I've been on just about every acne treatment there is, including three courses of isotretinoin (Accutane). Accutane did clear me completely but after a couple of months being off it, my acne would return, although not as bad as it had before. After my last course of accutane I was left with mild/moderate acne and I felt nothing else could work. I looked back through my treatments and realized I'd never been offered a Benzoyl Peroxide based treatment. This is the only product as far as I know that contains BP that can be bought over the counter in the UK. I tried it as a last-ditch effort and the results have been great. I use it once or twice a day with a moisturizer and for me the dryness is not even noticeable. However, if you suffer from dry or sensitive skin, it may be too harsh.