Hi guys, i'm really surprised not to read any stuff about this new cream that's currently in its testing phase. Produced by a research lab called 'Novan', here are a couple of articles (you can find plenty of press releases on it from the last couple of months).
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How it works (white paper).pdf file
Obviously it's a little way to go on it's testing yet, and I can think of one or two instances where I've seen drugs companies develop acne meds and then never release them to market - but with the pressure mounting against Accutane you never know this could be the time. Keep your fingers crossed that it goes well, it's time that modern medicine sorted this acne cr*p out once and for all!
I wish I knew a way to show some support to these guys, I hope they look around at forums like this one and see how many be they'd help and how enormous their potential market (and profit margin!) could be.
This actually looks fairly legit. It's the first time I've heard of an NO(2) compound being used to treat oily skin, I'm curious as to how this turns out.
Unfortunately, it's probably less than 50% through the testing phase, by the time this hits the market for the general public I'll be married LOL
It's testing phase is expected to be completed in 2014, which sounds great - I'm guessing medical products have to go through a few more safety tests before they can be marketed but you never know, perhaps in 3 years time we'll all be slathering this stuff on our clear skin! It's just nice to have a bit of hope for once.
Pretty much. This website explains it well
https://www.breastcancer.org/treatment/clinical_trials/phases
But what it means though is the first two phases mean little because the sample size is so small.
Most consider the Phase III trial to be the definitive one though, because it has such a large sample size and the efficacy of the drug in comparison to others in checked. Phase III is unfortunately where most drugs fail.
I don't know where this drug is exactly, but I read they mentioned in-vivo and in-vitro testing; this is sometimes called Phase 0. It has to be farther along though because I doubt it'd have made news otherwise lol.
Just thought i'd post a link to the patent, here. It's got a brief outline of what the medicine hopes to achieve:
On 6/10/2013 at 9:58 PM, CBIOT13 said:Most consider the Phase III trial to be the definitive one though, because it has such a large sample size and the efficacy of the drug in comparison to others in checked. Phase III is unfortunately where most drugs fail.
This doesn't appear to be correct. According to the following sources, the phase 2 is where most drugs are rejected:
http://www.fda.gov/ForPatients/Approvals/Drugs/ucm405622.htm
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If you have better sources or reasons to believe that it's different for acne drugs, I'd be happy to read.
As for Novan's SB204, phase 2b clinical trial results are expected this quarter. It covers 200 patients. Phase 3 is expected to start in Q1 2016.
They have a shiny new website at http://www.novantherapeutics.com/ where they post news about the drug. I'm hopeless and skeptical about any new acne drugs (they take long years to go through clinical, most are scrapped at some point, and I have yet to see anything that delivers results comparable with isotretinoin), but I still follow this stuff because there's not much else I can do.
I hope it does come that soon, but each phase of testing usually takes a couple of years. There's a lot of work involved, even if it does work perfectly well without side effects.
They're just about to commence Phase 3 testing for SB204 and after that they need to get approval for the drug from government bodies e.g the FDA. I reckon it's still going to be 3 - 5 years.
However, the fact remains that it's very exciting!
Info about phase 3:
https://clinicaltrials.gov/ct2/show/NCT02667444
https://clinicaltrials.gov/ct2/show/NCT02672332
This is going to be a lengthy one:
Estimated Enrollment: 1300
Study Start Date: February 2016
Estimated Study Completion Date: October 2017
Estimated Primary Completion Date: April 2017
Phase 3 will be complete in October 2017 and there will still be a lot of work required to get it to market. I'd be surprised if it's out before the end of 2018. And that's assuming it's sanctioned for public release by the authorities.
Hopefully it will make it. I'm just intrigued by it's anti-sebum properties. I've been oily since the 90s, so welcome being a little dryer!
Sadly, things aren't looking good for SB204. The first trial failed, the other showed merely minor improvements: https://endpts.com/discordant-data-strikes-a-sour-note-for-novans-phiii-studies-of-a-new-acne-drug/