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Does anyone know of anything serious in the pipeline for regulating the sebaceous gland? I am really thinking systemic treatments rather than topical. Topicals such as ASC-J9 could potentially have merit but something that acts on sebaceous glands at a systemic level (e.g. preventing them from responding to androgens) would seem like a better solution.
I am presuming that SMT D002 is dead in the water. Only other vaguely promising one I have come across is isoprenylcysteine:
IPC analogs have also been shown to modulate GPCR signaling, suggesting a potential role in regulating sebum control through inhibition of the GPCR melanocortin 5 receptor (MC5R) (critical for sebaceous gland lipogenesis)
Bit dubious about this, but it claims to be a 5a-reductase inhibitor and to have reduced sebum production by >50% in a trial...
http://www.dsm.com/en_US/downloads/dnpna/DNPNA_PC_953-01_Factsheet_ALP-SEBUM_6203.pdf