I have been in orthocyclen for over a year and 75 mg of spironolactone since March. Ive seen improvement. Some months I continue to breakout mid cycle (usually between days 17-21). I do have both PCO and endometriosis. My dermatologist recommended bumping the spironolactone up to 100 mg on days 12-21 to see if that helps the mid cycle breakout. He also said if it was easier, I could just take 100 mg all month long.

Im wondering if anyone has tried bumping the dose up during certain weeks and saw improvement. I like the idea of taking more medication only when I seem to need it, but wonder if it will cause issues because of the shifting back and forth.

Thanks for any insight!