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The big difference is that most over the counter BPs are much higher in strength like 5% or a lot are at 10%...Dan's BP is only 2.5% so it won't be as harsh. But try the others, just don't slather on a lot of the 10% unless your skin can handle it! If you find too much irritation with the OTC stuff then buy it from this site and try the 2.5%.