Differin is the only product to finally clear my cystic acne. I am 38 years old, and started my battle with the dreaded chin cysts in my early 20's. I will share my story in hopes it helps you. I am red head and fair skin that is not only sensitive and reactive but also partly oily and was prone to painful, ugly, embarrassing cysts. All of the other acne products caused redness and flaking. An old boyfriend once told me, Eew, it looks like your face is peeling off. That was horrifying. No amount of makeup would help and actually often made it look worse. As I have become older and became more established in my career it has been even more embarrassing to show up with acne. So anyways fast forward to today, September 2018. I discovered Differin OTC in May 2017. I was afraid of the dreaded purge and other side effects of retinoids like flaking peeling and dryness. So I started VERY slowly. I mean i used a pea sized amount once every 3 or 4 days. And lots of gentle moisturizer. And NO OTHER ACNE PRODUCTS. I emphasize because i had literally no negative sode effects and I think it was because I was serious about being careful. About 3 or 4 months later I was able to use Differin every night. I can honestly tell you I have not had a single cyst since May 2017. And I did finally get one this month, but it helped me realize it's been over a year since I had to deal with a cyst, and that's not bad. So i did end up going to my Derm for a cortisone injection, and she recomend I move up to the stronger Rx Adapalene now. Apparently it might aslo be good for wrinkles so that's cool, too.