BocaBurgler 0 Share Posted November 6, 2004 the first day i took accutane, i experienced lethargy, drugged feeling, and slight confusion. Im not worried, i just dont think my body is use to this medicine at all. I even noticed a difference with my skin on the first day. I got a few small zits, which healed much faster than usual. I just hope i dont have a bad break out.anyone else notice similar effects while taking accutane? Quote Link to post Share on other sites