I use make-up in ALL of my times using the regimen... except those two weeks where I had make-up on twice because I was really sick. Your skin/acne will take a lot longer to heal because you are using other products other than just having the regimen on your face and leaving it be for the rest of the day.I would recommend using a primer before putting all that make-up on so your skin is more likely to be protected of irritation from make-up. If you want to be very careful and precise of what make-up you should use, visit this link to help yourself. https://www.acne.org/makeup-acne.html