thetruth24

Listener,   I think the reason people suffer from those side effects is because, like you said, the dosage is too high. Ask people who took really lose dosage accutane. Most if not all, experienc...

Jemini,   Here is what I am taking for adrenal fatigue.     Thats a pretty interesting theory. So maybe acne is just another "side effect" of a larger genetic predisposition?   I ...

OK for everyone!   What do you guys think about adrenal disorders and acne?   Someone in this forum said taking adrenal fatigue support supplements helped him get rid of his acne.   T...

Autonomous,   Me too! Since I've learned that it has something to do with the RXR receptors, I've been thinking about the significance of it, and the roles it plays in the pathogenesis of acne. ...

It's crazy though, that there are so many ideas of why we get acne, what causes excess sebum and what causes hyperkeratinization.   I guess the main stay of belief for the cause of excess sebum i...

Thanks for the advice Jemini.   The thing though, is that I am very interested in medicine. I would like to go into research, but as you stated, that is too many years to be in school. My family ...

Thats some great research Autonomous! Thanks for sharing.   I thought though, that PPAR alpha maybe the downregulated receptor, while gamma and delta were working "regularly". Earlier in this thr...

Jemini,   Really? Thats EXACTLY what I want to do. I wanna become a pharmacist, and I know that a strong grasp on chemistry and biology is needed. In you're opinion, is it difficult? What kind of...

Autonomous,   Man, I find all that stuff very interesting! I dream about curing all kinds of diseases!

Sounds Good Listener! Ill keep you updated!   Damn, 10 grams?! How many pills is that?

Jemini,   Haha, damn, do you have a degree in this field of something?! All you're rationales are very logical and are things I would have never thought about. I'll be going to college in the fal...

Listener,   Hmmm, thats strange. On Testosterone's website, it says it does the opposite. Its suppose to support testosterone. I've been taking it for a 4 days now, nothing to report. Ill continu...

Jemini,   Thanks for clearing that up for me.   Actually, I am into lifting weights, and I see alot of guys who juice with clear skin. It makes sense though, that stimulating any kind of ho...

Today was the third time I took Chlorophyll. (Chloro Combo)   I mix it with orange juice and drink 1 cup in the morning and 1 cup at night. It really helps with bowel movements and it feels like ...

Jemini,   Thats some real interesting thinking!   What exactly are the metabolites of isotretinoin? Would taking something with a higher affinity for the RXR receptors have the saem effect ...

Here's a little tidbit about androgens and ppars     Sebocyte Glands   Activation of PPARgamma and PPARalpha by their respective specific ligands, thiazolidinedione, rosiglitazone and ...

That was a very informative and sorta fun watch! Thanks for sharing.   I went to Vitaminshoppe today to pick up some Cholorophyll and ended up getting something called the Cholor-Combo.   It...

Ahhh alright, thanks for clarifying that up a bit.   Just to be straight, when 13 cis retinoic acid binds to RXR, the cells become stable and the life and death cycle is returned to normal?  ...

Autonomous,   That is indeed very interesting!   "Structural analyses of material in active fractions pointed to the saturated diterpenoid phytanic acid, which induced RXR-dependent transcri...

Hey Guys,   I came across this very interesting study on acne and androgens.   It is a very long read, but well worth it.  

Autonomous,   That we will never know. I am just speaking from anecdotal experiences. My friend for example, had very bad acne for about 2-3 years of high school. All of a sudden, when he hit 18 ...

That is very interesting Jemini.   But I still can't understand then, why people outgrow acne. Do these PPARs naturally stabilize? Some people on accutane, I believe 50% are cured after one cours...

I know I probably stated this before, but on wikipedia it says:   "All PPARs dimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes."   Correct m...

Ahhh alright, gotcha!   So basically chlorophyll, fish oil, berberine and possibly resveratrol as natural supplements.   I think the reason this stuff would work better topically as because...

Thanks Jemini!   Would you mind joining the Resveratrol discussion? We are discussing exactly whats going on with PPARs and the different receptors.   It is suggested that the alpha receptor...