Acne.org Products
http://www.google.com/patents/US3622668
This was posted here before many years back. All of the drugs used to make the it are easy to find and buy on the net. I can't seem to understand the mixing ratio, and there is one other issue. The "88% phenol" at it's full 88% concentration can kill you in 90 seconds if you apply it to a 10inch x 10 inch area of skin. I'm hoping someone around here can read through this and explain the mixing ratios more clearly.
It has been found that when appropriate portions of Vitamin A" Vitamin D," olive oil, and a suitable aromatic hydroxyl derivative (PHENOL) are mixed together to form a homogeneous lotion, that the lotion compounded therefrom will provide the following synergistic effect. First, the skin laceration is disinfected, Second, regenerative healing of the endodermal layer is accelerated while the healing process of the epidermal layer is temporarily suspended. Third, the keratoid or comified tissue, but not the soft nonnal tissue, of the endodermal layer is dissolved or otherwise prevented from accumulating. The synergistic result of certain homogeneous mixtures of these four ingredients is to promote a rapid healing of a skin laceration, commencing at the cross-sectional periphery thereof, so as to provide scar-free characteristics in the ultimately healed skin laceration.
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Again, discovered in 1969! I would like to understand how to make this stuff. I do not understand the mix ratios or how one might consider altering them for human testing. It was used on larger heavier animals than man.I can get my hands on all the ingredients used to make this stuff.
I suggest to stop looking for the difficult way and next time use aloe vera and slippery elm paste on wound.
If it heals incomplete then try b,f&c ointment from dr christopher.
http://www.google.com/patents/US3622668
This was posted here before many years back. All of the drugs used to make the it are easy to find and buy on the net. I can't seem to understand the mixing ratio, and there is one other issue. The "88% phenol" at it's full 88% concentration can kill you in 90 seconds if you apply it to a 10inch x 10 inch area of skin. I'm hoping someone around here can read through this and explain the mixing ratios more clearly.
It has been found that when appropriate portions of Vitamin A" Vitamin D," olive oil, and a suitable aromatic hydroxyl derivative (PHENOL) are mixed together to form a homogeneous lotion, that the lotion compounded therefrom will provide the following synergistic effect. First, the skin laceration is disinfected, Second, regenerative healing of the endodermal layer is accelerated while the healing process of the epidermal layer is temporarily suspended. Third, the keratoid or comified tissue, but not the soft nonnal tissue, of the endodermal layer is dissolved or otherwise prevented from accumulating. The synergistic result of certain homogeneous mixtures of these four ingredients is to promote a rapid healing of a skin laceration, commencing at the cross-sectional periphery thereof, so as to provide scar-free characteristics in the ultimately healed skin laceration.
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Again, discovered in 1969! I would like to understand how to make this stuff. I do not understand the mix ratios or how one might consider altering them for human testing. It was used on larger heavier animals than man.I can get my hands on all the ingredients used to make this stuff.
I suggest to stop looking for the difficult way and next time use aloe vera and slippery elm paste on wound.
If it heals incomplete then try b,f&c ointment from dr christopher.
Panos you're promoting snake oil. I run right through your posts here because they defame hydrogel and defend thieves and con-artist. I don't know why you do it, but it's ruining the credability and direction of this "Scarless Healing" thread. I've been here for a long time now and I've had my ear to the ground for a solution for a lot longer. I use to talk to Mark Furgeson when he was trying to find investors for Renovo before it was even an ipo. I believe in 3 things for "Scar free" wound healing right now.
Egg oil (with intact proteins)
Hydrogel
The Phenol Vit A Vit D lotion combo
You are talking to deaf ears. The guy who filed for this patent paid thousands of dollars to secure it. Can someone else here please help me concerning the mixing ratios.
This hydrogel is devoid of growth factor and cell, totally biomaterial. Do you guys think JHU can do this after Dr Sun left the team?Maybe that's why no progress made yet?
It doesn't need anything added. In the objective data, inside the scientific document, the material degraded rapidly and got complete regeneration.
That's true!
But it looks like that Dr Sun started this during his PhD study and carried on at JHU. As for me, it's just weird that he is not working on this any more...
This hydrogel is devoid of growth factor and cell, totally biomaterial. Do you guys think JHU can do this after Dr Sun left the team?Maybe that's why no progress made yet?
It doesn't need anything added. In the objective data, inside the scientific document, the material degraded rapidly and got complete regeneration.
That's true!
But it looks like that Dr Sun started this during his PhD study and carried on at JHU. As for me, it's just weird that he is not working on this any more...
Well, he's not working on that exact hydrogel because I don't think he owns the patent. Some time ago a poster on this board was talking to Dr. Harmon and said that they were working out the patent issues.
In terms of progress being made, there has been. JHU, through their technology transfer, is working with Gerecht to create a start-up company for her. Trials on larger animals started this summer and are probably still going on right now. Their timeline in the article posted a bit ago on here and on the JHU technology transfer site said that they anticipate human applications would be possible in 18-24 months. The article was written some time ago so we're probably looking at 14-20 months now if not less as long as they're on schedule. These things take time and money, but that's not a bad estimate at all!
This hydrogel is devoid of growth factor and cell, totally biomaterial. Do you guys think JHU can do this after Dr Sun left the team?Maybe that's why no progress made yet?
It doesn't need anything added. In the objective data, inside the scientific document, the material degraded rapidly and got complete regeneration.
That's true!
But it looks like that Dr Sun started this during his PhD study and carried on at JHU. As for me, it's just weird that he is not working on this any more...
Well, he's not working on that exact hydrogel because I don't think he owns the patent. Some time ago a poster on this board was talking to Dr. Harmon and said that they were working out the patent issues.
In terms of progress being made, there has been. JHU, through their technology transfer, is working with Gerecht to create a start-up company for her. Trials on larger animals started this summer and are probably still going on right now. Their timeline in the article posted a bit ago on here and on the JHU technology transfer site said that they anticipate human applications would be possible in 18-24 months. The article was written some time ago so we're probably looking at 14-20 months now if not less as long as they're on schedule. These things take time and money, but that's not a bad estimate at all!
I talked to some researchers, they told me those who conducted the research, in most cases, not the professors, can do better
This hydrogel is devoid of growth factor and cell, totally biomaterial. Do you guys think JHU can do this after Dr Sun left the team?Maybe that's why no progress made yet?
It doesn't need anything added. In the objective data, inside the scientific document, the material degraded rapidly and got complete regeneration.
That's true!
But it looks like that Dr Sun started this during his PhD study and carried on at JHU. As for me, it's just weird that he is not working on this any more...
I personally don't know if it is different or not. Golfpanthers post seems reasonably explained imo.
This hydrogel is devoid of growth factor and cell, totally biomaterial. Do you guys think JHU can do this after Dr Sun left the team?Maybe that's why no progress made yet?
It doesn't need anything added. In the objective data, inside the scientific document, the material degraded rapidly and got complete regeneration.
That's true!
But it looks like that Dr Sun started this during his PhD study and carried on at JHU. As for me, it's just weird that he is not working on this any more...
Dr. Sun isn't at JHU anymore because funding ran out for his position. They likely wanted to give the funds to a new post-doctoral fellow.
He is still working on hydrogels and scar free healing though (he told me an email response I got from him). But as I said before, I don't think he owns the patent, at least not outright, so he probably can't continue working on the exact same idea. I might be wrong about that though. It might just be that he doesn't want to work on the same thing because JHU is still researching it and even if he did succeed with the Dextran Hydrogel he'd likely have to pay the patent holder for the right to use it, which would make commercialization less feasible.
Castor oil will eliminate scars in fresh and recently healed wounds, but it takes a long time and if the wound/scar is really big it will be difficult to keep the castor oil wrap in place. It isnt easy or enjoyable to keep a large wounds/scar covered 24-7 like this. i have large scars I want to remove, and I need something different to do it.
Cayenne pepper will cauterize a wound but it wont heal it scarfree- so throw that theory away.
Slipper elm does not work- toss that one out as well. It's as effective as aloe oil. Aloe doesn't remove scars. Show me one case were it did.
Iodine will flatten scars but it will also make the scar tissue thicker- toss that theory away.
Castor oil works but it also take up to a year to remove old scars and at least 4 months or more in new wounds. I know I got rid of all my cutter scars on my arm using it. Castor oil is not effective for my needs. I cant keep a wrap on that large of an area for that long. I can do 30 days easy with something else, but theres no way in hell I can do 1 year under the oil for my situation
.
Which wrap are you using?Plastic or cotton?
I cut the toe skin from a fridge,closed it with cayenne(it closed in 1 minute) and then applied honey.
Now after almost 3-4 weeks a can barely see wound where it was and i assume in a couple of months it will be vanished.
Without a control wound, that doesn't mean anything. It could be that it would have healed normally anyways. It depends on the severity of the cut, location, and a number of other environmental features.
Which wrap are you using?Plastic or cotton?
I cut the toe skin from a fridge,closed it with cayenne(it closed in 1 minute) and then applied honey.
Now after almost 3-4 weeks a can barely see wound where it was and i assume in a couple of months it will be vanished.
Without a control wound, that doesn't mean anything. It could be that it would have healed normally anyways. It depends on the severity of the cut, location, and a number of other environmental features.
I also hae removed some flat moles without even been able to seen it now with a toothpick and close it with chilli powder.Now i really cant see it 
So dont toss that theory so fast
Which wrap are you using?Plastic or cotton?
I cut the toe skin from a fridge,closed it with cayenne(it closed in 1 minute) and then applied honey.
Now after almost 3-4 weeks a can barely see wound where it was and i assume in a couple of months it will be vanished.
sterile cotton gauze soaked in castor oil held in place with sewing thread wrapped around it. but this was on the arms and it took over a year to remove the scars, and i didn't take pictures. i have a scar on my face i want to get rid of, but it's hard to keep a swatch of cotton in place on this area for long periods of time. It works but you have to keep it on the scar 24/7 for a long long time. I dont trust plastic wrap with castor oil. only use dye free natural fabrics that dont have plastics in them. I avoid skin care products with Parabens and Hexanes as well.
Which wrap are you using?Plastic or cotton?
I cut the toe skin from a fridge,closed it with cayenne(it closed in 1 minute) and then applied honey.
Now after almost 3-4 weeks a can barely see wound where it was and i assume in a couple of months it will be vanished.
Without a control wound, that doesn't mean anything. It could be that it would have healed normally anyways. It depends on the severity of the cut, location, and a number of other environmental features.
I also hae removed some flat moles without even been able to seen it now with a toothpick and close it with chilli powder.Now i really cant see it
So dont toss that theory so fast
I removed these from my arms and legs using a pair of flat fingernail clippers. Neosporin. No scars
Alright, so they've definitely started testing on pigs. Check this out:
https://aiche.confex.com/aiche/2013/webprogram/Paper337043.html
And we now have a date that will reveal more information (one would think anyway) about how things are going; November 6th.
It's only going to be an 18 minute presentation (per the itinerary for the conference) so it might not be thorough but I'm sure we'll learn something about how it's progressing.
Alright, so they've definitely started testing on pigs. Check this out:
https://aiche.confex.com/aiche/2013/webprogram/Paper337043.html
And we now have a date that will reveal more information (one would think anyway) about how things are going; November 6th.
It's only going to be an 18 minute presentation (per the itinerary for the conference) so it might not be thorough but I'm sure we'll learn something about how it's progressing.
thank you for the updates.
I really hope this will be the answer to the mystery of scars.
Alright, so they've definitely started testing on pigs. Check this out:
https://aiche.confex.com/aiche/2013/webprogram/Paper337043.html
And we now have a date that will reveal more information (one would think anyway) about how things are going; November 6th.
It's only going to be an 18 minute presentation (per the itinerary for the conference) so it might not be thorough but I'm sure we'll learn something about how it's progressing.
thank you for the updates.
I really hope this will be the answer to the mystery of scars.
No worries! It's nice to have a date too. I feel like I can stop bugging the researchers at least until that conference takes place.
the link says there are going to apply hydrogel in diabetic mice, thus will know whether hydrogel works only in healthy or ill people also in this style (diabetic human be). by the way we talk about greater epithelium in this page but not talking about normal skin cured by what I see is talk of reducing scar only.
the link says there are going to apply hydrogel in diabetic mice, thus will know whether hydrogel works only in healthy or ill people also in this style (diabetic human be). by the way we talk about greater epithelium in this page but not talking about normal skin cured by what I see is talk of reducing scar only.
The tests on diabetic mice are likely to see what efficacy the treatment might have for humans with chronic wounds caused by diabetes (e.g. diabetic foot ulcers). The verbiage they use in this abstract is exactly the same as was used in the paper for the dextran hydrogel and for the paper on implanting human vasculatures. I don't see any talk of "reduced scarring" anywhere in the paper. Rather, they're just using the same terms that are in the cited scientific paper (e.g. enhanced re-epithelialization).
The fact they're using it on diabetic mice is just to see how broad the applications for the hydrogel might be. They already shown the efficacy for full thickness burn wounds, but there's huge market potential if it can treat chronic wounds as well. And I'm not sure if you were trying to say they aren't testing on pigs, but if so, that's not true. It's right there in the release:
"Current studies extended our dextran hydrogel treatment in a porcine model for full thickness burn injury."
the word enhanced re-epithelialization is like the word reduced scarring for me. path i'm wrong you right. i don't trust.
Well, since they're referencing the tests that were performed and cited in the paper we all know, I don't think enhanced really means reduced scarring. Rather, I'd imagine it's the technical term they have to apply to any outcome (complete regeneration or not) that is better than a control outcome. I agree that enhanced does leave some room for ambiguity, but I think that's just the standard way papers refer to an outcome that exceeds the norm.
A healthy amount of skepticism is fine though. I'm just going to wait until Nov. 6th to see what can be gleaned from the conference. At this point I know what it can do in mice since that's already been tested and shown to be "complete regeneration" (term used in the published paper) with appendages. I'm much more interested in the results on porcine subjects because they heal very similarly to humans.
I always tell the truth, no matter what it takes, no matter if it sounds negative I analyze and study for decades this issue and see that the only solution if there is one, is, is gene therapy to cure all diseases
If you ask a chemist, will tell the simple rule of thumb, the bigger, stronger, as this can project to medicine: the more genes are handled better result. I do not think a physical element as hydrogel us a solution. perhaps help in scar reduction but I do not regenerate normal skin and perfect routed least follicles.
the only cure is gene therapy and yes, we're screwed, this will be true in a hundred years (although probably illegal dark laboratories already be experiencing advanced countries with this), also can not give this therapy light that would be illegal, have to go through shit that would lead approvals so long.
On the other hand, the human skin is unique in having sweat glands and create elevated scars skin which other mammals do not think are similar to us
the solution will come because there is a group of people looking for it and although technology is far to be people looking for things the answers will come, but not today, this is the reality i live in the real thing im not dream any more
indeed, Vladislav, the one who said here that the regeneration is much more complicated than you think ... I did, is what I say since I registered here. on the other hand seabs always said it was a simple process where only secreted more collagen so the always thought that would be the solution decorin, but maybe now in the end he understood that I was right
I always tell the truth, no matter what it takes, no matter if it sounds negative I analyze and study for decades this issue and see that the only solution if there is one, is, is gene therapy to cure all diseases
If you ask a chemist, will tell the simple rule of thumb, the bigger, stronger, as this can project to medicine: the more genes are handled better result. I do not think a physical element as hydrogel us a solution. perhaps help in scar reduction but I do not regenerate normal skin and perfect routed least follicles.
the only cure is gene therapy and yes, we're screwed, this will be true in a hundred years (although probably illegal dark laboratories already be experiencing advanced countries with this), also can not give this therapy light that would be illegal, have to go through shit that would lead approvals so long.
On the other hand, the human skin is unique in having sweat glands and create elevated scars skin which other mammals do not think are similar to us
the solution will come because there is a group of people looking for it and although technology is far to be people looking for things the answers will come, but not today, this is the reality i live in the real thing im not dream any more
indeed, Vladislav, the one who said here that the regeneration is much more complicated than you think ... I did, is what I say since I registered here. on the other hand seabs always said it was a simple process where only secreted more collagen so the always thought that would be the solution decorin, but maybe now in the end he understood that I was right
I appreciate your skepticism. I think it's good that we all don't fall head over heels for the hydrogel until it's made it through pre-clinical testing and has results in humans.
However, some of what your write just sounds like fatalism. First, scarring isn't a disease, it's a biological response at the site of an injury. It's the human body's natural response to that event. And we've done plenty of manipulation to the body's natural responses, and diseases, without gene therapy up to this point in medical history. So while gene therapy may one day be able to achieve scar free healing, it's irresponsible to say it's the only way.
I'm not sure what you're note about asking a chemist means. It might be a language barrier thing, but I could just as easily cite Occam's Razor, or diagnostic parsimony, as a reason why the hydrogel could the answer. Basically, you look for the fewest possible causes for why, in this case, we couldn't heal scar free. As seabs said some time ago, we don't need to know every minute detail about how and why something operates the way it does. It's enough to know only what's needed and that it works. And for your case you could site Hickum's Dictum, which is pretty much the exact opposite of Occam's Razor.
In essence, it's entirely possible that things like gene therapy will fail, or take forever, simply because they're looking for an incredibly complex solution to a problem that can handled with a much simpler one. That's not to say that the process of wound healing isn't complex because it is. But I think we should all realize that understanding something in total isn't always necessary for achieving results. Conversely, I'll acknowledge that sometimes more complex solutions are the answer (e.g. Hickam's Dictum).
I would never say the hydrogel is definitely going to or not going to work and no one else should for that matter. That would be foolish. I have neither the expertise or information to make such a claim and my guess is that no one else on this board does either. Heck, the researchers don't even enough information to make that claim. So unless one of us decides to change careers and dedicate his or herself to researching wound healing, biomedical engineering and biology any speculation or absolute claim anyone else makes on this board about it is bunk.
It's fine that I have a positive outlook based on the information and you do not. But speaking in absolutes about the hydrogel when we simply do not know the answer isn't useful. All we know for sure is: it resulted in complete regeneration in mice, it's not being tested on diabetic mice and pigs and they speculate the timeline for human application to be sometime in the next two years. That's it.
On a somewhat related topic, Atala's team at Wake Forest has been give 24 million by the US Dept. of Defense to make tiny organs on a chip. This way we could test treatments directly on human cells to see their response rather than animal models. I'm not sure how much this would apply to wound healing but it's a good sign that things could speed up a good bit over the next few years.
Link:
http://www.foxnews.com/health/2013/09/16/tiny-3d-printed-organs-could-enable-better-drug-testing/
I always tell the truth, no matter what it takes, no matter if it sounds negative I analyze and study for decades this issue and see that the only solution if there is one, is, is gene therapy to cure all diseases
If you ask a chemist, will tell the simple rule of thumb, the bigger, stronger, as this can project to medicine: the more genes are handled better result. I do not think a physical element as hydrogel us a solution. perhaps help in scar reduction but I do not regenerate normal skin and perfect routed least follicles.
the only cure is gene therapy and yes, we're screwed, this will be true in a hundred years (although probably illegal dark laboratories already be experiencing advanced countries with this), also can not give this therapy light that would be illegal, have to go through shit that would lead approvals so long.
On the other hand, the human skin is unique in having sweat glands and create elevated scars skin which other mammals do not think are similar to us
the solution will come because there is a group of people looking for it and although technology is far to be people looking for things the answers will come, but not today, this is the reality i live in the real thing im not dream any more
indeed, Vladislav, the one who said here that the regeneration is much more complicated than you think ... I did, is what I say since I registered here. on the other hand seabs always said it was a simple process where only secreted more collagen so the always thought that would be the solution decorin, but maybe now in the end he understood that I was right
I appreciate your skepticism. I think it's good that we all don't fall head over heels for the hydrogel until it's made it through pre-clinical testing and has results in humans.
However, some of what your write just sounds like fatalism. First, scarring isn't a disease, it's a biological response at the site of an injury. It's the human body's natural response to that event. And we've done plenty of manipulation to the body's natural responses, and diseases, without gene therapy up to this point in medical history. So while gene therapy may one day be able to achieve scar free healing, it's irresponsible to say it's the only way.
I'm not sure what you're note about asking a chemist means. It might be a language barrier thing, but I could just as easily cite Occam's Razor, or diagnostic parsimony, as a reason why the hydrogel could the answer. Basically, you look for the fewest possible causes for why, in this case, we couldn't heal scar free. As seabs said some time ago, we don't need to know every minute detail about how and why something operates the way it does. It's enough to know only what's needed and that it works. And for your case you could site Hickum's Dictum, which is pretty much the exact opposite of Occam's Razor.
In essence, it's entirely possible that things like gene therapy will fail, or take forever, simply because they're looking for an incredibly complex solution to a problem that can handled with a much simpler one. That's not to say that the process of wound healing isn't complex because it is. But I think we should all realize that understanding something in total isn't always necessary for achieving results. Conversely, I'll acknowledge that sometimes more complex solutions are the answer (e.g. Hickam's Dictum).
I would never say the hydrogel is definitely going to or not going to work and no one else should for that matter. That would be foolish. I have neither the expertise or information to make such a claim and my guess is that no one else on this board does either. Heck, the researchers don't even enough information to make that claim. So unless one of us decides to change careers and dedicate his or herself to researching wound healing, biomedical engineering and biology any speculation or absolute claim anyone else makes on this board about it is bunk.
It's fine that I have a positive outlook based on the information and you do not. But speaking in absolutes about the hydrogel when we simply do not know the answer isn't useful. All we know for sure is: it resulted in complete regeneration in mice, it's not being tested on diabetic mice and pigs and they speculate the timeline for human application to be sometime in the next two years. That's it.
On a somewhat related topic, Atala's team at Wake Forest has been give 24 million by the US Dept. of Defense to make tiny organs on a chip. This way we could test treatments directly on human cells to see their response rather than animal models. I'm not sure how much this would apply to wound healing but it's a good sign that things could speed up a good bit over the next few years.
Link:
http://www.foxnews.com/health/2013/09/16/tiny-3d-printed-organs-could-enable-better-drug-testing/
Was noticed? being realistic in this life is always confused with negativity or fatalism, welcome to real life golf, some day you gimme me the reason as did many...
I'll give you the chance to believe that there is another solution for wounds not only the genic teraphy. Now I ask you do you believe that this solution will be soon? Do you think that applying a water-based hydrogel on your skin you regenerate your skin out? I do not believe in fairy tales believed in them for 10 years now with experience I see that impossible things are not easy to obtain.
You are probably too young. when I was a teenager always said that in a decade would be obtained all the solutions to my problems as technology would exist. Spielberg also made it into the 80's with a movie that simulated a world of flying cars in the year two thousand. those flying cars will exist as is, but it will take much longer. not by technology (in the case of flying cars) the problem is the implementation. to implement something that will change the lives of people in a very dramatic, you have to make a gradual implementation before many rules
is like telling society than ignorant and not be a victim of consumerism is not necessary to change the ipod for a new one every year or go to mcdonald for it is to be outside the system
gene therapy already exists (im not sure for scars path yes in other problems like deseases). happens that is illegal even sure that somewhere is practiced, it is easy simply to an injection in the body solves everything.
tomorrow you can not go into the world and say,'' I have the solution for scars heals thanks to gene therapy'' as perhaps some have it. simply because they would go to jail for experiments without authorization., 'authorizations' that hinder international organizations and
in this case I think the solution to scars probably does not exist for very complicated humans are mammals
Why I think there is no solution maybe? because the evolution never wanted. to have a perfect skin you must have a perfec dermis a that it can give a grow of 'junk' keratin, that's what you see as 'skin', if you look at your skin with a magnifying glass will see that the surface of the skin are a sea of irregular keratocytes. that's the perfect epidermis irregular zone of keratin waste created from a perfect dermis
The evolution for an unknown reason reduced the mandibular musculature and thus left over space in the brain and thus could enlarge. thanks to this we can reason. humans evolved through thousands of years but never the body will give the order to 'regenerate' evolution always see immediate cure most important because evolutionary
Why there are diseases? that the human body is made up of thousands of soldiers (globules genes microbes) that work together, when something does not work, generate disease, is very difficult to regenerate skin because the skin is on the outside. internal organs can regenerate but being outside evolution can not give that order
in fact we will be more in the future ugly pollution as a scientist said we will resemble much of what is now understood as an alien with big eyes and a nose with filters
to be a more hostile future pollution, evolution will actually do more heal with scar
Hi folks, I am not scientist even English is not my first language and I do not Wright English correctly, but this web is to talk about scars not about me.
If they can heal a mice 3rd degree burn and regrow hair and glands. (Nobody did it before even in mice) in humanas will be posible as well, I know that mice and humans are different but both are mammals. I think they found the correct path, I am realistic I do not know how much time it will takes,,months, years, but the hydrogel with the proper ajustments, readjustments and with the right proportions can work in humans also.
Scar is not a disease, although stem cells are usefull and in the future will be even more, many illness and body problems in humans and animals has been cured and solved without stem cells and gene therapy.
Examples: 1)Your leg is borken, are you ill? No, but you need to go to the doctor and the problem will be solved with a cast and some rest.
2)Yoy have a big wine color stain in your face; are you ill? of course not, some years ago the vacular (pulsed dye laser) has been invented and the stain can be easily removed. (Gene therapy is useful but not always necessary).
It is healthy to have expectation using science though. It is ok to have a reliable prediction, and have an expectation because of the science that has went on before hand.
E.g. if say, John an engineer, modelled a new bridge to scale in a lab.
John then stress tested it against a reliable control.
The control being a reliable scale bridge, a well built sold bridge that has been developed and tested over x amount of years previously.
Lets say, in the results and conclusion, it was found that John's bridge can handle 50% more stress and is better in design.
John and that lab, could then strongly expect reliably that when this bridge is scaled up to span a river that it will handle 50% more stress than the previous bridge, and will be a better bridge.
This is the same logic. We know this degrades much faster with the neutrophils, than the control (a control that degrades at a similar rate in all mammals) and that it got complete regeneration after being digested were the control did not get complete regeneration.
The expectation from the science that this will digest the same to scale in with the control is massive. The expectation from the science that this wont follow suit, and not go to scale with the control, is tiny.
I would never say the hydrogel is definitely going to or not going to work and no one else should for that matter.