Onexton : Clindamycin Phosphate (1.2%) and Benzoyl Peroxide (3.75%) Gel

9 Reviews

Active Ingredients:
Each gram of ONEXTON Gel contains 12mg Clindamycin Phosphate (1.2%), equivalent to 10 mg (1%) Clindamycin, and 37.5mg Benzoyl Peroxide (3.75%).

Inactive Ingredients:
Carbomer 980, Potassium Hydroxide, Propylene Glycol, and Purified Water.

The list of ingredients above is provided for informational purposes only. Always check the actual product label in your possession for the most accurate ingredient information due to product changes or upgrades that may not yet be reflected on our web site.


Used Onexton : Clindamycin Phosphate (1.2%) and Benzoyl Peroxide (3.75%) Gel? Rate It:

Choose from 1 to 5 stars
April 2, 2023
Love It. Game Changer for Me
For me, this was a game changer! I've had acne as my sad companion since my late teens (now 45). I've done three rounds of accutane, in which the last round did not clear it. Two months later I was out back on spironolactone (which never clears me completely on its own but helps) and onexton cream. The combo has kept me clear the last three years. Just a pimple here and there, which I'm completely okay with compared to past! If I feel one coming I just make sure to put a bit extra cream on that spot and dries up so fast. I use it all over face once at night.
January 2, 2018
Working for adult acne
History - I'm in my mid 30's and have been struggled with breakouts since my early teens. I've tried everything known to man and most of it works for a little then stops working and then i'm on to the next thing. I finally went to a dermatologist again and gave her my history, I told her that the only time I have clear skin is when i'm on antibiotics (if I have an ear infections, tonsillitis, etc). She gave me a bunch of samples of Onexton, it's been 3 weeks and it's still working!!!! I have very sensitive combination skin (more on the dry side in the winter). The few pimples that I am still getting are not painful and they seem to come to the surface and then go away in a day. Current routine: shower at night and wash face with an exfoliating washcloth with Cetaphil antibacterial bar, then I apply a SMALL amount of onexton to my problem areas only, once it's dry I use my night cream (burts bees sensitive night cream). In the morning I wash my face with my hands in the sink with the Cetaphil antibacterial bar, apply my day cream (burts bees sensitive skin day cream), and then apply my makeup/cover up. I hope this continues to work and that it works for others!
December 9, 2017
Didn't do anything for me, increased skin sensitivity
I was extremely excited to receive this product from my dermatologist in early September! My acne wasn't severe, just a few pimples spread out across my cheeks and a patch near my hairline on the right side of my face. The morning after initially applying it, the skin on my cheeks became very inflamed and sensitive. I continued using it and saw no results, it didn't make me break out any worse but it surely didn't help at all. If you're looking for a topical, I'd go with Epiduo. It worked well for me as a spot treatment for about a year before stopping, and I'm pretty sure that wasn't even related to me growing immune to it. Onexton was just too harsh on my skin and didn't give me any positive results.
March 25, 2017
worth a try!
This stuff really does clear up your skin! As soon as I started using this, I noticed my skin was clearer the very next day. You gotta give it at least 2-3 months for it to really kick in. Highly recommend using a good moisturizer cause this stuff will dry your skin out! Also caused my skin to be somewhat flaky :/ but really did clear things up.
March 16, 2016
Starting today, will update
About a year and a half ago I started on minocycline and aczone. This cleared my face like no other! But I've decided recently to start family planning, so I thought it best to discontinue the minocycline. I've broken out into a million black heads across my forhead and chin. along with about 10 or so white heads. I've yet to get any cyctic since i started the aczone, so i'm hoping this will clear up the remaining and keep the white heads from getting so inflamed. I was on Duac years ago but the BP content was higher and dried my skin out. WEEK ONE: Across my face all the pimples are healing and no longer inflamed. Nothing really new popping up, besided two really small white heads. once i popped them, couldn't even see them. skin is tight but no dry patches Morning:onexton +acuzone+philosophy clear days a head moisturizer + clinique dramatically different gel Night:onexton +acuzone+philosophy clear days a head pads+ clinique dramatically different gel
This Was Helpful

2 user(s) found this helpful

January 28, 2017
I take spironolactine...50 mg morning and 50 mg at night. No bad side effects
December 27, 2015
Onexton--great results
I have been fighting cystic acne for over ten years now. They are terrible on my chin. I have tried numerous topical products that only worked as bandaids. The only thing that actually got rid of my cysts were the cortisone shots I received in my derm's office. I have been on this product for a month now, and I am seeing great results. It keeps my skins, for the most part, even. One can never expect perfection, especially if his/her acne is caused by hormones and hair growth, but the Onexton actually got rid of a cyst in three days. That is amazing! I know my derm wants me to take oral medication, but I refuse. (In fact, if you use oral meds and love it, please let me know which one (other than birth control) you use.) My cystic acne, I am sure, is more hormonal as opposed to environmental. The side-effects to those oral meds ( I have read) are overwhelming. And although my acne causes me a lot of stress, I am determined to find alternative methods. So far, Onexton has been a great method. I also use a strict cleansing regime of Skinceuitcal products every morning and night. I also clean my make-up applications (sponges) DAILY. As far as how I used it: I started off small, and I recommend you doing this. I put a small amount only on part of my chin where I get the cysts. I wanted to see how my skin reacted to the gel. I did this twice daily. I followed with a great moisturizer (Dermological) to help with the drying. I then moved to the areas around my nose, and now (a month later), I'm using it on my entire face. It gets red at first, but then quickly dissipates. I don't expect this to work forever as I'm convinced that skin builds a tolerance, but for now, it's a great product. Give it a try!
This Was Helpful

6 user(s) found this helpful

August 20, 2015
Best Treatment Tried!
My son has had persistent mild to moderate acne for a few years now. He has tried numerous things and nothing has ever really worked. He recently saw a new derm, who recommended Onexton. And so far, it's amazing! His skin looked better within days and now at one month, he has no active acne. Previously, he had tried Retin A, Tazorac, the regimen, Finacea, salicylic acid, glycolic acid, and they either didn't work at all, or only gave minimal improvement. Onexton really works!
This Was Helpful

5 user(s) found this helpful

July 10, 2015
I used every Rx thinkable in the last 2 years. Tomorrow marks 5 weeks on this drug and nothing has worked this well. I have 1 or 2 stragglers here and there but that's its. 1 full coverage before work, it dries clear, spot treat at night. I'm washing with ceravae once a day and use retin-A .25 before bed. It's expensive and there's a generic, which I used for a year, so your insurance will probably argue with you over it. Luckily I was able to get it approved and had a manufacturers coupon so it was affordable. But it is worth the money. No idea why it works better than the generic but it does. Get this drug. You won't be sorry.
This Was Helpful

5 user(s) found this helpful

June 4, 2015
This drug is a miracle. I have tried everythinggggg...even acutane. Acutane cleared my skin but approx. 6months after using that drug I started to break out again. Onexton cleared my skin incredibly fast and cleared my skin better than acutane did. I HIGHLY recommend this drug
This Was Helpful

8 user(s) found this helpful

July 7, 2015
Hello, I've been on onexton as well as Tazorac for 3 weeks now. And my skin has gotten incredibly worse than when I had first started. I'm curious... Did you experience this? Did your skin have a bad "purge"?
September 11, 2015
Tazorac and other retnoids like differin and retin-a make my skin break out like crazy! They're terrible for me. Maybe stop that and see what happens because I've heard only good things about onexton. I just got my prescription today so hopefully it works!