Acne.org Products
> Good luck with recovering.
I am recovered. My body functions as it did before, more or less.
I went from being able to eat nearly nothing to being able to eat most things. 130 lbs to 167 lbs at 6'. Dead to alive.
Everything else I tried at best let me maintain a little longer, hold back the decline another month or year. Only LDN mattered.
----
What you guys should do is buy a Xenforo license, then build a forum that is a combination of personal communities / support groups in one section and organized, disciplined topical information in the other.
This would give you a spam-resistant long-term platform. Your efforts are crippled in this format, as you've repeatedly observed.
If someone else will buy the license, I will do the hosting, installation, configuration, and training for the admin/mod team. But it would greatly help my enthusiasm for the project if someone tried LDN properly and reported back.
There is no possibility of a scam here. The license remains in the hands of the buyer and can't even be transferred for 6 months. I already do this for a different (private) project, in exactly the same way.
Just get the basic license. No addons needed. Post here first if you're going to buy it so two people don't buy it.
I really do hate Roche, I really do pity the horrible ongoing suffering. I really did almost lose everything to this. I really do want to stop another person from taking Accutane.
But I had to think long and hard about making this offer. I'm busy with things that matter even more to me. I'm not sure whether I can count on followthrough from this debilitated, demoralized community. At first, I wrote this post as advice, not an offer. But then I realized thatit would take a large amount of time and effort for someone to duplicate what I can do easily and quickly.
I think there are serious, organized, dedicated, intelligent people here. And there are also bleeding souls who need a place to vent, without it getting in the way of business. Channeled properly, we might even fell the giant that laid us low. They owe me 10 years of shame. I want that back, with interest.
The aforementioned serious, organized, dedicated, intelligent people are the ones I'd count on to be moderators, because it's not something I have the bandwidth for.
Talk is cheap, but the Xenforo license is $140. I'd be nuts to invest the kind of work I'm talking about if there wasn't sufficient community interest to cover that. No, I won't accept partial donations. Let someone else here you know and trust do that, if none of you can cover the whole price.
Otherwise, if you want to go the nearly free DIY route, use phpBB with Nearlyfreespeech.com. Namesilo will give you a cheap non .com domain. However, I won't be involved.
One thread, 417 pages. Wow.
6 hours ago, hatetane said:That's all sounds reasonable to a point but I did research this drug. I knew the association with suicide but as we see every day and the doctors will tell you - kids commit suicide every day. I knew that quite a few people claimed to get IBS and bowel related problems. The side effects on the packet are extremely scary but you could say that about any drug. This is what I want you to understand; when you look up a drug that you are just about to take you will google side effects. Tell me - why would you goole accutane sexual side effects? I might do that now I obviously didn't nearly four years ago. Go on youtube (like I did) and tell me if seeing the stories about accutane on there are enough to put you off taking accutane. Aside from lingering depression not much else is said - prove me wrong if you can.
The only person who really has any impact is indigo and even he doesn't really strongly enough get the full picture across.
He is one amongst millions claiming that accutane is poison and he is seen as a bit of a crank by most people although we all know better.
Most people find this forum when they type in post accutane problems - it is way to late by then.
So please tell me what you have done to stop people taking this drug. What have you done to warn people (young kids) about the life destroying, long term, permanent side effects of this drug. Are you on youtube or anywhere other than a post accutane forum.Why don't you make a youtube video and direct every young person considering taking accutane to look on this forum.
Admittedly in the last few years there has been more and more about the serious side effects of accutane especially regarding sexual sides but I can assure you that when I researched accutane i saw nothing relating to chemical castration.So unless I am wrong and you are really pro-active in preventing young innocents from taking this drug then it is you who is the moron and you greatly offend me!
Well im sorry if I offended you but my rant wasn't directed at you, I just used it about "new members". I might've gone overboard on the moronic front but it does piss me off that people are still taking this drug when it's so avoidable - that's why doctors shouldn't be handing it out like candy.
I guess though that a new forum member could be someone who's here for the first time after the taking the drug some time ago.
You're right, there are plenty of people doing YouTube posts etc on the dangers of tane, I haven't done anything like that but I have had some influence on family friends and young people who are thinking of taking it. Thankfully I've been able to share my story and talk them out of it, I'm very glad for that.
Over the years I must of seen 30-50 doctors/specialist who I've also told my story to and again I can only hope that it's resonated strongly with them and helped them form an opinion about its dangers. In turn I hope that they too have influenced other young people not to take it.
I really do hope that young people do their homework about tane - there is plenty of info out there these days to access. Much more than I ever had....
You guys should try a supplement called alpha brain heared good things about it.
Mainly UFC fighters use it .
I would say say getting punched in the head often enough would eventually cause brain damage / trauma , due to MRI's we now know isotretinoin has similar effects on the brain.
On 8/1/2016 at 8:51 PM, Gladiatoro said:Go back to pub med.com were you belong the rest of us are reading natural news.com.If you ask any honest derm he will tell you isotretinoin IS a controlled POISONING, end of story.
Why do you think 1/3 of derms around the world won't even use it in there practice ? One derm said and I quote " we don't know the long term outcome of these patients ". It is the worlds most dangerous DRUG. FACT , simply because of its long term side effects.
Is that a joke? Are you saying pub med is not credible or are you just trying to be funny? Again, you just made multiple accusation with no basis, and really stupid and extreme ones too that I have no reason to believe. If you actually knew anything about drugs you'd know that every drug is a controlled poison. Haven't you ever heard the dose is what determines the poison? Even alcohol is a poison and people choose to drink it. And there are lots of drugs where the long term side effects are unknown. I doubt there is any drug they know everything about and if they needed to find out all the long term side effects before a drug was released it could and would never be released. I think you are all overreacting and scaring eachother. I used to come on these blogs thinking that accutane destroyed my life too and then I took a step back for a little bit and realized that nothing about me has changed. I only thought something had changed after I spent hours reading the horrible things people said about accutane that I did not have any proof were true and then looking so close at my life that any change I noticed I determined to be severe and due to accutane. It was a horrible way of living. I advise you all to get off these blogs and relax for a bit and think did accutane really do all these horrible things? Could a drug even do all of these things? Just use your common sense. But your right, I probably should go back to pub med because most of you don't want to believe me anyway. You'd rather just blame all your problems on a drug, feel sorry for yourself, and take the easy way out the rest of your life. I'm not saying accutane doesn't have any side effects, but for those of you that spend hours complaining about your life on these blogs, its pathetic.
And as for you, your post has no substance.
On 8/1/2016 at 8:41 PM, macleod said:You do realize your entire post is a contradiction. You basically said all of our "accusations" are anecdotal and you followed up with your anecdotal experience. Everyone in this thread is now dumber for having read that. I award you no points, and may god have mercy on your soul.
Little history...my 13 year old son ( at that time ) developed moderate to severe cystic acne, pretty much out of nowhere after a long hot summer of sports and puberty I suppose. He had it on his back, neck, chest and later face. Off to the dermatologist we went. She prescribed Acticlate, Fabior and a BP. At the very first visit, she discussed Accutane as the next step.
I had certainly heard of Accutane but didn't know a lot about it. I was hopeful the antibiotic and topicals would do the trick. Well it took about 4 months to start to see improvement. Those 4 months were pure hell. Every follow up visit, was the Accutane talk. I was feeling desperate for him so I began to research Accutane.
It didn't take long to find this website and eventually this thread. Over the next few months, i read much about your experiences and suffering. This website and thread was all I needed to make the decision of 'hell no to Accutane'. I would have spent any amount of money to help him and stop the madness of the severe acne but I would never risk his well-being and health over hateful acne.
Although, you may not feel as though you are accomplishing much with your posts, you, my friends gave me the strength and confidence to say NO to ACCUTANE now or ever!! I imagine there are countless others you have helped.
I am forever grateful....blessings to you all
1 hour ago, TrueJustice said:Well im sorry if I offended you but my rant wasn't directed at you, I just used it about "new members". I might've gone overboard on the moronic front but it does piss me off that people are still taking this drug when it's so avoidable - that's why doctors shouldn't be handing it out like candy.I guess though that a new forum member could be someone who's here for the first time after the taking the drug some time ago.
You're right, there are plenty of people doing YouTube posts etc on the dangers of tane, I haven't done anything like that but I have had some influence on family friends and young people who are thinking of taking it. Thankfully I've been able to share my story and talk them out of it, I'm very glad for that.
Over the years I must of seen 30-50 doctors/specialist who I've also told my story to and again I can only hope that it's resonated strongly with them and helped them form an opinion about its dangers. In turn I hope that they too have influenced other young people not to take it.
I really do hope that young people do their homework about tane - there is plenty of info out there these days to access. Much more than I ever had....
Fair enough but we all got to do more, every single person who has been hurt by accutane and knows first hand the destruction it causes has a duty to stop others from taking it. I personally believe that dermatologists know that they are prescribing a death sentence; some of you may disagree with this. The fact is they will never stop prescribing it; therefore our only option is to try and get young kids, especially the u18's who are too young to be making the decision for themselves to stop taking this drug. I maintain that there is not enough hard hitting information out there on the long lasting/permanent side effects of accutane. Sure if you look a little deeper and definitely, post accutane problems, you will find quite a lot more.
There is strength in numbers so everyone needs to speak up. It goes without saying that all side effects should be reported.
Annuity and anyone else who is brave enough should do a video on youtube.
The 1 in 10,000 or even the 1in 1,000 is not cutting it with me. The 2% I an not buying either. Talking about sexual sides alone, it has been suggested that a whopping 30% will suffer some form of sexual dysfunction. This goes way back to the mexican report that roche knew about and ignored.
If you say to a young man that he may suffer from depression or get IBS or any other know accutane side effect - in exchange for getting rid of acne; he will most likely go ahead and take that risk.
If you say there is up to a 30% chance of suffering from long lasting low libido, ED or permanent chemical castration - I suspect many would avoid this drug.
We somehow need to gain some credibility and stop being seen as cranks.
PFS has managed that. We have a long way to go.
Until then there will be no research into any cures - so there we have it!
8 minutes ago, Never Losing Hope said:Little history...my 13 year old son ( at that time ) developed moderate to severe cystic acne, pretty much out of nowhere after a long hot summer of sports and puberty I suppose. He had it on his back, neck, chest and later face. Off to the dermatologist we went. She prescribed Acticlate, Fabior and a BP. At the very first visit, she discussed Accutane as the next step.
I had certainly heard of Accutane but didn't know a lot about it. I was hopeful the antibiotic and topicals would do the trick. Well it took about 4 months to start to see improvement. Those 4 months were pure hell. Every follow up visit, was the Accutane talk. I was feeling desperate for him so I began to research Accutane.
It didn't take long to find this website and eventually this thread. Over the next few months, i read much about your experiences and suffering. This website and thread was all I needed to make the decision of 'hell no to Accutane'. I would have spent any amount of money to help him and stop the madness of the severe acne but I would never risk his well-being and health over hateful acne.
Although, you may not feel as though you are accomplishing much with your posts, you, my friends gave me the strength and confidence to say NO to ACCUTANE now or ever!! I imagine there are countless others you have helped.
I am forever grateful....blessings to you all
Hear hear. Thank you and I am so happy your son never took accutane. We just got to make sure that at the very least everyone visits this forum /thread before making the decision to take accutane.
36 minutes ago, Amar21 said:I I used to come on these blogs thinking that accutane destroyed my life too and then I took a step back for a little bit and realized that nothing about me has changed.
See, but that is macleod's precise point. You assume that just because you are okay, everyone else must not really be suffering. It must be in their heads.
36 minutes ago, Amar21 said:I advise you all to get off these blogs and relax for a bit and think did accutane really do all these horrible things? Could a drug even do all of these things? Just use your common sense. But your right, I probably should go back to pub med because most of you don't want to believe me anyway. You'd rather just blame all your problems on a drug, feel sorry for yourself, and take the easy way out the rest of your life.
Please note that a lot of us have made drastic, life-altering changes to deal with our problems. We are not simply complaining, but instead, actively learning and trying new things. What you're doing is thinking back to your perception of your former self, and applying it to all of us. Well, n=1 is n=1. Speak for yourself.Hey, while you're on Pub Med, please do not overlook the following studies.
http://www.ncbi.nlm.nih.gov/pubmed/25689814
"A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)."
http://www.ncbi.nlm.nih.gov/pubmed/15863802
A 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.
http://www.ncbi.nlm.nih.gov/pubmed/15251924
We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/
"This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/#R173
"Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression."
"In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage."
https://www.ncbi.nlm.nih.gov/pubmed/20708044
"13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice."
http://www.ncbi.nlm.nih.gov/pubmed/22239608
"Systemic isotretinoin and antibiotic treatments in acne patients precisely caused variations in the microbial floras of several sites of the body, while isotretinoin was commonly more responsible than antibiotics."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/#R39
"We have learnt that retinoids provide an essential, early signal that initiates a cascade of events leading to changes in proliferation, differentiation and predominantly apoptosis affecting most CRABP-2 expressing somatic cells as well as the stem cell compartments.8We have to appreciate that isotretinoin does not exclusively targets apoptosis of the sebaceous glands as proapoptotic drug effects have been observed in several unrelated cell systems and explain all adverse effects of isotretinoin and other retinoids (Table 2). The asthonishing functional overlap of changes in FoxO-mediated gene transcription and isotretinoinmediated gene transcription (Table 1) strongly suggests that isotretinoin and its isomerization product ATRA induces upregulation of FoxO-signaling and exerts apoptotic effects in multiple cell types like the muscle, the bone and the brain."
(Never mind the studies Roche conducted in the 1980s which demonstrates how Accutane can erode the intestinal tract. These studies were finally uncovered in the late 2000s thanks to lawsuits.)
36 minutes ago, Amar21 said:Could a drug even do all of these things?
So literally yes.
14 minutes ago, Never Losing Hope said:Little history...my 13 year old son ( at that time ) developed moderate to severe cystic acne, pretty much out of nowhere after a long hot summer of sports and puberty I suppose. He had it on his back, neck, chest and later face. Off to the dermatologist we went. She prescribed Acticlate, Fabior and a BP. At the very first visit, she discussed Accutane as the next step.
I had certainly heard of Accutane but didn't know a lot about it. I was hopeful the antibiotic and topicals would do the trick. Well it took about 4 months to start to see improvement. Those 4 months were pure hell. Every follow up visit, was the Accutane talk. I was feeling desperate for him so I began to research Accutane.
It didn't take long to find this website and eventually this thread. Over the next few months, i read much about your experiences and suffering. This website and thread was all I needed to make the decision of 'hell no to Accutane'. I would have spent any amount of money to help him and stop the madness of the severe acne but I would never risk his well-being and health over hateful acne.
Although, you may not feel as though you are accomplishing much with your posts, you, my friends gave me the strength and confidence to say NO to ACCUTANE now or ever!! I imagine there are countless others you have helped.
I am forever grateful....blessings to you all
Hear hear. Thank you and I am so happy your son never took accutane. We just got to make sure that at the very least everyone visits this forum /thread before making the decision to take accutane.
10 hours ago, hatetane said:That's all sounds reasonable to a point but I did research this drug. I knew the association with suicide but as we see every day and the doctors will tell you - kids commit suicide every day. I knew that quite a few people claimed to get IBS and bowel related problems. The side effects on the packet are extremely scary but you could say that about any drug. This is what I want you to understand; when you look up a drug that you are just about to take you will google side effects. Tell me - why would you goole accutane sexual side effects? I might do that now I obviously didn't nearly four years ago. Go on youtube (like I did) and tell me if seeing the stories about accutane on there are enough to put you off taking accutane. Aside from lingering depression not much else is said - prove me wrong if you can.
In fact, all of my anxieties about Accutane were soothed after my doctor told me his/her own children successfully used the drug. That's really the problem. Doctors are viewed as possessing superior medical knowledge. It seems totally reasonable to trust their judgement against what you see on TV or read online. Besides, the doctor is the one who will potentially prescribe a cure to your pesky skin problem! You already WANT to trust him/her!
The bottom line is I don't personally blame people for trying Accutane. Even today. Although I get annoyed when I see people posting about how they are scared about going on the drug and want reassurance, I have to understand I was in those shoes at one time too. There is no way everyone can be expected to approach Accutane rationally when there is such a large disconnect between what doctors say and what the research says. A discouraged 16-year-old who has been mocked relentlessly for his/her skin cannot possibly be expected to see past the large political forces that have (somehow) kept Accutane legal following some close calls with the FDA. We need to fundamentally change the way doctors prescribe this drug. If prescribed at all, it should be exclusively for adults with severe, nodular acne. And, above all, we need to identify why some people have such a TERRIBLE, adverse reaction to it.
On that note, I put my face on Youtube today. I completely forgot I have actually made a video about this in the past as well. So, I'd love to see some other people join in.
13 hours ago, ACCUiTy_drANE said:Well, that's the troubling thing. I went on this drug in 2012, shortly following the era in which law firms were attempting to recruit people who suffered from IBD after exposure to Accutane (via television ads). I also read some anecdotes regarding Accutane-related depression. However, when I looked online, I did not immediately find many anecdotes related to gastrointestinal side effects. I suppose I reasoned that "greedy lawyers" were preying on those who "happened" to develop IBD post-Accutane. I had no idea that Roche had concealed studies showing a casual relationship between Accutane and IBD. I had no idea what a "gut flora" was and how Accutane tampers with it to a larger degree than antibiotics do.In fact, all of my anxieties about Accutane were soothed after my doctor told me his/her own children successfully used the drug. That's really the problem. Doctors are viewed as possessing superior medical knowledge. It seems totally reasonable to trust their judgement against what you see on TV or read online. Besides, the doctor is the one who will potentially prescribe a cure to your pesky skin problem! You already WANT to trust him/her!
The bottom line is I don't personally blame people for trying Accutane. Even today. Although I get annoyed when I see people posting about how they are scared about going on the drug and want reassurance, I have to understand I was in those shoes at one time too. There is no way everyone can be expected to approach Accutane rationally when there is such a large disconnect between what doctors say and what the research says. A discouraged 16-year-old who has been mocked relentlessly for his/her skin cannot possibly be expected to see past the large political forces that have (somehow) kept Accutane legal following some close calls with the FDA. We need to fundamentally change the way doctors prescribe this drug. If prescribed at all, it should be exclusively for adults with severe, nodular acne. And, above all, we need to identify why some people have such a TERRIBLE, adverse reaction to it.
On that note, I put my face on Youtube today. I completely forgot I have actually made a video about this in the past as well. So, I'd love to see some other people join in.
Exactly the drug should only be prescribed for people with severe nodular acne NOT kids young adults with a few pimples that's absolutely CRIMINAL.
Acne Vulgaris:A Disease of Western Civilization
http://archderm.jamanetwork.com/article.aspx?articleid=479093
4 hours ago, JosephBuchignani said:Apparently there's no interest in creating a forum. I'll check back once or twice more, maybe, and I've thrown it onto my "someday/maybe" to do list.
I think a forum would be a great idea. I'm just not sure whether our community is large enough to have fill it. If one was made though, I would contribute
14 hours ago, ACCUiTy_drANE said:
See, but that is macleod's precise point. You assume that just because you are okay, everyone else must not really be suffering. It must be in their heads.
Please note that a lot of us have made drastic, life-altering changes to deal with our problems. We are not simply complaining, but instead, actively learning and trying new things. What you're doing is thinking back to your perception of your former self, and applying it to all of us. Well, n=1 is n=1. Speak for yourself.Hey, while you're on Pub Med, please do not overlook the following studies.
http://www.ncbi.nlm.nih.gov/pubmed/25689814
"A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)."
http://www.ncbi.nlm.nih.gov/pubmed/15863802
A 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.
http://www.ncbi.nlm.nih.gov/pubmed/15251924
We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/
"This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/#R173
"Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression."
"In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage."
https://www.ncbi.nlm.nih.gov/pubmed/20708044
"13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice."
http://www.ncbi.nlm.nih.gov/pubmed/22239608
"Systemic isotretinoin and antibiotic treatments in acne patients precisely caused variations in the microbial floras of several sites of the body, while isotretinoin was commonly more responsible than antibiotics."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/#R39
"We have learnt that retinoids provide an essential, early signal that initiates a cascade of events leading to changes in proliferation, differentiation and predominantly apoptosis affecting most CRABP-2 expressing somatic cells as well as the stem cell compartments.8We have to appreciate that isotretinoin does not exclusively targets apoptosis of the sebaceous glands as proapoptotic drug effects have been observed in several unrelated cell systems and explain all adverse effects of isotretinoin and other retinoids (Table 2). The asthonishing functional overlap of changes in FoxO-mediated gene transcription and isotretinoinmediated gene transcription (Table 1) strongly suggests that isotretinoin and its isomerization product ATRA induces upregulation of FoxO-signaling and exerts apoptotic effects in multiple cell types like the muscle, the bone and the brain."
(Never mind the studies Roche conducted in the 1980s which demonstrates how Accutane can erode the intestinal tract. These studies were finally uncovered in the late 2000s thanks to lawsuits.)
So literally yes.
All these studies agree that impaired brain function/metabolism is caused by Accutane. While it may not be the sole cause of symptoms, I think it would still be wise to do the brain nutrition(fish oil, zinc and Creatine are the main 3, as well as being readily available).
I've mentioned the studies before, and they are easily found and undisputed, so due to all the potential upside and low to nil potential for downside I think it's something we should all be doing because at very least it's a step in the right direction.
Infact that is why I began keto as well
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/
"Beneficial changes in the brain energy profile have been observed in subjects who are on a ketogenic diet (28). This is a significant observation because cerebral hypometabolism is a characteristic feature of those who suffer from depression or mania"
which directly responds to oneof your studies
http://www.ncbi.nlm.nih.gov/pubmed/15863802
A 4-month treatment trial with isotretinoin was associated with adecrease in brain functioning in the orbito-frontal cortex,a brain region implicated in depression.
Keto, along with fish oil, zinc, Creatine, etc, also promotes neurogenisis,addressinghippocampal cell production, which is a key point in many of the Accutanestudies
@hatetane
@john86
@accuity_drane
Some more discussion regarding research on the lastingsides.org Accutane forum.
On 9/5/2016 at 8:27 PM, Amar21 said:Again, you just made multiple accusation with no basis,
And you made yours with...None. Anecdotal evdience, I forgot. Strike One.
On 9/5/2016 at 8:27 PM, Amar21 said:that I have no reason to believe.
Who cares what you believe?
On 9/5/2016 at 8:27 PM, Amar21 said:If you actually knew anything about drugs you'd know that every drug is a controlled poison.
Do you have any credentials in chemistry or biology? Do you even have an education background in Science whatsoever? Strike Two.
On 9/5/2016 at 8:27 PM, Amar21 said:I think you are all overreacting and scaring eachother.
Who cares what you think? Are you a doctor? Or are you just a guy named Amar?
On 9/5/2016 at 8:27 PM, Amar21 said:I used to come on these blogs thinking that accutane destroyed my life too and then I took a step back for a little bit and realized that nothing about me has changed. I only thought something had changed after I spent hours reading the horrible things people said about accutane that I did not have any proof were true and then looking so close at my life that any change I noticed I determined to be severe and due to accutane. It was a horrible way of living.
Sounds feeble minded.
On 9/5/2016 at 8:27 PM, Amar21 said:and think did accutane really do all these horrible things? Could a drug even do all of these things?
Yea, there's a reason why the FDA requires them to put warnings on the medication. Millions of dollars won in multiple lawsuits. So, apparently a federal judge and court of law have, on several occasions, found the drug can cause side effects. Oh, I forgot I should call and tell them Amar said that he knows more than a court of law. Amar also knows more than the scientists investigating the potential side effects such as intracranial pressure ( https://clinicaltrials.gov/ct2/show/NCT02149615?term=isotretinoin+intracranial&rank=1) Which happens to be one of my many side effects that I have been diagnosed with and deal with every day. Shit, I forgot, I should call my neurologist and tell him that his diagnosis is wrong! Amar doesn't think that extreme dosing of retinoids is capable of side effects.
On 9/5/2016 at 8:27 PM, Amar21 said:I'm not saying accutane doesn't have any side effects, but for those of you that spend hours complaining about your life on these blogs, its pathetic.
Oh, now Accutane CAN have side effects. Well, thanks for clarifying that. it wasn't very apparent in the beginning of your post. Thanks for the 180. In fact, all I got from your post was insulting people that may, or may not, have medical issues, with no substantiated proof. Thank you for wasting everyone's time again and making the world a stupider place.
On 9/5/2016 at 8:27 PM, Amar21 said:And as for you, your post has no substance.
And, as for you, I'm holding up a finger to the monitor. Can you guess which one it is?
> I think a forum would be a great idea. I'm just not sure whether our community is large enough to have fill it. If one was made though, I would contribute
This community leaks like a sieve due to the terrible format, and despite that it's still overcrowded. The flamewar surrounding amar is just the latest example demonstrating that this format is crippled.
There's no shortage of users. What's missing are mods, leaders, people willing to invest in the project's success. Primarily, this means keeping up with the moderation queue and putting out small fires. This prevents "broken window" syndrome, wherein a small amount of entropy encourages everyone to disrespect the platform further.
It's pointless to start a forum without a dedicated mod team, because you'd just have to immediately lock it. Otherwise an entropy debt would build that would discourage any future moderator from accepting the role.
If you don't have any leaders, then you're going to keep flaming amars forever.
12 hours ago, macleod said:And you made yours with...None. Anecdotal evdience, I forgot. Strike One.Who cares what you believe?
Do you have any credentials in chemistry or biology? Do you even have an education background in Science whatsoever? Strike Two.
Who cares what you think? Are you a doctor? Or are you just a guy named Amar?
Sounds feeble minded.
Yea, there's a reason why the FDA requires them to put warnings on the medication. Millions of dollars won in multiple lawsuits. So, apparently a federal judge and court of law have, on several occasions, found the drug can cause side effects. Oh, I forgot I should call and tell them Amar said that he knows more than a court of law. Amar also knows more than the scientists investigating the potential side effects such as intracranial pressure ( https://clinicaltrials.gov/ct2/show/NCT02149615?term=isotretinoin+intracranial&rank=1) Which happens to be one of my many side effects that I have been diagnosed with and deal with every day. Shit, I forgot, I should call my neurologist and tell him that his diagnosis is wrong! Amar doesn't think that extreme dosing of retinoids is capable of side effects.
Oh, now Accutane CAN have side effects. Well, thanks for clarifying that. it wasn't very apparent in the beginning of your post. Thanks for the 180. In fact, all I got from your post was insulting people that may, or may not, have medical issues, with no substantiated proof. Thank you for wasting everyone's time again and making the world a stupider place.
And, as for you, I'm holding up a finger to the monitor. Can you guess which one it is?
I have the same side effect pseudo tumor ,. It's a direct side effect of isotretinoin FACT.
DHA and fatty acids and retinoic acid. Hi-Dose essential fatty acids could knock off residual accutane from receptors? it would compete with retinoic acid. Accutane causes lowered amounts of fatty acids. cholestasis causes Essential fatty acid deficiency.
Hi amounts essential fatty acids upregulate UGTs up to a 100x fold needed to detoxify accutane metabolites.
hi amounts of essential fatty acids upregulate PPARs also needed for liver detoxification.
Phospholipid composition of liver in rats fed high levels of 13-cis retinoic acid.
Abstract
The composition of liver phospholipids was studied in rats fed for 4 weeks diets containing 0, 100 or 300 mg 13-cis retinoic acid per kg diet. There was a significant decrease in phosphatidylcholine content, whereas the levels of phosphatidylethanolamine were slightly increased in liver phospholipids of rats fed 13-cis retinoic acid. The fatty acid composition of total phospholipids, PC, PE, and P1 + PS fractions revealed a general increase in the levels of 18:2 and 20:3 omega 6, whereas the levels of 20:4 omega 6 and C22 fatty acids were reduced in most of the hepatic phospholipids isolated from rats fed 13-cis retinoic acid containing diets. A decrease in the double-bond index of fatty acids was also observed in phospholipids of rats fed 13-cis retinoic acid. The data suggest that high levels of 13-cis retinoic acid may possibly be influencing the activities of microsomal desaturating and chain-elongating enzymes in the liver.
Omega-3 Fatty acids and hippocampal neurogenesis in depression.
Abstract
The mammalian brain and central nervous system are especially dependent on the omega-3 (n-3) fatty acid docosahexaenoic acid (DHA) for normative signaling and function, and research suggests that n-3 fatty acid deficiencies are one contributing factor in the increasing prevalence of depressive disorders. However, the reasons for which n-3 fatty acids and mood are connected remain unknown. Atrophy in the hippocampus is one of the most significant neuroanatomical findings in depressed patients, and current therapies for depression tend to increase hippocampal neurogenesis. We recently discovered that the fat-1 transgenic mouse, which has enriched levels of DHA in the brain because it can convert n-6 to n-3 fatty acids, exhibits increased hippocampal neurogenesis. This finding suggests a mechanism by which omega-3 could influence depression and mood; here we expand on the argument that n-3 fatty acids, and DHA in particular, may help prevent and treat depression by virtue of their effects on neurogenesis in the hippocampus. Because DHA can be obtained through the diet, increasing DHA intake in depressed patients or those at risk for depression may be one way of managing the disease and perhaps providing aid to those who have not been able to achieve remission via pharmacological means.
Beneficial effect of docosahexaenoic acid on cholestatic liver injury in rats.
Abstract
Bile duct obstruction and subsequent cholestasis are associated with hepatocellular injury, cholangiocyte proliferation, stellate cell activation, Kupffer cell activation, oxidative stress, inflammation and fibrosis. Docosahexaenoic acid (DHA) is an essential polyunsaturated fatty acid that has been shown to possess health beneficial effects, including hepatoprotection. However, the molecular mechanism of DHA-mediated hepatoprotection is not fully understood. In the present study, we report the protective effect of DHA on cholestatic liver injury. Cholestasis was produced by bile duct ligation (BDL) in male Sprague-Dawley rats for 3 weeks. Daily administration of DHA was started 2 weeks before injury and lasted for 5 weeks. In comparison with the control group, the BDL group showed hepatic damage as evidenced by histological changes and elevation in serum biochemicals, ductular reaction, fibrosis, inflammation and oxidative stress. These pathophysiological changes were attenuated by chronic DHA supplementation. DHA alleviated BDL-induced transforming growth factor beta-1 (TGF-1), intereukin-1beta, connective tissue growth factor and collagen expression. The anti-fibrotic effect of DHA was accompanied by reductions in -smooth muscle actin-positive matrix-producing cells and Smad 2/3 activity critical to the fibrogenic potential of TGF-1. DHA also attenuated BDL-induced leukocyte accumulation and nuclear factor-B (NF-B) activation. Further studies demonstrated an inhibitory effect of DHA on redox-sensitive intracellular signaling molecule extracellular signal-regulated kinase (ERK). Taken together, the hepatoprotective, anti-inflammatory and anti-fibrotic effects of DHA seem to be multifactorial. The beneficial effects of chronic DHA supplementation are associated with anti-oxidative and anti-inflammatory potential as well as down-regulation of NF-B and transforming growth factor beta/Smad signaling probably via interference with ERK activation.
Phytanic acid and docosahexaenoic acid increase the metabolism of all-trans-retinoic acid and CYP26 gene expression in intestinal cells.
Abstract
Retinoids are essential for growth and cell differentiation of epithelial tissues. The effects of the food compounds phytol, the phytol metabolite phytanic acid, and the fatty acid docosahexaenoic acid (DHA) on the retinoid signaling pathway in intestinal cells were studied. Phytol inhibited the formation of all-trans-retinoic acid (RA) from dietary retinol in intestinal cells. Phytanic acid, a known retinoic X receptor (RXRalpha) and peroxisome proliferator activating receptor (PPARalpha) activator, also activated PPARdelta, and to a lesser degree PPARgamma, in a transactivation assay. Phytanic acid had no effect on intestinal RA hydroxylase CYP26 (also named P450RAI) gene expression and metabolism of all-trans-RA in intestinal Caco-2 cells. However, in combination with retinoic acid receptor (RAR)-ligands (all-trans-RA or synthetic Am580) phytanic acid enhanced the induction of CYP26 and RA-metabolism in comparison to treatments with all-trans-RA or Am580 alone. Also treatment with DHA did not affect CYP26 gene expression and RA-metabolism but cotreatment of the cells with DHA and all-trans-RA or Am580 enhanced the induction of CYP26, in comparison to the induction caused by all-trans-RA or Am580 alone. This study indicates that food compounds such as phytanic acid and DHA that are RXR-agonists and have an impact on intestinal CYP26 gene expression and metabolism of all-trans-RA in intestinal cells.
also:
http://www.naturalnews.com/055200_water_hydration_disease_prevention.html
Dr. Bremners focus is on Accutanes effect on the brain and it makes sense that he would not have much interest i n sexual side effects alone. Nevertheless, he is currently making a movie parodying his clash with Roche that is to be released in the next year: The Goose That Laid the Golden Egg. He is on our side and we can hopefully share a mutually beneficial alliance with him. When that movie comes out, it will give us an opportunity to make some noise again.
Same with Dr. Healy. He is on our side. He believes those of us with sexual dysfunction from Accutane suffer from a form of PSSD, but can only do so much to help. He has done quite a bit to publicize the horrors of drug side effects and featured several stories about Accutane, Propecia, SSRIs, and Lupron on the RxISK site
13 hours ago, tryingtohelp2014 said:DHA and fatty acids and retinoic acid. Hi-Dose essential fatty acids could knock off residual accutane from receptors? it would compete with retinoic acid. Accutane causes lowered amounts of fatty acids. cholestasis causes Essential fatty acid deficiency.
Hi amounts essential fatty acids upregulate UGTs up to a 100x fold needed to detoxify accutane metabolites.
hi amounts of essential fatty acids upregulate PPARs also needed for liver detoxification.
Phospholipid composition of liver in rats fed high levels of 13-cis retinoic acid.
Abstract
The composition of liver phospholipids was studied in rats fed for 4 weeks diets containing 0, 100 or 300 mg 13-cis retinoic acid per kg diet. There was a significant decrease in phosphatidylcholine content, whereas the levels of phosphatidylethanolamine were slightly increased in liver phospholipids of rats fed 13-cis retinoic acid. The fatty acid composition of total phospholipids, PC, PE, and P1 + PS fractions revealed a general increase in the levels of 18:2 and 20:3 omega 6, whereas the levels of 20:4 omega 6 and C22 fatty acids were reduced in most of the hepatic phospholipids isolated from rats fed 13-cis retinoic acid containing diets. A decrease in the double-bond index of fatty acids was also observed in phospholipids of rats fed 13-cis retinoic acid. The data suggest that high levels of 13-cis retinoic acid may possibly be influencing the activities of microsomal desaturating and chain-elongating enzymes in the liver.
Omega-3 Fatty acids and hippocampal neurogenesis in depression.
Abstract
The mammalian brain and central nervous system are especially dependent on the omega-3 (n-3) fatty acid docosahexaenoic acid (DHA) for normative signaling and function, and research suggests that n-3 fatty acid deficiencies are one contributing factor in the increasing prevalence of depressive disorders. However, the reasons for which n-3 fatty acids and mood are connected remain unknown. Atrophy in the hippocampus is one of the most significant neuroanatomical findings in depressed patients, and current therapies for depression tend to increase hippocampal neurogenesis. We recently discovered that the fat-1 transgenic mouse, which has enriched levels of DHA in the brain because it can convert n-6 to n-3 fatty acids, exhibits increased hippocampal neurogenesis. This finding suggests a mechanism by which omega-3 could influence depression and mood; here we expand on the argument that n-3 fatty acids, and DHA in particular, may help prevent and treat depression by virtue of their effects on neurogenesis in the hippocampus. Because DHA can be obtained through the diet, increasing DHA intake in depressed patients or those at risk for depression may be one way of managing the disease and perhaps providing aid to those who have not been able to achieve remission via pharmacological means.
Beneficial effect of docosahexaenoic acid on cholestatic liver injury in rats.
Abstract
Bile duct obstruction and subsequent cholestasis are associated with hepatocellular injury, cholangiocyte proliferation, stellate cell activation, Kupffer cell activation, oxidative stress, inflammation and fibrosis. Docosahexaenoic acid (DHA) is an essential polyunsaturated fatty acid that has been shown to possess health beneficial effects, including hepatoprotection. However, the molecular mechanism of DHA-mediated hepatoprotection is not fully understood. In the present study, we report the protective effect of DHA on cholestatic liver injury. Cholestasis was produced by bile duct ligation (BDL) in male Sprague-Dawley rats for 3 weeks. Daily administration of DHA was started 2 weeks before injury and lasted for 5 weeks. In comparison with the control group, the BDL group showed hepatic damage as evidenced by histological changes and elevation in serum biochemicals, ductular reaction, fibrosis, inflammation and oxidative stress. These pathophysiological changes were attenuated by chronic DHA supplementation. DHA alleviated BDL-induced transforming growth factor beta-1 (TGF-1), intereukin-1beta, connective tissue growth factor and collagen expression. The anti-fibrotic effect of DHA was accompanied by reductions in -smooth muscle actin-positive matrix-producing cells and Smad 2/3 activity critical to the fibrogenic potential of TGF-1. DHA also attenuated BDL-induced leukocyte accumulation and nuclear factor-B (NF-B) activation. Further studies demonstrated an inhibitory effect of DHA on redox-sensitive intracellular signaling molecule extracellular signal-regulated kinase (ERK). Taken together, the hepatoprotective, anti-inflammatory and anti-fibrotic effects of DHA seem to be multifactorial. The beneficial effects of chronic DHA supplementation are associated with anti-oxidative and anti-inflammatory potential as well as down-regulation of NF-B and transforming growth factor beta/Smad signaling probably via interference with ERK activation.
Phytanic acid and docosahexaenoic acid increase the metabolism of all-trans-retinoic acid and CYP26 gene expression in intestinal cells.
Abstract
Retinoids are essential for growth and cell differentiation of epithelial tissues. The effects of the food compounds phytol, the phytol metabolite phytanic acid, and the fatty acid docosahexaenoic acid (DHA) on the retinoid signaling pathway in intestinal cells were studied. Phytol inhibited the formation of all-trans-retinoic acid (RA) from dietary retinol in intestinal cells. Phytanic acid, a known retinoic X receptor (RXRalpha) and peroxisome proliferator activating receptor (PPARalpha) activator, also activated PPARdelta, and to a lesser degree PPARgamma, in a transactivation assay. Phytanic acid had no effect on intestinal RA hydroxylase CYP26 (also named P450RAI) gene expression and metabolism of all-trans-RA in intestinal Caco-2 cells. However, in combination with retinoic acid receptor (RAR)-ligands (all-trans-RA or synthetic Am580) phytanic acid enhanced the induction of CYP26 and RA-metabolism in comparison to treatments with all-trans-RA or Am580 alone. Also treatment with DHA did not affect CYP26 gene expression and RA-metabolism but cotreatment of the cells with DHA and all-trans-RA or Am580 enhanced the induction of CYP26, in comparison to the induction caused by all-trans-RA or Am580 alone. This study indicates that food compounds such as phytanic acid and DHA that are RXR-agonists and have an impact on intestinal CYP26 gene expression and metabolism of all-trans-RA in intestinal cells.
also:
So in other words take fish oil, is that right??
I take "Udo's blend" very good product in of itself but not a cure for tane side effects unfortunately!!
Pls share other recommended products?? How many have tried that "Blue Ice" fish oil?
9 hours ago, TrueJustice said:So in other words take fish oil, is that right??I take "Udo's blend" very good product in of itself but not a cure for tane side effects unfortunately!!
Pls share other recommended products?? How many have tried that "Blue Ice" fish oil?
udos doesnt have DHA. even their DHA blend only has 100mg
need hi dose DHA. .. several 1000mg
On 9/7/2016 at 7:50 PM, Gladiatoro said:http://www.naturalnews.com/055200_water_hydration_disease_prevention.htmlDr. Bremners focus is on Accutanes effect on the brain and it makes sense that he would not have much interest i n sexual side effects alone. Nevertheless, he is currently making a movie parodying his clash with Roche that is to be released in the next year: The Goose That Laid the Golden Egg. He is on our side and we can hopefully share a mutually beneficial alliance with him. When that movie comes out, it will give us an opportunity to make some noise again.
Same with Dr. Healy. He is on our side. He believes those of us with sexual dysfunction from Accutane suffer from a form of PSSD, but can only do so much to help. He has done quite a bit to publicize the horrors of drug side effects and featured several stories about Accutane, Propecia, SSRIs, and Lupron on the RxISK site
Why are you quoting one of my statements from another forum verbatim and linking it to a totally unrelated page on naturalnews?
Hi everybody!
I wanted to provide an update. I am working with a local cannabis consultant, who researches the stuff extensively and also makes cannabis oil tinctures. I have been taking CBD oil internally for months now, and it has ameliorated joint pain and anxiety, I also put a few drops in a base oil like olive, jojoba, cococnut oil, etc. and then rub it all over my body after heating it up, including my scalp where things are absorbed very readily. The idea behind this is that the skin is damaged and also needs moisturizing, in addition, the CBD oil can penetrate deep into the tissues, both internally and externally. Over time, it's supposed to help with healing of internal tissues by reducing inflammation and several other processes which you can simply google to find some good articles. I also take CBN oil at night for sleep. CBN is the chemical in cannabis that promotes sedating effects, so it has virtually eradicated my insomnia (when I take it so far). It calms down my accutainted hyper-alertness and neurological/dermal sensitivity perfectly. The CBN for me has provided the most relief. That's what knocks you out when you actually smoke wee. Fun fact. I'd recommend getting some if you can and working on medical Mx card if you live in a cool state. Also been focusing on candida and SIBO and making very positive strides. Less thirsty all the time, more energy, less itchy, less joint pain, etc. Also doing methylation protocol which definitely helps my joints and energy level further. I am a poor methylator, had genetic confirmation of this. I'm going at this from all angles and I FINALLy feel as though I am making real head-way.