Used to be on diane35. Now i use saw palmetto in conjuction with vitex. I have read that vitex is balancing the estrogen and progesteron, and the sp the testosterone levels. Generally this combo is suggested by homeopath doctors. I am several months on sp, added vitex a bit later, and now i am seeing improvment. It definately works on the pms symptoms, so i hope in acne too. I havent had a breakout for twenty days now and my period is close. I want to check on the potential breakouts for a couple of cycles to be assured. But, overall it works through time! No side effects.