I suffered from mild acne as a pre-teen/teenager with some moderate cystic acne here and there, but it was totally manageable with spot treatments and OTC face cleansers. Around age 21/22, my face erupted with cystic acne. My jawline was often covered with extremely sensitive, inflamed cysts. I would break out during ovulation and then again during PMS (so about every week and a half). So as soon as one breakout would even start to clear, another one would start.Birth control didn't help (may have in fact made it worse) and topical treatments did absolutely nothing. Antibiotics would help for short periods, but this is NOT a long-term solution. I came across reviews for DIM and did not have high hopes, but was willing to try everything. I use Nature's Way DIM-plus Estrogen Metabolism formula (https://www.amazon.com/gp/product/B0009F3RP6/ref=oh_aui_detailpage_o00_s00?ie=UTF8&th=1). I take the recommended 2 capsules, twice a day for intensive use. After just a month, my jawline was starting to clear and no new cysts were appearing with ovulation or PMS. If anything did pop up, it would be one or two cysts maximum (which to some, may be a terrible breakout, but to me, was a drastic improvement). It has now been about 4-5 months since I started taking this supplement and I plan on continuing. After another 3-4 months, I plan on reducing to 1 capsule twice a day so as not to take the intensive dose. I highly recommend for anyone suffering from hormonal cystic acne (especially if you're on birth control). This has been a total life changer!!