Absolutely possible.

I feel like my acne significantly flares up on days I take my adderall. My face feels much more irratated and sensitive as soon as my medication kicks in

yea if you check addforums.com there are tons of people who have breakouts from adderall. I recently took it and had a bad breakout, but I also was less strict with my diet and drank alot of alcohol. I can't say for sure that adderall broke me out. But for others, yes it does.