Hello, so I have been using acne.org products for a couple years, loved them, the do help, but it's expensive and time consuming, don't want to buy regular and travel size etc. My mom had deep, deep acne as a kid and still has scars at 53 as we know cystic acne can be genetic My acne is mostly on my chin, cheeks, near mouth, on neck, and back indicating a HORMONAL link. I get deep ones on my neck and cheeks especially I tried to balance my hormones to combat it and eat little dairy to help that as well. I exercise and carry a massive 64 oz water bottle that i go through 2-3 times a day every day. I get 6-10 hours of sleep every night usually around 7. Never sleep with makeup on, always go through my elaborate skin care regimen (mostly acne.org stuff besides cleanser, and also use glossier aha+ solution.) And have little stress in my life that's unman aged, I meditate, have a good attitude, and rarely have to face anything too terrible so that's not it. So I'm doing all the things you're supposed to...... I tried Skin care exposed acne.org many generic drug store products (cetophyl, nutragena, Clearasil, etc.) ACNE LASERS (do not recomend, it actually got worse, and I'm not sure why. I did over 10 treatments I believe because my boyfriend wanted to help me conquer this he paid for it so I'm not certain, but it was very painful, expensive, and ineffeftic sadly.) Trtroin cream and gel Many cycles of antibiotics (doxy) Llysiene DIM (did help a lot but didn't fully clear, best thing I've found besides spironolactone though, but more expensive.) Etc. (We've all tried lots of things, you get it, but I thought it might be relevant for people trying to figure out what they should try first or what might work for them based on our possible similarities) Important part: My roommate had really bad, scattered, cystic acne and one day it really started clearing up I asked what she had been doing and she said her doctor prescribed spironolactone. I asked my doctor to do the same, she was all for it. I take 50 mg The first month was really bad, I broke out REALLY hard. But I had seen all the positive reviews and photos that said this would happen and to stick it out, so I did. Month 2.5 I was so happy with my skin, it's SO SOFT and clear. It's incredible to be able to touch my neck and face without tons of textures. My skin did peel really badly around month 1.5-3 so be prepared. It was annoying, but worth it. MONTH 3 I HAVE ZERO active pimples and some red spots that are still healing (I did kind of keep picking throughout the months but I think I will break that as I have nothing left to pick) My makeup goes on incredilbly, I am so, so, so grateful. I was so close to trying accutane but have been putting it off as a last resort because of the side effects. Now I'm free. I sent my doc a thank you card I'm so happy. Please, if you know anyone with hormonal ance, tell them about it, or try it yourself. With my very basic, terrible insurance it's FREE I don't pay a dime for it which is just yet another amazing perk I have before and after pics that are incredible, but it won't let me post them, so if you want to see e-mail me at firstname.lastname@example.org and I'd be more than happy to share. I want other people to be able to find their solution too.
Did Not Work
This product did not work for me, and I was on it for roughly 4+ months. I have moderate acne and oily skin.
Better than OCP
I have been on 150mg Spironolactone for 6 months. I'm 27 and I have had mild-moderate acne on only my face for my entire adult life, it's very much hormonal and my face/hair has always been oily. Multiple doctors tried to sell me on accutane and I refused for years. I have tried everything you can think of, I'm currently on spironolactone, hormonal birth control pills, and use aczone. . . my skin looks the best it has in years. I also moved from Florida to the PNW and this helped my skin because I spend less time in the sun, sweaty and hot. I mostly am just tired of having elaborate facial routines and ruining my clothes/towels/sheets with acne products/bleaching. I have always drank lots of water, exercise every day, eat pretty good and wear sunscreen every day (I'm incredibly fair skinned). I honestly think this pretty good and I prefer Spironolactone every day to hormonal birth control for helping clear up my skin.
Spironolactone can take away your dermal (lip) filler on your face! Manufacturer of the pill matters!
So my face cleared in a month on pills manufactured by Activas, but my pharmacy changed the manufacturer to Julibant and my face was horrible for 2 months straight. I didn't put two and two together until two days ago and I picked up refills by the manufacturer Amneal (I think they just bought Activas out) and my face is noticeably clearing up and i feel so much dryness. If you've been taking the pill for 2 months and your face hasn't cleared up pay attention to the manufacturer!! It makes a difference. I keep the dosage as 50mg bcs the side effect on 100mg is so much that it takes away the dermal fillers on my face. My body shrinks, too and my butt got flat.
DONT GIVE UP, IT WILL GET BETTER
okay, so this is going to be a fairly long review because i want to give details for anyone feeling discouraged or about to start. I was on birth control for 2 and a half years and i suffered with minor acne prior to going on, like very minimal would get the odd cystic spot but i was in the sun a lot so my spots kept at bay, i went on birth control and my skin cleared up completely, then after 2 and a half years when i was on birth control i started to get minor acne again, so i came off and for a good year my skin was on and off, minor acne, annoying but nothing too crazy! and then all of a sudden BAM it just hit me outta nowhere and i started getting really bad cystic acne all over my chin and they started to move up my face, id get a few on my cheek and a few on my forehead like horrible sore red cystic lumps. and i dont know why i didnt go to the dermo then and there but i tried acupuncture, had an amazing diet already but went all in and tried an alkaline diet and nothing worked. So i went to the dermo and she put me on 100mg of spironolactone a day and told me to apply retin A cream every evening and Zindaclin every morning. First month was horrendous, the retin A cream made my skin purge, i was literally shredding like a snake, so sore and red i cried nearly every day, couldnt wear makeup, didnt leave the house, and the spiro made me exhausted, felt so down and weak and my skin purged so i broke out so badly in cystic spots it was awful. Second month was slow, my spots were at bay, and the side affects lifted after 6 weeks and i felt normal again, but my skin was at a standstill, spots had gone down a hell of a lot and because of the retin a cream my scars started fading and my skin got used to the cream so i stopped shredding hallelujah!! but kept getting the odd breakout and didnt really move. Now i am at the end of my third month and thank god, i have finally only just stopped getting breakouts, my face has cleared up 90% and its happened in the last few weeks really quickly! and the cream has taken the scars away like a dream, i have about 5% of scars left on my face, i feel like a new woman. So girls please stick with it, they say around the 3 month mark youll start seeing a difference, and everyones bodies are different but stick with it because i drove myself mad with reading constant review thinking why isnt my face getting clearer, but one day youll wake up and start noticing a change and itll happen quick!!
I have been off this site for awhile since my acne went away. However, I thought it was important to let others know my journey. I only had mild to moderate acne since a teenager up to my adult years. There's was constantly always at least one on my face. During the past few years, I was on yaz birth control and that pretty much helped kept everything under control. I decided to not be on it anymore and that's when my face exploded. I started to have tons of bumps everywhere 4 months after stopping bc. I was horrified. I thought it was just stress, but it was more than that. Everything started to creep up in March and by May I had cystic spot everyday. It was so bad that I kept my head down when talking to people. Then by the second month I decided to go back on bc. As bc took long to start kicking in, I went to a dermatologist and she prescribed me spiro two times a day for 100mg a day. It took at least 3 months to see results. Now it has been 7 months and have zero acne. I know how hard it is but please stick with it. Also, be cautious with your diet. I quit eating dairy and sugar all together. I believe this played a huge factor as well. Feel free to ask any questions!
week 4 still waiting...
I know that it might be too soon to review but I am so sad. I am 19 and I've always had what I thought was acne prone skin. Looking back my skin used to be perfect and I took it for granted. This all started in December when I decided to stop taking my birth control,about 2 months later all hell broke loose on my face. I went to see my dermatologist as soon as possible and she prescribed me spironolactone 50 mg twice a day. I started taking Spironolactone almost 4 weeks ago and I have not noticed any changes in my skin. My dermatologist says it will take 8 weeks to start showing signs of improvement, but im feeling so discouraged. However, I know that if I stick with Spiro my skin will get better. I have been taking progress pictures and noticed that around 2 weeks after starting Spiro my skin began to break out or "purge". Then around 3 weeks my skin started to clear. I thought I was seeing the light at the end of the tunnel and my skin was improving, I was SO happy(I was wrong). Within 2 days after the 3 week mark my skin broke out so bad. I am still in the middle of this breakout. Wondering if the "purge" stage comes in waves? Has anyone else had this experience???
PLS DON'T GIVE UP
I've had chronic cystic acne for the past 5 or 6 years. It started on my forehead, then traveled down to my chin/mouth area and then more recently reached it's very worst, covering my cheeks/sides of face/jaw line. I tried to treat it naturally with diet, etc (but was never perfect or very committed). I did one short course of accutane a year ago. It cleared me up but within 2 months of ending it, I broke out terribly and it's lasted for months. I have hypothyroidism and I know that must have started this spiral of hormone imbalances and subsequent bad skin. As a result, I also had high androgens and very low progesterone. I started taking Spironolactone a little over 3 months ago. It is only in the last 2 weeks that it has started working. So, when they say to wait 3 months... they mean it. I was SO discouraged the first 2 1/2 months. My skin was making NO progress. I felt it was getting worse. But I PROMISE it get's better. I had the SAME breakout for 3 months on my face. The blemishes would not budge. They were huge, red, swollen, and sore. And I kept getting more. In the past 2 weeks or so the breakout has cleared up and I have not gotten a single new blemish, despite being in my ovulatory phase which is always the phase I get a terrible break out in. Please keep at it and don't get discouraged! It takes time but it will work. I also advise you to go see an endocrinologist or other dr that specializes in hormones so you can get tested for imbalances or deficiencies.
Spironolactone is the BOMB
I've been struggling with inflammatory and cystic acne for well over 30 years and have tried every conceivable treatment, including all the topicals, retinoids, oral contraceptives and various antibiotics, and 4 (yes, FOUR) 20-week rounds of Accutane. I would regularly get kenalog shots for the really deep, painful ones. My acne was NO JOKE and was leaving deep scars. Nothing kept my skin consistently clear until spiro. I take 100mg/day now. If I do no topicals at all and just the spiro, I'll get a bunch of small (non-scarring) pimples, but nothing too crazy. But when I add the Acne.org topical regimen to the spiro, my skin stays 100% clear indefinitely. So this is the routine I've been doing for almost 2 years now and it's been life changing!
Spironolactone - Heart palpitations, panic attacks, chest pain, anxiety
I would give this product 0 stars if I could. I have never written a product review in my entire life. I'm a 22 year old, perfectly healthy female. I exercise regularly, I eat a well balanced diet and have suffered from moderate acne for the majority of my teens/early 20s. I am completely mentally stable, I don't do drugs, have great friends / job / self esteem etc. After coming off the pill and roaccutane my acne started to re appear and so my dermatologist reccommended spiro. It worked alright for the first 3 months until I started getting horrible horrible heart palpitations which lead to 10 panic attacks in 2 weeks. I HAVE NEVER HAD ANXIETY OR A PANIC ATTACK IN MY WHOLE LIFE. The worst was when 4 in a row in 2 hours and had to be taken to the emergency room. Everyday for those 2 weeks I was constantly experiencing chest pain and heart palpitations, constantly fighting off another panic attack with deep breathing etc. I had a million theories why it might be happening, but the doctors assured me it wouldn't have been aldactone! Only after my GP and I did some research (I'm a psych student studying psychiobiology), and I went off spiro, did I return completely back to normal. PLEASE NOTE: this drugs HAS NOT been TESTED systematically for ACNE. It is and OFF LABEL DRUG. Be careful what you take, it may not have the same effects, but be goddam careful.
Spironolactone is the only treatment that worked
I've been taking Spiro for 9 years now and it has been the only thing that has kept my moderate acne away. I never had cystic acne but had many painful pimples and pustules. Prior to Spiro I tried topicals, oral antibiotics, and even Accutane. I tried different things for over a decade and none of it worked. The only acne scars I have, I got while taking Accutane, which made my skin flare up terribly. I was also constantly sick to my stomach the entire month and a half I took Accutane. If you're an adult female and still suffer with acne, please try Spironolactone before resorting to Accutane. The side effects of Spiro are minimal, if any, and it's very effective at combating hormonal acne. I had to ask my dermatologist to prescribe it to me. She didn't believe it would work. Thankfully, she was wrong.
Game Changer for Hormonal Acne
I have tried almost every type of acne treatment there is out there. Spironolactone is the only thing that made a real difference. Not only do I rarely have acne, but when I get a spot it goes away quickly! It's important that your dermatologist starts you off on a low dose. I started with 25 mg. Then went to 25 mg twice a day. Then 50 mg twice a day. You should be drinking a lot of water while on this--I drink like four liters a day. I personally didn't have any side effects besides having to pee a lot--could just be the water though. Also, you will gain weight easily if you have a high intake of potassium. I also take Junel Fe 1.5/3.0 for both birth control and acne/hormonal control. Everyone should know that this will make your birth control less effective, so think about using another form of birth control in addition.
I had severe acne since middle school. I would have acne on my face, back, and chest. Senior year of high school, my acne was so embarrassing that I could never leave the house without makeup because I was so scared of what people would think about me. I went to the dermatologist and she prescribed spironolactone 50mg for my skin. I would take one pill in the morning and one at night. I was also prescribed epiduo which is a gel that you rub into your face after you wash it at night. On top of these two medications I would wash my face with benzoyl peroxide 10% with a Clarisonic electric brush. So just a recap I would take my 50mg spironolactone twice a day, wash my face with 10% benzoyl peroxide twice a day, and then rub epiduo gel on my face. Although it took 3 months to see a difference, the wait was worth it. All three of these things have completely cleared up my acne and I feel like I can finally be myself again. I hope this helps.
Dont give up!!!
Started getting acne at age 14/15, tried everything (aczone, doxycycline, tazorac, facials, changing pillow cases, cutting out dairy). Even went on Accutane. It got so bad that I stopped going out, would always try to cover my face when talking to people, etc. Finally I broke down to my dermatologist and she prescribed me spironolactone (50/mg). Two, three, four weeks in I didn't notice any improvement but acne also did not get worse like others have mentioned. Finally after 7 weeks its COMPLETELY CLEAR, after a decade of acne. Heres my regimen : wash face nightly with Cetaphil gentle cleanser, take spironolactone, drink tons and tons of water. I do not have any side effects from the medication that I have noticed. Im still dairy free just because I feel better that way! Short story: don't give up, I wanted to quit after 3 weeks but don't. You will get there!
Depression new low/suicidal thoughts (TRIGGER WARNING)
I'm 19 years old and have been dealing with acne of all sorts since I was 12. Different things have worked for me at different times for the most part (epiduo at age 12-14, ortho tri cyclen at 15) but since graduating high school about 2 years ago, I've had this acne that I have not been able to get to go away no matter what I try. About a month ago, I went to the dermatologist and ended up being prescribed spironolactone and cefadroxil. The cefadroxil was supposed to be for the period of time that it takes for the spiro to "kick in" but I ended up discontinuing it due to side effects and seeing absolutely no difference in my acne. I was prescribed these because I expressed my concern with taking hormonal birth control considering I had extreme depression while on ortho tri cyclen and when I had an IUD. I also was not ready to go for Accutane (and unfortunately never will be). So, with no warnings from the dermatologist, I was feeling hopeful about the spironolactone. A few days ago, I had an intense dissociative/depressive episode where I had to be physically held back by my boyfriend for 1-2 hours because I was trying to leave his house so I could go to mine and take my life. I did not feel like myself, and certain details from the night seem to be very fuzzy in my memory. All I can seem to remember is seeing an image of a pill bottle (oxycontin) in my mind for at least 20 minutes straight and feeling as though it was calling my name, telling me to come take all of the pills. I also remember I was extremely angry at my boyfriend for trying to stop me, and was trying to push past him as he tried to talk me out of it. I should note that NOTHING like this has EVER happened to me before. I've definitely been in a funk the past month while on this medication, but I wrote it off because I suffer from mild depression anyways. My mom and I were surprised and angered to find that there are a plethora of hits when you search spiro and depression. TL;DR: Spironolactone increased my depression to an extremely dangerous point, and in the mean time didn't even work on my acne. NOT worth it at ALL.
Patience is key
I've had acne for over a decade. When I was 19, my skin cleared up and I stopped using acne products altogether. Then I got my nexplanon put in and all hell broke loose on my face. I got the worst acne of my life and even started getting occasional cystic acne (which I had never had before). That's when I made my first derm appointment and he prescribed me a combination of 100mg spironolactone, aczone, and ovace lotion. I started all three at the same time, so I can't tell you which caused it, but my face immediately ceased 80% of its oil production. The only side effect was that I noticed that I got light headed a little easier when I stood up, but that's it. For the first month, I broke out terribly and officially had the worst acne of my life since I had my nexplanon inserted. It wasn't until I was on spironolactone for about a month and a week that I noticed any changes in my acne. Instead of having 20-30 pimples on my face at all times, I had 4 or 5. I'm still only about a month and a half into this, and I see my acne disappearing more and more each day. I am so happy with the results. My suggestion is to STICK WITH IT because it took a while for it to work for me and much longer for other people. In fact, it seems like it worked unusually fast for me.
great with doxycycline but really awful side effects
I was originally prescribed 25mg once a day for a month, had a really bad IB a day before my period during that month but has since cleared up. I'm up to 50mg once a day now (second month in) and although i'd say 70% of my acne cleared up, the side effects SUCK. I've gotten my period 3 times already this past month month and a half (every 2 weeks), and the medicine tastes SOO BAD!! It leaves such a bad after taste in your mouth ugh... but it's so worth it. You also need to get bloodwork done every 2-3 months or so which kinda sucks. I'm also on 100mg of doxycycline once a day and that didn't clear up my acne alone but with spiro I feel like this combo truly is amazing for hormonal and cystic acne. Just be prepared to stock up on pads! I also started getting a weird feeling in my lower back down to my knee caps (sort of like a tingling feeling or the pain you get after working out without properly stretching?) and I was wondering if anyone else has similar pains?
Before I started taking this medication, I had severe cystic acne for 6 years. I would stay home from school because I felt ugly and I was in constant pain. 3 months after I started taking spironolactone, my entire life changed. My skin has been clear ever since. I've been taking this medicine for 2 years now, and it's helped me tremendously. If you want to take it, get ready to drink lots of water!
I read several great reviews on here about Spiro and was convinced it was the answer to my hormonal acne problems. After a month I didn't see much of a difference but didn't feel any negative side effects either so I asked to double my dosage to 50 mg a day. Within 5 days I started having chest pains and terrible anxiety. I had a full blown anxiety attack and even after going back down to 25 mg a day the anxiety didn't go away and my skin continued to break out. I've been on it for two and a half months and have decided to quit due to emotional health. I even had to go on anxiety meds. I'd rather go back on birth control than continue with this. If you have emotional reactions to this, don't let your doctor try to convince you it's not from the Spiro, it very well might be and you should discontinue right away.
Back to the drawing board
This drug is primarily for high blood pressure, I took it for a few months and it worked fine for my acne then after maybe 8 months it just stopped working, I didn't really have any side effects from it but a year later I am now taking it for high blood pressure.
Iâ€™m about 30 years old and this drug makes me feel 70
The WORST medical decision I ever made. After the first two months of the 'initial break out' that only some doctors warn you about, I decided I couldn't take the other side effects. It was after getting off of the drug, however, that creates my biggest concern/complaint/warning for you. For the first time in my life, my hairline started to recede, and I developed more facial hair. I know it seems counterintuitive, but I asked my dermatologist about it, and he said it could be an effect of this drug. If you use this medicine, I strongly encourage you to read the potential side effects before you start the regimen. Especially considering that I was only on it for a couple of months and had such a negative response even after getting off of the drug, I feel it is necessary to warn other people.
starting to give up?
Ive been using it for almost a month and my skin has never broken out this bad, I talked to my derm and they said it gets worse before it gets better but i dont know if i can take it anymore. Im fine with breaking out when starting a medication because i usually do but with this one my face, chest and shoulders are just covered with small itchy pimples. Before this my skin was extremely oily but now its really itchy, dry and flaky and i dont know if i should keep using it or not.
READ THIS NOW!! IT COULD SAVE YOUR LIFE AND SKIN!
Hi all, Let me start from the very beginning - I used to have good skin, only a few spots here and there, but being 16 I was very fussy and self conscious and wanted perfect skin. I went to the doctors and they put me on dianette (a strong birth control pill) which made my skin beautiful but also made me VERY fat. I stayed on for about 6 months and not being able to tolerate the weight, I came off and ended up getting the worst acne of my life. I tried to treat it naturally but nothing was working, so after a year of bad acne I went on the Yasmin pill, and started low dose spirinolactone too (this being self medicated as my doc would not prescribe it.) this combo worked perfectly, and my skin was as clear as ever and I never ever got any breakout no matter what I ate or what skin products I did or didn't use. After a few years on this combo, and suspecting Yasmin for causing my hair loss and flat, emotionless state and spironolactone for bad side effects, I weaned myself off of both meds and used Angus castus and Spearmint capsules and tea to balance my hormones and skin. This worked ok and my skin did well for about 2 years, and I managed to lose all the weight, however this dramatic weight loss triggered another breakout which kept getting worse and worse. I tried for 6 months to increase spearmint etc tried all different skin products but nothing was helping, in fact everything I did or used seemed to make my skin even WORSE. I had enough and started to self medicate spironolactone again, starting July 11th 2017 at a dose of 50mg. I slowly increased my dosage to 150 mg, and throughout this stage my skin was at it's worse ever, as you all probably know by now, it definitely gets a lot worse before it gets any better. My skin started to improve around the 3 months mark, by which this stage I had increased my dosage to 150mg in the morning (before 3pm is more effective as this is when androgens are at their highest) WITH food, and 50mg at night time with a snack. Taking it with food is very important. I also did a hell of a lot of research and at 200 mg the side effects were quite severe but it was the dosage that worked best for my skin, so I kept reading up on different things to alleviate this. What I found is that LICORICE ROOT (I take the Swanson Licorice root capsules - 2 with my 150mg morning dosage) works synergistically with spironolactone as Licorice root increase blood pressure and lowers potassium - where as spiro decreases blood pressure and increases potassium. So taking the Licorice root with the spironolactone ensures a good balance where blood pressure is not lowered so much, and potassium levels are not increased so much, every thing is balanced perfectly and it reduces the side effects to ZERO for me. I went from taking 200 mg and having bad heacahes, bad dizziness, non stop pissing, palpitations, to being able to take my dosage with none of those side effects and feeling great and healthy with CLEAR skin all by adding LICORICE ROOT to my regime. Try it! Ps it has now been just over 4 months of being on 200mg with the Licorice and my skin is 95% clear, I maybe get one tiny spot every week that you can't see only feel, I only have marks left from the old acne and even that is fading from doing lactic acid peels and using oils. I am positive my skin will be 100% clear and free of marks very soon, and imagine I went from getting 3-4 new cystic acne every day. Try it!!
amazing drug to try after trying everything else
I had very mild acne through high school and college (which I regret not appreciating at the time haha), but soon after graduating from university I decided to stop other meds (ADHD, depresssion), and the combination of that with finally getting some breathing room after 8 years of very intense schooling, probably released a bunch of toxins and caused my hormones to go into haywire. I tried antibiotics, Accutane, all the creams, facials. Nothing worked as well as spironolactone. I started on 100mg/day, but was really dehydrated, then went down to 75mg. After a year and a half of that dose, I went down to 50mg and am comfortable with this dosage. I and still get an occasional pimple but it will clear up in a day or so, whereas when I wasn't on spirono, I couldn't know when it would go away. However, I feel like I'm dependent on the medicine. I hope to, in the next year or so, go to 37.5 then 25, and eventually go off of it altogether, but I am anxious about the difficulty of that. Also, if you are hoping to get pregnant, you have to be off of this for at least a month before you can safely conceive. So if that is an immediate desire, I would stay away from this drug. If you don't want kids, I totally recommend it. It has redeemed my self esteem, but I'm unsure what the long term effects are. I do have occasional cramps and my periods are sometimes irregular, and I drink a ton of water, but my skin looks amazing. (I also use Rodan & Fields unblemish line, which helped me reduce to 50mg, with Oil of Olay Regenerist, as well as a prescription retinoid). I also think it might aggravate depression in some people, particularly with alcohol. So I would recommend reducing or remove alcohol altogether. In conclusion, I would say try everything else-with regards to foods, sugar intake, etc. before starting this, especially if you are hoping to become pregnant. But if that isn't a desire for you, I would try this incredible medicine. And if you do, be patient. It will work. But continue to listen to your body. *~~*~~*
TRUST ME AND READ THE WHOLE THING
I'm a 21 year old female that is caucasian and has fair skin that is extremely sensitive. Although my skin is sensitive, I struggle with oily acne prone skin. A couple of years ago I was given Bactrim at a pretty high dose to try and combat my acne. It worked! almost a week in, the acne was gone and the scars were disappearing. It was seriously an acne miracle. Although, every time I went off of the medication my acne returned with a fight. My derm didnt want me to be on bactrim forever since it is a pretty intense drug and isnt meant for forever use. Finally, I asked my dermatologist for me to try spironolactone. I have PCOS and knew my acne must be related to hormones. It was deep and cystic and never was a simple pimple or two. The first week (50 mg) my acne was the same. The second week (50 mg) my acne got worse. During this time I was still taking a pretty high dose of bactrim to get me through the initial breakout phase. After a month the initial breakout started to end and my skin returned back to its normal self (cystic acne like normal) I then upped my dose to 100 mg. My skin then had another initial breakout but wasn't nearly as bad as before. At about 2 months is when I saw some improvement in my skin. Anytime before that my skin was the same if not worse. My skin at this time was softer and my pores were smaller. I started to decrease my bactrim dose and to my surprise I wasnt breaking out as much as I would have before if I had lowered my bactrim dose. Before, my skin would breakout if I went even a day without taking my bactrim medication. At three months my skin improved even more. It was softer and i wasnt getting deep cystic acne but moreso regular pimples like anyone else. At four months my skin was getting softer, firmer, and less oily while having no cystic breakouts and no antibiotic medication. The first couple of months were rough but trust me, you just have to wait! It gets better. My skin is NOT perfect. but its 90 percent better than before.