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ABOUT HYDROGEL:
Digital color images of the researchers and the hydrogel available; contact Mary Spiro or Phil Sneiderman
Malditon if you google Digital color images of the researchers and the hydrogel available; contact Mary Spiro or Phil Sneiderman. You see the article you got the emails from. Just for clarity and context this specific quoted information is not on the paper, it comes from the article.
The paper does not hide any images, you can see the images after 3weeks, and 5 weeks in the paper where you can see appendage growth verse the control.
@ Chuckstonchew:
Sorry for the late reply. I'm afraid the EPO related patent doesn't mention this method beeing used on a full thickness excision.
Also in one of the examples, where this has been used on a child with deep second-degree and third-degree scalding injuries, only the second-degree spots healed without scars and the third-degree spots only improved.
I still think this is interesting as there are several variations of this method mentioned in the patent. The EPO can be applied by injections or via hydrogel. For cases where a lot of the original tissue is lost, the patients own stemcells can be added into the hydrogel.
I just wonder if additional EPO and dermal stemcells would improve the regenerative capabilities of a rapidly degrading hydrogel.
ABOUT HYDROGEL:
Digital color images of the researchers and the hydrogel available; contact Mary Spiro or Phil Sneiderman
Malditon if you google Digital color images of the researchers and the hydrogel available; contact Mary Spiro or Phil Sneiderman. You see the article you got the emails from. Just for clarity and context this specific quoted information is not on the paper, it comes from the article.
The paper does not hide any images, you can see the images after 3weeks, and 5 weeks in the paper where you can see appendage growth verse the control.
so what? I'm helping novice users so they can send email to the creators. from the web that say you have to have Windows mail or a mail client to post,some people do not like to use email client.
@ Chuckstonchew:
Sorry for the late reply. I'm afraid the EPO related patent doesn't mention this method beeing used on a full thickness excision.
Also in one of the examples, where this has been used on a child with deep second-degree and third-degree scalding injuries, only the second-degree spots healed without scars and the third-degree spots only improved.
I still think this is interesting as there are several variations of this method mentioned in the patent. The EPO can be applied by injections or via hydrogel. For cases where a lot of the original tissue is lost, the patients own stemcells can be added into the hydrogel.
I just wonder if additional EPO and dermal stemcells would improve the regenerative capabilities of a rapidly degrading hydrogel.
That user was reported for insulting another.
for the creator of hydrogel: these people can not understand what it is to live so desperate without a solution, believe it is a no more aesthetic problem. this bureaucrats who invent these things and do not care to speed things up to get them out for sale. how those who invent products and then let the years pass and do not accelerate to get the products on sale.
I can not understand what the hell is so difficult find a cure, a solution, regenerate skin without scarring in humans, it is impossible to think, is beyond belief ...
2013 and there is no cure for scars, and then say (the world) there is technology ... I believe we are in the caveman era, we have nothing, just lies. only garbash technology like windows 7,8, ninteno wii, playstation 3, android 4 cpu 11111 core...i mean...garbash
ABOUT HYDROGEL:
Digital color images of the researchers and the hydrogel available; contact Mary Spiro or Phil Sneiderman
Malditon if you google Digital color images of the researchers and the hydrogel available; contact Mary Spiro or Phil Sneiderman. You see the article you got the emails from. Just for clarity and context this specific quoted information is not on the paper, it comes from the article.
The paper does not hide any images, you can see the images after 3weeks, and 5 weeks in the paper where you can see appendage growth verse the control.
buy hydrogel
@maldition, I respect your opinion that the research concerning the hydrogel might be a scam and agree that any news when it comes to scar-free healing should be met with skepticism. However, Johns Hopkins conducted legitimate research with documentation that was vetted by the scientific community. It isn't as if they said, "Here's a great theory we have now please come throw gobs of money at us!"
Ironically, as much as a certain level of skepticism is healthy, it can also in part explain why Dr. Gerecht and her lab have not received the additional funding they need to continue the research. Investors, DoD etc. are all probably very worried about spending large sums of money on tech that may or may not work on humans. Even though results such as the one the 80/20 hydrogel provided have never before been achieved in any mammal it's hard to get past all the prior failures and con-man like Ferguson. Hopefully that does not continue to be the case.
chuckstonchew has been in touch with two people involved directly with the research; Dr. Sun and Dr. Harmon. Dr. Sun is no longer with Gerecht's lab due to budgetary limitations but Dr. Harmon has been very forthcoming with information that chuckstonchew has relayed to us here. Keep in mind that he only wants us to get involved with funding should the DoD either fall short or fail to provide funds at all.
I think you're missing an important distinction when it comes to the research. The investigators are different than the bureaucrats. Think about it. The researchers have every reason to want the tech to go on the market ASAP because that's how they stand to make money. The FDA and organizations like them could be part of some larger conspiracy with the drug companies to keep this kind of tech off the market but it's much more likely that they are just worried about keeping their jobs. No one wants to be the one to sign off on something and have it go nowhere or worse yet do more harm than good.
The above photos obviously show improvement but not on the order that I personally would be interested in. That being said if it helps someone's self esteem than great and go for it.
On a somewhat tangential note, Ray Kurzweil was recently hired by Google to direct their engineering lab. A curious move and I'd pay a pretty penny to see what projects they're working on.
Here some of my research of the past, from 2009 until 2011 but I am since 2008 but was not registered.
Juvista
http://www.acne.org/...270482-juvista/
About the reducers of TGF-B1
http://www.acne.org/...cers-of-tgf-b1/
Apitherapy
http://www.acne.org/...123-apitherapy/
Blocking of calcium channels
http://www.acne.org/...lcium-channels/
About TGF-B3 Modulation on Scar Tissue Formation
http://www.acne.org/...ssue-formation/
Hyaluronic acid
http://www.acne.org/...yaluronic-acid/
Kitoscell
http://www.acne.org/...1587-kitoscell/
Interesting. That means we should focus our attention only on potential scar free healing solutions and not scarless healing solutions, humans are 'spiritual machines' that are much more complex that Space Shuttles, Seabs is right, we should forget about mechanisms and information processing basis of scar free healing, there is a lot of junk science even outside of scarless healing, take for example this project:
http://www.humanbrainproject.eu/
The aim of that project is to reverse engineer the whole human brain in just 10 years and to simulate the human neocortex (the most important part of the human brain) in a supercomputer by 2018, so they seek 1 billion euros grant from the European Commission, the fact is that the human neocortex has 300 million neurons but scientists are still unable to reverse engineer the 'brain' of the tiny worm C. Elegans with only 302 neurons, it is obvious the project will be a failure.
And this was probably one of the best known and biggest multi-billion dollar hoaxes in the history of science:
http://en.wikipedia....ence_Initiative (1980s)
But those were failure stories, here are some success stories:
http://en.wikipedia....ificial_bladder (2006)
http://www.bbc.co.uk...health-14047670 (2011)
So if we focus ourselves only on a scar free scientific research hopefully one of those scar free research will be a success.
Just read this:
http://www.pnas.org/...8.full.pdf html
By day 21, burn wounds treated with hydrogel developed a mature epithelial structure with hair follicles and sebaceous glands. After 5 weeks of treatment, the hydrogel scaffolds promoted new hair growth and epidermal morphology and thickness similar to normal mouse skin. Collectively, our evidence shows that customized dextran-based hydrogel alone, with no additional growth factors, cytokines, or cells, promoted remarkable neovascularization and skin regeneration and may lead to novel treatments for dermal wounds.Hydrogels, structurally similar to the natural extracellular matrix, can be designed to provide instructive environments for the three-dimensional assembly of vascular networks. Many studies of hydrogel-based scaffolds have focused on applications in healing wounds (5, 1621). Beyond their utility as scaffolds, hydrogels can also deliver cytokines and growth factors (22, 23), antibiotics (20), and cells (24, 25) to allow complete skin regeneration.
http://ijl.sagepub.c.../4/264.abstract
A mixture of hUC-MSCs, Whartons jelly, and skin microparticles were transplanted to 10-mm diameter, full-thickness, middorsal, excisional skin wounds of mice. After 7 days, the tissue sections were sampled for reconstruction analysis and histological examination. After transplantation, there was a remarkable development of newborn skin and its appendages. We could see newly generated layers of epidermis, sebaceous glands, hair follicle, and sweat glands clearly. This innovative strategy could be very promising and may significantly increase the quality of repair and regeneration of skin in injuries.
http://people.hofstr...ed Factor-1.pdf
Furthermore, 38% of SDF-1-treated wounds were fully healed at day 9 (vs. none in controls) with very little evidence of scarring.
Well and don't forget about the use of EPO for woundhealing:
http://www.sumobrain...2012031778.html
Although you might be skeptic as the headline says "scar-free healing" and the first paragraph in english says "significantly less scarring", in the german text it clearly says this method achieved scarfree healing in second degree scalding injuries and improved the healing of third degree scalding injuries.
I hope they test this method in full thickness excisions, because they mention that additional dermal stemcells in combination with the use of EPO improve the woundhealing effect of the EPO but no example where this has been done is included in the patent.
Also, I wonder if this could work in combination with a rapidly degradable hydrogel.
Interesting. That means we should focus our attention only on potential scar free healing solutions and not scarless healing solutions, humans are 'spiritual machines' that are much more complex that Space Shuttles, Seabs is right, we should forget about mechanisms and information processing basis of scar free healing, there is a lot of junk science even outside of scarless healing, take for example this project:
http://www.humanbrainproject.eu/
The aim of that project is to reverse engineer the whole human brain in just 10 years and to simulate the human neocortex (the most important part of the human brain) in a supercomputer by 2018, so they seek 1 billion euros grant from the European Commission, the fact is that the human neocortex has 300 million neurons but scientists are still unable to reverse engineer the 'brain' of the tiny worm C. Elegans with only 302 neurons, it is obvious the project will be a failure.
And this was probably one of the best known and biggest multi-billion dollar hoaxes in the history of science:
http://en.wikipedia....ence_Initiative (1980s)
But those were failure stories, here are some success stories:
http://en.wikipedia....ificial_bladder (2006)
http://www.bbc.co.uk...health-14047670 (2011)
So if we focus ourselves only on a scar free scientific research hopefully one of those scar free research will be a success.
Just read this:
http://www.pnas.org/...8.full.pdf html
By day 21, burn wounds treated with hydrogel developed a mature epithelial structure with hair follicles and sebaceous glands. After 5 weeks of treatment, the hydrogel scaffolds promoted new hair growth and epidermal morphology and thickness similar to normal mouse skin. Collectively, our evidence shows that customized dextran-based hydrogel alone, with no additional growth factors, cytokines, or cells, promoted remarkable neovascularization and skin regeneration and may lead to novel treatments for dermal wounds.Hydrogels, structurally similar to the natural extracellular matrix, can be designed to provide instructive environments for the three-dimensional assembly of vascular networks. Many studies of hydrogel-based scaffolds have focused on applications in healing wounds (5, 1621). Beyond their utility as scaffolds, hydrogels can also deliver cytokines and growth factors (22, 23), antibiotics (20), and cells (24, 25) to allow complete skin regeneration.
http://ijl.sagepub.c.../4/264.abstract
A mixture of hUC-MSCs, Whartons jelly, and skin microparticles were transplanted to 10-mm diameter, full-thickness, middorsal, excisional skin wounds of mice. After 7 days, the tissue sections were sampled for reconstruction analysis and histological examination. After transplantation, there was a remarkable development of newborn skin and its appendages. We could see newly generated layers of epidermis, sebaceous glands, hair follicle, and sweat glands clearly. This innovative strategy could be very promising and may significantly increase the quality of repair and regeneration of skin in injuries.
http://people.hofstr...ed Factor-1.pdf
Furthermore, 38% of SDF-1-treated wounds were fully healed at day 9 (vs. none in controls) with very little evidence of scarring.
IMO the term scarless healing, has also allowed nonsense mechanisms like tgf bs , without results to be propogated and forecasted. It is a piss poor term. The term has got so many get out clauses all over it, it is not darwinistic enough. And allows someone to write essays and essays about about nonsense mechanisms which capture the imagination, and sell this bs, but with the comfort of having no standards set. What is scarless healing? What is waterless water? I reckon people should have a rule to only talk up about something if it has something cited on a document that is complete regeneration/scar free healing. But consensus is impossible on a messageboard. Newcomers wouldn't know the etiquette and other might disagree with that sentiment.
Interesting. That means we should focus our attention only on potential scar free healing solutions and not scarless healing solutions, humans are 'spiritual machines' that are much more complex that Space Shuttles, Seabs is right, we should forget about mechanisms and information processing basis of scar free healing, there is a lot of junk science even outside of scarless healing, take for example this project:
http://www.humanbrainproject.eu/
The aim of that project is to reverse engineer the whole human brain in just 10 years and to simulate the human neocortex (the most important part of the human brain) in a supercomputer by 2018, so they seek 1 billion euros grant from the European Commission, the fact is that the human neocortex has 300 million neurons but scientists are still unable to reverse engineer the 'brain' of the tiny worm C. Elegans with only 302 neurons, it is obvious the project will be a failure.
And this was probably one of the best known and biggest multi-billion dollar hoaxes in the history of science:
http://en.wikipedia....ence_Initiative (1980s)
But those were failure stories, here are some success stories:
http://en.wikipedia....ificial_bladder (2006)
http://www.bbc.co.uk...health-14047670 (2011)
So if we focus ourselves only on a scar free scientific research hopefully one of those scar free research will be a success.
Just read this:
http://www.pnas.org/...8.full.pdf html
By day 21, burn wounds treated with hydrogel developed a mature epithelial structure with hair follicles and sebaceous glands. After 5 weeks of treatment, the hydrogel scaffolds promoted new hair growth and epidermal morphology and thickness similar to normal mouse skin. Collectively, our evidence shows that customized dextran-based hydrogel alone, with no additional growth factors, cytokines, or cells, promoted remarkable neovascularization and skin regeneration and may lead to novel treatments for dermal wounds.Hydrogels, structurally similar to the natural extracellular matrix, can be designed to provide instructive environments for the three-dimensional assembly of vascular networks. Many studies of hydrogel-based scaffolds have focused on applications in healing wounds (5, 1621). Beyond their utility as scaffolds, hydrogels can also deliver cytokines and growth factors (22, 23), antibiotics (20), and cells (24, 25) to allow complete skin regeneration.
http://ijl.sagepub.c.../4/264.abstract
A mixture of hUC-MSCs, Whartons jelly, and skin microparticles were transplanted to 10-mm diameter, full-thickness, middorsal, excisional skin wounds of mice. After 7 days, the tissue sections were sampled for reconstruction analysis and histological examination. After transplantation, there was a remarkable development of newborn skin and its appendages. We could see newly generated layers of epidermis, sebaceous glands, hair follicle, and sweat glands clearly. This innovative strategy could be very promising and may significantly increase the quality of repair and regeneration of skin in injuries.
http://people.hofstr...ed Factor-1.pdf
Furthermore, 38% of SDF-1-treated wounds were fully healed at day 9 (vs. none in controls) with very little evidence of scarring.
IMO the term scarless healing, has also allowed nonsense mechanisms like tgf bs , without results to be propogated and forecasted. It is a piss poor term. The term has got so many get out clauses all over it, it is not darwinistic enough. And allows someone to write essays and essays about about nonsense mechanisms which capture the imagination, and sell this bs, but with the comfort of having no standards set. What is scarless healing? What is waterless water? I reckon people should have a rule to only talk up about something if it has something cited on a document that is complete regeneration/scar free healing. But consensus is impossible on a messageboard. Newcomers wouldn't know the ettiquate and other might disagree with that sentiment.
you're right with the term (in fact I was the first to tell you, do not know if you remember a couple of years ago, I was the one who said to tell from Tom Mason rename this thread by the scar-free healing).
but failure to do so, and this thread is called scarless healing.
you're right with the term (in fact I was the first to tell you, do not know if you remember a couple of years ago, I was the one who said to tell from Tom Mason rename this thread by the scar-free healing).
but failure to do so, and this thread is called scarless healing.
I've not liked the term ever malditon. Then you are not the first to 'tell' anyone their own mind.
you're right with the term (in fact I was the first to tell you, do not know if you remember a couple of years ago, I was the one who said to tell from Tom Mason rename this thread by the scar-free healing).
but failure to do so, and this thread is called scarless healing.
I've not liked the term ever malditon. Then you are not the first to 'tell' anyone their own mind.
So what's your idea for hydrogel? Here we can do as a community to accelerate hydrogel? Is there anything we can do to speed up the test phase of hydrogel in humans?
indeed, for all I think a good thing is to focus on several possibilities not just one. hydrogel could be something, but not only that.
I hope, for your good and mine that hydrogel is the solution.
Could anyone researching Canadian discovery of the antibiotic that reduces scar by 50%? in theory an old antibiotic change the molecule and do this to reduce scarring.
vladislav maybe find something on the net. (something more extensive than basic link news web I uploaded here on the previous page).
you're right with the term (in fact I was the first to tell you, do not know if you remember a couple of years ago, I was the one who said to tell from Tom Mason rename this thread by the scar-free healing).
but failure to do so, and this thread is called scarless healing.
I've not liked the term ever malditon. Then you are not the first to 'tell' anyone their own mind.
indeed, for all I think a good thing is to focus on several possibilities not just one. hydrogel could be something, but not only that.
It is a good idea to focus on other possibilities that cite a like standard.
eg another link with a cited standard http://ijl.sagepub.c.../4/264.abstract but I havent checked its paper.
How much money is needed to support the Hydrogels funding, research and development? Why not launch a Kickstarter page ( i know it sounds very unconventional- but it's a brave new world). All they need is a video showing it works on mice and a description of what it is, what it does. Quite a few Kickstarter projects crossed the million dollar mark (The iForm 3d printer comes to mind). This new discovery needs to go viral, the investors are there at a per donation based citizen level.
It's something lots of people want. It will help tons of people feel comfortable in their own skin, it will restore physical comfort, function, performance and appearance to others who were horribly scarred from tragic accidents and 3rd degree burns. The money and the market is out there. All you have to do is shout loud enough for them to find you.
How much money is needed to support the Hydrogels funding, research and development? Why not launch a Kickstarter page ( i know it sounds very unconventional- but it's a brave new world). All they need is a video showing it works on mice and a description of what it is, what it does. Quite a few Kickstarter projects crossed the million dollar mark (The iForm 3d printer comes to mind). This new discovery needs to go viral, the investors are there at a per donation based citizen level.
I would be happy to support any product which has shown potential; you could also include this http://ijl.sagepub.c.../4/264.abstract (or anything akin) if we are given a little more information. But all we are is little people on a messageboard on the internet.
I found this interesting article about crowdfunding and medical projects:
http://www.newstatesman.com/business/2012/11/can-we-crowdfund-clinical-research
It seems that CureLauncher is the only site for crowdfunding medical projects at the moment and is quite new itself new [it started in October of this year]
It also says in this article that NIH funding often takes up to 2 years to materialize :/ Which is just a horrible thought in general for all scientists trying to find cures... And may explain the hydrogel teams delay and why they are now trying to approach business and the army for funding
also - here is an article on aids and the issue:
http://www.huffingtonpost.com/zachary-barnett/crowdfunding-an-hiv-vaccine_b_2338874.html
I wonder does anyone have even a ballpark figure at the moment of how much a hyrogel next stage experiment would cost
Happy New Year All 
Mars
vladislav whats its your opinion about this
Well I don't know, I've never heard anything about that drug, frankly the second picture looks even worse that the first one, the third and the fourth look the same, only the sixth looks significantly better than the fifth, her scar looks charming on the sixth picture but it could be a manipulation with Photoshop, lights, powders and things like that so I have more faith in randomized controlled trials than in 'before and after' pictures. And as I can see there are possible side effects, I love myself and a healthy life, I'm perfectly healthy (although I have no spleen but it doesn't matter because it is not a vital organ) and I want to stay healthy in the future so I wouldn't like to experiment on myself, now I'm investigating trends about the number of publications related to regenerative medicine and stem cells, I've just found some new figures for 2010 and 2011, so as far as I can see in 2010 and 2011 in the US there were even more new stem cells related papers than in 2009 and 2008, so hopefully that should mean that there are constantly more and more regenerative medicine and stem cells related research, it™s a good thing! And the other thing I™m thinking now is about decorin at 200nm that is able to stop proliferation of fibroblasts, but Seabs said decorin usage is impractical, so it™s just an idea and nothing more, well if scientists cannot stop proliferation of fibroblast cells with decorin at 200nm then they can convert them into other cell types, for example: they can covert fibroblasts into heart cells (cardiomyocytes) or adult skin cells (fibroblasts) into brain cells or adult skin cells (fibroblasts) into embryonic stem cells,... etc so scientists at the Gladstone Institute are doing that kind of research, they are able to convert one cell type to another cell type,it™s just like a magic! So I™m investigating induced pluripotent stem cells (iPS cells) and the Gladstone Institute and their research, the discovery of iPS cells was awarded with the Nobel Prize in this year (the recipient is Shinya Yamanaka who is now working at the Gladstone Institute and back in 2006 and 2007 he was successful in converting adult skin cells/fibroblasts into embryonic stem cells by using some kind of viruses and 4 genes or something like that, I™m not sure), and they were successful in repairing damaged hearts (heart scarring) after a heart attack, they said that heart scarring is No.1 killer in developed countries, I™m still not sure if it is something relevant for us or not or is it scarless or scar free healing, this document says iPS cells are relevant for skin scarring:
http://www.scientiar...rg/pdfs/240.pdf
And happy New Year for all! 
It seems that CureLauncher is the only site for crowdfunding medical projects at the moment and is quite new itself new [it started in October of this year]
Indiegogo allows it too and they've been around for longer and are well established.
How much money is needed to support the Hydrogels funding, research and development? Why not launch a Kickstarter page ( i know it sounds very unconventional- but it's a brave new world). All they need is a video showing it works on mice and a description of what it is, what it does. Quite a few Kickstarter projects crossed the million dollar mark (The iForm 3d printer comes to mind). This new discovery needs to go viral, the investors are there at a per donation based citizen level.
Crowd funding is our plan and I plan to discuss it with Dr. Harmon when I speak to him next. I'd personally like this method best as well. I'd rather the project be completely in the hands of the JHU team and not under the jurisdiction of the army.
