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s.m.

Question. Low dose accutane for 6 months + ?

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Hello, I'm currently on a 10 mg course. I was wondering if any members had any experience taking low dose, 10-20 mg for more then 6 months.

I'm considering the idea of extending my course to about 8 months.

Has anyone had any experience taking accutane 10-20 mg for more then 6 months ?

Input very much appreciated.

Thanks

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the idea of accutane is to have it saturate your body (reach a certain mg/kg) over a short course so you have a high chance of complete remission. I doubt 8 months at 10mg would reach a cumulative dose enough to give you the same chances of long-term remission as a higher dose would unless your unbelievably slim.

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Back to work !

I would be very grateful for any input from actual low dose users !

ISOTRETINOIN THERAPY IN ACNE VULGARIS: A 10-YEAR RETROSPECTIVE STUDY IN SINGAPORE

MOHAMMED SHAHIDULLAH, M.B.B.S., D.D.V. 1 , SIEW NEE THAM, M.MED. 1 , CHEE-LEOK GOH, M.R.C.P. (UK) 1

1 From the National Skin Centre, Singapore.

Address for correspondence: A/Professor Chee-Leok Goh, M. R.C.P. (UK), Medical Director, National Skin Centre, 1, Mandalay Road, Singapore 1130.

Background. The use of isotretinoin, a first generation synthetic retinoid, in the treatment of patients with severe acne vulgaris was a major therapeutic advance in dermatology. This 10–year retrospective study reviews the effectiveness of isotretinoin in patients with acne vulgaris seen in a skin clinic in Singapore.

Methods. The case records of 250 cases of severe inflammatory and nodulocystic acne treated with isotretinoin were analyzed with reference to the demographic data, response to isotretinoin, dosage and cost of isotretinoin used, adverse effects, clinical follow-up, and relapse.

Results. Two hundred and fifty patients, 171 men (68.4%) and 79 women (31.6%), with different types and grades of acne vulgaris were studied. The dose of isotretinoin used ranged from 0.33 to 1.0 mg/kg/day (median 0.5 mg/kg/day) for a period ranging from 1 to 12 months (median 4 months). Response was excellent in 127 (50.8%) patients, good in 86 (34.4%), fair in 30 (12.0%) and poor in 7 (2.8%). Relapse occurred in 14 (5.6%) patients over a 6–month follow-up period. Adverse effects were noted in 140 (56.0%) patients and were mild in most cases. Eighteen (7.2%) patients had to discontinue the drug due to significant side effects.

Conclusion. This study confirms that isotretinoin is very effective for severe acne, and complete remission can be induced in more than 90% of cases even with lower dosage regimens. Significant clinical improvement can be achieved with the use of lower doses (mean 0.5 mg/kg/day) for an average of 4 months of treatment with lower risk of adverse effects.

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Ive been on a course of 10mg a day for almost 18 months with around 3 1 or 2 month breaks during this period.

It keeps me completely clear of actives but whenever I come off it the acne starts to come back. I've recently lowered my dose to a weekly 10mg maintainance dose aswell as make some drastic dietary changes and started taking certain supplements to try and stop the acne from coming back

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Ive been on a course of 10mg a day for almost 18 months with around 3 1 or 2 month breaks during this period.

It keeps me completely clear of actives but whenever I come off it the acne starts to come back. I've recently lowered my dose to a weekly 10mg maintainance dose aswell as make some drastic dietary changes and started taking certain supplements to try and stop the acne from coming back

Joe , if you don't mind me asking , how severe was your acne before you started accutane ?

how bad was your acne when it came back during the 1-2 month breaks ?

how much do you weigh and what is your height ?

how has the weekly dosage been working out for you ? side effects from weekly dosage ?

Bottom line is, make sure you reach your cumulative dose.

i have read many studies that suggest reaching a cumulative dose isn't necessary for full remission. one of which i posted above

Edited by s.m.

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Joe , if you don't mind me asking , how severe was your acne before you started accutane ?

It was extremely severe at one point, and then became moderate/severe when I started accutane

how bad was your acne when it came back during the 1-2 month breaks ?

Not as bad as before but I felt that if I stayed off tane any longer it would come back perhaps even full blown

how much do you weigh and what is your height ?

5'11 and about 150lbs

how has the weekly dosage been working out for you ? side effects from weekly dosage ?

The weekly dosage is working ok, but Ive also changed alot of things including taking a whole bunch of supplements, and also changing my diet (no dairy,gluten or sugar) so its hard to tell what is working. The side effects are pretty much non existent, but my dry skin is still here, and I think it will be dry until I compeltely stop accutane altogether.

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