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Possible Side Effects Of Spiro--Weight Gain, Depression, Muscle Pain? Am I Alone? (Read On Please) I know what you are going thru. I started Spiro in Sep 2011 on 25mg. Within a week, my skin became less oily. Within a month, I had considerably less zits. At two months, my skin was nearly perfec... | In forum Hormonal acne | 13 years ago |