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Got blood tests back... the only thing out of range was DHEA, and it was too high. 442! I read through some of the earlier posts and many of you guys had low DHEA and were worried about that. Many other people online with high DHEA had hair loss, too.
Your adrenal glands produce DHEA! High DHEA can be a sign of Poly Cystic Ovarian Syndrome, Tumor on the Hypothalamus/adrenals or some type of adrenal dysfunction /disorder like hyperplasisa (?) Cushing's usually is both high cortisol & DHEA. Some with Thyroid disorders and soo on.....
What other labs or work up have they done, or let me guess they are blowing off the high DHEA levels????
Your adrenal glands produce DHEA! High DHEA can be a sign of Poly Cystic Ovarian Syndrome, Tumor on the Hypothalamus/adrenals or some type of adrenal dysfunction /disorder like hyperplasisa (?) Cushing's usually is both high cortisol & DHEA. Some with Thyroid disorders and soo on.....
What other labs or work up have they done, or let me guess they are blowing off the high DHEA levels????
Nope, I got an ultrasound two days ago to check for PCOS. I really don't think I have it, since my periods, weight, cholesterol, etc... are all normal. The only symptoms I would have are hair loss, excess facial/body hair, and hormonal acne.
I'll know in two weeks if I have PCOS. If I don't, I have a feeling they're going to put me on spiro, which I've done a good amount of research on.
dhea is not bad in the regular amounts. It regulates many things, and plays an important role in your hair/skin and sex drive etc. But if its out of range in females it can cause issues. I had high DHEA in my blood tests due to pcos, was put on metformin by my endo, she said it would lower it but then my acne got WORSE and i read that metformin can INCREASE DHEA which is why my acne was getting bad.
I took some saw palmetto and it did help lower it from 557 to 273 in 3 months. I am now off the metformin but i take BCP.
If females have high DHEA its not good for the skin, you can also test for andrenal hyperplasia but it has to be WAYYYY off the endo said, like, in the 3000+ range.
Your adrenal glands produce DHEA! High DHEA can be a sign of Poly Cystic Ovarian Syndrome, Tumor on the Hypothalamus/adrenals or some type of adrenal dysfunction /disorder like hyperplasisa (?) Cushing's usually is both high cortisol & DHEA. Some with Thyroid disorders and soo on.....
What other labs or work up have they done, or let me guess they are blowing off the high DHEA levels????
Nope, I got an ultrasound two days ago to check for PCOS. I really don't think I have it, since my periods, weight, cholesterol, etc... are all normal. The only symptoms I would have are hair loss, excess facial/body hair, and hormonal acne.
I'll know in two weeks if I have PCOS. If I don't, I have a feeling they're going to put me on spiro, which I've done a good amount of research on.
Regarding cholesterol read this , it' not cholesterol we have to worry about rather inflammation.
http://www.naturalnews.com/037105_cholesterol_myth_heart_health_diet.html
dhea is not bad in the regular amounts. It regulates many things, and plays an important role in your hair/skin and sex drive etc. But if its out of range in females it can cause issues. I had high DHEA in my blood tests due to pcos, was put on metformin by my endo, she said it would lower it but then my acne got WORSE and i read that metformin can INCREASE DHEA which is why my acne was getting bad.
I took some saw palmetto and it did help lower it from 557 to 273 in 3 months. I am now off the metformin but i take BCP.
If females have high DHEA its not good for the skin, you can also test for andrenal hyperplasia but it has to be WAYYYY off the endo said, like, in the 3000+ range.
So the saw palmetto helped lower it form 557 to 273 in three months wow that is great . I cycle it once per year and usually take it for a couple of
months , it has done wonders for my hair loss.
Well, I connected the dots as to why going low oxalate may be helping me.
High DHEA = higher sensitivity to oxalates. There have been studies.
I don't think the dietary changes are enough, though... I want to try dexamethasone to lower my levels.
All over the internet, people with high DHEA have tried it and their levels have dropped and their hair loss has gone away...
On 4/7/2013 at 8:00 PM, IndigoRush said:I have low cortisol/ high DHEA, but I'm not sure really what that indicates.
This was from my test over a year ago.
If it was a tumour, it didn't kill me yet [Edited image out]
Another piece to add to the puzzle.
Low cortisol and high DHEA can be related to hypothyroid and or adrenal fatigue, in which hypothyroid causes adrenal fatigue
my only symptoms of pcos was hormonal acne, slightly irregular periods, used to be over weight, and cysts on ovaries on scan and imbalanced LH:FSH ratio.
I never had anything else, no raised cholesterol etc. I still suffer the symptoms, and i lost a lot of weight, my waist measures in at 24 and i still had the symptoms so i take the pill. There are a lot of slim ppl with it too.
My DHEA is elevated as well, a bit over 1000. Adrenal/pituitary gland malfunction might cause that. Worth checking out.
Thyroid was next on my list and turns out I have seronegative (no elevated antibodies) hashimoto thyroiditis. A sonogram is necessary for this diagnosis, blood levels don't suffice. Started taking low dose thyroxin today. I'll see how that goes.. if it doesn't work, then I'll check adrenals/pituitary gland and probably take hydrocortisone and/or try rhodiola&ashwaganda.
I'm also seeing a kinesiologist but not 100% sure that's legit 
How bad is your hairloss at this point?
Is your hair completely dead and drive out also?
Is it regrouping at all and are the new hairs finer and un pigmented?
Well... it's hit and miss. I have some good days where I only lose a couple of hairs (like I used to!) and some days where it's bad. Not really clumps anymore, but a fair amount. I haven't been counting hairs. It's all in the dumping process of going low oxalate: my body is expelling the stored oxalate. Cutting out these supplements may help me-- I only just learned about that this morning. So many pieces to the puzzle!
My hair's getting thinner and thinner... I kind of want to cut it off to pixie again. I've noticed regrowth around my forehead under my bangs-- hairs that are a little finer than normal, but my natural color. I'm not really seeing any baby hairs/vellus hairs/transparent hairs. I'm lucky for that.
Now I've just got to keep on with the low oxalate and wait the 2 weeks until the doctor puts me on something that will help me...
Well expect more to pop up on this thread! They just approved and new generic will be hitting the U.S. Market! http://technews.tmcnet.com/news/2013/03/29/7025846.htm
Well expect more to pop up on this thread! They just approved and new generic will be hitting the U.S. Market! http://technews.tmcnet.com/news/2013/03/29/7025846.htm
Zenatane a fancy name for POISON , er chemotherapy , Big Pharma has to make more money I guess , there handing this stuff out to
teenagers and young adults like candy , due to our
diligence not so many will take isotretinoin now , the word is out , I don't think any of us had cancer hmmm....
I read a study a while back asking doctors themselves in the U.K if they or a family member had cancer
would they opt for chemotherapy a amazing 75% said they would not take chemo to treat there cancer. And treat there cancer with
alternative methods , I guess the docs know how toxic chemotherapy is to the body .
here is the definition of Chemotherapy.
Chemotherapy (often abbreviated to chemo) is the treatment of cancer with one or more cytotoxic antineoplastic drugs ("chemotherapeutic agents") as part of a standardized regimen. Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. It is often used in conjunction with other cancer treatments, such as radiation therapy or surgery. Certain chemotherapeutic agents also have a role in the treatment of other conditions, including ankylosing spondylitis, multiple sclerosis, Crohn's disease, psoriasis, psoriatic arthritis, systemic lupus erythematosus, rheumatoid arthritis, and scleroderma.
Traditional chemotherapeutic agents act by killing cells that divide rapidly, one of the main properties of most cancer cells. This means that chemotherapy also harms cells that divide rapidly under normal circumstances: cells in the bone marrow, digestive tract, and hair follicles. This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss).
Here is a scientific article about the isotretinoin mechanism. I came across this section:
"In fact, all isotretinoin-mediated effects on sebocyte apoptosis, sebaceous lipogenesis, anti-inflammatory activity, downregulation of ROS can be explained by upregulation of nuclear levels of FoxO transcription factors. All isotretinoin-induced adverse effect on hepatic glucose and lipid metabolism, retinoid-induced dyslipoproteinemia, loss of bone density, myotoxic effects, mucocutaneous side effects, adverse psychiatric effects, chemopreventive effects and isotretinoin's teratogenicity appear to result from a common mechanism, i.e., FoxO-mediated changes of gene expression. In contrast, increased insulin/IGF-1 signaling of puberty and western diet due to high glycemic load and consumption of insulinotropic milk and milk products downregulates nuclear FoxO levels and thus promotes the development of acne."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/
So in my own words: Isotretinoin upregulates FoxO transcription factors. A high glycemic load and milk products downregulates nuclear FoxO levels. Would this mean, that the consumption of milk, milk products would help to overcome the longterm ISO side effects? Can it be so simple?
Here is a scientific article about the isotretinoin mechanism. I came across this section:
"In fact, all isotretinoin-mediated effects on sebocyte apoptosis, sebaceous lipogenesis, anti-inflammatory activity, downregulation of ROS can be explained by upregulation of nuclear levels of FoxO transcription factors. All isotretinoin-induced adverse effect on hepatic glucose and lipid metabolism, retinoid-induced dyslipoproteinemia, loss of bone density, myotoxic effects, mucocutaneous side effects, adverse psychiatric effects, chemopreventive effects and isotretinoin's teratogenicity appear to result from a common mechanism, i.e., FoxO-mediated changes of gene expression. In contrast, increased insulin/IGF-1 signaling of puberty and western diet due to high glycemic load and consumption of insulinotropic milk and milk products downregulates nuclear FoxO levels and thus promotes the development of acne."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/
So in my own words: Isotretinoin upregulates FoxO transcription factors. A high glycemic load and milk products downregulates nuclear FoxO levels. Would this mean, that the consumption of milk, milk products would help to overcome the longterm ISO side effects? Can it be so simple?
Another piece of the puzzle , thanks for the info.
Here is a scientific article about the isotretinoin mechanism. I came across this section:
"In fact, all isotretinoin-mediated effects on sebocyte apoptosis, sebaceous lipogenesis, anti-inflammatory activity, downregulation of ROS can be explained by upregulation of nuclear levels of FoxO transcription factors. All isotretinoin-induced adverse effect on hepatic glucose and lipid metabolism, retinoid-induced dyslipoproteinemia, loss of bone density, myotoxic effects, mucocutaneous side effects, adverse psychiatric effects, chemopreventive effects and isotretinoin's teratogenicity appear to result from a common mechanism, i.e., FoxO-mediated changes of gene expression. In contrast, increased insulin/IGF-1 signaling of puberty and western diet due to high glycemic load and consumption of insulinotropic milk and milk products downregulates nuclear FoxO levels and thus promotes the development of acne."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/
So in my own words: Isotretinoin upregulates FoxO transcription factors. A high glycemic load and milk products downregulates nuclear FoxO levels. Would this mean, that the consumption of milk, milk products would help to overcome the longterm ISO side effects? Can it be so simple?
Here is a scientific article about the isotretinoin mechanism. I came across this section:
"In fact, all isotretinoin-mediated effects on sebocyte apoptosis, sebaceous lipogenesis, anti-inflammatory activity, downregulation of ROS can be explained by upregulation of nuclear levels of FoxO transcription factors. All isotretinoin-induced adverse effect on hepatic glucose and lipid metabolism, retinoid-induced dyslipoproteinemia, loss of bone density, myotoxic effects, mucocutaneous side effects, adverse psychiatric effects, chemopreventive effects and isotretinoin's teratogenicity appear to result from a common mechanism, i.e., FoxO-mediated changes of gene expression. In contrast, increased insulin/IGF-1 signaling of puberty and western diet due to high glycemic load and consumption of insulinotropic milk and milk products downregulates nuclear FoxO levels and thus promotes the development of acne."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/
So in my own words: Isotretinoin upregulates FoxO transcription factors. A high glycemic load and milk products downregulates nuclear FoxO levels. Would this mean, that the consumption of milk, milk products would help to overcome the longterm ISO side effects? Can it be so simple?
That would tend to explain why a yoghurt + meat diet is the only way I can survive.I'm functional, social outings and tutoring engagements lined up for next week. Had to add back in scallops after hitting micronutrient deficiency (too dizzy to stand for most of day), but the scallops straightened that right out. No gut rejection reaction to them. So 1L yoghurt + free range low fat meat + 5 quarter-sized scallops per day is my formula. Plus UDCA. Not even taking digestive enzymes now. And smoking of course, which upregulates glutathione, but nobody wants to hear about that.Next experiment, trying skim milk to see if I can make further gains. Right now I'm just "ok" most of the time. Not superman, healthwise. But it's a consistent "ok". Keeping on top of my work and self tracking. Which is a huge improvement.
Just wondering Joseph how many mg total did you take of the poison????
I hope that's true. I've been eating dairy like crazy since it's allowed on my diet, and calcium actually impedes oxalate absorption. I douse almost everything with parmesan cheese and love Greek yogurt smoothies.
Actually, I think the times my hair loss was the worst was when I was trying some kind of modified paleo... not for me!