18 hours ago, mariovitali said:

@guitarman01

Have you ever had any of these tests?

-Ceruloplasmin
-Serum Copper
-Serum Zinc
-Total Bile Acids (TBA)

So looking at the two biggest labs in the states, one being Labcorp(walkinlab) and the other being quest diagnostics(directlabs) the only bile test I see is through direct labs, its a urine test and not cheap at $179 . Is this the test your refering too? https://www.directlabs.com/TestDetail.aspx?testid=1922

Looking up cholestasis on medscape their seems to be a bile serum test, but this isnt offered through quest or labcorp, at least locally, without a doctor visit. (which can be a headache in itself trying to get a specific test) There also seems to be other tests. looking at my last liver labs my bilirubin and direct bilirubin were well within range.

So in your case were you convinced the drug was still in your body and the liver was unable to properly detox it, or are you saying it more so changed the function of your liver or caused damage that you are trying to reverse?

http://emedicine.medscape.com/article/927624-workup

Laboratory Studies

Even though this probably doesn't mean shit in regards to any permanent solution. I'm gonna start blasting testosterone for 10-12 weeks followed by long term pct and see where that gets me. (Mostly for anabolic purposes, but id love to feel good again with high T levels)

gonna use HCG alongside the full cycle

my only concern is I'm probably gonna get hella acne. And I'm not too sure if I wanna jump onaccutane for that (LOL)

5 hours ago, guitarman01 said:

So looking at the two biggest labs in the states, one being Labcorp(walkinlab) and the other being quest diagnostics(directlabs) the only bile test I see is through direct labs, its a urine test and not cheap at $179 . Is this the test your refering too? https://www.directlabs.com/TestDetail.aspx?testid=1922

Looking up cholestasis on medscape their seems to be a bile serum test, but this isnt offered through quest or labcorp, at least locally, without a doctor visit. (which can be a headache in itself trying to get a specific test) There also seems to be other tests. looking at my last liver labs my bilirubin and direct bilirubin were well within range.

So in your case were you convinced the drug was still in your body and the liver was unable to properly detox it, or are you saying it more so changed the function of your liver or caused damage that you are trying to reverse?

http://emedicine.medscape.com/article/927624-workup

Laboratory Studies

See the list below:

• Serum bilirubin levels are elevated in virtually all patients with cholestasis.
• Total serum bile salt concentration levels are elevated in virtually all cholestatic diseases.
• Qualitative serum and urine bile acids by mass spectroscopy are used to identify genetically determined errors in bile acid synthesis.
• The total serum cholesterol level is elevated in virtually all obstructive cholestatic diseases, whereas the high-density lipoprotein (HDL) level is within the reference range or low. Total cholesterol is within the reference range in certain hepatocellular cholestatic diseases, whereas the HDL level is within the reference range or low.
• Serum lipoprotein-X levels are elevated in virtually all obstructive cholestatic diseases.
• Serum alkaline phosphatase levels, serum 5'-nucleotidase levels, and serum gamma-glutamyl transferase (GGT) levels are elevated in virtually all obstructive cholestatic diseases and most hepatocellular cholestatic diseases.

I was referring to this Test , it appears it is offered by LabCorp :

https://www.labcorp.com/test-menu/21086/bile-acids-fractionated-and-total-lc-ms-ms

6 hours ago, Washer said:

Read up on ultraviolet lamps - they can produce vitamin d so you won't have to take the D supplement. The reason why I'm against supplementing with fat soluble vitamins such as A, E and D is because I've heard from a lot of post-accutane people that they react badly to synthetic fat soluble vitamins and it also makes a lot of sense to me that we should avoid synthetic fats since Accutane (from my perspective) is engineered in a way that can change the way you absorb and store fat. 

If you want to experiment with synthetic fats such as vitamin A supplements take something like Bile acids, chinese bitters, UDCA, TUDCA, various chinese liver tonics, Liv52, apple cider vingear or lots of fresh beetjuice since it helps your body break down fat. Coconut Oil is the most safe fat for us since it doesn't require bile to be digested. The safest route is of course to stay away from all vit a, d, e and k supplements.

I've never had problems with digesting fats myself, but I know some people on here have like Joseph, Chico etc.

Also be careful what your doctors, nutrionists etc. want to put you on. Even if you explain it to them they won't understand how badly Accutane has affected your body and made it extremely hypersensitiv towards everything that stimulates your organs. When you've been unfortunate to get hit with side effects after ingesting Accutane the best people to seek for advice are us here on this forum (and the other post-accutane forums, but they are kinda  dead now a days). Some people on here have been trial and erroring for years on end (me included) so we know excatly how different foods and supplements affect us - be it good or bad.

http://nhsjs.com/2014/effect-of-ultraviolet-led-radiation-on-vitamin-d-production-in-human-skin-a-novel-device-for-vitamin-d-synthesis/ Never been a fan of mega-dosing it at 30-60mg /day. I've done it in the past and I felt worse on it esp. in terms of sun sensitivity. It was when I was early in my Iodine treatment though so I'll prob. tolerate it better now, but i'll keep off it at least for some years.

So what you saying is  we can try get all vit a, d, e, and K from veg juice like beetroot, kale and so on... But preffer NOT too  but is it soo bad to get the vitamins naturally, like eating a cellery or juicing... ??

sorry for asking you this out of nowhere... My Life joy is just runing out...

http://www.lowdosenaltrexone.org/

1 hour ago, hatetane said:

http://www.lowdosenaltrexone.org/

It does sound extremely interesting, but how the hell do we get a doctor to prescribe it. You know they don't listen.

Be carful taking iodine and zink.vitamins can be dangerous diet is key
there is not one single case of someone dieing because of vitamin deficiency.there are many people who have been in life threatening situations through taking too many vitamins
i think vitamin supplements should be banned and require a prescription

On 3/2/2017 at 5:03 PM, Walden Rev said:

[Edited link out]

lol fair enough - I'd be a little worried about trying it without a doctors supervision though.

Also, aren't all the doses too high. I've been reading about people starting on 0.125

I am seeing a doctor tomorrow after having my bloods taken on Monday to check thyroid, if they say theres nothing wrong and won't do anything then after reading about LDN, i seriously think i will make an order from that website.

Hi guys to all again. This is my opinion 7 years experience old.
1. I think that food definatly not solve the problem.
Our brain is not be physically damage, but maybe just not work functionaly
Because all off us have mental disorder let say ( brain don't work like shoud do)
We need to look on depression just like consecvences not cause(although i go to the therapist 1 year but she can help me about brain fog, crazy thoughts and etc.
So, we all know how brain works the neurocell are link together and when is no connection between, serotoni stop produce and we are go into depression and so many bad effects.
I thnik that all of us fell in 5 second great i 1day sometimes... so have that in mind!
2. The hormones not works properly that's definitely
I'm not sure what cure is but i know what really helps. NO STRESS at all, (which is imposible today) lightfood, a lot of WATER, Phisical excercise, Swiming, sex, get social, get social, get social all time - because is very healthy) - But i'm sure that isn't the key!.
The key for me only for know is to shoot in the head and rip out some organs and not living life like this because i know that i 'm not crazy at all, but actually fucked up.

8 hours ago, TriedmanyThings said:

So what you saying is  we can try get all vit a, d, e, and K from veg juice like beetroot, kale and so on... But preffer NOT too  but is it soo bad to get the vitamins naturally, like eating a cellery or juicing... ??

sorry for asking you this out of nowhere... My Life joy is just runing out...

Why do you prefer to get your vitamins from supplements? It's only synthetic fat soluble vitamins I'm warning against. Vitamin supplements contain synthetic vitamins and thats why I'm not a fan of said supplements.

Just juice organic vegetables everyday. You are better off that way.

You could try an 'anti ageing' Dr. Usually they are GPs who are interested in hormones, supplements, etc and can be a lot more open minded. My own one suggested LDN. Or if you can only see your current GP, try to explain and bring in some studies on LDN, if there are any. At the end of the day, it has no abuse potential. Drs might refuse as they are just unfamiliar with it.

3 years passed since my last pill. I took 40mg/day for two months in 2014 Jan/Feb.
Stopped after I realised that I could not achieve an erection.
Other symptoms started after I stopped Accutane.

This is the list of my problems since:

-ED:
Still no connection between penis and brain.
I can not move it in flaccid, it is just attached to my body.
I do have morning woods, sometimes hard rock, sometimes weak.
The top of my penis is not full, the blood can not circulate till top when erected also in flaccid state.
There is a small dent in penis muscle at the bottom (between testicles and penis area) in flaccid, dissappears when erected.
I dont have prostate tingle feeling.
I dont have libido.
The flaccid state get worse after urinate or shit, used to be the opposite.
There are some times where I get horny or flaccid state gets bigger but does not last long,
The changes are so rapid, overall ED status changes in hours.
- Tinnitus: still there, biggest concern after ED.
- Vision problems: floaters are gone by 95%. But I am still night blinded and have some visual snow and double vision.
- Tremors: Gone
- Weak urine: still there sometimes. Definitely the prostate is involved in all this.
- Hair: I lost lots of hair. But the thickness improved somehow after 3 years. I can say I dont have menopause hair anymore.
- Dry eyes, nose, mouth: I never had these.
- Panic attacks, anxiety, suicidal state: Gone
- Energy: Better, just as pre accutane.
- Flexibility: Improved, %80

Overall I am Ok but I miss my old me.
I feel old and expired. A man who can not perform. This is sad.

12 hours ago, mariovitali said:

I was referring to this Test , it appears it is offered by LabCorp :

https://www.labcorp.com/test-menu/21086/bile-acids-fractionated-and-total-lc-ms-ms

Wow ok unfortunately that test is 389 dollars out of pocket, unless I can get a doctor to order it, but without cause I'm not sure if insurance would cover it or not. So theoretically what would a person do to treat this if the test showed abnormal results?

2 hours ago, guitarman01 said:

Wow ok unfortunately that test is 389 dollars out of pocket, unless I can get a doctor to order it, but without cause I'm not sure if insurance would cover it or not. So theoretically what would a person do to treat this if the test showed abnormal results?

OK i see. Well Cholestasis is usually treated with UDCA / TUDCA however a Doctor needs to evaluate this. If TBAs are elevated then the next step is to have an Ultrasound of Liver and Gallbladder to check for Cholestasis. Too many stones in Gallbladder can elevate the TBAs (i think) but there are many other causes.

Do you have 23andme data available btw?

3 hours ago, mariovitali said:

Do you have 23andme data available btw?

no, I just kind of consider it a novelty and not really sure what it would show in my case as pertaining to having taken accutane. I wouldn't know how to interpret the raw data anyways.(i know there's software for this, but still) I'm aware more then a few people on here have this data, and I would gladly spend the money for the test if it could possibly lead to anything.

If a drug is capable of modifying DNA, can it be capable of modifying hereditary genes? Like say the 23andme data could be different before and after accutane? Have you seen any correlations with the tests you've received already?

12 hours ago, Washer said:

It's only synthetic fat soluble vitamins I'm warning against. Vitamin supplements contain synthetic vitamins and thats why I'm not a fan of said supplements.

Just juice organic vegetables everyday. You are better off that way.

I tried that for a while. The problem is that genetics play a role in the metabolism of various vitamins. Some peoples' bodies do poorly with dietary sources of B12 and Folate. Supplementing with the Methyl forms may be anything from a game-changer to essentially a water-pill, depending on genetics. Vitamin D is an extra complicated case. For one thing, it is difficult to find a reliable dietary source of vitamin D. If you live up north or are susceptible to skin cancer, sun exposure may not be a viable choice. In addition to ALL of those factors, some peoples' bodies are more or less effective at converting vitamin D in the body, so the amount needed may vary wildly from one person to the next.

23 hours ago, ehohel said:

Even though this probably doesn't mean shit in regards to any permanent solution. I'm gonna start blasting testosterone for 10-12 weeks followed by long term pct and see where that gets me. (Mostly for anabolic purposes, but id love to feel good again with high T levels)

I'm sure the honeymoon phase will be nice. Who knows. Maybe megadosing Testosterone will downregulate your androgen receptors to a more normal level, assuming our androgen receptors are ****ed the same way ex-Finasteride users' receptors are. I'd be curious to know how you would respond to therapeutic T supplementation, even if the dose was slightly higher than normal. I will certainly experiment with that (using a clinic) in the coming year or so. Finances are a big issue for me right now.

For now, I'm going to continue playing around with the kiddie supplements. Next on my list is SAM-E. (I talked to someone with the same cognitive symptoms as me, who has also responded to similar supplements as me, and he swears by SAM-E. So I can't pass it up.) Next, Pregnenolone and possibly low-dose Prozac (NOT AN SSRI). Neurosteroids are absolutely part of this puzzle. Pregnenolone will break my hormone virginity. DHEA is usually discussed alongside Preg. Tread carefully if you experiment with DHEA. Many ex-Accutane users have high DHEA levels as is, and high DHEA levels are associated with schizophrenia. We know Accutane acts on some of the same receptors associated with schizophrenia, and a lot of us exhibit the negative symptoms of said disease.

I am also contemplating NSI-189 again. It was the most solid thing for anhedonia, next to Agmatine and Sarcosine. My moods have been all over the place lately. Just a few days ago, I could barely stand to be awake. I couldn't get a reaction out of myself if my life depended on it. This was right around the time I quit a few things. If you find the right supplements, they can help. You may not realize it until you stop. I often fantasize about how good I would feel with NSI-189 plus testosterone replacement therapy. Then again, I have zero experience with T right now and would need more extensive testing first. Plus I may or may not be vain enough to go back on Accutane if I get a breakout while on T, just as you alluded to, lol. (I'd like to think I'm kidding.)

2 hours ago, ACCUiTy_drANE said:

I tried that for a while. The problem is that genetics play a role in the metabolism of various vitamins. Some peoples' bodies do poorly with dietary sources of B12 and Folate. Supplementing with the Methyl forms may be anything from a game-changer to essentially a water-pill, depending on genetics. Vitamin D is an extra complicated case. For one thing, it is difficult to find a reliable dietary source of vitamin D. If you live up north or are susceptible to skin cancer, sun exposure may not be a viable choice. In addition to ALL of those factors, some peoples' bodies are more or less effective at converting vitamin D in the body, so the amount needed may vary wildly from one person to the next.

I'm sure the honeymoon phase will be nice. Who knows. Maybe megadosing Testosterone will downregulate your androgen receptors to a more normal level, assuming our androgen receptors are ****ed the same way ex-Finasteride users' receptors are. I'd be curious to know how you would respond to therapeutic T supplementation, even if the dose was slightly higher than normal. I will certainly experiment with that (using a clinic) in the coming year or so. Finances are a big issue for me right now.

For now, I'm going to continue playing around with the kiddie supplements. Next on my list is SAM-E. (I talked to someone with the same cognitive symptoms as me, who has also responded to similar supplements as me, and he swears by SAM-E. So I can't pass it up.) Next, Pregnenolone and possibly low-dose Prozac (NOT AN SSRI). Neurosteroids are absolutely part of this puzzle. Pregnenolone will break my hormone virginity. DHEA is usually discussed alongside Preg. Tread carefully if you experiment with DHEA. Many ex-Accutane users have high DHEA levels as is, and high DHEA levels are associated with schizophrenia. We know Accutane acts on some of the same receptors associated with schizophrenia, and a lot of us exhibit the negative symptoms of said disease.

I am also contemplating NSI-189 again. It was the most solid thing for anhedonia, next to Agmatine and Sarcosine. My moods have been all over the place lately. Just a few days ago, I could barely stand to be awake. I couldn't get a reaction out of myself if my life depended on it. This was right around the time I quit a few things. If you find the right supplements, they can help. You may not realize it until you stop. I often fantasize about how good I would feel with NSI-189 plus testosterone replacement therapy. Then again, I have zero experience with T right now and would need more extensive testing first. Plus I may or may not be vain enough to go back on Accutane if I get a breakout while on T, just as you alluded to, lol. (I'd like to think I'm kidding.)

Yeah if my joint pain disappears on T and I'm getting acne. its like what more harm could low dose accutane do. I doubt my symptoms will get worse. All speculation though.

i mean finances are an issue. The underground route is quite cheap...

4 hours ago, guitarman01 said:

no, I just kind of consider it a novelty and not really sure what it would show in my case as pertaining to having taken accutane. I wouldn't know how to interpret the raw data anyways.(i know there's software for this, but still) I'm aware more then a few people on here have this data, and I would gladly spend the money for the test if it could possibly lead to anything.

If a drug is capable of modifying DNA, can it be capable of modifying hereditary genes? Like say the 23andme data could be different before and after accutane? Have you seen any correlations with the tests you've received already?

Absolutely. If i had these data available in 1999 (when i first took finasteride) coupled with the knowledge i have i probably wouldn't take it.

So coming in our case : If there was a "one for all" regimen it would have been found by now. So the solution (if a solution exists) lies to a personalized regimen. The goal is to look at all Genes having to do with Oxidative stress and then support these Genes through supplementation and certain foods. For example MSRA Gene may be supported by Selenium.

I would strongly suggest that you take the 23andme test at some point.

All I'm taking is himalaya liv 52
vitamins are worthless

I REMEMBER YETANOTHERACCUTANEVICTIM POSTING HIS ATP7B GENES AND I DIDNT REALLY LOOK AT THEM OR UNDERSTAND THEM AT THE TIME. HE'S GOT MULTIPLE MUTATIONS THAT MIGHT POINT TO WILSONS DISEASE. YOU CLICK ON THE LINKS THEN CLICK ON CLINICAL SIGNIFICANCE, STARTING FIFTH LINE DOWN.

HIS COPPER LEVELS CONTINUED TO BECOME ABNORMAL OVER TIME.

1 year post-accutane(Dec 3013)
ceruloplasmin 21 ref 18-36
serum copper 81 ref 70-175
non-ceruloplasmin copper: 18 ref 5-15
-----------------------------
3.5 years post-accutane (2016)

stay away from any kind of steroids,dhea , is very dangerous prohibited at any sport ,also makes no reversible damage at liver and other parametres.huge more protocols is everywhere .for fully recover your liver take a combo of milkthistle,phicroriza,curcumin ,first priority imo
i strongly recomend a protein powder ,is very usefull to break fat deposit on liver ,al so regenarates tissue and neurones at any organs .
very effective protocol but hard ,is cofee enema ,less painful nac cysteine booth ae strong antioxidants ,free radical scavengers ,
if liver problems are moderate to severe i recomend first of all colloidal silver

bye

26 minutes ago, nicholas gr said:

stay away from any kind of steroids,dhea , is very dangerous prohibited at any sport ,also makes no reversible damage at liver and other parametres.huge more protocols is everywhere .for fully recover your liver take a combo of milkthistle,phicroriza,curcumin ,first priority imo
i strongly recomend a protein powder ,is very usefull to break fat deposit on liver ,al so regenarates tissue and neurones at any organs .
very effective protocol but hard ,is cofee enema ,less painful nac cysteine booth ae strong antioxidants ,free radical scavengers ,
if liver problems are moderate to severe i recomend first of all colloidal silver

bye

If steroids make me feel normal, I'm doing steroids.

Thats coming from someone who's spent $5,000+ on fairy dust drugs/supplements

1 hour ago, ehohel said:

t If steroids make me feel normal, I'm doing steroids.

Thats coming from someone who's spent $5,000+ on fairy dust drugs/supplements

On 3/2/2017 at 2:58 AM, ehohel said:

Even though this probably doesn't mean shit in regards to any permanent solution. I'm gonna start blasting testosterone for 10-12 weeks followed by long term pct and see where that gets me. (Mostly for anabolic purposes, but id love to feel good again with high T levels)

gonna use HCG alongside the full cycle

my only concern is I'm probably gonna get hella acne. And I'm not too sure if I wanna jump onaccutane for that (LOL)

35 minutes ago, hatetane said:

I've tried clomid and an AI, what are you trying to point out from the video?

2 hours ago, oli girl said:

steroids oh steroids.....I am a one who used steroids shortly after Accutane and had many symptoms improve, only thing was It also exuberated certain things....only to find out that Accutane had effected my pancreas....so though they helped my joint painand energy....itexpedited my demise of my pancreas.

besides outside of type 1 diabetes, long use of steroids can cause Cushing's and other issues....tread lightly my friend

like I've mentioned I'm mostly just going for anabolic gains. I'm in a pretty good spot right now I just need to get rid of my joint pain which a user on small dose TRT claims that testosterone did stop that.

Basically just gonna blast one cycle 500mg/wk and probably be done with it. If it's super great I'll probably just stick with TRT.

apperciate the concern but i genually don't give a shit about trying risky things even if there's a slimmer of hope for accomplishing my goals.