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Acne's stage1: "Abnormal Keratinization"

I Knew it! I knew all that bs about excess sebum was wrong! I always noticed this buildup of flakiness on my skin, and I'm not at all oily. I don't think oil is the problem but rather an exacerbating factor that contributes to the plug.

That's why sulfur helps I guess, it increases cell turnover so skin cells don't have enough time to get stuck.

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I Knew it! I knew all that bs about excess sebum was wrong! I always noticed this buildup of flakiness on my skin, and I'm not at all oily. I don't think oil is the problem but rather an exacerbating factor that contributes to the plug.

That's why sulfur helps I guess, it increases cell turnover so skin cells don't have enough time to get stuck.

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I Knew it! I knew all that bs about excess sebum was wrong! I always noticed this buildup of flakiness on my skin, and I'm not at all oily. I don't think oil is the problem but rather an exacerbating factor that contributes to the plug.

That's why sulfur helps I guess, it increases cell turnover so skin cells don't have enough time to get stuck.

well the stuff about sebum isn't wrong, if there wasn't seebum there wouldn't be acne. but abnormal keritinization is the main issue, and that is what retinoids correct.

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Its also the composition of the sebum that allows the skin cells to help klump together as well, so you may not be very oily, yet you still form plugs so it can be the quality not the quantity. But acne is always a combined result of skin cells and sebum, but some cases could be more one then the other.

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The thing is my skin is very dry in that there's not much oil at all, so i always wondered why there was so much emphasis on over production of sebum when in my case it seemed more like too much flakiness is plugging my pores. I know no one's skin is 100% oil free, that would be a serious skin disease, and there has to be enough oil for the cells to stick together to cause acne, but I know I don't have excess sebum. My point being, all these threads trying to find cures by reducing oil production just wouldn't work for me, whereas, i think if the keritinization problem was addressed, most people's acne would be taken care of. Hence why vit A, retinols, accutane work..not by reducing oil, but by increasing cell turnover. So the emphasis needs to be more on cell turnover rather than on oil production. I've seen some oily people with no acne, I don't think oil is the problem.

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I Knew it! I knew all that bs about excess sebum was wrong! I always noticed this buildup of flakiness on my skin, and I'm not at all oily. I don't think oil is the problem but rather an exacerbating factor that contributes to the plug.

That's why sulfur helps I guess, it increases cell turnover so skin cells don't have enough time to get stuck.

well the stuff about sebum isn't wrong, if there wasn't seebum there wouldn't be acne. but abnormal keritinization is the main issue, and that is what retinoids correct.

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Everyone's right here. :P

Oil contributes to inflammatory and comedonal acne but of course it is not the only factor in the genesis of acne. If the pores didn't get clogged up with dead skin cells and sebum there would be no acne. The viscosity of the sebum plays a great role, too, although a person with normal sebum and abnormal keratinization will likely also have acne. Both play a part.

The retinoids and AHA products do feel to me that they improve the viscosity of the sebum while also exfoliating the skin, normalizing keratinization, and thus keeping the acne at bay.

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Well this has always kinda been the core of the problem I guess, but nothings ever been done about it. This is why I wish they could use stem cell research or something to create a treatment that corrects keratinization because, correct me if im wrong, if you dont have that problem, then all the millions of other shit that cause acne wouldn't really matter.

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I agree, without the keratin problem being oily wouldn't do anything other than make you shiny. The oil by itself isn't thick enough to clog anything. You can attest to that yourself just by feeling the oil on your own face. In order it to be thick enough, it would have to literally be solid at body temperature, which it obviously isn't. It needs the piled up skin cells building up to create the plug. Without that, there's no way to block the pore.

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Well this has always kinda been the core of the problem I guess, but nothings ever been done about it. This is why I wish they could use stem cell research or something to create a treatment that corrects keratinization because, correct me if im wrong, if you dont have that problem, then all the millions of other shit that cause acne wouldn't really matter.

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Everyone is correct here especially the karatin problem. But I dont think keratin problem is the only culprit for the pathogenesis of acne. In some cases it can also have anything to do with food sensitivities, liver problems, digestive problems, stress, hormone imbalances... that's why some women develops acne (mostly on jawline only) during their "time of the month" only. :)

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There is a keratinization problem BECAUSE of sebum. As you get older and into adolescence, sebum gets produced at a more constant pace. As more sebum is made and reaches the surface(even a little bit), it rehydrates dead skin cells not allowing them to flake off properly. This is what causes the more skin cells to build up clogging a pore.

And when the skin is stripped of its moisture by constant washing with detergents, it produces more oil. NOW WAIT. I'm not saying the skin will make extra oil. I am saying that when you take off more oil than you are supposed too, the pore is going to have to "fill up" all over again. When the skin is dried out like that, dead skin cells can get deeper in the pore. And when the glands are producing a lot of oil due to being stripped combines with the clogged pore, it can cause a pimple. The more dead skin cells, the worse the pimple.

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There is a keratinization problem BECAUSE of sebum. As you get older and into adolescence, sebum gets produced at a more constant pace. As more sebum is made and reaches the surface(even a little bit), it rehydrates dead skin cells not allowing them to flake off properly. This is what causes the more skin cells to build up clogging a pore.

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Well I'm glad to see that this article has sparked a conversation. I always had a feeling that killing Propionibacterium doesn't stop the issue of how your pores are getting clogged in the first place. If careful consideration is taken into the shape of the pore, readers would understand that various forms of topical ex-foliation can not reach deep enough inside the pores to remove the keratin blockade. Common sense tells us that no brush-bristle or micro-bead in our cleansers are small enough to ex-foliate the lining of the pores as it would the surface of the skin. According to wiki Propionibacterium "When a pore is blocked this anaerobic bacteria overgrows and secretes chemicals that break down the wall of the pore, spilling bacteria such as Staphylococcus aureus into the skin, forming an acne lesion (folliculitis)", a pore must first be 'blocked' before Propionibacterium "secretes" chemicals that break down the follicular wall break which causes inflamed acne. This tells us that in order to stop inflammation, using Benzoyl Peroxide is a great way to kill Propionibacterium but it does nothing in unclogging the pore?

Some important things to highlight according to Healthy Skin By Design:

There are three types of hair follicles that occur on the face: vellus, sebaceous and terminal. Acne only takes place in the sebaceous follicles.

Sebaceous follicles have unique aspects that make them the appropriate target for the acne process. Such as:

* The oil glands in these follicles are extremely large

* The structure of the follicle is deep and cavernous

* Large masses of horny keratinized cells occupy the follicle

Normally, the cells shedding in the follicle are "flushed" to the surface via various lipid substances ex­creted in the follicle. In those individuals who are prone to developing acne, a pecu liar change occurs in the manner and pattern in which the dead cells line the follicle. For example, the cells being produced are thicker and sturdier and thus more resistant to the normal "flushing" process of the follicle. Secondly, the cells begin to stick together forming a "kernel" of dead cells. This microscopic kernel is referred to as a microcomedone. The development of this abnormal cellular adhesion is a key factor that enables the acne process to move forward. It also appears that the normal intercellular cement that we all produce, changes in some fashion and evolves into a glue that is nearly im­possible to breakdown. As the cells stick together, they compact tightly like bricks and form a solid mass that steadily contin­ues to expand into a formidable blockade within the follicle.

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There is a keratinization problem BECAUSE of sebum. As you get older and into adolescence, sebum gets produced at a more constant pace. As more sebum is made and reaches the surface(even a little bit), it rehydrates dead skin cells not allowing them to flake off properly. This is what causes the more skin cells to build up clogging a pore.

And when the skin is stripped of its moisture by constant washing with detergents, it produces more oil. NOW WAIT. I'm not saying the skin will make extra oil. I am saying that when you take off more oil than you are supposed too, the pore is going to have to "fill up" all over again. When the skin is dried out like that, dead skin cells can get deeper in the pore. And when the glands are producing a lot of oil due to being stripped combines with the clogged pore, it can cause a pimple. The more dead skin cells, the worse the pimple.

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http://www.eyeofscience.com/eos2/english/g...dizin/haut1.jpg

01. Medical science: skin, lateral cut

Electron microscopy

A section through human skin. The skin layers, from top to bottom, are the stratum corneum (flaky, brown), composed of flattened, dead skin cells that form the surface of the skin.

The dead cells from this layer are continuously being shed and replaced by cells from the living epidermal layer below (red) The lowest layer seen here is the dermis (grey-brown, lower centre), a thick layer of fibrous connective tissue that supports and nourishes the epidermis. In the middle, a sweat gland can be seen. Coloured scanning electron micrograph, Magnification: x50."

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There is a keratinization problem BECAUSE of sebum. As you get older and into adolescence, sebum gets produced at a more constant pace. As more sebum is made and reaches the surface(even a little bit), it rehydrates dead skin cells not allowing them to flake off properly. This is what causes the more skin cells to build up clogging a pore.

And when the skin is stripped of its moisture by constant washing with detergents, it produces more oil. NOW WAIT. I'm not saying the skin will make extra oil. I am saying that when you take off more oil than you are supposed too, the pore is going to have to "fill up" all over again. When the skin is dried out like that, dead skin cells can get deeper in the pore. And when the glands are producing a lot of oil due to being stripped combines with the clogged pore, it can cause a pimple. The more dead skin cells, the worse the pimple.

LOL you should know better considering that you've been in this forum longer than others. Now give me some credible evidence/study that shows a pore will "fill up" because it's stripped by constant washing. lol I gotta see this.

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There is a keratinization problem BECAUSE of sebum. As you get older and into adolescence, sebum gets produced at a more constant pace. As more sebum is made and reaches the surface(even a little bit), it rehydrates dead skin cells not allowing them to flake off properly. This is what causes the more skin cells to build up clogging a pore.

That's wrong for a few reasons. 1: If that was true, everyone in the world would have acne, 2: oil doesn't hydrate skin cells, water does. 3: I have too little oil, very dry skin, and I have acne. 4: Plenty of people have oily skin with no acne, 5: the article says says Step 1, not Step 2.

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There is a keratinization problem BECAUSE of sebum.

I find that hard to believe for the following reasons "The production of sebum itself may not be as important as the fact that sebum is "fed on" by Propionibacterium Acnes (P acne bacteria). The P acne bacteria then excretes certain highly inflammatory by-products which add to the process." and the only time Sebum no longer functions to protect the skin is when it can no longer expel to the skin's surface to do it's job. When Sebum is trapped behind a blocked pore it only feeds the multiplying Propionibacterium, and that's when Sebum defeats it's purpose: http://www.healthyskinbydesign.com/acne.cfm

Abnormal Keratinization is not due to Sebum. However, as Wynne says "The viscosity of the sebum plays a great role, too..." and that may hold ground but I'd have to read up on Sebum viscosity.

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