I started the regimen about a week and a half ago, and I am taking spironolactone. Some ppl say that spiro can cause zits to basically harden so that when you pop it, not much comes out except a little hard white thing. I have those ALL over my face, whether it's an actual zit or just a tiny bump, those hard white things are in most of my pores. I find that with a zit if I don't get this thing out, it will just keep coming back until I do. However with the regimen I've been careful not to touch or pick at my face... So if I don't pop them and get those out, where the hell do they go? If it's a regular zit I understand it would dry up but these things are really hard and definitely don't seem to be going anywhere. I just wish my pores would go away!! ;(