and maybe we need just Glycine? not TMG.especially if taken at a higher dose?

we already get 2 grams of glycine a day from food

glycine is normally self produced in the liver

So for my next trick I am going to take 20g of straight glycine powder per day and see what happens.
I just bought a kilo

hi, Guys, in the last pages talking about methionine , sam -e , taurine , glycine .What I can try to start ? my accutane effects are 90 % , sexual problems , low muscle development , apathy , " tired mind "

God, this shit does go in a endless loop. I see Tryingtohelp was all about glycine awhile back.

8 hours ago, Modeaa said:

 '
tryingtohelp- read the next,taurine stuff their.
http://www.ncbi.nlm.nih.gov/pubmed/2871479
''Bile acid-induced liver toxicity: relation to the hydrophobic-hydrophilic balance of bile acids.''

http://www.ncbi.nlm.nih.gov/pubmed/14534721
'' The cytotoxicity of hydrophobic bile acids is ameliorated by more hydrophilic bile acids in intestinal cell lines IEC-6 and Caco-2.''

All-trans retinoic acid potentiates cisplatin-induced kidney injury in rats: impact of retinoic acid signaling pathway.
http://www.pubfacts.com/detail/26659823/All-trans-retinoic-acid-potentiates-cisplatin-induced-kidney-injury-in-rats-impact-of-retinoic-acid-

vs.

Protection effects of Taurine supplementation against cisplatin-induced nephrotoxicity in rats.

http://www.pubfacts.com/detail/11901256/Protection-effects-of-Taurine-supplementation-against-cisplatin-induced-nephrotoxicity-in-rats

Taurine supplementation attenuated CDDP-induced nephrotoxicity which was manifested by jeopardizing the elevation in serum creatinine and BUN levels and the reduction in serum albumin and calcium levels. Moreover, taurine supplementation restored kidney GSH content and GSH-Px activity

we need everything working in this diagram

The 4 things needed:
SAM-E (we skip any MAT enzyme problems)
b12 (potentially folate)
b6
TMG (betaine ..methyl groups + glycine)

http://ajcn.nutrition.org/content/86/1/14.full
 

http://ajcn.nutrition.org/content/86/1/14.full

the absolute best paper out there on SAM-E , TMG, b12 , folate etc

On 1/23/2016 at 9:34 PM, trantran83333 said:

Ok I will make an effort to go get my condition clinically tested by another doctor to be 100% sure. To be honest I was a little sceptical with kinesiology. I have never heard of it but apparently it is widely practiced in Australia with chiropractors as such.
I also read somewhere that you can also get colloidal silver IV's for chronic candida infections. Haven't looked into that much.
As for smoking, I started because of the depression. I hate it I want to quit, but easier said than done. Tried two times to go cold turkey, but one time with bad migraine that lasted all day, and second time I was just real tired all day. Might have to fork out another $200 for a hypnotherapy session. A work colleague of mine did it and succeeded. She was a heavy smoker for 40yrs and quit with no side effects nothing.
Would be nice if Roche would pay for all my expenses, yeah rite!

Which digestive enzymes were you talking about specifically? I do have a bottle of it here along with ox bile.

thanks relentless1k

I recently quit myself after smoking 2,5years because of accutane depression. It sure sucks to quit but the outcome is much better and we save a lot of money. I use a nicotine spray whenever i want a cigarette (which is rare now)

I was talking about the enzymes that you take on an empty stomach to deal with biofilms. I guess they are mostly the same though, i dont know if they work.. This is one http://iherb.com/Kirkman-Labs-Biofilm-Defense-60-Capsules/58795

On 1/23/2016 at 7:39 AM, tryingtohelp2014 said:

modeaa, from these studies... retinol and methionine have an inverse relationship. excess retinol clears the body of excess methionine and SAM-E... wouldnt the reverse be true? retinoids reduce hepatic sulfur limiting their availability for every other function the body needs (this can account for EVERY SINGLE one of our side effects)

lets reverse this process!!!!!! by adding lots of SAM-E. today i went to get a serum b-12/homocysteine/full cbc panel and a methylmalonic lab test done. This should show if im not able to recycle homocysteine back into methionine. If we have damaged livers, we might need to take SAM-E direct to bypass this, as the MAT1 enzyme isnt working as well after accutane. Dr. Rich Van K thought to take high doses of folate to knockdown the GNMT enzyme. i believe we can do this by replacing the catabolized methionine in massive doses once and for all. I believe this will also be dose dependent.

these tests will also rule out pernicious anemia.

I will wait for the result of these labs before increasing the doses... but i 1000% believe this is the path. This should provide us with all of the GAGS (glucuronic acid) and taurine to conjugate anything we need to get rid of and or reverse any epigenetc switch.

Could you look into what to watch out for when taking a lot of SAM-e? I know it can disrupt certain things or make something too low. I cant recall what but its something with homocysteine or something related.

I know it makes me feel much better but i wonder how safe it is.
But sam-e, methylfolate, methylb12 and taurine is probably our best contenders at the moment eh

14 hours ago, guitarman01 said:

So for my next trick I am going to take 20g of straight glycine powder per day and see what happens.
I just bought a kilo

Glycine does some weird shit to me when i go over 5-6g, i cant understand the mechanism but it causes histamine release in a weird new way that i dont get otherwise. I have great success with it combined with taurine though.

+ it has so much good benefits for health and longevity its good to take anyway. At least in the 3-6g range for healthy ppl

Hope you do well with 20g of it, stack it with SAM-e, taurine and methylfolate/b12 if you can

On 1/24/2016 at 8:45 PM, tryingtohelp2014 said:

i dont know. i think vitamin D and K2 could be dangerous without fixing the underlying problem! we know for a fact accutane causes excess calcium in serum. this causes the bone spurs etc. if you add vitamin D or k2... you could exacerbate the problem by causing more calcium to be deposited.

again... anything that doesnt have anything to do with excretion of retinoic acid or its metabolites....probably wont do anything for us. at best will mask symptoms, at worst, fuck your liver up really bad. there was a lady named patti lodes who took vitamin D i think, and she got really messed up.

if we could just start with a clean slate, everything else would fix itself in short order.

Interesting, i do well with d3 and k2 and dont have high blood calcium that i know of. I restrict calcium intake though

I react poorly to b vitamins and methylfolate, so much weird side effects. Anyone else have this?

5 hours ago, Modeaa said:

more correctly LRH1 IS BEING shut (BY FXR which send shb i think to sut lrh1) in order to repress bile synthesis because.
LRH1 IS NEEDED FOR BILE SYNTHESIS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903807/
Bile acid activation of FXR upregulates the expression of the small heterodimeric partner (SHP, NR0B2) and fibroblast growth factor 19 (FGF19). The latter two in turn repress CYP7A1 expression (10, 13, 14). As a negative regulator, SHP inhibits the activation of HNF4 and LRH-1 in hepatocytes

http://onlinelibrary.wiley.com/doi/10.1111/hepr.12290/full
a key enzyme in hepatic taurine biosynthesis from cysteine, was significantly decreased by cholic acid and significantly increased by cholestyramine. CSAD mRNA levels in the liver were also significantly decreased in mice treated with a synthetic FXR ligand (GW4064) and significantly increased in SHP^/mice. These findings imply that FXR activation downregulates taurine biosynthesis.

The ratio of bile acid conjugation to glycine and taurine (G/T ratio) generally depends on the amino acid balance in oral intake and on the free taurine content in the liver.[4] There are also species differences in the G/T ratio, with this ratio being lower in rodents than in humans. This may be due to the higher rate of taurine biosynthesis in rodents. However, the G/T ratio does not seem to influence the total output of bile acids from the liver or fat absorption in the intestine. Thus, it is unclear if one purpose of FXR activation is to induce an increase in the G/T ratio through repression of taurine biosynthesis in mice.

Beneficial effects of taurine on liver diseases have been established in many previous studies, including those from our laboratory.[5-8] Both intestinal absorbance of taurine from an exogenous source and cellular taurine uptake are carried out through a specific taurine transporter (TAUT). A study in a TAUT-knockout mouse showed that maintenance of the taurine poolin vivois important to prevent liver damage and that the hepatic taurine pool in mice depends mainly on exogenous uptake, rather than on endogenous biosynthesis.[9] Inhibition of taurine biosynthesis induced by FXR activation would further increase the need for oral taurine intake.
In these studies, taurine feeding resulted in significantly enhanced fecal bile acid excretion and increased CYP7A1 activity and mRNA expression. The mechanism of CYP7A1 regulation by taurine is unclear, but taurine may influence activation of liver X receptor- (LXR), a promoter of CYP7A1 transcription.[11] However, a binding site for LXR on the cyp7a1 gene is present in mice but not in humans, indicating that there also may be a species difference in taurine regulation of cholesterol metabolism between humans and mice.

what if we just have systemic dryness caused by accutane and thats that? and because of this, numerous processes in the body dont function properly because of the inflammation caused by the dryness. image your body completely moisturized from inside out. could you picture alot of these problems going away?

.

David Chow, the man who started RAG-forum and a leading member of the Roaccutane Action Group, committed suicide last month after 21 long years of suffering severe depression and painful physical complications brought about by Accutane.

Coroner asks for review of acne drug Roaccutane after photographers suicide
http://www.eadt.co.uk/news/coroner_asks_for_review_of_acne_drug_roaccutane_after_photographer_s_suicide_1_4337597

1 hour ago, Dubya_B said:

.

David Chow, the man who started RAG-forum and a leading member of the Roaccutane Action Group, committed suicide last month after 21 long years of suffering severe depression and painful physical complications brought about by Accutane.

Coroner asks for review of acne drug Roaccutane after photographers suicide
http://www.eadt.co.uk/news/coroner_asks_for_review_of_acne_drug_roaccutane_after_photographer_s_suicide_1_4337597

I got news while I was away...My HEARTBREAKS AT THIS NEWS!!!!!!!!!!!!!! If any of you know or Knew David or the old rag forum then you know what a tremendous loss it is.....For those of you who don't,we wouldn't be this far if it wasn't for him....He suffered so bad, imagine having such tremendous Chelitis of the lips for all those years that you can't eat,nothing can totouchyour lips.....etc..... As tearsagain roll down myface...I say to you my friends stay strong!!!!!!

P.S. It was out of his control, but a tremendous loss that the forum (both) closed!

1 hour ago, Dubya_B said:

.

David Chow, the man who started RAG-forum and a leading member of the Roaccutane Action Group, committed suicide last month after 21 long years of suffering severe depression and painful physical complications brought about by Accutane.

Coroner asks for review of acne drug Roaccutane after photographers suicide
http://www.eadt.co.uk/news/coroner_asks_for_review_of_acne_drug_roaccutane_after_photographer_s_suicide_1_4337597

This is unbelievable sad news. I hope he finds peace now.

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there is so many more links I could post! I remember our first conversation, my first question " was I going to die" that was 9-10 yrs ago! words can't express such sorrow  

On 1/26/2016 at 3:32 PM, oli girl said:

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there is so many more links I could post! I remember our first conversation, my first question " was I going to die" that was 9-10 yrs ago! words can't express such sorrow  

so fucking sad.  i hope all of these roche people burn.

i remember reading this  aquatic-ape site.  its ironic that guitarman brought up being "dried out"   its essentially one of our main problems.  if you read Nathan Carr's site, he mentions TEWL and hyaluronic acid many times.  
 

"Then Matthew found another important link to his other side effects. Accutane, also switches
off the production of hyaluronic acid, the water-holding molecule in the connective tissue
between living cells in the body. Hyaluronic acid is concentrated in the joints, skin, scalp, and
eyes, exactly where all of Matthew™s symptoms were concentrated. Scientific studies appear to
confirm Hamilton™s suspicions regarding hyaluronic acid. The destruction of hyaluronic acid
would explain the universal symptoms of dryness associated with Accutane use, the dry eyes,
hair, skin, and joints.

œJust as Accutane causes the drying up of secretions from the sebaceous glands, it also inhibits
the secretion from other glands as well. Accutane is not specific to the oil glands in the skin. It
dries out the whole body."

Hyaluronic acid is just another GAG.  So why would accutane destroy the ability to make this?!  just another coincidence  .....
[Edited links out]

A novel composition having strong hyaluronic acid production-promoting capability is provided. The present invention provides a composition for promoting hyaluronic acid production that comprises S-adenosylmethionine and phytic acid. The inventors solved this issue on the basis of the unexpected discovery that a composition comprising S-adenosylmethionine and phytic acid promotes hyaluronic acid production. The inventors confirmed that hyaluronic acid production is promoted by a composition that comprises S-adenosylmethionine and phytic acid, regardless of the fact that none of the components of S-adenosylmethionine and phytic acid promote hyaluronic acid production.

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cyclodextrin is in there too!! lol

So if you want to try this... its SAM-e and the supplement IP6

whoever wrote the above patent is a  moron though... methionine is what all GAGs are started from? 

FUCK!!!! WE HAVE THIS...WE JUST NEED TO FIGURE OUT THIS LAST STEP!

So can the dryness effects be treated/band aided with a really good hyaluronic acid supplement (or any arthritis supplement) ?

I remember a guy here trying a supplement callad "baxyl",that is like a liquid form of hyaluronic acid or something like that, and having succes with it,or at least some relief.

Did anyone else tried this ? Or recommend a supplement,at the very least?

(link to the supplement https://cogentsolutionsgroup.com/products/baxyl )

@tryingtohelp2014Just paste the significant parts of the study, not the full thing. 95% of the people reading the thread just has to scroll past it. You can rather have a convo/group message on acne.org inbox with the ppl u want to share the full thing with

Interestingly enough i just got my blood test results and my serum calcium is high on a low calcium diet.
Testosterone is way above reference range as well which is really weird since im skinny as hell, its 46 with a 35 max. (40 is 1150ng/dl for you US based people)

B12 and folate way above range but thats expected considering i take a lot. Potassium low because of folate intake.

All other stuff perfect

57 minutes ago, Francopld said:

So can the dryness effects be treated/band aided with a really good hyaluronic acid supplement (or any arthritis supplement) ?

I remember a guy here trying a supplement callad "baxyl",that is like a liquid form of hyaluronic acid or something like that, and having succes with it,or at least some relief.

Did anyone else tried this ? Or recommend a supplement,at the very least?

(link to the supplement https://cogentsolutionsgroup.com/products/baxyl )

No.

32 minutes ago, Chloe123 said:

Took my first accutane pill this morning and just came across this log. I don't know what to do anymore I'm so scared now :/ wtf

Quit while you still got the chance, you can get rid of acne with other means

44 minutes ago, Relentless1k said:

@tryingtohelp2014Just paste the significant parts of the study, not the full thing. 95% of the people reading the thread just has to scroll past it. You can rather have a convo/group message on acne.org inbox with the ppl u want to share the full thing with

Interestingly enough i just got my blood test results and my serum calcium is high on a low calcium diet.
Testosterone is way above reference range as well which is really weird since im skinny as hell, its 46 with a 35 max. (40 is 1150ng/dl for you US based people)

B12 and folate way above range but thats expected considering i take a lot. Potassium low because of folate intake.

All other stuff perfect No. Quit while you still got the chance, you can get rid of acne with other means

wow super high testosterone? you're libido is dead? I on the other hand have levels of about 400 and im 21. Doctor doesn't want to do anything about it but i'm miserable. thinking about ordering online.

and yes I have tried every single possible way to get it up naturally. And the test was first thing in the am on a fasted state.

2 hours ago, Francopld said:

I remember a guy here trying a supplement callad "baxyl",that is like a liquid form of hyaluronic acid or something like that, and having succes with it,or at least some relief.

taking oral hyaluronic acid doesnt work. many have tried. your body cant absorb it. medical studies back this up. injections into the joints seem to help. you have to make it yourself internally. i just posted how to make your own?

1 hour ago, Relentless1k said:

@tryingtohelp2014Just paste the significant parts of the study, not the full thing. 95% of the people reading the thread just has to scroll past it. You can rather have a convo/group message on acne.org inbox with the ppl u want to share the full thing with

i did post the relevant paragraph. .. and im not doing private conversations. everyone needs to read this. couldve saved Chloe already.....and if its too long, and they dont want to know every possible thing that might be going wrong with them, they can skip it. their loss.

did you get a methylmalonic acid test? serum b-12 by itself doesnt confirm anything.

Two years after accutane. 135mg/kg. No pimple. No marks. Not a single pimple since.

7 hours ago, Relentless1k said:

Interestingly enough i just got my blood test results and my serum calcium is high on a low calcium diet.
Testosterone is way above reference range as well which is really weird since im skinny as hell, its 46 with a 35 max. (40 is 1150ng/dl for you US based people)

You guys talk about Testosterone what about DHT has anyone had the combination of high testosterone low DHT? I read post Tane users have a problem converting this and it could show up as low DHT which is similar to the PROPECIA users that have problems

BTW high Dose FOLATE or this supplement NADH at 10mgs dried the hell out of me and gave me a limp D*ck(this shit better come back). not sure which one did it yet so a caution to anyone trying these supplements.
That being said if it was the FOLATE maybe it antagonised something and this could be looked into as a cause for some of our problems.

On 1/27/2016 at 4:16 AM, guitarman01 said:

You guys talk about Testosterone what about DHT has anyone had the combination of high testosterone low DHT? I read post Tane users have a problem converting this and it could show up as low DHT which is similar to the PROPECIA users that have problems

 

My free testosterone is low-ish, but DHT is quite high, near the top of the reference range. Some others have seen the same.

Also someone on the ATM forum has posted up the 2 recent finasteride recoveries, both of which are quick recoveries following the same protocol, which is the antibioticmetronidazole, along with a diet excluding sugar. Worth keeping an eye on..

Quote

1. Random guy recovers: "The antibiotics that cured me were metronidazole (500mg 3x a day for 10 days) and paromomycin (1,000mg 3x a day for 5 days). Relief came pretty quickly--I felt 90% on top of the world by day three.
He also states that he has a zero-sugar diet, took things like HumaWorm and ParaGone and Lactoferrin prior to taking the antibiotics.
http://www.curezone.org/forums/am.asp?i=2276109

2. Another guy replicated this recovery: "This person says he took - metronidazole (500mg 3x a day for 10 days) and paromomycin (1,000mg 3x a day for 5 days) and was cured. So I went to my doctor and requested to be put on this same treatment, and sure enough, just like the poster I felt completely cured physically, sexually and mentally, night and day difference. I did the exact dosing as above and didn't start the paromomycin until the 7th day. So metroni (flagyl) 500 mg 3x a day for 10 days and on the 7th day I started paromomycin for five days straight and ate NO SUGAR to avoid feeding whatever it is that was in me. I felt better after about day 8 or 9. I should also add I was taking high doses of probiotics of the entire duration and still am, most doctors will recommend this with antibiotic treatment.

He also states the he took tons of probiotics like PrescriptAssist and VSL3 during and after as well as a low-sugar diet.
http://solvepfs.com/viewtopic.php?f=11&t=930

Link to the atm forum;

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