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Repairing the long-term damage from Accutane

 
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(@gladiatoro)

Posted : 03/11/2016 9:18 pm

There are many causes of acne , diet is a big factor , believe it or not vaccine damage and antibiotics contribute to acne later in life in reality most people in poorer country's have 0 acne , think about it . It's our western living and it's slowly killing us. Processed junk food is the biggest culprit .

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223
(@gladiatoro)

Posted : 03/11/2016 9:54 pm

Why do you think people who go on chemotherapy DIE think about it it's &:(( POISON that's why. You can take it if you want I won't stop you but I refuse to ever take another synthetic drug in my life.

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(@justmom)

Posted : 03/11/2016 10:02 pm

I'm sure you're right in most cases. My son had beautiful clear skin as a tiny babe, then infant acne at about 4 months old. Blackheads all over his baby face. The pediatrician said it was hormonal. It cleared up during toddlerhood, then back with a vengeance in his teens. I remember asking the pediatrician when he was a baby if the infant acne meant that he would have it as a teenager and she said not necessarily, but since it was hormonal there wasn't anything we could do about it anyway. But I confess, though I also pushed veggies on my kids, we ate junk food as well.

But Gladiatoro, did you put yourself on Accutane as an adult? If not, surely you don't blame your parents? I think the blame should be put squarely on those who know what the drug does and allow it to be legal anyway. The drug companies and the government agencies that "regulate" them.

Even with the information in hand, though, there are still those who will take it. A week or so ago, I caught a glimpse of someone on this web site asking about dosages and getting to the amount needed in a short period of time. I replied, sending them to this thread and warning them off, as I've seen others from this thread do as well. The poster ignored me and got excited about another answer that said there wouldn't be any reason not to take double the dose in half the time. Oh well, I tried......

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1803
(@guitarman01)

Posted : 03/11/2016 10:04 pm

copper study
http://www.ncbi.nlm.nih.gov/pubmed/24096552 There were no effects on serum Cu concentration or ceruloplasmin (protein) and hepatic transaminases. Supplementation of 8 mg Cu for 6 months had no effect on lipid profile of apparently healthy Chilean men with adequate Cu status.

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1803
(@guitarman01)

Posted : 03/11/2016 10:51 pm

Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development

Dietary selenium is known to protect skin against UV-induced damage and cancer and its topical application improves skin surface parameters in humans, while selenium deficiency compromises protective antioxidant enzymes in skin. Furthermore, skin and hair abnormalities in humans and rodents may be caused by selenium deficiency, which are overcome by dietary selenium supplementation. Most important biological functions of selenium are attributed to selenoproteins, proteins containing selenium in the form of the amino acid, selenocysteine (Sec). Sec insertion into proteins depends on Sec tRNA; thus, knocking out the Sec tRNA gene (Trsp) ablates selenoprotein expression. We generated mice with targeted removal of selenoproteins in keratin 14 (K14) expressing cells and their differentiated descendents. The knockout progeny had a runt phenotype, developed skin abnormalities and experienced premature death. Lack of selenoproteins in epidermal cells led to the development of hyperplastic epidermis and aberrant hair follicle morphogenesis, accompanied by progressive alopecia after birth. Further analyses revealed that selenoproteins are essential antioxidants in skin and unveiled their role in keratinocyte growth and viability. This study links severe selenoprotein deficiency to abnormalities in skin and hair and provides genetic evidence for the role of these proteins in keratinocyte function and cutaneous development.

Selenium is also antibacterial.

Selenium nanoparticles inhibitStaphylococcus http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152473/

Staphylococcus aureusis a key bacterium commonly found in numerous infections.S. aureusinfections are difficult to treat due to their biofilm formation and documented antibiotic resistance. While selenium has been used for a wide range of applications including anticancer applications, the effects of selenium nanoparticles on microorganisms remain largely unknown to date. The objective of this in vitro study was thus to examine the growth ofS. aureusin the presence of selenium nanoparticles. Results of this study provided the first evidence of strongly inhibited growth ofS. aureusin the presence of selenium nanoparticles after 3, 4, and 5 hours at 7.8, 15.5, and 31 g/mL. The percentage of live bacteria also decreased in the presence of selenium nanoparticles.

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223
(@gladiatoro)

Posted : 03/11/2016 10:51 pm

13 hours ago, Justmom said:

I'm sure you're right in most cases. My son had beautiful clear skin as a tiny babe, then infant acne at about 4 months old. Blackheads all over his baby face. The pediatrician said it was hormonal. It cleared up during toddlerhood, then back with a vengeance in his teens. I remember asking the pediatrician when he was a baby if the infant acne meant that he would have it as a teenager and she said not necessarily, but since it was hormonal there wasn't anything we could do about it anyway. But I confess, though I also pushed veggies on my kids, we ate junk food as well.

But Gladiatoro, did you put yourself on Accutane as an adult? If not, surely you don't blame your parents? I think the blame should be put squarely on those who know what the drug does and allow it to be legal anyway. The drug companies and the government agencies that "regulate" them.

Even with the information in hand, though, there are still those who will take it. A week or so ago, I caught a glimpse of someone on this web site asking about dosages and getting to the amount needed in a short period of time. I replied, sending them to this thread and warning them off, as I've seen others from this thread do as well. The poster ignored me and got excited about another answer that said there wouldn't be any reason not to take double the dose in half the time. Oh well, I tried......

I was an adult 20 years old but at the time there was no internet for me so I could not make an informed decision , it was roughly 25 years ago to this day I still suffer from side effects Nowadays there is no excuse it's all out in the open on the damage this drug causes one derm said it saves more lives than it takes .

I don't know how this stuff is even legal is what I say. It is after all a pure poison and they still claim that they don't know how it actually works , i don't believe that for a minute I think it's a major coverup because if the truth got out on really the damage. this synthetic drug causes to kids and young adults then there would be endless law suits we already know it damages the brain that's just one of many side effects that are btw permanent. As far as I can tell.

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(@gladiatoro)

Posted : 03/12/2016 12:23 am

My moto is educate don't medicate.

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(@vicecaz)

Posted : 03/12/2016 5:36 am

Gladiataro, i know how you feel. Same here. But even with the internet , I read many testimonials of people who took accutane And everything was fine, all the side effects disappeared the moment they have stoped the drug . I rarely but sometimes saw people who have had issues with this drug butit was nothing more than skin/eyes dryness post accutane. I was saying to myself " Oh, if it happen to me , it will be Ok with a cream " . Then your Derm say there is no problem with this drug, you also know some friends who took this drug without problems.. And you are suffering from acne ( even not severe acne, but enough to feel ugly with ) everyday, you lack self confidence cause of it And have the feeling to miss funny Times cause you're not confident enaugh .. It was enough to take this drug to meunfortunately.

I heardbad stories about this drug ( depression etc ) but I thought It was only temporary, or that those people had psychiatric problems before...

I do have regrets. Sometimes I ask myself why couldn't I wait 3/4 years, my acne would have probably disappeared . But once again I was probably too young and couldnt imagine such a bad Scenario.

but the good News is, we can recover. It takes time surely but if at least 15 people claim to get cured with evidence , we can do it as well
Personaly, since i'm convinced that i'll recover, I'll be able to say that finally having took this drug was a bless, because all the important knowledge I have learned finding a solution to get cured .
'What does not kill you makes you stronger

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(@anthony180)

Posted : 03/12/2016 10:20 am

Ok guys i just finished my accutane course.I took 20 mg first month, 40mg second month, 30 third month, 60mg 4th month, 70 mg 5th month, 80 mg 6th month and then I was supposed to take another 80mg the 7th month but only did 10 days of it and quit. My total culcumative dosage was 9800.

Now one thing that really worries me is 3 days after finishing I started to experience pain in my spine and I feel like my hairline is recedding. I do have very long hair for a male but everytime I run hand through my hair a couple hairs are left on my hand.

I'm def not bald but I feel like my hair is fragile and brittle and I feel like my hairline is def recedding.

Another thing is I took ALOT of olive oil (didn't measure, would just pour onto pasta) in order for the accutane to be "absobred properly, since it says that accutane should be taken with fat in order for it to be absorbed properly.

Now my spine is hurting, my rib cage is hurting, an injury on my shoulder I had from a fight 7 months ago is still there ( I took the accutane right after that), my neck feels fragile, and I don't feel like I can do any exercises, wish ABSOLOUTELY kills me because I am a boxer and it's taken away the only thing that helps with THIS HORRIBLE depression and anxiety I have because of accutane or all the symptoms that are happening to me.

I truely feel that I am a totally different person and I can't accept that which makes me cry for the whole day at times and puts me at insane stress levels that I have no idea how to handle.

I've been 5 days without the pill exactly, do you guys think I received permanent damamge because of all the olive oil and fat I was taking with my pill caused me to absorb much more accutane than I should have.

I also drank white grapefruit juice, wish I had no idea I wasn't supposed to drink during the course, and I believe that may have damaged me as well.

So I've read a bunch of post but can someone elaborate what's the best supplements and diet to take, do you feel like my situation is one of permanent damage? I do have OCD and go crazy over many things but my body feels like that of an 80 year old man.

Weird thing is the spine pain and rib pain didn't come until 3 days after I completed the last pill. I also ran 4 miles and worked out a lot during my time with the pill which I believe was a horrible idea.

I feel like theres no hope and want to quit at times.

I would love any advice or sense of hope because I lost my girlfriend because of this, my family, everything. I'm alone. Is vitamin A stuck in my liver and will never be removed? Will I ever be able to drink again or is my liver far too damaged?

Please help and thank you!

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(@macleod)

Posted : 03/12/2016 11:44 am

after reading all of yourposts back to 2010...

2nd courseof accutane for a handful of pimples. Life constantly in "stress". And now looking for motivational inspirational quotes.

You freaked out over "red marks" before your treatment. And now you are freaking out over sides after your treatment. I really needed to read that you are a boxer, you ate olive oil, and drank white grapefruit juice. You sound like a child that doesn't just stopand think. You are 25 years old. Let's put your big boy pants on for a second.

It may very well be that after your second course of accutane, that you have developed some side effects, temporary or permanent, who knows, time will tell.

maybe it's a sign.that you should stop worrying about your looks and start focusing on the important things in life.

You want supplements? re-read the 350 pages of this forum. Now you know as much as us.

And you want advice or motivation and reassurance? I can't help ya there because it would be a big reality check. This isn't like an MTV show where the people literally breathe, think, and talk AIR. C'mon man.

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223
(@gladiatoro)

Posted : 03/12/2016 1:10 pm

What's the point in having no acne if you can't have sex anymore I don't get it that's just $$&@ed especially for young adults that's robbIng them of something great in life and it's so wrong im one of the lucky ones no Ed only brain fog that comes and goes but it's all dosage related if you take 10 grams or more then I think 99% have problems with urine flow and erections .

My dosage was only 2.5 grams I stopped after I lost 50 percent of my hair in a 1.5 month span it was highly traumatizing for me as you can imagine as a young man going baled and told the doc to go fuck himself they wanted me on it for 6 months but deep down I knew I was getting severely poisoned thank GOD I stopped things could have been much worse for me btw it did nothing for my mild acne.

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(@macleod)

Posted : 03/12/2016 2:25 pm

Gladiatoro, I hear you, but we can't dwell in the past. Obviously hindsight is 20/20. Most of us didn't know what we were getting into. the universe is very complex and it may just be we are all here for a reason. look, we all feel regret, but we need to focus on the future. It happened and we will get through this.

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(@anthony180)

Posted : 03/12/2016 3:39 pm

3 hours ago, macleod said:

after reading all of yourposts back to 2010...

2nd courseof accutane for a handful of pimples. Life constantly in "stress". And now looking for motivational inspirational quotes.

You freaked out over "red marks" before your treatment. And now you are freaking out over sides after your treatment. I really needed to read that you are a boxer, you ate olive oil, and drank white grapefruit juice. You sound like a child that doesn't just stopand think. You are 25 years old. Let's put your big boy pants on for a second.

It may very well be that after your second course of accutane, that you have developed some side effects, temporary or permanent, who knows, time will tell.

maybe it's a sign.that you should stop worrying about your looks and start focusing on the important things in life.

You want supplements? re-read the 350 pages of this forum. Now you know as much as us.

And you want advice or motivation and reassurance? I can't help ya there because it would be a big reality check. This isn't like an MTV show where the people literally breathe, think, and talk AIR. C'mon man.

Wow , Didn't expect such a hostile post from people here trying to support each other. Man if you don't want to help, just dont help, you have no idea the stress or what I've been through in my life and I don't know yours. That's why I don't attack you. I've been in very very low stages in life due to circumstances totally out of my control.

I don't get what you meant by " I really needed to read that you are a boxer, you ate olive oil, and drank white grapefruit juice."

I was worried the olive oil over consupation made me absorb too much of the accutane, and my spine and bones hurt now so yeah, of course I'm worried.

Sorry I thought people here were supporting each other, and I have read over 30 pages of this but that's a lot of reading. It would be nice instead of you going through my past posts, if you could talk about what has helped people recover in the past since it seems like you've been researching for awhile.

But that's fine man, if you want to be hostile and mean to people going through similar situations as you, so be it. Insulting me really wasn't neccesary neither and telling me to re-read 350 pages is showing you have no intent in helping when I'm sure since when this was created in 2011 there are some known supplements, diets, etc that have helped people and that's all I was asking for.

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(@gladiatoro)

Posted : 03/12/2016 6:26 pm

In Chinese medicine the liver is the most important part of the body if it is contaminated the whole body suffers makes sense.

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(@guitarman01)

Posted : 03/12/2016 7:35 pm

im really starting to think my ear fullness, dizziness, nasal congestion, sinus problems, yellow, white coating on tongue is some sort of acid reflux. one of the only supplements i have left to look at is selenium. it is involved in gut health, inflammation, and immune response. also a factor in producing glutathione. il be taking 400 to 600mcg per day and see how that goes(anyone done this before?). also might take berberine, oil of oregano complex that includes thyme and sage to kill any bacteria/fungus that might be going on. then il take florastor to keep everything in check. if this shit dont work. then im going to look at allergy meds again nasonex and singulair. or I could just have a party and take everything at once.but then i wont know whats what.

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(@abi72)

Posted : 03/12/2016 10:54 pm

On 3/11/2016 at 9:55 PM, Justmom said:
ViceCaz, thanks for your explanation. I've been trying to understand how RSO could help as much as those cured by it say it does. I've read multiple accounts of cancer being cured by it and I marvel at how many diverse stories there are. I asked the helpful dude in the medical dispensary how it works, and he said, "It does a scrub and reset of the brain." So I guess in a word, homeostasis, right? Your explanation makes me think that it would not only help in the ED only cases, like my son, but the multiple-organ problems as well.

I'm hoping to come back with an encouraging update on how my son is doing, but we are still in the building tolerance stage. He already had to drop one class this semester (I think because of brain fog) and the RSO this soon in is making him pretty flakey. We're also having difficulty getting it in him every 8 hours for the same reason, also because he does have to drive to get to school. I'm hoping over spring break to get him up to the recommended dose.

Your doing great. As you say, you have the holidays ahead. The slow and easy approach has to to be the best way forward plus keeping any stress/pressure to a minimum. good luck.

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148
(@oli-girl)

Posted : 03/12/2016 11:00 pm

7 hours ago, anthony180 said:
anWow , Didn't expect such a hostile post from people here trying to support each other. Man if you don't want to help, just dont help, you have no idea the stress or what I've been through in my life and I don't know yours. That's why I don't attack you. I've been in very very low stages in life due to circumstances totally out of my control.

I don't get what you meant by " I really needed to read that you are a boxer, you ate olive oil, and drank white grapefruit juice."

I was worried the olive oil over consupation made me absorb too much of the accutane, and my spine and bones hurt now so yeah, of course I'm worried.

Sorry I thought people here were supporting each other, and I have read over 30 pages of this but that's a lot of reading. It would be nice instead of you going through my past posts, if you could talk about what has helped people recover in the past since it seems like you've been researching for awhile.

But that's fine man, if you want to be hostile and mean to people going through similar situations as you, so be it. Insulting me really wasn't neccesary neither and telling me to re-read 350 pages is showing you have no intent in helping when I'm sure since when this was created in 2011 there are some known supplements, diets, etc that have helped people and that's all I was asking for.

Well it is possible that you Accutane has effected your joints and bones. To what extent is hard to say! Many have tried certain things that have helped and your old injury you might want to have that looked at, though Accutane is known to cause a delay in wound healing et.

Sheefa who was a long time member on this board has a post from way back when on suggestions for joint pain etc. Your probably low in Vit D which most are after Accutane. if you decide to take fish oil make sure it's not cod liver oil or it doesn't have any Vit A in it.

If you have MPB that runs in your family then it will speed up the process or you could just be dry brittle hair or T.E. For a lot of us we don't do well ingesting Vit A there is a los a hair loss thread and you can google on different things like coconut oil etc. for your hair and body.

Also remember Roche themselves states the drug continues to work up to 2-3 months after you have stopped. It's really hard to say if your side effects are permanent or not.

I eat a very clean diet, no processed foods, sugar etc.

you can try GLA, or Hyaluronic Acid (baxyl) you can try cumin, Vit D, etc. Do stretching. Do your bones crack?

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(@abi72)

Posted : 03/13/2016 12:17 am

On 3/11/2016 at 9:15 PM, dakiramir said:

Hi guys, can someone tell me if there's any info out there on how long retinoic acid binds to a receptor for? Or even, how long vit A or D stay at the receptor. I read something about it being possible to recommend accutane patients to load up on vit A before their course to limit the amount of receptors available to the crappy retinoic acid version. I'm just curious how long that retinoic acid could remain at the receptor. Surely it can't be permanently there. Unless it's so crappy that it fools the body into thinking it has sufficient vitamin A but is unable to use the crappy retinoic acid, so you're stuck in a loop of your body not binding any normal vit A because retinoic acid is blocking the receptor?

Just wanted to know if anyone knows if the shit breaks down or leaves the receptor, or is it stuck there indefinitely.

Also, if anyone is interested, copper supplements seem to have drastically reduced the burning I was feeling in my joints. I still have the pain migrating everywhere, but waking up to 75% of my joints burning has subsided significantly. I still have the pain though, after standing for a while or being active, and I feel like it's affecting more joints, but I seem to wake with less pain.

Again though, anyone know how long Retinol/A/D stay at the receptors?

Hello

http://www.ncbi.nlm.nih.gov/pubmed/24613207?dopt=Abstract

[removed]

I saw a program ages ago comparing the best diets in the word. One of the top diets was the Mediterranean (high oil).
Worth a bit of research I think.

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(@anthony180)

Posted : 03/13/2016 9:42 am

10 hours ago, oli girl said:
Well it is possible that you Accutane has effected your joints and bones. To what extent is hard to say! Many have tried certain things that have helped and your old injury you might want to have that looked at, though Accutane is known to cause a delay in wound healing et.

Sheefa who was a long time member on this board has a post from way back when on suggestions for joint pain etc. Your probably low in Vit D which most are after Accutane. if you decide to take fish oil make sure it's not cod liver oil or it doesn't have any Vit A in it.

If you have MPB that runs in your family then it will speed up the process or you could just be dry brittle hair or T.E. For a lot of us we don't do well ingesting Vit A there is a los a hair loss thread and you can google on different things like coconut oil etc. for your hair and body.

Also remember Roche themselves states the drug continues to work up to 2-3 months after you have stopped. It's really hard to say if your side effects are permanent or not.

I eat a very clean diet, no processed foods, sugar etc.

you can try GLA, or Hyaluronic Acid (baxyl) you can try cumin, Vit D, etc. Do stretching. Do your bones crack?

Ok Would vitamin D with calcium be good or just vitamin D? My bones crack in some places but my neck no longer cracks (Which I used to crack alot). The only joint paint im experiecing is my spine and my right shoulder (which was previously injured from a fight and then I immediatly got on accutane). I'm hoping I don't have chemo brain and body. I would really be destroyed if I can't do the sport that helps deal with my anxiety. Not only that this pain really sucks in my spine. I'm hoping for a recovery and wanna do anything possible to get this out of my system and be able to jog again, etc.

And yeah I'm def low on vitamin D, I avoid the sun at all costs because the dermatologist told me to. And I'm afraid it will darken my hyperpigmentation left by the acne.

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223
(@gladiatoro)

Posted : 03/13/2016 10:03 am

Accutane damages the brain no question mri's prove it , it is after all chemotherapy.

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(@anthony180)

Posted : 03/13/2016 11:27 am

My fingers, ankles and knees all crack so that's remained the same.. not sure if that's good. Btw i appreciate the kind and helpful response from the bottom of my heart. Also do you think absorbing too much fat (especially huge amounts of olive oil in pasta) made me absorb the pill too much and cause these side affects? Because the first time around I had no joint pain and I was playing basketball everyday, and just ate normally without trying to get as much fat possible.

I even worked out in the gym and didn't experience side affects until I did those push ups now next day my spine is hurting and seems fragile. My neck was stiff but it seems to be getting better thank God.

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1803
(@guitarman01)

Posted : 03/13/2016 2:05 pm

4 hours ago, Gladiatoro said:

Accutane damages the brain no question mri's prove it , it is after all chemotherapy.

Well actually i did have a MRI. And they didn't say anything about brain damage. So at least i got that going for me

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223
(@gladiatoro)

Posted : 03/13/2016 4:22 pm

DOES ISOTRETINOIN CAUSE BRAIN DAMAGE ....ANSWER

1) Yes, the brain is affected in a negative way. Metabolism is measured to sink with 20% in certain parts of the brain.
FACT. What is interesting here is why it sinks. If it is due to pure nerve-cell loss, it is not good. If it is due mainly to altered cells, that is better. I think that the answer lies somewhere inbetween. The problem is that your lasting functioning metabolism has to carry a "greater load" through the rest of your life-time.

If you look at face-expressions from people that have taken Accutane, you often see that their mouth doesn't move as freely as it does before. Does not necessarily mean that the person is unhappy at the moment and does not necessarily say that the brain-effect is life-threatening but it says something, about nerve-status.

2) About the life-effects

Definitely you are at higher risks to develop diseases later in life, due to weakened immune-defense, diabetes, you may also be prone to have difficulties finding a stable body-weight, due to a falling metabolism. Diabetes and metabolic diseases have become one of the leading theories regarding other more serious problems such as elderly dementia. This in itself constitutes a risk to life-time.

The effects on life time expectancy are currently being investigated both for syntheticvitamin A, and also for conditions such as diabetes, fat-metabolsim and insulin insensitivity.

It can not be clearly said right now, what the statistical risks are, but there is a likelyhood that life-time-expectancy drops after using Accutane.

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231
(@fchawk)

Posted : 03/13/2016 4:22 pm

On 6 March 2016 at 9:36 AM, guitarman01 said:
im not sure about this. you might be able to deal with vitamin a/accutane all together differently then some people on here to begin with. hence there really arent too many people that have grazed this forum compared to the millions that have taken accutane. i have also dabbled in higher dose vitamin a, and think it did more harm then good.still have eye floaters from it. so anyone else considering this proceed with caution. but if we did have vitamin a stuck in our cells/liver i would think this would only compound the problem. glad your doing well though.

What dosage did you have for vitamin A? Also do you have bigots spots on your eyes? I drafted a much longer response but my phone crashed.
long and short of it is that I think those who have the most adverse effects to even small amounts of vitamin a are the most likely to have a deficiency, as there body has gotten used to Isotretinoin, and that even small vitamin a supplements may help.
i am obviously a proponent of pro vitamin a, but I myself got eye floaters 5 months ago in one eye, which I believe could be very well due to vitamin a deficiency/isotretinoin over crowding, as well as taurine deficiency. My 2 cents

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(@abi72)

Posted : 03/13/2016 4:39 pm

http://drmyhill.co.uk/wiki/CFS_-_The_Central_Cause:_Mitochondrial_Failure

If you read the full article you well see that Mitochondria damage can be caused by chemo.

Anyone looked into this - I know many have taken the supps that Myhill is suggesting.

Also this test looks really interesting - I know many of you in the US get tested but anyone have this paticular tes

t.

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