen often, in bed with a girl was impossible.
- Bleeding gums. At first all I had to do was suck on my gums and it was like turning on a tap. After a few years, only after brushing.
- Brain fog. Really confused trying simple tasks, people would say 'space cadet'.
- Chronic flatulence. Always, was weird.
- Eye floaters
- Apathy
- Dry skin
- Itchy scalp particularly
- Muscle aches
- Still had acne
- Insomnia for a few months
- Twitching muscles
There's probably a lot more things i've forgotten, but basically my life sucked.
Ive tried many things though. The biggest perhaps being:
-Nutritional balancing program for about a year.
-Saunas every day or thereabouts, mostly with coffee enemas while massaging my liver, again for about a year.
-Mannnny supplements, focus on anything to boost dopamine and serotonin.
-About 7 months of PMO reboot.
-Gym 5 days a week for 6 months.
-Had, like most hundreds of blood tests with little to no results.
-Did have low testosterone at the start, so took 2 shots for that.
-lots of other weird shit.
______________________________________________________________________________________________________________________
Where Im at now:
I would say ive pretty much fully recovered. Mentally I am in a great place, there are no problems I have to deal with in terms of emotions, anxiety etc. I find it easy to learn (at uni) and am passionate about meeting new people, getting with girls, events, music, laughing etc. I have recovered from all the listed sides except eye floaters and dry skin, but that's really not a big deal. To be fair I got hit with mostly mental sides and so its understandable to be able to heal from those, but It wasnt easy, in fact my life was super shit for a good 4 years. I still have problems digesting fat though, but yeah more or less Im ok.
I hope others recover, its amazing how good life can be, and what opportunities and incredible moments present them self to you when your world isnt chaotic and you aren't suffering. I wont go on here, could get deep but nah.
Hope this helps someone
18 hours ago, Iamme. said:Hey,
Probably best that I check in as I think Im pretty much done with this page now.
To recap, I took accutane when I was 19, at the end of 2011 and after 3 months developed a variety of negative repercussions.
- Terrible stammer, forming sentences was nearly impossible, I remember thinking somedays, 'ok, today will be the day when I don't trip over my words at least 5 times, and that would rarely happen, I sounded stupid af.
- Short/long term memory loss. Remembering events from school and how to complete simple tasks was painful. I always lost my keys or found myself freezing on the spot, trying to remember what I was doing.
- 0 Libido. Chasing girls had no relevance to my life. While before accutane, being 18 and able to drink and party, this was all I was doing.
- Depression. everything sucked basically, not very attractive to friends let alone girls.
- Anxiety. Would start to feel cold around people, start shaking, I found it hard to have a smooth breathing pattern, always nervous sort of.
- ED.Possibly from the anxiety but even alone in my room I suffered. Mostly, and while it didnt happen often, in bed with a girl was impossible.
- Bleeding gums. At first all I had to do was suck on my gums and it was like turning on a tap. After a few years, only after brushing.
- Brain fog. Really confused trying simple tasks, people would say 'space cadet'.
- Chronic flatulence. Always, was weird.
- Eye floaters
- Apathy
- Dry skin
- Itchy scalp particularly
- Muscle aches
- Still had acne
- Insomnia for a few months
- Twitching muscles
There's probably a lot more things i've forgotten, but basically my life sucked.
Ive tried many things though. The biggest perhaps being:
-Nutritional balancing program for about a year.
-Saunas every day or thereabouts, mostly with coffee enemas while massaging my liver, again for about a year.
-Mannnny supplements, focus on anything to boost dopamine and serotonin.
-About 7 months of PMO reboot.
-Gym 5 days a week for 6 months.
-Had, like most hundreds of blood tests with little to no results.
-Did have low testosterone at the start, so took 2 shots for that.
-lots of other weird shit.______________________________________________________________________________________________________________________
Where Im at now:
I would say ive pretty much fully recovered. Mentally I am in a great place, there are no problems I have to deal with in terms of emotions, anxiety etc. I find it easy to learn (at uni) and am passionate about meeting new people, getting with girls, events, music, laughing etc. I have recovered from all the listed sides except eye floaters and dry skin, but that's really not a big deal. To be fair I got hit with mostly mental sides and so its understandable to be able to heal from those, but It wasnt easy, in fact my life was super shit for a good 4 years. I still have problems digesting fat though, but yeah more or less Im ok.
I hope others recover, its amazing how good life can be, and what opportunities and incredible moments present them self to you when your world isnt chaotic and you aren't suffering. I wont go on here, could get deep but nah.Hope this helps someone
Thank you so much - sharing is caring and we certainly could do with some of that.
Congratulations on your diligence - I am so happy it paid off.
Look to the future now and be kind to yourself - you have 4 years to make up.
Good luck with uni.
St John's Wort during the day and melatonin at night has dramatically improved things for me recently.
I never thought serotonin would be the thing to put some life back into my penis, but it's finally starting to react to visual and audio stimuli like it should. Also woke up today with morning wood for the first time in years.
I've explored so many different theories from thyroid issues, low testosterone, and vitamin deficiencies. Can't believe anti-depressant supplements could be my savior
@lamme,
congrats on your recovery, I join TrueJustice on his question. Are you still on some kind of diet ?
However your skin issue hasn't been cured, while yours doesn't look that serious, mine is a biggest side, it's like I was seriously sunburned everyday.
Looks like skin problems are the hardest to cure..
2 hours ago, QuietSoldier said:St John's Wort during the day and melatonin at night has dramatically improved things for me recently.
I never thought serotonin would be the thing to put some life back into my penis, but it's finally starting to react to visual and audio stimuli like it should. Also woke up today with morning wood for the first time in years.
I've explored so many different theories from thyroid issues, low testosterone, and vitamin deficiencies. Can't believe anti-depressant supplements could be my savior
What anti-depressants are you taking? Have you ever taken anti depressants before?
1 hour ago, hatetane said:3 hours ago, QuietSoldier said:St John's Wort during the day and melatonin at night has dramatically improved things for me recently.
I never thought serotonin would be the thing to put some life back into my penis, but it's finally starting to react to visual and audio stimuli like it should. Also woke up today with morning wood for the first time in years.
I've explored so many different theories from thyroid issues, low testosterone, and vitamin deficiencies. Can't believe anti-depressant supplements could be my savior
What anti-depressants are you taking? Have you ever taken anti depressants before?
As I stated above, SJW. And melatonin which is a product of serotonin if I'm not mistaken. And no I haven't taken anti-depressants before
9 hours ago, QuietSoldier said:As I stated above, SJW. And melatonin which is a product of serotonin if I'm not mistaken. And no I haven't taken anti-depressants before
That's good news. I was confused as you did in addition to SJW and melatonin mention anti-depressants.
I think and hope that everyone who visits this forum knows to avoid anti-depressants at all costs.
there are some things i'd like to get back to but,
just had a crazy idea, what if our body got used to and adapted to a different type of vitamin a? then after withdrawal of this vitamin it was looking for more, but never got it. It didnt treat normal vitamin a the same afterwards because our body was changed. I wonder how I would react to a extremely low dose of accutane years after I had taken it. I dont know if you could make a dose small enough though that id feel good about taking it.
The whole cell death, stopping cells from dividing thing, I was wondering if this could also have a anti aging effect and sure enough,
Oral isotretinoin as part of the treatment of cutaneous aging.
Abstract
BACKGROUND:
A number of drugs have been used to prevent aging changes. However, studies of oral isotretinoin, the commonly used acne drug, as an antiaging drug are lacking.
OBJECTIVE:
To determine improvement in cutaneous aging utilizing oral isotretinoin combined with different procedures of facial rejuvenation.
METHODS:
Sixty patients ranging in age from 35 to 65 years, in whom additional modalities of rejuvenation were also used, were randomly assigned to receive treatment with oral isotretinoin (10-20 mg three times a week for 2 months, group A). Their results were compared with 60 patients who had undergone the same surgical procedures but with no oral isotretinoin (group B).
RESULTS:
All patients treated with oral isotretinoin noted improvement in wrinkles, thickness and color of the skin, size of pores, skin elasticity, tone, and reduction in pigmented lesions and mottled hyperpigmentation. A statistically significant difference was found in the improvement of group A (Wilcoxon test <0.01). Using minimal amounts of this drug, the side effects were practically negligible.
CONCLUSION:
Utilizing various procedures with oral isotretinoin allowed us to improve the effects of cutaneous aging. Our results using isotretinoin in these cases have been satisfactory. We believe that this is one of the first reports of the use of oral isotretinoin in intrinsic and photoaged skin.
[Edited link out]
Note how they say depression may not go away after stopping treatment because the depression may have been pre existing - what a joke!!!!
On 4/8/2017 at 1:28 AM, hatetane said:Thank you so much - sharing is caring and we certainly could do with some of that.
Congratulations on your diligence - I am so happy it paid off.
Look to the future now and be kind to yourself - you have 4 years to make up.
Good luck with uni.
What was the idea behind just 2 shots of T? did it kickstart your T in some way?
I guess your T level rose - any direct improvements because of the 2 shots?
It really is preposterous how they handle seemingly rare cases like these. In my limited experience of visiting doctors this year, I've noticed how difficult it is to present any case as a "lay person" in to what you believe is wrong or the affected area, just to give them an idea, and they will almost always decline to read any research you have on the matter. I was only about a quarter of the way through my symptoms before being told by a neurologist, "usually when we have a patient with all of these subjective symptoms..." So, they sort of tune you out if you bring them a handful of symptoms or more. It wasn't until I said, "I don't understand why a doctor is so willing to accept my subjective symptom of anhedonia, and want to treat it, yet dismiss my other subjective complaints." Which got him to sort of pause and hear me out.
It pains me to think how difficult it may be to others who are not as intelligent or adept in articulating or conveying to a doctor what they think is going on, and how helpless they may feel after a brief 30 minute visit.
I've noticed a pattern in visits, where a doctor will say "I know what you're going through, I've battled with depression myself, and seeking treatment was the best thing I did." In military recruitment they use a similar psychological tactic, "I was once like you", etc. etc. And if a potential recruit is still hesitant, then they will switch stances and use reverse psychology and say "well, i don't care if you join, it doesn't matter to me either way." I just get the feeling that they are not treating patients on an individual basis and that they are going off of a textbook approach practicing allopathic medicine. I think practicing medicine is the key phrase one should realize, as that is what I believe is ultimately going on.
We really need to stick together and support one another in how we should handle situations like these should they arise. I really think we have no one else to turn to except our respective Government bodies. We really need their help.
11 hours ago, guitarman01 said:there are some things i'd like to get back to but,
just had a crazy idea, what if our body got used to and adapted to a different type of vitamin a? then after withdrawal of this vitamin it was looking for more, but never got it. It didnt treat normal vitamin a the same afterwards because our body was changed. I wonder how I would react to a extremely low dose of accutane years after I had taken it. I dont know if you could make a dose small enough though that id feel good about taking it.
The whole cell death, stopping cells from dividing thing, I was wondering if this could also have a anti aging effect and sure enough,
Quite an interesting idea. They prescribe low dose isotretinoin too. But what would be the correct dose if this theory were true? If I were to try this I'd probably get prescribed low dose and take a pill once in a week, to see the effects. I won't be the first to try this though..
hope you all are having a good one. there is nothing wrong with a lazy sunday. i had a coffee and i am thinking it was a mistake here i am with anxiety. i think my boss thinks im a crack head off of one cup of coffee but that is exacly what accutane did to me. Made me more aware of my surroundings and stuff. Like I can only hyperfocus on stuff. Carrots do something weird to me too. I cant decide if they are good or bad. I know eating fat from meat has helped me but its almost like this Accutane anxiety is the normal me now. Besides can we really change how we act everyday, we are who we are and the brain fog pretty much makes me a unattractive person unless I try not to be. Which is very tiring. Just comparing notes because the anxiety and thoughts have been my worst side effect aside from bone and weird body and vision problems. Here we go again complaining I mean does this crap ever end? Is there any way out of the Accutane life? I have had it a long time ago but am too taned out to do anything about it what a vicious cycle. Ultimately things are what they are which helps but boy Accutane sure did rob me of me. Almost part of how it makes nothing else matter. We already experienced the worst, ya know couldnt get any worse LOL. Although I took a lot of character and power in my personality before Accutane so even many years later I am still angry. Just venting. It Is what it is.
Something about this thread tells me no one deserved any of this, and we were lied to and tricked being told it would be a short price to pay for clear skin. Does anyone really even think of there skin problems anymore? No. we just think about Accutane and all the hyper anxiety and problems it caused to us. And oh the digestive gremlins. My stomach sounds like a garbage disposal. Almost like I can hear it louder outside of my body. We know it, we all do. Maybe they gave us too high of a dose. I remember that day in the office what a crock of crap. I was a normal, charming young man. Prescribed the WORST posion pills possible. No wonder I spent senior year introverted and everyone wondered what happened to my personality I was on f**** Accutane. Never will be the same. How the hell are you guys making recoveries lets hear it please. Its like im watching my new bad life out of a window.
I just have to say it.. I think we were all good people, who got screwed.
Maybe some peoples personailitys were effected as much but I know that my personality was great before and now I am just another introvert and we all know how great being an introvert is not
Maybe its time for no fap again, everything else is in tune. T levels, diets PURRFECT (lol). I fapped this morning because I wanted too. Keep hitting about 4 day mark and lose it. If I could grasp the no fap thing I know I could see improvments but its hard as hell lately. I made it to 20 something days once, felt pretty good. Im sure there are things we can do but idk struggling lol. Really am. Like I know everythings alright but im not content with myself. Pmo has got to go. Any tricks on that? I guess once again its pure will power. I come to say, I failed no PMO, and also, that one day when we meet our maker, this will all not be worth us making it so hard on ourselves. I promise my next post will be more positive but this is kind of my about me post, in a rant and heart style format.
I truly hope you guys all have an alright week this week.
I really wonder what is behind this thinned yet excessive hair growth...?
I've noticed my arms are hairier in spots I used to never have hair (like on the bottom side of my forearm) and the hair is super thin and whispy and yet my body hair is still falling out? It's so bizarre. My chest hair also doesn't grow how it used to. It's not thick and coarse, and has been replaced with thin, whispy hair that is extremely easy to shave.