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If acne (and hair loss) are controlled by elevated dihydrotestosterone, via conversion from bioavailable testosterone by 5 alpha-reductase. Then some factor(s) most control an increased 5 alpha-reductase activity.
In women with PCOS scientist has found higher triglycerides and VLDL-cholesterol (1).
In both males and females with androgenic alopecia, scientists came to same conclusion (and also found lower HDL-C values compared to control)(2)
In acne patients some scientist found the same thing (3)
Another study was made to determine the mitochondria in acne suffers, and found that compared to control acne suffers experienced overactive mtorc1 from bad food. In the following the scientist gives his explanation how to reverse it:
"These new insights into Western diet-mediated mTORC1-hyperactivity provide a rational basis for dietary intervention in acne by attenuating mTORC1 signaling by reducing (1) total energy intake, (2) hyperglycemic carbohydrates, (3) insulinotropic dairy proteins and (4) leucine-rich meat and dairy proteins. The necessary dietary changes are opposed to the evolution of industrialized food and fast food distribution of Westernized countries."(4)
Could it be the first nail in the coffin if mtorc1 had some interaction with cholesterol?
Well several scientists has theories that it has (5) (Please be advised this study is in rodens. Other studies i could find concerning cholesterol and mtorc1 has also been done in rodents)
A lot of other scientists also think acne is caused by western food. (6) (7) (8) (9) (10) (11)
What do you think? Lower your LDL, triglycerides raise HDL and get rid of acne?
(3) http://jhs.pharm.or.jp/data/53 (5)/53_596.pdf
(6)Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults. Landro et. al.
(7)Mediterranean diet and familial dysmetabolism as factors influencing the development of acne. Skroza et. al.
(8)Diet and acne update: Carbohydrates emerge as the main culprit. Mahmood, Bowe
(9)Leucine and mTORC1/ a complex relationship
- Kayleigh M. Dodd , Andrew R. Tee
(10)Oily Skin: An Overview
- Thais H. Sakuma, Howard I. Maibach
(11)Beyond weight loss: a review of the therapeutic uses of very-low- carbohydrate (ketogenic) diets
- A Paoli et al.